정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

분편 인플루엔자백신(split influenza vaccine)의 임상효과 및 면역원성에 관한 연구

우흥정,김동림,정희진,천병철,이주연,안정배,김지희,박찬,신영규,김우주,김민자,박승철 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.1

목적 : 아단위 인플루엔자 백신 접종 후 백신의 인플루엔자 예방효과, 인플루엔자 방어 항체형성, 인플루엔자 백신의 안전성을 조사하고자 하였다. 방법 : 총 571명을 대상으로 인플루엔자 백신 접종을 하였고, 이들 접종자에서 인플루엔자 양질환의 이환을 조사하여 인플루엔자 백신의 인플루엔자예방효과를 알아보았고, 백신의 접종 전 및 접종 4주 후 혈청에서 혈구응집억제물(Hemagglutination Inhibition : HAI) 항체 검사를 실시하여 백신의 방어항체생성을 조사하였고, 백신의 안전성을 알아보기 위해 백신접종 후 1주일 이내의 부작용을 조사하였다. 결과 :백신 접종군과 백신 비접종군에서 인플루엔자 양 질환의 이환을 조사한 결과 접종군 28.35%, 비접종군 35.88%으로 나왔으며, p 값이 0.001로 통계적으로 접종군에서 유의하게 낮았고, 인플루엔자 양 질환의 예방 효과는 20.97%를 보였다. 백신의 방어항체 형성의 평가를 위해 유럽의 인플루엔자 백신 허가 기준을 조사하였는데 B/Guangdong/5/94균주의 백신접종 후 항체가 40이상의 비율을 제외한 다른 기준은 모두 만족 시켰다. 부작용은 전체 조사자 521명중 149명(29%)으로 주로 접종 부위의 국소 부작용을 호소했고, 전신 부작용은 2% 내외였으며 특별히 심각한 부작용은 발견되지 않았다. 결론 : 분편 인플루엔자 백신은 인플루엔자양질환의 예방과 방어항체생성에 효과 있으며 안전한 것으로 사료된다. Background : The safety and effectiveness of influenza vaccine are well known in developed country. The influenza vaccination has been recommended as one of the tentative immunization schedule for indicated persons since 1997 in Korea. But there are still no available data about them, even though nearly 5 million doses of influenza vaccine were used in 1997-1998 season. So it is immediately needed to investigate the safety. efficacy and immunogenicity of influenza vaccine among Korean. Methods : We studied the clinical efficacy of influenza vaccine by monitoring Occurrence of influenza-like illness in influenza risk group(vaccination ; 300, non-vaccination; 215) from December in 1997 to March in 1998. We used the split quadrivalent influenza vaccine containing 15 microgram of hemagglutinin of A/Beijing/262/95(HlNl), A/Wuhan/359/95(H3N2), B/Mie/1/93 and B/Guangdong/5/94. Hemagglutination inhibition(HA1) antibody titers were determined before immunization and 1 months after vaccination And we evaluated adverse effect of influenza vaccination at 7 days after vaccination. Results : Influenza vaccination was associated with si@icant reductions in influenza-like spptoms(vaccination group; 28.35%, non-vaccination group, 35.88%, p=0.001). The preventive effect of influenza-like i3lne.s among influenza risk goup was 20.97%. And immunogenicity of influenza A and B exceeded all of the European licensure criteria for immunogenicity except postvaccination proportion of titers 240 of B/Guangdong/5/94 strain. And the adverse effects were mainly local injection site problem and no serious adverse effect was noted. Conclusion : Split influenza vaccine is safe, inmunogenic and eff'tive in influenza risk group in Korea.

[논문]결정화 유리첨가에 의한 BNT 계 세라믹 복합체의 소결 및 유전특성

이우석,이병철,류봉기 釜山大學校生産技術硏究所 2003 生産技術硏究所論文集 Vol.62 No.-

본 연구에서는 BaO-Nd2O3-TiO2계 마이크로파 유전체 세라믹스에 결정화 유리를 첨가하여 적충일체형 RF 수동소자 모률 구현을 위한 저온소결 유전체소재를 개발하고자 하였다. BaO-Nd2O3-TiO2에 결정화 유리를 5~3Owt% 범위로 첨가하여 소결온도를 1300°C 에서 1050 °C 로 낮추었으며, 첨가량의 증가에 따라서 소결밀도의 증가 및 입성장이 뚜렸이 일어났고 결정화 유리를 20wt% 첨가하여 1050 °C의 소결온도에서 95% 이상의 상대밀도를 갖는 소결체를 얻을 수 있었다. 이때 유전율(Er),72,품질계수(Q . f),1500, 공진주파수 온도계수(tf), 22 ppm/°C 을 나타내었으며 이는 LTCC 재료로서 응용가능성이 있다고 판단되었다.

