랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구

김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

지체장애 아동의 놀이 환경 기본 계획에 관한 연구

김영은,강병근,성기창,이건하 한국의료복지시설학회 2003 의료·복지 건축 Vol.9 No.2

The elements of a medium for gathering the able bodied and the disable bodied children are examined within the scope of this study. Starting from the importance of play for the children, the characteristics and the properties of middle childhood are closen as domain. This study showed that though most of the playground sites were accessible to Physically disabled Children, and were safety. For Physically disabled Children. the opportunities to play in a play area depend largely on the accessibility of the facilities. this study also explored the play experience of children with disability. The play spaces and the playgrounds including the equipment are examined. The results of study suggest there be creatived planning items in terms of accessibility and domain, which in detail. are summarized in following six points: Accessibility. Barrier-free. convenience, movement, safety. domain. A guideline on the design of an accessible & safety playground for Physically disabled Children should be made.

횡문근 용해증이 동반된 원발성 갑상선기능 저하증 1예

김하영,조정구,박병현 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1

순천만 갯벌의 식생에 관한 연구

김종욱,임현빈,김하송,이점숙,임병선 木浦大學校 沿岸環境硏究所 1998 沿岸環境硏究 Vol.15 No.1

순천만 조간대 염생식물조사를 위하여 주요 염생식물군락을 선정하고 식생분포 및 현존량을 조사하였다. 우점군락은 갈대군락(Phragmites communis community), 칠면초군락(Suaeda japonica community), 부들군락(Typha orientalis community), 나문재군락(Suaeda asparagoides community), 모새달군락(Phacelurus latifolius community), 가는갯능쟁이군락(Atriplex gmelini community), 갯잔디군락(Zoysia sinica community), 갯질경군락(Limonium tetragonun community) 및 실망초군락(Erigeron bonariensis community)으로 구분되었다. 칠면초군락은 순천만지역에서 가장 넓게 분포하고 있으며, 군락의 높이는 25∼38cm, 식피율은 90∼100%, 단위면적당 368∼608개체/㎡이었고, 갈대군락의 높이는 100∼250cm, 식피율은 85∼100% 및 단위면적당 320∼368개체/㎡으로 순천만 하구 주변을 중심으로 분포하고 있으며, 해안 염소택지와 하구 기수역을 중심으로 생육하고 있었다. The coastal vegetation was classified by the Braun-Blanquet's method at the wetland of Suncheon-Man. The vegetation of the study area was classified with 9 coastal communities as follows : Phragmites communis community, Suaeda japonica community, Typha orientalis community, Suaeda asparagoides community, Phacelurus latifolius community, Atriplex gmelini community, Zoysia sinica community, Limonium tetragonun community and Erigeron bonariensis community. Suaeda japonica community was major dominant species and was 25∼38cm in height, 90∼100% in cover and 368∼608 individuals per ㎡, and Phragmites communis community was 100∼250cm in height, 85∼100% in cover and 320∼368 individuals per ㎡.

에스테르 交換反應에 對한 醋酸鹽 觸媒의 影響에 關한 硏究

孫秉淸,金德夏 弘益大學校 1982 弘大論叢 Vol.14 No.2

The transesterification reaction between dimethylphthalate and ethyleneglycol was kinetically investigated in the presence of various metal acetate catalysts at 185℃ The reaction was followed by the measurement of distilled methanol from the reaction vessel. The transesterification was found to obey thiry-order kinetics with respect to dime thylphthalate and ethyleneglycol and catalyst. From the examination of relationship between rate constants and reciprocal absolute temerature, the activation evergy has been calculate as 25.90 Kcal with cobalt acetate catalyst. The highest reactivities were found for the metal acetate catalysts with the electron egativity values between 1.4 and 1.7.

DP-Matching과 HMM을 이용한 온라인 필기 한자 인식

윤병훈,김형태,하진영 강원대학교 정보통신연구소 2007 정보통신논문지 Vol.11 No.-

On-line handwritten Chinese character recognition systems should be fast and yield accurate results in order to be practical systems. DP-matching method for variable length input requires building several allographs (multiple models) per class, which inevitably reduces the recognition speed. HMM is a good alternative, since one HMM per class is usually sufficient to model large variation of data. We proposed a recognition system in which HMM and DP-matching method are combined to improve the recognition speed and recognition accuracy at the same time. The HMM method using structure code features produces recognition candidates, then DP-matching method using chain code features reorders the candidates to get more accurate results. In doing so, we accomplished fast and accurate recognition results for 2,362 Chinese character classes. We also adopted result verification method to discriminate confusable character classes. We got 97.44% recognition accuracy using the proposed method in 113 ms per character in average.

