우리나라 인수공통전염병의 발생 현황과 관리 대책

임현술,김홍환 東國大學校醫學硏究所 2003 東國醫學 Vol.10 No.1

인수공통전염병(zoonoses)은 사람과 하등 척추동물간 또는 사람과 척추동물간에 발생하는 공통질환이다. 세계보건기구에 의하면 인수공통전염병은 200여종이나 되며, 우리 인간과 밀접한 관계가 있는 중요 질병만도 100여종이 된다고 한다. 인수공통전염병을 세균성, 리케차성 및 바이러스성 등으로 분류하여 수의학 및 의학 분야에서 연구발표된 논문과 정부에서 발표하는 통계자료를 중심으로 조사하여 우리나라에서 인수공통전염병의 발생 현황을 살펴보고 관리대책을 수립하고자 하였다. 우리나라에서 인수공통전염병은 과거부터 있었으리라 생각하지만 최초로 발생한 사례와 최근 재발생한 질환은 1975년 리스테리아균, 1977년 한탄 바이러스, 1982년 파스튜렐라병, 1988년 참굴큰입홉충, 1992년 Qduf, 1995년 작은와포자충증, 1997년 야생토끼병, 1998년 장출혈대장균 0-157, 1999년 라임병이 처음으로 보고 되었다. 1984년 렙토스피라증, 1988년 쯔쯔가무시병, 1994년 탄저병, 2002년 브루셀라증 등이 재발생하였다. 우리나라에서 최근 법정전염병 중에서 주요 인수공통전염병의 발생 현황은 쯔쯔가무시병, 신증후출혈열, 렙토스피라병, 발진열, 장출혈대장균병, 일본 뇌염등의 순으로 감소하여 발생하고 있다. 살모넬라증, 리스테리아증, 캄필로박터증, 여시니아증 등이 지속적으로 발생하고 있다. 가축 숙주에 의한 인수공통전염병으로 국내에서 발생한 질환은 공수병, Q열, 탄저병, 리스테리아증, 결핵, 파스튜렐라병 등이다. 야생동물 숙주에 의한 인수공통전염병으로 국내에 발생한 질환은 일본뇌염, 공수병, 발진열, Q열, 브루셀라증, 야생토끼병, 리스테리아증, 렙토스피라증, 사상충병등이다. 해외 유입 인수공통 기생출 질환은 우리나라 사람이 외국 여행 도중 감염된 경우와 외국인이 자국 또는 타국에서 감염되어 입국한 경우가 있으며, 바베스열원충증, 피부리슈만편모충증, 주혈홉충증, 이혈홉충증, 광동주혈선충증, 유극악구충증, 유충 피부이행중, 포충증 및 오구충증 등이 있다. 인수공통전염병은 인구 및 가축 수의 증가, 교통의 발달, 산업화에 기인한 생태 변화, 기상 이변 등 그 발생기전 역시 매우 복잡한 역학적 특성을 나타내며, 추후 예방 및 진단에 대한 각별한 대책을 요구하고 있다. 앞으로 인수공통전염병에 대하여 신속한 감시, 병원체 연구, 예방 및 관리를 효율적으로 운영할 수 있는 체계를 강화하여야 할 것이다. Zoonoses are diseases that primarily affect wild and domestic animals, but any infectious disease, which can be contracted by man. At present, about 200 human diseases are included in zoonoses and about 50 diseases are of importance in terms of number of cases and seriousness in human illness. Although some of zoonoses are generally recognized as significant health problems, actual prevalence and incidence of many zoonotic infections in humans and animals are not well determined. Therefore we reviewed important zoonoses, which were prevalent in the past and are prevalent at present in Korea in order of bacterial, rickettsial, and viral zoonotic infections. Important animal zoonoses in terms of seriousness in illness, which are newly prevalent in animals, are anthrax and rabies. Incidence of bovine tuberculosis dropped markedly but brucellosis is increasingly reported. Important human notifiable zoonotic infections in terms of number of cases reported and seriousness in illness, which are prevalent increasingly, are tsutsugamushi disease, hemorrhagic fever with renal syndrome, leptospirosis, and murine typhus. Incidence of Japanese encephalitis, anthrax. Q fever and rabies are rarely reported. Other non-notifiable human zoonoses such as salmonellosis, campylobacter infection, yersiniasis, listeriosis are also sometimes reported. Physicians and veterinarians must be concerned about specific environments and clinical patterns of zoonoses. They must make efforts to recognize, evaluate, and control the zoonotic diseases.

