만성 두부외상 환자에서 99mTc - HMPAO Brain SPECT의 임상적 유용성

서정호(Jung Ho Suh),김동익(Dong Ik Kim),정태섭(Tae Sub Chung),이종두(Jong Doo Lee),박창윤(Chang Yoon Park),정진일(Jin Ill Chung),김영수(Young Soo Kim) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1

N/A Minima1 deterioration of cerebral perfusion or microanatomical changes were undetectable on conventional Brain CT or MRI. So evaluation of focal functional changes of the brain parenchyme is essential in chronic head injury patients, who did not show focal anatomical changes on these radiological studies. However, the patients who had longstanding neurologic sequelae following head injury, there had been no available imaging modalities for evaluating these patients precisely. Therefore we tried to detect the focal functional changes on the brain parenchyme using Tc-99m-HMPAO Brain SPECT on the patients of chronic head injuries. Twenty three patients who had suffered from headache, memory dysfunction, personality change and insomnia lasting more than six months following head injury were included in our cases, which showed no anatomical abnormalities on Brain CT or MRI. At first they underwent psychological test whether the symptoms were organic or not. Also we were able to evaluate the cerebral perfusion changes with Tc-99m-HMPAO Brain SPECT in 22 patients among the 23, which five patients were focal and 17 patients were nonfocally diffuse perfusion changes. Thus we can predict the perfusion changes such as local vascular deterioration or functional defects using Tc-99m-HMPAO Brain SPECT in the patients who had suffered from post-traumatic sequelae, which changes were undetectable on Brain CT or MRI.

아시아 지역 폐렴 구균의 항균제 내성 현황 및 변화 양상 : Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study

정숙인,김나영,손준성,기현균,고관수,서지연,장현하,김연숙,오원섭,백경란,이남용,송재훈,항생제 내성 감시를 위한 아시아 연합 (ANSORP) 대한감염학회 2004 감염과 화학요법 Vol.36 No.1

목적 : 1980년대부터 페니실린을 비롯한 β-lactam 계열과 비 β-lactam 계열 항균제에 대한 폐렴구균의 항생제 내성이 급격하게 증가하여 국내 뿐 아니라 세계적인 문제로 대두되고 있다. ANSORP 에서는 아시아 지역에서 폐렴구균의 항균제 내성과 그 변화 추이, 내성의 기전 및 위험인자를 분석하고자 본 국제 공동 연구를 시행하였다. 재료 및 방법 : 1999년 11월부터 2001년 8월까지 아시아 지역 12개국의 14개 기관에서 폐렴구균 감염증 환자의 임상 검체로 분리된 침습성 폐렴구균을 대상으로 액체배지 미량희석법을 이용하여 16개 항생제의 MIC를 구하였다. 위험인자의 분석을 위하여 폐렴구균 감염증 환자를 대상으로 의무기록지를 조사하였다. Quellung 반응을 통해 혈청형을 결정하였다. 결과 : 총 685균주 중 52.4%가 페니실린에 대하여 비감수성(중등도 내성 22.9%, 내성 29.5%)을 보였고, 그 빈도는 베트남(92.1%), 스리랑카(85.7%), 홍콩(67.9%), 한국(64.5%)의 순이었다. Erythromycin에 대한 비감수성 비율은 베트남(92.1%), 대만(87.7%), 한국(80.6%), 홍콩(76.8%) 등에서 높게 나타났고, 베트남, 대만, 한국, 홍콩 등의 erythromycin의 MIC_(90)이 32㎍/mL를 넘는 고도내성을 보였다. 홍콩, 싱가포르, 대만, 인도에서는 fluoroquinolone에 대한 내성 균주가 출현하였다. 전체 균주 중 다제내성 균주의 비율은 47.7%였다. 혈청형은 19형과 23형이 가장 많았고, 그 외 6형, 14형 등이 있었다. 페니실린 비감수성 감염증의 위험인자로는 5세 미만(OR=1.7; 95%, CI, 1.2-2.4; P=0.002), 기관지폐질환(OR=2.0; 95%, CI, 1.3-3.1; P=0.003), 악성종양(OR=2.3; 95%, CI, 1.2-4.6; P=0.015), 스테로이드의 사용(OR=2.8; 95%, CI, 1.1-7.4; P=0.032)이 확인되었다. 결론 : 침습성 폐렴구균 균주를 대상으로 한 본 연구의 결과 아시아 국가들에서 페니실린, β-lactam 및 macrolide에 대한 폐렴구균의 내성률 및 내성 정도가 급증하고 있음을 확인하였다. Background : Emergence of pneumococcal resistance became a global issue since 1990s. According to the ANSORP studies with clinical isolates and carriage isolates between 1996 and 1999, some Asian countries showed alarmingly high prevalence of resistance to penicillin and other antimicrobial agents. To investigate the changing trends of pneumococcal resistance, ANSORP study group has performed a multinational surveillance study with invasive pneumococcal isolates from Asian countries. Methods : All isolates from various invasive pneumococcal diseases were prospectively collected from 14 centers in 12 countries between November 1999 to August 2001. Broth microdilution tests with 16 antimicrobial agents were performed according to the NCCLS procedures. Serotyping was performed by means of Quelling reaction with use of group-specific antisera. Results : A total of 685 isolates were collected. Overall, 52.4% of invasive isolates from Asian countries were not susceptible to penicillin (intermediate (1), 22.9%, Resistant (R), 29.5%). Vietnam showed the highest prevalence of penicillin non-susceptibility (1 20.6%, R 71.4%) followed by Sri Lanka (1 71.4%, R 14.3%), Hong Kong (1 24.1%, R 76%) and Korea (1 9.7%, R 54.8%). China (I 19.8%, R 23.4%) and Malaysia (1 9.1%, R 29.5%) also showed remarkable increase in penicillin resistance compared with previous ANSORP data, which were less than 10%. Vietnam (92.1%), Taiwan (87.7%), Korea (80.6%), and Hong Kong (76.8%) showed high prevalence of erythromycin resistance. MIG_(90)S for ciprofloxacin were 4 ㎍/mL (Hong Kong) and 2 ㎍/mL (11 Asian countries except Hong Kong), respectively. Conclusion : Compared with previous data from ANSORP studies, antimicrobial resistance among invasive pneumococcal isolates has markedly increased in Vietnam, Sri Lanka, Taiwan, China, and Malaysia. Continuous surveillance of pneumococcal resistance in Asia is strongly warranted.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

