서울시 公園樹 選定 條件에 관한 硏究

韓炳權,沈慶久 成均館大學校 科學技術硏究所 1992 論文集 Vol.42 No.2

This study was conducted to investigate the selection conditions and the appropriate plants of woody landscape plants for park. The study was progressed the questionaire survey of conditions and field survey of woody landscape plants in park of Seoul. A total of 272 questionaire were analysis by S.P.S.S sub-program. The results obtained are summarized as follows : The common propel, students of major, professional men were answered 'city tolerance', 'relation to surroundings', and 'client requirementa' that it was the main conditions of woody landscape plants for park. The result of Crosstabs Test, the selected conditions are similar. The selected of woody landscape plants for of Seoul were 55 species and `Rhododendrone', 'Magnoliaceae', 'Aceraceae' were preferenced the woody landscape plants for park of Seoul.

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

허혈성 심질환에서 염증지표에 관한 연구

번정득,권영주,박상호,한대희,이상철,강진환,김명구,심규혁,최병조,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background : Atherosclerosis is the chief underlying cause of ischemic heart disease and there is increasing evidence that inflammation is an important determinant of the development of atherosclerosis. We assessed the levels of inflammatory markers in patients with ischemic heart disease and normal group who has normal coronary angiograms. Materials and Methods : Coronary angiography was performed in 142 patients. 107 patients of ischemic heart disease(stable angina pectoris 58, unstable angina pectoris 30, Acute myocardial infarction 19) and 38 normal control subjects. We assessed the level of inflammatory markers, such as CRP, ESR, fibrinogen and leukocyte. Results : CRP, ESR and fibrinogen values of the patients with stable angina pectoris and unstable angina pectoris were higher than that of normal control group, but there were no statistical significance. Leukocyte value of the patients with unstable angina pectoris(9003.3±701.5/mm^(3)) was significantly higher than that of the patients with stable angina pectoris(6685.5±245.8/mm^(3)) and normal control subjects(6394.3±235.1/mm^(3)). CRP, ESR and fibrinogen values of the patients with acute myocardial infarction were also higher than that of normal control subjects. CRP was 3.88±2.05 mg/dL in acute mocardial infarction group, and 0.29±0.15 mg/dL in normal control subject group(p<0.05). Fibrinogen was 541.6±45.1 mg/dL in acute myocardial infarction group, 321.4±25.6 mg/dL in normal control subject group(p<0.05). Leukocyte was 10942.1±737.6/mm^(3) in acute myocardial infarction group, 6394.3±235.1/mm^(3) in normal control subject group(p<0.05). Conclusions : This study demonstrate that CRP, fibrinogen and leukocyte values of acute myocardial infarction group were significantly higher than that of control group and stable, unstable argina pectoris group. Leucokyte values were significantly elevated in unstable angina group, but CRP values were not in unstable angina group.

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.

건강검진 수진 여성에서 초음파검사를 이용한 갑상선결절의 유병률

임창훈,오한진,정호연,한기옥,장학철,윤현구,한인권,한병희,이경상,조병제 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Thyroid nodules are commonly found in clinical practice, and the recent development of thyroid ultrasonography has allowed for the detection of small nodules previously undetectable by routine palpations. Since previous studies on thyroid ultrasonography have been focused on patients with known thyroid disorders, we aimed to determine the prevalence of thyroid nodules in a female population. Methods: We studied women in the age range 30 to 70 years visiting the health promotion center at Samsung Cheil Hospital for routine health check-ups. After excluding patients with previous thyroid disorders, 1300 women where selected to undergo thyroid ultrasonography for the detection of the presence of thyroid nodules. If nodules were found, their size and numbers were recorded, and these data correlated with the patients age. Results: Of the 1300 subjects, thyroid nodules were detected in 490 (37.7%) with their prevalence (p=0.009), and that of multinodularity of thyroid nodules (p=0.001), increasing with the increasing age of the patients (Age 30 to 39: 30.8%, 40 to 49: 37.0%, 50 to 59: 41.5% and 60 to 69: 65.2%). Among these study subjects, nodules larger than 15 mm in size were detected in 29 and after performing fine needle aspirations on 18 nodules, 17 were found to be benign, with 1 papillary carcinoma, which required a total thyroidectomy. Conclusion: The prevalence of thyroid nodules in our female study population was 37.7%, with their prevalence, and that of multinodularity of thyroid nodules, increasing with increased age

Molecular Genetic analysis of Cheju Native Horse

Cho, Byoung Wook,Lee, Kil Wang,Kang, Han Seok,Kim, Seon Ku,Shin, Teak Soon,Kim, Yong Gyun 밀양대학교 농업기술개발연구소 2001 農業技術開發硏究所報 Vol.5 No.1