우리나라 인수공통전염병의 발생 현황과 관리 대책

임현술,김홍환 약업신문사 1984 의약정보 Vol.10 No.1

도시지역에서 선행강우지수를 고려한 저수유출 시뮬레이션 모형

허창환,임기석,송시훈,지홍기 대한상하수도학회 2003 상하수도학회지 Vol.17 No.1

This study is aimed at the development of a deterministic runoff model which can be used for low flow runoff. The model is formulated by the watershed runoff model. Based on the assumptions that runoff system is nonlinear, the proposed watershed runoff models are the conceptual model and artificial neural network model. In the model structures, the conceptual model divide the runoff system into a surface structure and a subsurface structure corresponding to the surface flow, and inter flow and ground water flow. The lag time effect of surface can be represented by the sub-tank of surface structure in the conceptual model. Fifteen neural networks models using Quasi-Newton technique were prepared to find the optimum parameters with each of them having different numbers of hidden layers and hidden layers nodes. The parameter calibration of inter flow and ground water flow in the subsurface structure of the conceptual model is made by separating the components with numeric filter. The runoff coefficient (α_2, K_1) is expressed as the function of antecedent precipitation index (API) in the conceptual model. The parameters related to the surface flow can be calibrated with the runoff coefficient (α_1, α_11, C_1, C_2) in the conceptual model. In the conceptual and ann model an algorithm are developed to calibrate the parameters automatically based on efficiency criteria. The conceptual model shows more closely to the observed hydrograph than ann model.

H₂- CO₂중에서 FeAl₂O₄의 생성기구와 CO₂중에서의 거동(II)

이홍림,정태환 연세대학교 산업기술연구소 1983 논문집 Vol.15 No.2

Fe₂O₃and Al₂O₃powders were mixed in molar ratio of Fe₂O₃/Al₂O₃= 1/2, and to these mixtures MgO powder was added 1,3,5,10,15,20 in weight %, respectively. The mixtures were pressed into pellets of 14mmΦ×14mm after well mixed in wet process using acetone. The pelletized specimens were heated at 1300℃ for 2 hours in air and again heated at 1200℃ for 5 hours in H₂- CO₂(H₂/CO₂=1/1) mixture before subjected to measurement of their electrical conductivities, compressive strengths, X-ray diffraction analyses etc. These specimens were again heated at 1200℃ for 5 hours in CO₂and their X-ray diffraction analyses and physical properties measurements were also conducted. Electrical conductivities, compressive strengths and other properties of the specimens were enhanced according to addition of MgO.

조기 및 진행성 위선암종에서 염증반응에 대한 면역조직화학적 그리고 전자현미경적 연구

김환정,임성철,서재홍 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Background and Object : Solid tumors progressively develop in parallel with a tumor stroma composed of new blood vessels, inflammatory cells and fibrosis Macrophages are a central component of this inflammatory reaction, and they can interact with the neoplastic as well as the stromal components of tumor tissue The "crophage balance' hypothesis was introduced to depict the ambivalent relationship between tumor and macrophages Macrophages might influence neoplastic growth and progression in opposite direction, with a prevailing protumor activity in the absence of therapeutic intervention in many neoplasms. Macrophages, when appropriately activated, are able to eliminate neoplastic target cells in vitro The killing of tumor cells by macrophages requires cell-to-cell contact, but little is known about the mechanisms by which tumor infiltrating macrophages exert their postulated effects in vivo The authors investigated the tumor-infiltrating cells in early gastric carcinoma and advanced gastric carcinoma and described the ultrastructural features and interactions of macrophages with tumor cells and other inflammatory cells Methods : Sections from 20 early gastric carcinomas and 56 advanced gastric carcinomas were stained by immunohistochemical methods for CD4, CD8, CD20, CD45 and CD68 Results : In all of the tumors, CD68-positive macrophages accounted for most tumor-infiltrating cells, followed by CD45-positive T lymphocytes, CD8-positive T lymphocytes &D4-positiveT lymphocytes in order of frequence The authors founded only a few CD20-positive B lymphocytes. Electron microscopy revealed macrophages with phagocytic vesicles and cellular debris The tumor cells in contact with macrophages showed no cymiddleathic changes Contacts among macrophages and other inflammatory cells formed a recurrent ultrastructural hallmark and suggest communication among various inflammatory cell types during the some host response to gastric carcinoma

