「『拙藁千百』 譯註」(7) : 권1「金文正公墓誌」의 분석을 중심으로

이진한(Lee, Jin-Han),김보광(Kim, Bo-Kwang),김규록(Kim, Kyu-Rok) 고려사학회 2014 한국사학보 Vol.- No.55

『졸고천백』은 2권으로 된 최해의 문집이다. 최해는 주로 고려에서 활동하다가 정치적으로 소외되어 크게 현달하지 못하고 40세 정도에 은퇴하였다. 그는 대신 이제현, 이곡, 최문도 등 당대 최고의 문인과 교유하였다. 이 논문에서는 『졸고천백』중 권1의 15번째 글인「김문정공의 묘지」라는 글의 특징을 살피고, 번역 및 주석의 작업을 하였다. 이 글은 고려후기의 인물인 김태현을 위한 묘지명이다. 1261년에 태어난 김태현은 1276년(충렬왕 2)에 과거 급제한 이래 1330년에 사망할때까지 거의 대부분의 시기를 관원으로 활동하였다. 이 시기에 고려는 충렬왕과 충선왕의 重祚, 충선왕의 활동 및 토번 유배, 입성책동 등 굵직굵직한 정치적 사건을 겪었다. 이러한 정치상황에 따라 그는 관직 경력 상의 부침을 겪었는데, 「김태현묘지명」에서 주목되는 몇 가지를 정리하면 아래와 같다. 1) 아버지인 김수에 대한 기록이 주목된다. 삼별초가 제주도로 들어가려 할 때 제주로 파견되어 이를 막으려다 전사하였다는 내용이 실려 있다. 2) 김태현이 1280년에 충렬왕이 직접 선발한 시험에 합격하여, ‘전시문생’이라 불리면서 충렬왕의 측근으로 활동했다. 3) 그래서 충선왕이 1298년에 즉위하였을 때 그가 면직되었다는 사실 등 여타 기록에서 찾을 수 없는 경력을 이 묘지명을 통해서 확인할 수 있었다. Cholgo Ch"onbaek is a two-volume anthology of Choi Hae. He mostly worked in Goryeo, then later became politically isolated and made an early retirement at around 40 without significant achievements. This study examined the characteristics of ‘the epitaph for Kim Tae-hyun,’ the 15th entry in the book, and translated and annotated the original text. Mr. Kim was born in 1261, passed the state examination in 1276, and served as a government official most of his life until his death in 1330. This was a politically turmoil period that saw the enthronement, dethronement, as well as reinstatement of King Chungryeol and King Chungseon, the exile of King Chungseon to the present-day Tibet (Tobun at the time), the Mongol intervention in the Goryeo territory. Amid these political unrest, Mr. Kim’s career fluctuated as well. Some of the events are recorded in the work, which cannot be found elsewhere: 1) His father Su Kim is mentioned, who was dispatched to Jeju Island and killed there while trying to keep Sambyeolcho(a special capital defense unit) from entering the island. 2) Mr. Kim passed a state test directly overseen by King Chungryeol in 1280, and worked as a close aide to the king with a title Jeonsi-munsaeng(king"s students). 3) He lost his post when King Chungseon was enthroned in 1298. 4) The record shows that in the early 1300s, the Yuan dynasty operated 11 stations between Gaepyung and Gamsukseong.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

정신장애인 치료에 중요 역할 담당자의 정신질환에 대한 태도조사

김병후,정선욱,강연화,김윤,김창엽,홍진표,한오수,조맹제,김용익 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.5

Objectives : Attitudes of families of mentally ill, health personnels and community leaders to the mentally ill after the development and utilization of the community mental health program and reintegration of the chronically ill patients into society. This study was designed to compare the attitudes toward the mentally ill patient of the persons who have important role in treating the mentally ill and to find the variables influencing the attitudes. Methods : We measured attitudes toward mental illness in psychotic patients' families(N=139), community leaders(N=180) and health personnels(N=324) including mental health personnels before the implementation of community mental health services in Yonchon county and Seodaemun district area. The instrument used to measure attitudes was Opinion about Mental Illness(O. M. I.) scale. Results : 1) Health personnel showed lower Authoritarianism(Factor A) and higher Benevolence(Factor B) scores on the average than community leaders and psychotic patients families. 2) Current residence affect the attitudes in psychotic patients' families, not in community leaders and health personnels. Families in urban area showed lower Authoritarianism(Factor A) and Social Restrictiveness(Factor D) and higher Benevolence(Factor B) scores than in the rural areas. 3) Many patient variables were correlated to the attitudes of families. Duration of illness, number of recurrence, number of admission, age of patient and family burden were positively correlated mainly to Social Restrictiveness(Factor D). 4) Sex and religion of respondents showed no or weak relationship with the factor scores. Conclusions : Education for community leaders and families is required to achieve successful community mental health services. Community support program should be developed for chronic, recurrent and burdensome psychiatric patients in the first place.

