정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

5-〔3-(N-Substituted Piperazinyl)Propoxy〕Indan類의 合成과 中樞神經抑制效果

黃熙喆,閔庚鎭,文勝煜,李萬佶,徐丙天 嶺南大學校附設 基礎科學硏究所 1985 基礎科學硏究 Vol.5 No.-

Five new indans, 5-[3-(N-substitued piperaziny) propxy]indans, were synthesized by condensation of 5-(3-bromopropoxy)indan, the intermediate, and N-substituted piperazines. The structure of the compunds were determined by means of IR, NMR spectoscopy along with elemental analysis. Each compound was tested for antimorphine and antiamphetamine effects as part of CNS depressant effects and for muscle relaxant action in mice. Thes compound exhibited less potent activity compared to chlordiazepoxide on CNS depressant effect. Muscle reaxant action of the compounds, the side effect of tranquilizer, however, was much weaker than that of chlordiazepoxide.

ZVS를 이용한 SEPP 고주파 공진 인버터의 특성해석

김동희,노채균,김종해,민병재,배상준 嶺南大學校 工業技術硏究所 1997 工業技術硏究所論文集 Vol.25 No.1

Applied the high frequency switching technology to the ower conversion circuits, the turn on and off loss of switch point out practically large the point at issue, in order to reduce switching loss, the switching method using tank resonant circuit be connected serial and parallel with load have been continuously investigated. This paper was described about principle and form of proposed circuit made use of soft switching technology ZVS(Zero Voltage Switching) and ZCS(Zero Current Switching) to reduce turn on and off loss at switching. Also, the analysis of the proposed circuit is described generally by using normalized parameter and basic operating principle and driving characteristics have been evaluated as to switching frequency and load parameter. Based on the charactristics value, a method of circuit design is proposed. In addition, Pspice's simulation and experimental waveforms are compared with theoretical ones. The experimental results shows that the proposed Inverter can be used practically such as power source system for induction cooker etc.

교육사회학의 연구 동향 분석

김경식,권민석,김병규,박형진,송승면,황정희 경북대학교 사범대학부속 중등교육연구소 2005 중등교육연구 Vol.53 No.3

한국, 일본, 미국, 영국의 교육사회학 학술지 논문을 주제별 내용분석을 통해 각각의 하위개념을 도출하고 개념의 유사성의 정도에 따라 다시 상위개념으로 분류하여 교육사회학의 주요 연구영역을 탐색하였다. 학술지에서 가장 많이 다루어진 영역은 교육과 평등/지위획득, 교육정책과 제도, 교육사회학의 성격/이론, 학교사회와 학업성취, 페미니스트(여성), 청소년 문제와 문화, 교사교육/교직사회, 공교육의 문제/교육개혁 등의 순으로 나타났다. 특히 교육정책과 제도 문제는 한국과 일본에서, 교육사회학의 발달과 정체성 문제는 영국에서, 학업성취 관련 내용은 미국에서 가장 많이 다루어졌다. The purpose of this study was to explore the research trend in sociology of education. To conduct the purpose of this study, the Korean Journal of Sociology of Education(KJSE), the Journal of Educational Sociology(JES), Sociology of Education(SOE), and Bitish Journal of Sociology of Education(BJSE)'s articles were analyzed. The findings of this study were as follows: First, though the major categories(major domains) of research areas were a few differences among nations, they were education & equality, educational policy, sociology of education theory, school society & academic achievement, feminism, adolescent problem & culture, teacher education, school crisis & education reform, course education, sociology of curriculum, and etc. Second, the most frequent research area was the educational policy & system problems in Korea and Japan; the development and identity of sociology of education in Britain; The school society & academic achievement in U.S.A.

광주지역 HIV/AIDS, 매독 혈청 양성률 및 임질 양성률 분포조사(2002-2006)

기혜영,최병선,서진종,김선희,김민지,김은선,박종태,정재근 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Background : The epidemic of human immunodeficiency virus (HIV) or sexually transmitted infections (STIs) is an important public health issue in the worldwide. Therefore, we investigated the trends of the seroprevalence of HIV and, syphilis and the gonorrhea positive rates in Gwangju from 2002 to 2006. Materials and Methods : The results of laboratory tests for HIV, syphilis and gonorrhea were collected from five public health centers and 19 hospitals in Gwangju. The number of tested patients from 2002 to 2006 was 348,202 cases for HIV, 80,115 cases for syphilis and, 103,548 cases for gonorrhea. Results : HIV/AIDS infections have rapidly increased at public health centers and hospitals. Especially, most of newly HIV-infected people were patients on ambulatory care/hospitalization, and they were also found via preoperation tests and according to the clinical symptoms. The gonorrhea positive rates have gradually decreased by year while the syphilis infection rates have slightly increased from 2002 to 2006. Conclusions : We have to determine the reasons why HIV and syphilis infections, but not gonorrhea, have increases simultaneously by the year. These results should be helpful to create a more effective STD prevention policy and the treatment guidelines for the people in Gwangju in the near future.