農民技術受容에 影響을 주는 要因의 比較分析 : 關係機關과 情報傳達媒體를 中心으로

鄭址雄,崔敏浩,金性洙,徐圭善,李昶植 서울大學校 農科大學 1984 서울대농학연구지 Vol.9 No.2

The purpose of the study was to analyze the variables affecting farmers' adoption process of agricultural innovations in Korea. Specific objectives of the study were to ; (1) review the adoption process and the variables associated with this process, (2) investigate the rate of adoption of selected agricultural innovations in the fields of rice production, animal husbandary and horticulture, (3) analyze communication media and change agencies or institutions which affected the adoption of agricultural innovations, and (4) identify the relations of the farmers' adoption and communication exposure behavior. Data for the study were collected from 393 cluster sampled farmers out of selected 17 rural villages in Korea. Five graduate students and three faculty members of Seoul National University participated in conducting interview with pre-tested questionnairs. The data were analyzed by HP 3,000 computer in the College of Agriculture, Seoul National University. Major statistical techniques used for the study were frequency distribution, chi-square and discriminant analysis. Statistical significance was tested at .05 level. The major findings of the study were as follows : 1. Variables associated with the agricultural adoption process were classified into the following six categories ; (1) perceived characteristics of agricultural innovations, (2) personality and characteristics of adopters, (3) the patterns of communication media or channels, (4) efforts of change agents. (5) priorities in agricultural development policies, and (6) characteristics of social system. 2. Rats of adoption were about 83% in application of silicate fertilizers on rice seed bed, 41% in feeding calf starter known as artificial milk to calves, 56% vinyl mulching practices in vegetable cultivation, and 67% in spreading raw rice straw on paddy land to improve soil conditions. 3. Time lag between awareness and adoption appeared to be about seven months in application of silicate fertilizers on rice seed bed, and about a year in feeding calf starter. 4. Change agent interpersonal communication revealed to be the most important factor affecting farmers' awareness in application of silicate fertilizers on rice seed bed, in feeding calf starter, and in spreading raw rice straw on paddy land, while localite interpersonal communication in vinyl mulching practices in vegetable cultivation. 5. Change agent interpersonal communication appeared to be the most important factor affecting farmers' adoption in application of silicate fertilizers on rice seed bed and in feeding calf-starter, Localite interpersonal communications were more important in vinyl mulching practices of vegetable cultivation and in spreading raw rice straw. Localite interpersonal communications were more important factor at adoption stage than at awarenss stage. 6. Agricultural extension agencies appeared to be the most important factor affecting farmers' adoption in application of silicate fertilizers on rice seed bed, in feeding calf starter, and in vinyl mulching practices. Based on the results of this study, the following are recommended for further development of agricultural extension services and effective adoption process of agricultural innovation. 1. The variables associated with the agricultural innovation decision process should be taken into consideration to improve effectiveness of change agencies or agricultural extension services. 2. Effective use of communication media along with the feedback messages from the change agency as well as client system be considered to increase effectiveness and meaningfulness of both systems. 3. Innovative agricultural research be continually sharpen its focus on the highest priority needs of client system by utilizing feedback from farmers through the communication link of change agents. 4. A long-term educational approach by using various communication media be emphasized, and regular field survey on innovation-decision process will prevent discontinuance of innovations.

