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        • KCI등재

          Unmet Clinical Needs in the Treatment of Patients with Thyroid Cancer

          김원배,전민지,김원구,김태용,송영기,김원배 대한내분비학회 2020 Endocrinology and metabolism Vol.35 No.1

          The increased incidence of thyroid cancer is a worldwide phenomenon; however, the issue of overdiagnosis has been most prominent in South Korea. The age-standardized mortality rate of thyroid cancer in Korea steeply increased from 1985 to 2004 (from 0.17per 100,000 to 0.85 per 100,000), and then decreased until 2015 to 0.42 per 100,000, suggesting that early detection reduced mortality. However, early detection of thyroid cancer may be cost-ineffective, considering its very high prevalence and indolent course. Therefore, risk stratification and tailored management are vitally important, but many prognostic markers can only be evaluatedpostoperatively. Discovery of preoperative marker(s), especially for small cancers, is the most important unmet clinical need for thyroid cancer. Herein, we discuss some such factors that we recently discovered. Another unmet clinical need is better treatment of radioiodine-refractory (RAIR) differentiated thyroid cancer (DTC) and undifferentiated cancers. Although sorafenib and lenvatinib areavailable, better drugs are needed. We found that phosphoglycerate dehydrogenase, a critical enzyme for serine biosynthesis, couldbe a novel therapeutic target, and that the lymphocyte-to-monocyte ratio is a prognostic marker of survival in patients with anaplasticthyroid carcinoma or RAIR DTC. Deeper insights are needed into tumor-host interactions in thyroid cancer to improve treatment.

        • 친환경농업 - 영양만점 어린잎채소의 친환경 안정생산

          김원배,Kim, Won-Bae 전국농업기술자협회 2012 농업기술회보 Vol.49 No.5

          셀러드나 생식, 요리장식 소재로 이용하는 어린잎채소(베이비채소)가 웰빙시대의 건강 식단으로 각광을 받고 있다. 농가의 고소득 작목으로써 재배가 해마다 늘어나고 있으며, 그동안 관련기술의 연구개발을 통하여 친환경 어린잎채소의 연중 안정적인 공급이 가능하게 되었다.

        • KCI우수등재

          DCP가교 Trans-polyoctenamer의 기초적 특성 -범용주파수 및 저주파수영역에서의 동력학적 및 기계적 성질-

          김원배,임승순 한국섬유공학회 1987 한국섬유공학회지 Vol.24 No.2

          The low frequency (10-2 to 1 Hz) dynamic mechanical properties were obtained over the temperature range of 55 to 150$^{\circ}C$ for trans-polyoctenamer networks prepared in the presences of 1, 1.5, and 2 parts dicumylperoxide. And also dynamic mechanical properties were obtained over the temperature range of -100 to 40$^{\circ}C$ for DCP crosslinked TOR. Incorporation of dicumylperoxide (DCP) with Trans-polyoctenamer(TOR) decreases the storage modulus and increases the mechanical loss(tan$\delta$). Glass transition temperature (Tg) is increased about 7$^{\circ}C$ for tenfold increase in frequency (11Hz-11OHz). The shift of Tg to higher temperature with increasing frequency has been occured in accordance with the time-temperature superposition. In dynamic mechanical properties of low frequency range, storage modulus is less sensitive for variation of frequency at higher crosslinking density. Activation energy and constant C1, C2 of W.L.F. eg. are increased by the increment of D.C.P. content in crosslinked TOR. But the values of C1, C2 are too large unusually. Thus, it is concluded that Arrehenius eq. is rather fitted than W.L.F. eq. for crosslinked TOR.

        • 고려인삼이 ACTH를 투여받은 어린 흰쥐의 부신 아스코르빈산 함유량에 미치는영향

          김원배,정하영 최신의학사 1972 最新醫學 Vol.15 No.5

          A study was planned to clarify the influence of ginseng upon stress mechanism in immature rats and to compare the findings with those observed in mature rats. Two hundred eighty immature male rats (body weight: 35-40 gm) were divided equally into the ginseng control, the saline control, the ginseng-ACTH and the saline-ACTH groups, according to the drugs they received. For 45 days the ginseng control and the ginseng-ACTH groups received 0. 5 ml/100 gm body weight of ginseng alcohol extract solution (4 mg of extract dissolved in 1 ml saline) while the saline-control and the saline-ACTH groups received the same amount of saline. Ten animals at a time of the ginseng-ACTH and the saline-ACTH groups received one dose of 0. 01 unit ACTH once on the 1st, 5th, 10th, 15th, 25th, 35th or on the 45th experimental day 1 hr after ginseng or saline administration. After another hour, these animals and 10 animals each of the ginseng control and the saline control group animals had their adrenal glands removed under deep anesthesia. Adrenal ascorbic acid content was measured colorimetrically utilizing the reduction of 2, 6-dichloro?phenol-indophenol sodium. Following results were obtained: 1. The adrenal ascorbic acid content of the ginseng control group did not differ significantly from that of the saline control group throughout the experimental period. 2. The adrenal ascorbic acid content of the ginseng-ACTH group was significantly less than that of the ginseng control group but significantly higher than that of the saline-ACTH group through the experiment. From the above results, it is inferred that the ginseng has no influence upon the adrenal ascorbic acid content of immature rats under normal condition, but that the drug does mitigate a fall in the ascorbic acid content under the influence of ACTH. The results are found to be in good accordance with those observed in mature rats.