簡易課稅者의 附加價値稅制 順應에 관한 實證硏究

박정철,나병우 한국세무회계학회 2003 세무회계연구 Vol.12 No.-

본 연구는 부가가치세제상 간이과세자의 납세순응(Compliance) 정도를 알아보기 위함을 목적으로 설문조사에 의하여 실시되었다. 과거 시행되었던 과세특례제도하에서 일반적인 소규모 영세납세자들은 일반과제자로 전환을 기피하는 현상이 지배적이었다고 할 수 있다. 정부에서 세제개혁의 일환으로 간이과세제도를 도입시행하고 있으나 일반과세자로의 전환을 기피하고 있는 실정이다. 설문을 이용하여 사업자의 인식정도와 순응실태의사를 과세구분에 따른 차이분석, 기장능력에 따른 차이분석을 조사한 결과 간이과세자보다는 일반과세자가 각종의무를 잘 이행하는 것으로 나타났으며, 기장대리를 맡기고 있는 경우에 과세 순응도가 높은 것으로 나타났다. 또한 사업자의 교육정도도 순응에 통계적으로 의미있는 차이점들을 얻을 수 있다.

곰쓸개 복용 후 발생한 육안적 혈뇨와 신유두부 괴사증 1예

김우진,한민석,김수항,박인형,박진석,선제형,홍세인,박옥영,신정현,이숭,신병철 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Renal papillary necrosis occurs most commonly in association with urinary tract infection, diabetes mellitus, sickle cell disease, vascular disease, and analgesic nephropathy. Clinical presentation may be related to symptoms of pyelonephritis such as flank pain, renal colic, hematuria, Proteinuria, recurrent fever. The necrotic tissue may be sloughed off, and the diagnosis can sometimes be made by finding piece of renal medullary tissue in the urine. Pyelography may demonstrate cavities and sinuses in the resion of papillae. Anuria & oliguria can lead to the acute renal failure, and especially prognosis and progress may be affect influenced by urinary infection. We report a case of renal papillary necrosis with ingestion of bear gallbladder. On pyelography, Persistent contrast is diagnostic clue of renal papillary necrosis. This case is not be related to urinary tract infection, but occurred acute renal failure. Expectant treatment was gone.

전기로 분진에서 납의 휘발반응에 대한 속도론적 연구

김병수,유재민,이재천,남철우,윤정모 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.4

"he removal of lead from electric arc furnace (EAF) dust is important in the process for recovering zinc by a reduction-volatilization method. In this study, experiments on kinetics of the volatilization reaction of lead by chlorine components as NaCl and KCl contained in the EAF dust were carried out in the temperature range of 973 to 1223 K under an air atmosphere using a weight-loss technique. As a result, the volatilization ratio of lead was about 99.0% at the temperature of 1223 K and the reaction time of 180 min. Jander equation was found to fit well the volatilization reaction rate over the entire temperature range. The volatilization reaction of lead is rate controlled by solid-solid diffusion. An activation energy of 175 kJ/mol(41.8 kcal/mol) was obtained. (Received January 8, 2004)

CAD를 이용한 양수장 및 배수장설비 설계의 표준화

권병철,권경우,김기길,명태식,박찬호,박귀용 한밭대학교 산업과학기술연구소 1995 논문집 Vol.3 No.-

This paper is to be illustrated automation in the design of Pumping Station and Draining Station. Program for design automation applying Auto LISP, DCL can be used to design and draw simultaneously. The study result are as follows. 1. Optimal design has been introduced and precise design has been possible using CAD. 2. Dialog design is possible with introduction the concept of design automation, and design cost can be reduced greatly.