천연물이 간대사에 미치는 영향에 관한 연구(Ⅱ)

최기환,김순선,박윤주,안미령,서수경,신윤용,김동섭,장영섭 식품의약품안전청 1997 식품의약품안전청 연보 Vol.1 No.-

천연물이 간대사에 미치는 영향페 대한 연구의 일환으로 세계 전 지역에서 널리 사용되고 잇으며 우리나라에서도 사용빈도가 높으나 간염등 간질환 유발사레가 보고되고 있는 마황, 황금 및 샐제 임상에서 이들 생약과 복합해서 자주 사용죄고 있는 대황을 선정하여, 띠들 천연물의 투여가 간 대사에 미치는 영향을 살펴보았다. 대황,마황, 황금 수침액을 1.09/kg의 용량으로 럿드에 7일간 경구 투여하고,최종투여 24시간 후 랫드의 간을 적출하였다. 간 대사에 미치는 영향을 살펴보기 위한 모질약뿔인 7-etliokycournarin을 적출간에 과관류하면서 2시간동안 일정시간 간격으로 관류액을 채취하여 생성된 7-ethoxycoumarin의 대사체인 7-hydroxycoin, glucuronide 포합체, sulfate포합체를 대조군과 배교 관찰하였다. 또한 긴독성 지표로서 혈청 ALT, AST를 측정하였으며 적출관류간에 대해 lipid peronidation 정도를 살펴보고 ÷t직병리검사를 실시하였다. 대촹 투여군에서는 7-ethoxycoumarin의 gulcuronidation이 갛소하였고fP<0.01), 마황투여군에서는 7-ethoxycoumarin의 o-deethylation이 증가하였다(P<0.01). 이러한 7-ethoxycoumariu 대사의 변화가 대황, 마황에 의한 관련 효소의 생합성 증가/감소에 의한 것인지 여부를 살펴보고자 일착로 CYPIAI, Ct'P2Bl CDHA primer를 사용하여 적출관류간 소포체에서 mRNA level을 측정하였다.마황투옥군에서 CVPIAI mRNA level의 증가가 관찰되었지만 통계적으로 유의한 차이를 나타내지는 않았다. 또한 이들 천연물에 의한 간독성 유발여부를 비교 평가한 결과 혈청 ALT 및 AST는 대조군에 비하여 유의한 차이가 없었다. 그러나 만성 간염정도를 나타내는 지표인 ALT/AST ratio는 마황 투여군에ㅓ 대조군에 비하여 유으한 차이를 나타내었고 대황투여군에서 간소포체내 lipid Peroxidation(MDA production)이 대조군에 비해 증가하였다.반면 조직학적 관찰결과는 대조군에 비하여 유의한 차이를 나타내지 않았다. 이상의 결과를 요약하면 랫드에서 대황 투여에 의해 7-ethoxycoumarin gtucuronidation이 감소되었으며, 마황 투여에 의해서 7-ethoxycoumarin의 o-deethylation은 증가되었고 마창 투여군의 경우 이러한 효소의 활성증가는 CYPIA1 induction에 의한 것일 수도 있다는 가능성을 제시하고 있다. In recent 3rears, hepatotoxicity concerned with Ephedrae herba or Scutellariae radixadmiBistration was case reported and Rhei rhizoma is commonly used with them. Tn order to study theeffect of Rhei rhizoma, Ep]ledrae herba and Scutellariae radix on hepatic metabolism, we exalnined theeffect of those pretreatment on the metabolism of 7-ethoxycoumarin(EC). Water extracts(Ig/fg) ofRhei rhiaoma, Ephedrae tterba and Scutetlariae radix were admi3tistered orally to rats for T days,respectively. Livers were t:ten isolated and perfused with 100uM EC for 2 hours. The metabolites of EC,7-hydroxycoernarin, sulfate conjugate and glucuronide conjugate, were measured in the perfusates dur-ing perfusion. The amount of glucuronide conjvgates was decreased iB ahei rhizoma pretreated rats (p <0.01) and 7-bfdroxycournarin was increased in Ephedrae herba pretreated rats(p < 0.01). To examineTrhether the change of enByme activity is related to the induction ,or inhibition of enzymes concerned,we measured the change oif CYPIAt and CYPaBl mRNA level in the perfused rat liver, which are con-sidered to be EC specifie. However, CYPIAI and CYPEBI rnRNA ilevel were not found to be changedwith Rhei rhizoma nor I]3hedrae herba pretreatmen·t. We also assessed the hepatic toxicity of Rheirhizoma,.:phedrae herba and Scutellariae radix. The activity of ALT and AST was assayed at 34hrsafter 7 dfyt ndrninistratiofl and it was not found to be changed- Only the ratio of ALT over AST was in-creased in Epedrae herbs. pretreated rats(p < 0.05), which implies possible chronic hepatitis. Lipidperoxidation was increased in Rhei rhizoma treatment(p <0.05) , while histopathological examinationperformed after liver perfusion did not show any difference compared with vehicle treatmeut. Theseresutts suggest that Ephedrae herba pretreatment increases the o-deethylation of 7- ethoxrcoumariB inrats, which Inay be mediated by CYPIAI mRNA induction.