이 연구는 Random Amplified Polymorphic DNAs (RAPD) 기법을 이용하여 제주마의 유전특성분석과 아울러 제주마 특이적인 유전적 Marker를 찾기 위해 수행되었다. 제주마, 더러브렛 각각 30두로부터 Genomic DNA를 추출하였으며, 품종간 다형현상 및 품종 특이적인 RAPD를 찾기 위해 임의의 Primer 800종류의 50~90% G+C 함량을 가지는 10-mer random primer를 이용하였다. 그중 34개의 primer들은 각각 품종간 및 개체간의 특이 다형현상을 보였다. This study was conducted to analyze genetic characteristics and to detect the specific marker for Cheju Native Horse(Cheju Horse) using RAPD (Random Amplified polymorphic DNAs). We collected blood samples from Cheju Native horse, and Thoroughbred and obtained genomic DNA from the blood of 30 individuals randomly selected within the breeds. eigh hundred primers were chosen randomly and were examined for polymorphism and 49 kinds of primer showed polymorphic RAPD band pattern between and among the breeds. Arbitrary primer MG 0034 showed dimorphic band pattern. Cheju horse specific bands were observed from the primer MG 6085, MG 4125, MG 6009, MG 0244 and MG 5177 analysis. Primer MG 0162 and MG 0244 showed the Thoroughbred specific band pattern in the genetic analysis between Cheju horse and Thoroughbred. The primer MG 5101, MG 5102, MG 6146, MG 5138 and MG 5140 created many bands from RAPD products and showed wide range of polymorphism within breed, resulting that RAPD amplification using primer MG 6146 was suitable for paternity test of family having pedigree and unrelated bands different from those of rarest might be a evidence for exclusion from pedigree of family A total of 34 polymorphic RAPD bands from ten different primers were used to analyze the genetic reationship of Cheju horse with other 2 breeds. Genetic similarities between breeds were estimated using these 34 RAPD markers.

Application of Polymerase Chain Reaction with Short Oligonucleotide Primers of Arbitrary Sequence for the Genetic Analysis of Cheju Native Horse

Cho, Byoung Wook,Lee, Kil Wang,Kang, Han Seok,Kim, Seon Ku,Shin, Teak Soon,Kim, Yong Gyun 밀양대학교 농업기술개발연구소 2001 農業技術開發硏究所報 Vol.5 No.1

본 연구는 Short Oligonucleotide Primer 이용하여 제주마의 유전 분석을 실시하고자 PCR 증폭 기법을 확립하고, 확립된 기술을 이용하여 국내 고유의 제주마와 더러브렛과 비교하기 위해 수행하였다. 각 품종별과 50두씩 혈액을 채취하고 DNA를 추출하였으며 RAPD 분석에 이용하였다. Random Primer는 10개의 nucleotide로 구성되었으며 G+C percent가 50∼90%의 범위에 해당하였다. 최적의 RAPD 증폭 조건을 확립하기 위해 Primer의 annealing temperature. Mg 이온의 농도, DNA의 양, Tag DNA Polymerase의 영향, PCR thermal cycler의 영향등을 조사하였으며, 800여개의 이용된 primer로부터 70개의 품종간 다형성을 보이는 primer를 선별하였다. 최종적으로 20개의 primer를 이용하여 개발된 50개의 다형표지 인자를 말의 유전 분석에 이용하였다. This study was carried out to establish the optimal RAPD condition using short oligonucleotide primers and then to compare the genetic characteristics of Cheju Native Horse with Thoroughbred. Each 50 individuals per breed were bled and DNA was extracted from collected blood. The primers used in this study were composed of 10 oligonucleotides of 50-80% G+C content. The optimization on the primer annealing temperature. concentration of Mg ion, amount of template DNA was conducted. From initial 800 primers, 70 polymorphic primers between individuals of same or different breeds were selected. And finally, 20 primers showing highly polymorphic and reproducible pattern were selected and 50 polymorphic markers were counted for estimation. Therefore, the RAPD technique using short oligonucleotide sequences was useful for genetic analysis in horse.

정신분열병 환자의 인지적/행동적 특성평가를 위한 가상현실시스템 구현

이장한 ( Jang Han Lee ),조원근 ( Won Geun Cho ),김호성 ( Ho Sung Kim ),구정훈 ( Jung Hun Ku ),김재훈 ( Jae Hun Kim ),김병년 ( Byoung Nyun Kim ),김선일 ( Sun I. Kim ) 한국감성과학회 2003 감성과학 Vol.6 No.3

Synthesis and Biological Evaluation of KRIBB3 Analogues on a Proliferation of HCT-116 Colorectal Cancer Cells

Lee, Sang-Ku,Kim, Jae-Nyoung,Min, Ji-Hye,Yoon, Kab-Seog,Shin, Ki-Deok,Kwon, Byoung-Mog,Han, Dong-Cho Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.12