도시지역 한방의료이용자의 질병양상 조사연구

강영우,조태현,김병하,남철현,조남춘,안창수,이재홍 慶山大學校 保健福祉硏究所 1997 保健福祉硏究 Vol.1 No.-

To provide the basic data for improving of curative measures in oriental medicine and for developing of health education and preventive program after understanding of classification of diseases in oriental medicine users, questionnaire interview was carried out with city dwellers, over 20 years old, selected randomly in big cities from 2nd Oct. to 11th Nov. 1995. The results were summarried as follows: 1. In the general characteristics of subjects, the highest portion of each part was 61.2% of female, 25.5% of thirties, 28.5% of high school graduate, 63.3% of middle class and 11.8% of lower class in economic status. 31.9% was housewife, 73.5% was merried and 55.1%, 38.1% came from big or small cities each. 2. By 21 classification of diseases, 19.7% was blood disorders, 17.6% was pregnancy & delivery complications and 15.2% was endorine & nutritional disorders. 3. As for age 22.6% of endocrine & nutritional disorders in twenties, 20.8%, 28.1%, 27.8% of blood & defence mechanism disorders in thirties, forties, sixties each and 24.9% of pregnancy & delivery complications in fifties were the higher than the other groups. 4. By educational level, 47.8%, 30.5% of blood & defence mechanism disorders in uneducated and middle school graduate were the higher than the other groups. 5. As for occupation, 20.8%, 32.9% of blood & defence mechanism disorders in housewives and sales each, were the higher than the other groups. 6. By economic status, 20.2% of blood & defence mechanism disorders in middle and high class, were the higher than the other groups. 7. By marital status, 21.3% of endocrine & nutritional disorders in singles, 22.0%, 25.7% of blood disorders in having partners, were the higher than the other groups. 8. As for living areas, 18.2% of pregnancy & delivery complications in big city dwellers, 21.3% of endocrine & nutritional disorders in town dwellers were the higher than the other groups. The distribution of diseases in oriental medicine users wes very different by chracteristics according the results. So It's important and essential project to improve curative technics and to develop.

열선을 장착한 보온재의 개발에 관한 연구

김광우,이재철,김병철,안재선 강원대학교 부설 석재복합신소재 제품연구센터 2002 석재연 논문집 Vol.7 No.-

본 연구에서는 복층유리 보온효율의 바로메터가 되는 열전도도의 정확한 측정을 위하여 복층유리의 열전도도 측정장치를 개발하고 이 측정장치에 대한 이론적인 모델을 제시하였다. 또한 이를 이용하여 다양한 복층유리에 대한 열전도도를 측정하였다. 열선을 장착한 복층유리의 경우 열선에 가한 전류의 증가에 따라 열전도도가 지수함수적으로 감소하였다. 판유리 및 공기층의 두께에 따라 다양한 복층유리가 생산되고 있으며, 본 연구에서는 유리의 두께를 일정하게 두고 공기층의 두께를 변화시키며 열전도도를 측정하였다. 공기층의 두께가 증가함에 따라 복층유리의 열전도도는 지수함수적으로 감소하는 것으로 나타났다. In this study, an apparatus for measuring thermal conductivity has been developed to accurately measure the thermal conductivity of pair glass, which is a barometer for efficiency of keeping warm, and the theoretical model for the apparatus was suggested. Then the conductivities of various pair of glasses were measured by using this equipment. The thermal conductivities of the pair glass in which the warm wire was installed decreased exponentially as the applied current increased. For the test fixing the thickness of glass in pair glass and varying the thickness of air layer, the conductivity also decreased exponentially as the air layer thickness increased.

다중 출력 MLP신경망을 이용한 한국어 음성인식에 관한 연구

鄭光宇,朴炳哲 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.1

In this paper, to improve the performance of the speaker-independent speech recognition system, a new reural network model and learning algorithm were proposed. Recognition algorithm for performance improvement of the recognition system had two kinds. Several experimental results were given to prove the performance of proposed algotithm on the isolated digit recognition of the speaker- independent. First, the algorithm for extraction of the feature vector was proposed. it imported, to stabilize the sequence of the feature vector to input speech, the 'Inertia Term' between neighbor frames. If, caused the reducing fluctuation components produced on the sequence of the feature vector of speech signal and tine suppressing superposition of probability distribution between feature vectors. As a result, the ability of phoneme discrimination was improved on the speaker independent speech recognition system or 3.9%. Second, the Multi-Output MLP(MO-MLP) neural network structure was proposed. It had, for reflecting the variation of the feature of the phoneme which was produced on the variable phonological environment, the structure which was assigned several output nodes to the same phoneme. So, the convergence characteristic of the neural network could be improved by the proposed structure for complex learning data and this structure could improve the ability of recognition system by generating the multi-template pattern on a neural network for 8.4%.