Research Trends in Young Children’s Theory of Mind using Keyword Network Analysis

Han,Yoo-Jin(Yoo-Jin Han),Kim,Ho(Ho Kim) 경인교육대학교 교육연구원 2022 교육논총 Vol.42 No.-

This study aims to investigate the trends in research and find implications for future research to understand the characteristics of young children’s theory of mind from 1997 to 2021. Out of the research papers published in journals in the field of early childhood education, 175 articles that fit the purpose of this study were analyzed using network analysis methods. The summary of the analysis results was as follows: First, in the study of young children’s theory of mind, “theory of mind”, “false belief”, “pretend play”, “emotion”, “executive function”, “social ability”, “story”, “young children”, “peer competence”, and “picturebook” showed high frequency. Second, it can be seen that the network structure for each period gradually changes from the first to the third periods. This demonstrated that while the research of theory of mind was somewhat slow but steadily active, the keywords identified in the early childhood theory of mind study evolved into a broad and rich array. Based on the results of this study, this study suggests diversification of the theory of mind research to perspectives of social cognition development of young children.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

한강시민공원 체육시설 현황과 효율적 활용 방안에 대한 연구

한진욱,김진호 경희대학교 체육과학연구소 1999 體育學論文集 Vol.27 No.-

The aim of this study is primarily to examine the current state of the sports facilities for the Han-Gang Citizens' Park and to propose its effective utilization plans for the coming 21st century. The main findings and conclusions can be described as follows: 1.Strengthening of publicity fucntions 2.To provide citizens with various means of easy access to the Park such as shuttle buses and samaul buses 3.Developments of new programs for the disabled and senior citizens 4.Extensive utlization measures for the evening hours 5.To make the Park distictive according to each distict 6.Reorganization of the Parks' administrative structures 7.Diversification of programs, and training and retaining instructors of an excellent caliber.

경찰관의 운동참여에 따른 직무 Stress와 직무만족에 관한 연구

김종달, 남덕현, 이한경, 반종진 용인대학교 체육과학연구소 2000 體育科學硏究論叢 Vol.10 No.1

This study is for the purpose of examining effects related to duty stress & duty satisfaction due to Police of officers' Physical exercise participation, helping more efficient duty Performance, and positive self-formation. Furthermore, providing basic data that can be helpful to the improvement of police duty. The objects of the study were police officers who were taking part in education program in Police Comprehensive Academy, and the number of police officers who answered the questionnaire is 356 police officers, but data used for real analyzation consist of 300 police officers. The tools for the study were based on Ivancevich's duty stress model in order to measure stress. And also questionnaire used on Kim yoon hee, Kim mae ja, Jo kyung soon, Lee hart kyung's study was used as a complementary tool. The instrument for measuring duty satisfaction rate was developed by Paula. And I used the instrument based on questionnaire that was used by Ko hee soon, Park ki hyung, Kim bum sik, Lee jong kil, Lim bun jang, Jo young chang, Hackeman, Lawlar and Oldham's study. Data analysis is Processed statistically with SPSS/PC+, I Performed T-verification, ANOVA-verification in accordance with the purpose of study after getting the percentage and the real number in case of general characteristics of the objects, and examine an average and standard variation in case of duty satisfaction and duty stress rate. And I set an err rate to 0.5. I verificated co-relation between stress and duty satisfaction with Pearson Correlation Coefficient. The result of the study is as follows, The first, among sociological characteristic and external factor of duty satisfaction, The married is more significant statistically(p< .01, p<.05) compared to the unmarried in terms of compensation system and working condition , which are subfactor of duty satisfaction . In terms of the length of one's service, the longer service term one has the higher significance level one shows in compensation system, working condition, safety, and external factor which are sub-factors of duty satisfaction In terms of an academic background, one who graduated from a high school shows significance statistically only in working condition which is a subfactor of duty satisfaction compared to other people (p<0.5) The second, among sociological characteristic and internal factor of duty satisfaction, the married is more significant statistically(P<.05) compared to the unmarried in terms of achievement which is a subfactor of duty satisfaction. In terms of age the older one shows higher significance level in stability which is a subfactor of duty satisfaction compared to younker one(p<.05) In terms of the length of one's service the longer service term one has ,the higher significance level one shows(p<.01, p<.05). The third, in terms of duty stress due to sociological variable, the married is more significant statistically(p<.05) in case of stress stems from police duty than the unmarried Interms of age, welfare and duty stress are significant statistically(P<.05) Interms of the length of one's service, police's work is significant statistically(P<.05). One who graduated from junior college is significant statistically in police's work, welfare, stress and gets a lot of stress in personal relations(p<.05). The forth, groups participating in exercise are more significant statistically in stability(p<.001), feeling of stability(P<.001), achievement(p<.001), internal factor(p<.01), external factor(p<.05) than croups not Participating in exercise. The fifth, groups participating in exercise are more significant statistically only in personal management than groups not participating in. The sixth co-relation between duty satisfaction and duty stress is r=-0.3814, (P<.001) ,which shows opposite co-relation. so, a result the more stress one has, the lower duty satisfaction he gets.

