정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Study on Reliability Improvement of Voltage Transformers by Increasing Voltage Factor

Tae‑Sik Kong,Hee‑Dong Kim,Hung‑Sok Park,Soo‑Hoh Lee,Soon‑Yong Kim,Pil‑Bum Joung,Jin‑Yeub Park 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.3

Voltage transformers (VTs) must be highly reliable as they are essential components of the electric power industry. VT failures can cause a signifcant impact for important facilities such as nuclear power plants. In fact, VTs which passed the international standard, were damaged and sometimes resulted in the shutdown of the nuclear power plants. In order to improve the reliability, VTs with various iron core was studied. The electromagnetic feld simulation, a saturation characteristics test, and an overvoltage breakdown test were conducted. The result shows that the magnetic fux density signifcantly afects the reliability of VTs. To increase the reliability of VTs, it is required to reduce the magnetic fux density by increasing the knee-point and voltage factor. Owing to limited installation space, increasing the size of the iron core is difcult. Instead, VT by decreasing the thickness of the conductor and increasing the number of turns, it was possible to reduce the magnetic fux density without the size change. Therefore, improved VTs were obtained by decreasing the thickness of the conductor and increasing the number of turns, and the improved reliability was verifed through a comparison test with existing VTs. The fabricated VTs shows a signifcantly higher saturation voltage and breakdown time than existing VTs. Thus, by proposed VTs can contribute the stable operation of the nuclear power plant and improve the manufacturer’s quality.

하악골에 발생한 골막 골육종

김태우,김승범,권혁찬,문선재,윤정훈,김형준,차인호,육종인,김진 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Periosteal osteosarcoma is a distinct entity of malignant bone tumor with characteristic clinical, morphological, and histological features within the group of juxtacortical osteosarcoma. Periosteal osteosarcoma is predominantly located in the tubular long bones, and extremely rarely involving the jaws. A case of periosteal osteosarcoma of the right mandible is presented. A 27-year-old woman complained of the gingival swelling and bleeding tendency of the right posterior mandible. Clinical examination revealed a reddish brown strawberry-like swelling on the affected mucosa, which measured 1.5㎝×1.5㎝. The tumor was located on the lingual cortex of the mandible and extended into the surrounding soft tissues. Microscopically, the tumor consisted exclusively of atypical chondroblastic cells with a small osteoblastic area. A minimal bone marrow involvement was noted and the adjacent cortex was free of tumor. These findings suggested that the tumor originated from the periosteal cambium layer, which lies between the periosteal fibrous layer and the cortex of mandible.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

수술의 함정 : 중심성 신경세포종 2례 2 Cases of Central Neurocytoma

김범태,주교성,장채칠,신원한,최순관,변박장 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.3

GIS와 항공정사사진을 이용한 산림정보 관리시스템 구축

김준범,조명희,권태호,김인호,조윤원,신동호 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.2

우리나라 산림행정 업무의 대부분은 서류 및 대장에 의존하고 있는 실정으로 신속, 정확하고 다양한 업무 처리를 위해서는 첨단의 공잔정보기술을 이용한 과학적인 산림정보 관리시스템의 개발이 시급하다. 특히 지리정보시스템(GIS)과 항공사진 활용기술의 도입은 산림이용기본계획이나 산지개발, 산림자원 관리 및 산림보호 정책 등의 의사결정지원에 효율적으로 기여할 수 있을 것이다. 본 연구에서는 GIS와 항공사진(1998년도 촬영)을 기반으로 주요 산림정보인 수치지도, 수치임상도, 임야도 및 관련 속성데이터 둥을 가공하여 DBMS(data base management system) 내에 저장하였으며, 이를 기반으로 세부 응용시스템인 지번별 임야정보 검색, 산지이용개발 정보관리, 법정제한림 정보관리, 산림자원 정보검색 등의 인터페이스를 개발함으로써 산림 관련 실무자가 산림정보의 종합적인 공간분석 및 질의 검색이 가능한 산림정보 관리시스템을 구축하였다. 본 시스템의 구축으로 산림의 효율적 관리는 물론, 경제적인 산림자원 및 임산업 육성과 쾌적한 산림환경을 조성할 수 있을 뿐만 아니라 관련 부서들 간의 표준화된 공간 자료 공유와 과학적인 정보체계의 연동으로 산림자원 관리를 위한 집약된 공간 및 전자 정보화 인프라 구축의 기반을 마련할 것으로 사료된다. Recently in order to more effectively and scientifically process forest official tasks, which have been focused on documents and inventories, they should be applied with the up-to-date spatial information technologies. Especially, the forest resource information management based on GIS (geographic information system) and aerial orthophoto is expected not only to play an important role as DSS (decision support system) for domestic forest conservation policy and forestry development industry but also to service forest resource information toward people such as the owners of a mountain rapidly. In this study, the important forest information such as digital topography map, digital forest type map, digital forest cadastral map, digital aerial photographs and attribute data were first reprocessed and constructed in DBMS (data base management system). In addition, forest officials could analyze and retrieve forest information by using detail sub-application systems such as forest cadastral retrieval, forest land development information management, reserved forest information management and forest resource information retrieval. For this, the user interface is developed by using Visual Basic 6.0 and MapObjects 2. 1 of ESRI based on CBD (component based development) technology. The result of developing this system will not only perform constructing economical forest and better environment but also be the foundation of domestic spatial technology for forest resource management.