Heterosigma akashiwo의 psbA 유전자 구조 특성

문병용,이진하,김상해 인제대학교기초과학연구소 1999 자연과학 Vol.3 No.-

Heterosigma akashiwo로부터 광합성에 중요한 psbA 유전자를 찾고 그 구조를 분석하였다. H.akashiwo에서 전체 DNA를 추출하고 psbA유전자에 특이적인 primer들을 사용하여 PCR로 증폭시켰다. 증폭된 약 1.2kb 크기의 DNA를 pGEM-3Z vector에 클로닝시키고 염기서열을 결정하여 유전자 구조를 조사하였다. 결과, 360개의 아미노산으로 구성된 D1단백질의 암호 지역과 원핵생물의 특징적인 promoter 구조 그리고 ribosome 결합자리를 확인하였으며 D1 단백질의 카르복시 말단 부위에는 엽록소 b를 포함하지 않은 cyanobacteria처럼 특징적인 7개 아미노산이 첨가된 특징을 알 수 있었다. 다른 광합성 생물들의 psbA 유전자와 비교하였을 때 고등식물과는 DNA 염기서열에서 83.3%, 아미노산 서열은 91%의 유사성을 보였으며, cyanobacteria와는 DNA 염기서열은 75.2%, 아미노산 서열은 82%의 유사성을 보였다. 또한 psbA mRNA의 5'-말단 부위에는 번역과정의 조절 부위로 작용할 수 있는 이차구조를 확인하였다. The psbA gene was isolated from Heterosigma akashiwo and its structure was characterized. The psbA gene of about 1.2kb size was amplified from genomic DNA of H. akashiwo by PCR and the nucleotide sequences were determined. A coding region for D1 protein containing 360 amino acids, a promoter element like prokaryotic promoter, and ribosome binding site exist in psbA gene of H. akashiwo. There was addition of the motif consisting of seven amino acids at carboxy terminus region like in cyanobacteria. As the nucleotide and amino acid sequences of H.akashiwo psbA gene were compared with those of higher plant, Spinacia and cyanobacteria, homologies in nucleotide and amino acid sequences between H.akashiwo and Spinacia were 83.3% and 91%, respectively. Those between H.akashiwo and cyanobacteria were 75.2% and 82%, respectively. A secondary structure being act as cis-acting element in translational regulation of psbA gene was showed at 5'-terminus of mRNA.

문자 단위 매칭과 유닛 단위 매칭을 이용한 온라인 필기 한자 인식

윤병훈,김형태,박미나,하진영 강원대학교 정보통신연구소 2006 정보통신논문지 Vol.10 No.-

This paper presents on-line Chinese character recognition methods based on DP-Matching. The recognition system consists of character matching and unit matching methods. The character matching method adopts DP-matching between the input data and models as a major matching method, while unit matching method uses relation matching between consecutive units (part of character) in addition to DP-matching between units. A couple of methods combining character matching and unit matching methods were examined also. We found that we got best recognition result applying unit matching methods to the recognition candidates from character matching method.

외고정 장치를 이용한 경골 원위부 개방성 분쇄골절의 치료

이병호,하상호,김경호 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Background and Objectives : To assess the clinical results of the open comminuted distal tibia fractures managed with two types of external fixators. Materials and Method : Thirty-nine patients, who were treated with Ilizarov (n=23) or Orthofix (n=16), were classified according to the AO classification: 8 B2; 9 B3; 5 C2; 10 C3. The average follow-up periods were 22 months. The clinical results were compared between the two types of external fixators based on the fracture pattern, severity of soft tissue injury, union rate, and complications. Results : The bony union rates were 65.2%(15/23) in Ilizarov external fixator group without secondary procedure, 25%(4/16) in Orthofix group without secondary procedure, and 87.5%(7/8) in Ilizarov group with secondary procedure, and 83.3%(10/12) in Orthofix group with secondary procedure. The incidence of complications was 52.2%(12/23) in Ilizarov group and 56.3%(9/16) in Orthofix group. Conclusion : Ilizarov external fixator is considered as a more useful method for treating the open comminuted distal tibia fractures of the adult compared with Orthofix external fixator. However, careful intraoperative management needs to avoid angular instability which can occur in Ilizarov method.