        • KCI등재후보

          재발한 분화갑상선암의 치료

          김원배 대한갑상선학회 2014 International Journal of Thyroidology Vol.7 No.1

          Patients with well differentiated thyroid carcinoma (WDTC) generally have good prognosis with appropriate therapy, but those with recurrences have higher disease specific mortality and poor quality of life requiring clinical attention. Recurrences occur in 5-20% as loco-regional form and as distant metastasis in 10-20% in long-term follow-up after initial therapy. Soft tissue recurrences as a form of local recurrence require aggressive therapy including wide excision and postoperative adjuvant therapy as they have dismal prognosis. There are controversies in proper management of loco-regional recurrences in neck lymph node, because improvement in clinical outcome of those patients through randomized, prospective study had never been documented and because it is not clear if lymph node recurrences could be a focus of further metastasis of cancer cells. Management includes surgery (compartment-oriented lymph node dissection), alcohol injection or radiofrequency ablation and simple observation. Adjuvant radioiodine therapy is not useful after re-operation, especially high dose radioiodine had been done as initial therapy. Recurrences as distant metastasis require thorough evaluation and proper management according to site and progression of each lesion. Palliative surgery if critical structure is endangered, radioiodine therapy in “radioactive iodine (RAI)-avid” lesions, external beam radiation therapy or IV bisphosphonate, embolization should be considered in bone metastasis according to clinical setting. RAI-avid lung metastasis can be managed with radioiodine, but there is no available therapeutic modality in ”non-RAI-avid” lung metastatic lesions. Clinical trials using new targeted agents can be considered in those patients. There had been many trials to enhance/restore iodine uptake in metastatic lesions, but there is no clinically available agent yet. Further studies are required for development of agents to restore/enhance iodine uptake to improve efficacy of RAI therapy.

        • KCI등재후보
        • KCI등재

          한국의 경제위기와 지역 탄력성

          김원배,신혜원 국토연구원 2013 국토연구 Vol.79 No.-

          As economic globalization deepens, economic crises occur frequently and thus the internal and external environment surrounding regional economies constantly fluctuates. Regional strategies to guarantee the long-term development of a region with adaptability to crisis and change are more than necessary. This study makes a preliminary investigation on how regions have been affected by the two crises, what structural changes regions have gone through, and why regions have had different experiences. Borrowing the concept of regional resilience, this study attempts to classify regional types. According to the time periods set up around the two crises, regional changes are explained by regional value added and employment. Simple correlation test is performed to find out which factors are responsible for the differential results by region. Based on changes in regional value added and employment, regions are classified into four types: thriving, stagnant, transformative and faltering. Finally, preliminary policy implications are derived from the above results. 경제의 세계화가 심화되면서 경제위기가 점점 빈번해지고, 지역을 둘러싼 내˙외부 환경도 부단히 변화해가고 있다. 위기에 대한 탄력성을 갖추고 장기발전을 담보할 수 있는 지역 전략이 무엇보다 필요하다. 본 논문에서는 두 차례의 경제위기에 따라 국내 지역이 어떤 영향을 받았으며, 어떤 구조적 변화를 겪었는지, 그리고 왜 지역에 따라 상이한 결과를 낳게 되었는지를 탐색하고 있다. 또한 최근 서구에서 논의되고 있는 지역 탄력성의 개념을 빌려 정책의 틀을 짜기 위한 지역유형 구분을 시도하고 있다. 구체적으로 두 차례의 위기를 중심으로 한 시기 구분에 맞추어 지역 총부가가치 및 고용의 증감률을 중심으로 지역경제의 변동을 설명하고, 상이한 결과에 영향을 미치는 인자들과의 상관관계를 분석하였다. 또한 총부가가치 및 고용 증감률을 기준으로 하여 지역 탄력성을 번성, 침체, 변환, 추락의 네 가지 유형으로 구분하였다. 이와 같은 지역경제의 탄력성에 대한 초보적 분석을 통해 지역경제의 장기 탄력성을 제고하기 위한 정책 시사점을 도출하고 있다.

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