요추 추간판탈출증 수술 후 임상 증상의 회복

신병준,김준범,조영훈,권희,서유성,김연일,나수균,최창욱 대한척추외과학회 1997 대한척추외과학회지 Vol.4 No.2

Study Design : The authors retrospectively analysed the recovery of clinical symptoms after surgical treatment of lumbar HIVD. Objectives : To investigate the incidence of clinical symptoms, the recovery rate and time after surgical treatment and the difference between L4-5 and L5-S1 lesion. Summary of Literature Review : There are many reports concerning the clinical result of surgical treatment for the HIVD. They usually describe the result as excellent, good, fair and poor. We can't get any information about the recovery rate and recovery time of each clinical symptom from the reports. Materials and Methods : Thirty-eight patients were treated by one level open discectomy from march 1991 to december 1995. The clinical symptoms and signs including SLR, motor deficit, sensory deficit, change of DTR and severity of radiating pain were periodically followed up on the predesigned protocol, Results : In preoperative examination, SLR was positive in 82%, motor deficit in 76%, sensory deficit in 74%, DTR change in 50%, and radiating pain in 100%. The recovery rate of SLR was 96.8%, motor deficit ; 93.6%, sensory deficit ; 78.6%, DTR change ; 21 % and radiating pain ; 84.2%. The average recovery time of SLR was 3.4 months, motor deficit ; 1.9 months, sensory deficit ; 5.3 months, DTR change ; 4.1 months and radiating pain ; 3.2 months. Motor and sensory deficit was more frequent in L4-5 lesion but DTR change was usually noted in L5-S] lesion. The recovery rate and time showed no great difference between the two level. Conclusions : The recovery rate was higher in SLR, motor deficit and radiating pain rather than sensory deficit and DTR change. The recovery time was fastest in radiating pain but variable nature was noted in sensory deficit. Above results may be helpful to explain the prognosis of the lumbar HIVD.