A Study on the 3D Model of Nam, Byeong- Cheol Armillary Sphere

Hong-Soon Choi,Geoyoung-Han Yoo,Byeong-Hee Min,Sang-Hyuk Kim,Kyoung-Uk Nam,Yong-gi Kim 한국천문학회 2023 天文學會報 Vol.48 No.1

Dimethylnitrosamine 유발 급성 간 손상 흰쥐에서 ^(99m)Tc-Lactosylated Serum Albumin을 이용한 간 기능의 평가

정신영,이재태,서명랑,유정아,배진호,안병철,황재석,정재민,하정희,이규보 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.6

목적: ^(99m)Tc-lactosylated serum albumin (^(99m)Tc-LSA)은 간세포에 특이적으로 결합하는 간수용체 영상용 방사성의약품으로 새로이 합성되었다. 간섬유화를 유발하는 dimethylnitrosamine (DMN)을 투여한 간 손상 휜쥐 모델에서 ^(99m)Tc-LSa의 역동학적인 간섭취를 조사하고 간효소치의 변화와 조직학적 소견을 비교하여, LSA의 간섭취가 간기능의 변화를 반영하는지를 연구하였다. 대상 및 방법: SD계 흰쥐에 DMN를 27 mg/kg으로 복강 내 주사하여 급성 간손상을 유도하고 대조군과 비교하였다. DMN을 주사한 흰쥐를 3일(DMN-3), 8일(DMN-8), 21일(DMN-21)에 ^(99m)Tc=LSA (1,665 mg/kg) 29 MBq를 정맥 주사하여, 30분 동안 동적 영상을 획득하고 간과 신장부위에 관심영역을 설정하여 간과 심장부위의 시간방사능 곡선을 얻었다. 간기능 평가를 위해 시간방사능 곡선을 이용하여 간섭취지수와 혈중제거지수를 구하였고 곡선 최적화를 시행하였다. DMN 투여군과 대조군의 간효소치의 변화와 간조직의 광학현미경 소견을 비교하였다. 결과: 대조군에서는 ^(99m)Tc-LSA가 빠르게 간에 섭취되고 혈중에서 제거되었으나 DMN을 처리한 군에서는 간섭취가 낮았다. 간섭취지수의 비교에서 대조군에 비해 DMN 처리군에서 유의하게 간섭취지수가 낮았다(DMN-3: 0.842, DMN-8: 0.898, DMN-21: 0.91, 대조군: 0.96, p<0.05). 혈중제거지수의 비교에서도 대조군에 비해 DMN 처리군에서 혈중제거지수가 유의하게 높았다(DMN-3: 0.731, DMN-8: 0.654, DMN-21: 0.604, 대조군: 0.473, p<0.05). 비선형 회귀분석에서 R_(2) 값은 0.9이상으로 좋은 일치를 보였고, 대조군에ㅓ K값이 DMN처리군에 비해 크고(DMN-3: 0.28, DMN-8: 0.41, DMN-21: 0.46, 대조군: 0.97, p<0.05), T_(1/2)값은 작았다(DMN-3: 2.5, DMN-8: 1.7, DMN-21: 1.5, 대조군: 0.7, p<0.05). 간효소치의 변화는 DMN-3군에서는 대조군에 비해 상승하였으나 DMN-8, DMN-21군에서는 간효소치의 상승이 관찰되지 않았다. 간조직 소견의 경우 DMN-3군에서 중심정맥 주위에 괴사가 관찰되었으나 DMN-8군, DMN-21군에서는 미약한 정도의 염증세포 침윤만이 관찰되었다. 결론: ^(99m)Tc-LSA 간신티그래피의 간섭취 정도는 간손상과 반비례하였으며 간섭취의 변화는 조직학적 손상이 심한 정도와 간손상후 회복되는 과정을 반영하여 주었다. ^(99m)Tc-LSA 간신티그래피가 간손상을 평가하고 간손상후 회복되는 과정을 추적하는 간수용체 영상용 방사성 의약품으로 사용될 수 있을 것으로 생각된다. Objects: ^(99m)Tc-lactosylated human serum albumin(LSA) is a newly synthesized radiopharmaceutical that binds to asialoglycoprotein receptors, which are specifically presented on the hepatocyte membrane. Hepatic uptake and blood clearance of LSA were evaluated in rat with acute hepatic injury induced by dimethylnitrosamine(DMN) and results were compared with corresponding findings of liver enzyme profile and these of histologic changes. Materials and Methods: DMN (27 mg/kg) was injected intraperitoneally in Sprague-Dawley rat to induce acute hepatic injury. At 3(DMN-3), 8(DMN-8), and 21(DMN-21) days after injection of DMN, LSA injected intravenously, and dynamic images of the liver and heart were recorded for 30 minutes. Time-activity curves of the heart and liver were generated from regions of interest drawn over liver and heart area. Degree of hepatic uptake and blood clearance of LSA were evaluated with visual interpretation and semiquantitative analysis using parameters (receptor index : LHL3 and index of blood clearance : HH3), analysis of time-activity curve was also performed with curve fitting using Prism program. Results: Visual assessment of LSA images revealed decreased hepatic uptake in DMN treated rat, compared to control group. In semiquantitative analysis, LHL3 was significantly lower in DMN treated rat group than control rat group (DMN-3:0.842, DMN-8: 0.898, DMN-21: 0.91, Control: 0.96, p<0.05), whereas HH3 was significantly higher than control rat group (DMN-3: 0.731, DMN-8: 0.654, DMN-21: 0.604, Control: 0.473, p<0.05). AST and ALT were significantly higher in DMN-3 group than those of control group. Centrilobular necrosis and infiltration of inflammatory cells were most prominent in DMN-3 group, and were decreased over time. Conclusion: The degree of hepatic uptake of LSA was inversely correlated with liver transaminase and degree of histologic liver injury in rat with acute hepatic injury.