성남시 어린이집 원아 어머니의 구강보건의식과 행태에 관한 조사연구

안용순,김은숙,임도선,정세환,이홍재 한국구강건강증진학회 2000 한국구강건강증진학회지 Vol.1 No.1

The purpose of this study was to evaluate behaviour about oral health of child's mothers in Songnam city, to obtain the data on oral health programs for young child of child care institutions. A self-developed questionnaire with 10 items was delivered to 713 mothers. Mothers were selected by a cluster sampling method. The 662 collected data was analyzed by profession state. The obtained results were as follows : 1. The house wives without job didn't appear the better behaviors about child's oral health than those with job except child's tooth brushing number per day. 2. There were needed to develop mothers' education program, caries prevention program, periodic oral exam program, refer system program after oral exam and tooth brushing program. 3. The 10 subjects were enumerated by contents of mothers' education program.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Poster Session 3 : Metabolism and Enzymology Apoptosis and Cell Cycle Neurobiology ; Activities of Antioxidant and Redox Enzymes in Young and Aged Rats

( Hong Gyum Kim ),( Sung Min Hong ),( Su Jung Kim ),( Hey Jung Park ),( Haeng Im Jung ),( Yuk Young Lee ),( Ji Cheol Kim ),( Seong Hwan Cho ),( Hye Won Lim ),( Chang Jin Lim ) 한국생화학분자생물학회 (구 한국생화학회) 2002 생화학분자생물학회 추계학술발표논문집 Vol.2002 No.-

Ecdysone‐responsive microRNA‐252‐5p controls the cell cycle by targeting Abi in <i>Drosophila</i>

Lim, Do‐,Hwan,Lee, Seungjae,Yun Han, Jee,Choi, Min‐,Seok,Hong, Jae‐,Sang,Seong, Youngmo,Kwon, Young‐,Soo,Sik Lee, Young Federation of American Society for Experimental Bi 2018 The FASEB Journal Vol.32 No.8

<P>The steroid hormone ecdysone has a central role in the developmental transitions of insects through its control of responsive protein-coding and microRNA (miRNA) gene expression. However, the complete regulatory network controlling the expression of these genes remains to be elucidated. In this study, we performed cross-linking immunoprecipitation coupled with deep sequencing of endogenous Argonaute 1 (Ago1) protein, the core effector of the miRNA pathway, in Drosophila S2 cells. We found that regulatory interactions between miRNAs and their cognate targets were substantially altered by Ago1 in response to ecdysone signaling. Additionally, during the larva-to-adult metamorphosis, miR-252-5p was up-regulated via the canonical ecdysone-signaling pathway. Moreover, we provide evidence that miR-252-5p targets Abelson interacting protein (Abi) to decrease the protein levels of cyclins A and B, controlling the cell cycle. Overall, our data suggest a potential role for the ecdysone/miR-252-5p/Abi regulatory axis partly in cell-cycle control during metamorphosis in Drosophila.Lim, D.-H., Lee, S., Han, J. Y., Choi, M.-S., Hong, J.-S., Seong, Y., Kwon, Y.-S., Lee, Y. S. Ecdysone-responsive microR-252-5p controls the cell cycle by targeting Abi in Drosophila.</P>

Clinical Value of Serum Uric Acid in Patients with Suspected Coronary Artery Disease

( Hong Euy Lim ),( Seong Hwan Kim ),( Eung Ju Kim ),( Jin Won Kim ),( Seung Woon Rha ),( Hong Seog Seo ),( Chang Gyu Park ) 대한내과학회 2010 The Korean Journal of Internal Medicine Vol.25 No.1

Background/Aims: Although increased serum uric acid (SUA) concentrations are commonly encountered in patients with risk factors for coronary artery disease (CAD), the clinical value of SUA has not been established. Methods: The study group comprised 687 consecutive patients with suspected CAD who had undergone coronary angiography. CAD was defined as stenosis≥50% of the luminal diameter. CAD severity was expressed as 1-, 2-, or 3-vessel disease. Metabolic syndrome (MS) was defined according to National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria, and aortofemoral pulse wave velocity (PWV) was obtained by arterial catheterization invasively. Results: In total, 395 patients had CAD. SUA was higher in patients with CAD as compared to those without CAD (5.5 ±1.0 vs. 5.2 ±1.0 mg/dL, p=0.004). In addition, SUA was significantly associated with the severity of CAD (p=0.002). However, after adjusting for significant confounding factors including age, diabetes, smoking, cholesterol, MS, and PWV, SUA was not an independent risk factor for CAD (p=0.151). Based on a subgroup analysis, SUA was more closely associated with CAD in women than in men, and in the highest quartile (≥ 6.4 mg/dL) than in the first quartile (< 4.8 mg/dL); however, these results were not significant (p=0.062, p=0.075, respectively). In a multivariate regression analysis, the most important determinant of SUA was MS (i.e., insulin resistance syndrome), which is strongly associated with CAD. Conclusions: In patients with suspected CAD, SUA was not an independent risk factor for CAD and may be merely a marker of insulin resistance. (Korean J Intern Med 2010;25:21-26)