ASYMUNT: 21개 Noncentric 점군이 갖는 X선 데이터의 asymmetric Units

서일환,박정란,박영수,이진호,이창희,김문집 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.2

결정학적 가설 ??은 anomalous dispersion을 나타내는 원자를 갖고있는 비대칭 결정에 대해서는 성립하지 않는다. 만약 이들의 결정구조가 Lane group 보다는 오히려 noncentric point group의 X선 강도 데이터의 asymmetric unit로부터 정해질 수 있다면, 그 구조는 강도 데이터가 2배로 증가하기 때문에 보다 신뢰성이 증가한다. 본 논문에서는, 21개 noncentric point group 각각에 들어가는 강도 데이터의 asymmetric unit 의 정확한 범위를 계산하는 프로그램을 제안하였다.

강원지역의 자원관리를 위한 지리정보시스템 개발

서백수,임길재,정영준,송화선,류창희,민경원,서희정 강원대학교 석재복합신소재제품연구센터 1997 석재연 논문집 Vol.2 No.-

강원도는 오랫동안 금속, 비금속, 석재 및 석탄과 같은 지하자원들을 공급하는 국내 주요생산지로 알려져 왔으나, 장기적인 채광과 비 계획적인 생산으로 인하여 매장량이 고갈되고 있으며, 대외적으로 생산 경쟁력 마저 잃어가고 있다. 이러한 문제점에 대한 해결방안의 일환으로 본 연구에서는 강원도내에 산재되어 있는 지하자원의 분포, 자원 생산시설 및 생산량, 경제성, 자원개발, 환경문제 등 자원관리에 필요한 제반사항을 수행할 수 있는 강원지역 자원 종합관리 GIS 시스템을 개발하였다. 이 시스템의 개발은 방대한 양의 정보 조사 및 저장, 오랜 개발기간, 많은 소요인력 및 개발 비용이 요구되기 때문에 본 연구에서는 조기에 자원관리 GIS 시스템을 개발하여 이와 관련된 생산 및 연구 분야에 조기에 적용할 수 있도록, 일차년도에는 현재 석재복합 신소재제품 연구센터의 집중적 연구대상 지역인 태백지역에 대한 탄광지역을 중심으로 자원 종합관리 GIS 시스템을 개발하였다. The Kangwon province has been well-known to be one of major underground resource producing districts which are mainly supplying metals, non-metals, stones, and coals. However, due to the long-term mining and unplanned production, the natural resource reserves have been rapidly drained and oversea production competition has been losing. In this study, we has developed a GIS system for regional resource management in the Kangwon province, which can operate, maintain, and manage the distribution of underground resources, resource production facilities, production and economic development, and environmental issues. The development of this system requires the collection, analysis, evaluation, and storage for a huge amount of research data, and in addition, the long period of time, the big research man power, and big development cost. Accordingly, to shorten the development period of time and to early apply itself to production, this stage of study has been intensively developed a regional resource GIS system for managing the mines scattered in the Tabak province, which is one of hottest RRC's research areas.

국소피판을 이용한 안면부 재건

서창덕,김석권,김성수 中央醫學社 1988 中央醫學 Vol.53 No.5

The facial scars or deformities, because of its characteristics of being easily noticeable and difficult to be camouflaged, are usually distressing to the patient not only in physiological aspect but also in psychological aspect. And so particular skill and attention is required for surgeons to unsightly scars by more effective reconstructive approach. There are wide varieties of methods available to reconstruct facial deformities and scars, that is, skin grafting, composite grafting, local or distant flaps, and free flaps. But local flaps provide non-delayed, rapid reconstruction with abundant tissues and blood supply, giving the most excellent color matching with surrounding tissues when performed adequately. But to achieve the favorable result by using the local flap, through knowledge about the facial anatomy and understanding of physiology and characteristics of each flap are essential. And to avoid distortion of the adjacent tissues and other undesirable effects, accurate design and performance based on high experience and technique are needed also. The authors in Busan National University Hospital had utilized local flaps for facial reconstruction in 68 patients, 80 cases from 1976 to 1985 and obtained favorable results in most cases, so, we would report these with review of some articles.

Four-circle Diffractometer를 이용한 결정방위행렬과 단위포상수 결정

서일환,이진호,심해섭,이정수,성백석,이창희,김문집 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.2

A theoretical process to determine the unit cell parameters a, b, c, , β, γ of single crystals and then to collect intensities of ?? using four-circle diffractometer has been shown.