만성정신분열병 환자에서 Haloperidol이 유지용량감소에 의한 임상효과 및 Haooperidol, Reduced Haloperidol의 혈장농도에 관한 연구

김형섭,황태연,박용범,김명식,김광현 용인정신의학연구소 1997 용인정신의학보 Vol.4 No.1

Horizontal Variation of Primary Productivity and Enviromental Factors in the Lake Soyang

김범철,조규송,안태석 江原大學校 附設 環境硏究所 1989 環境硏究 Vol.6 No.-

소양호 일차생산력의 계절적 변화와 수평적 변이를 존사하기 위하여 Chlorophylla의 농도를 측정하고 Bannister의 model에 의해 일차생산력을 추산하였다. Bannister는 Smith의 P vs, I 관계식인 P=P_(max)I/(I_(k)^(2) + I^(2)^(1/2)을 변형하여 P=12Q_(max)K_(c)CI/ I^(2)^(1/2)과 같은 P vs. Chl. a의 관계식을 만들었다. 이 Model에 의해 추산된 소양호의 일차생산력을 보면 하류의 댐앞에서 연중 200∼2000mgC/㎡/day로서 봄에 가장 높고 여름과 겨울에 낮게 나타나는 계절적 변이를 보인다. 연간 생산량은 하류에서 약 250gC/㎡/yr로서 mestotrophic lake 수준인 것으로 판정된다. 상류에서 하류에 이르기까지 10여개의 정점에서 조사된 결과를 보면 수역에 따라 큰 차이를 보이고 있다. 대체로 봄과 가을에 하천의 유입부 근처에서 높은 값을 보이며 10,000mgC/㎡/day이상에 이르기도 한다. 이는 이곳에 우점 식물플랑크톤인 Peridinium이 밀집하는 현상때문이다.

편측안면경련에 대한 미세혈관압술시 수술시야 확보를 위한 방법으로서 소뇌피질동맥 박리술 - 수 술 수 기 -

김범태,임수빈,장재칠,신윈한,최순관,변박장 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.11

응급실내 중환자의 단기간 진정을 위한 Midazolam의 지속적 정주

김범주,정태오,진영호,이재백 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: The mechanically ventilated patient's stay in the emergency department(ED) is brief but ventilatory management and intervention must be optimal. Agitation, anxiety, distress, and discomfort are common complications for the ventilated patient. So, sedation is necessary to reduce these complications. Methods: Patients were monitored and mechanically ventilated. Midazolam was intravenously administered as loading dose(3-5mg), followed by continuous infusion at a rate of 0.06mg/kg/hr, titrated to achieve a predetermined sedation level(Ramsay's sedation score: 2-5 points, Glasgow coma score scale: 8-11 points). Results: After onset of predetermined sedation, systolic and diastolic blood pressure and heart rate remained stable during continuous infusion when compared with those of the initial state. Arterial blood gas and peak inspiratory pressure remained unchanged but respiratory rate was decreased to allowable ranges. Conclusion: A short-term continuous infusion of midazolam was a safe and effective method for sedation of ventilated patients in ED.