제왕절개술 환자에서 수술전 투여한 ketamine의 혈청 interleukin-6 및 수술후 통증에 대한 효과

김진수,김유재,안기량,김천숙,김일호,한찬수 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

The inflammatory reaction to tissue damage during surgery may induce central sensitization followed by hyperalgesia. Previous studies suggest that central sensitization is related to N-methyl-D-aspartate (NMDA) receptor activation, which can be blocked with NMDA antagonist, ketamine. Thus, we compared the effect of preoperative intravenous and epidural low doses of ketamine with placebo on serum interleukin-6 (IL-6) level and postoperative pain. ASA class I and II women scheduled for C-sections received intravenous ketamine 0.15mg/kg(group 2) or placebo(group 1), or epidural ketamine(0.15 mg/kg) before the operation. IL-6 levels were measured before and during the operation, and 8, 24, and 48 hrs after the operation. Visual Analogue Scales(VAS) and Verbal Ration Scales(VRS) were measured at 8, 24, and 48 hrs after the operation. Serum IL-6 levels at 8, 24, and 48 hrs after the operation were significantly lower in the intravenous ketamine and epidural ketamine groups than in the control group. VAS at 8 hrs and 48 hrs after the operation were significantly lower in the epidural ketamine group. VAS at 8 hrs and 48 hrs after the operation were significantly lower in the epidural ketamine group than in the control and intravenous ketamine groups. In conclusion, in the preoperative intravenous and epidural administration of low doses(0.15mg/kg) of ketamine, both are effective in reducing postoperative IL-6 levels. Epidural Ketamine is more effective than intravenous ketamine in postoperative pain control.

배달 미니 게임 개발:"최고의 웨이터를 꿈꾸며"

김정훈,정한교,김영옥,김중곤,박정윤,윤진성,김경식 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

본 미니 게임은 웨이터라는 직업을 모티브로 하여서 남녀노소 누구나 재미를 느낌과 동시에 기억력 향상시켜 주는 게임제작이라는 목적아래 제작되었다.본 논문에서는 이 게임의 제작과정을 기술하고자 한다.이 게임은 제3회 AGC(한국 아마추어 게임제작 공모전)에서 우수 작으로 선정되었다.

Differential Manifestation of Ocular Phenotypes in TALEN-mediated p19arf Knockout FVB/N and C57BL/6J mouse lines

Jin‑Sung Park,Joo‑Il Kim,Hyun‑Jin Lim,Soo‑Kyung Ryu,Euna Kwon,Kang‑Min Han,Ki‑Taek Nam,Han‑Woong Lee,Byeong‑Cheol Kang 한국유전학회 2020 Genes & Genomics Vol.42 No.9

Background p19arf, primarily known as a tumor suppressor, has also been reported to play an essential role in normal development of mouse eyes. Consistently, lack of p19arf has been associated with ocular defects, but the mixed background of the knockout (KO) mouse strain used raised a concern on the accuracy of the phenotypes observed in association with the targeted gene due to genetic heterogeneity. Object We carried out a study to investigate into the efect of genetic background on the manifestation of p19arf KO associated phenotypes. Methods We characterized the phenotypes of novel p19arf KO mouse lines generated in FVB/N and C57BL/6J using a transcription activator-like efector nuclease (TALEN) system in comparison to the reported phenotypes of three other p19arf-defcient mouse lines generated using homologous recombination. Results Ninety-fve percent of FVB/N-p19arf KO mice showed ocular opacity from week 4 after birth which worsened rapidly until week 6, while such abnormality was absent in C57BL/6J-p19arf KO mice up to the age of 26 weeks. Histopathological analysis revealed retrolental masses and dysplasia in the retinal layer in FVB/N-p19arf KO mice from week 4. Besides these, both strains developed normally from birth to week 26 without increased tumorigenesis except for a subcutaneous tumor found in a C57BL/6J-p19arf KO mouse. Conclusion Our fndings demonstrated surprisingly variable manifestation of p19arf-linked phenotypes between FVB/N and C57BL/6J mice, and furthermore between our mouse lines and the established lines, indicating a critical impact of genetic background on functional study of genes using gene targeting strategies in mice.