The value and potential of Purpureocillium sp. JB-4 as biological control agents with nematicidal activity

Byeong-Min Lee,Jong-Hoon Kim,Min-Kyoung Kang,Dong-Jin Park,Hyeon Ji Jeong,Ho-Yong Park,Chi-Hwan Lim,Kwang-Hee Son 한국응용곤충학회 2023 한국응용곤충학회 학술대회논문집 Vol.2023 No.04

Reproducibility of Spectral-Domain Optical Coherence Tomography RNFL Map for Glaucomatous and Fellow Normal Eyes in Unilateral Glaucoma

Suh, Min Hee,Yoo, Byeong Wook,Park, Ki Ho,Kim, Hyunjoong,Kim, Hee Chan Raven Press 2015 Journal of glaucoma Vol.24 No.3

PURPOSE:: To compare the reproducibility of the optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness map between glaucomatous and fellow normal eyes of unilateral glaucoma patients. METHODS:: In this prospective case-control study, Cirrus HD-OCT was performed for 79 unilateral glaucoma patients 3 times on the first visit and on 3 subsequent visits within a 2-month period. Test-retest standard deviation (TRT-SD) and tolerance limit based on the 1.645×√2×TRT-SD formula were derived for RNFL thicknesses at the respective superpixels of the RNFL thickness map. RESULTS:: The TRT-SDs and tolerance limits of the glaucomatous eyes (TRT-SD: 2.75 to 20.25 μm; tolerance limits: 6.40 and 47.11 μm) were significantly smaller than those of the fellow normal eyes (TRT-SD: 2.73 to 26.49 μm; tolerance limits: 6.35 and 61.63 μm) in the superotemporal, inferotemporal, and superonasal areas (P <0.05). The TRT-SDs in most areas showed a significant positive correlation with the RNFL thicknesses (P<0.05). CONCLUSIONS:: The test-retest variabilities of the Cirrus HD-OCT RNFL thickness map of the glaucomatous eyes were lower than those of the fellow normal eyes, especially in areas of high diagnostic importance. Moreover, variability was positively correlated with the baseline RNFL thicknesses. Therefore, adjusting the tolerance limits on the basis of the baseline RNFL thickness values might help improve the ability to recognize progression. Further prospective studies on this issue are warranted.

Correlation between depth and area of retinal nerve fiber layer defect as measured by spectral domain optical coherence tomography

Suh, Min Hee,Yoo, Byeong Wook,Park, Ki Ho,Kim, Jung Yup,Kim, Hyunjoong,Kim, Hee Chan Springer-Verlag 2015 Graefe’s archive for clinical and experimental oph Vol.253 No.6