http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
권민석,최영준,사모아,박수형,신의철 대한면역학회 2018 Immune Network Vol.18 No.6
Immune checkpoint inhibitors (ICIs), such as anti-PD-1 and anti-PD-L1 Abs, have shown efficacy for the treatment of various cancers. Although research has actively sought to develop new ICIs and immunomodulators, no efficient in vitro assay system is available to evaluate their functional activities. In the present study, we established a two-round MLR with human PBMCs for evaluation of the T cell-activating capacity of anti-PD-1 and other immunomodulators. We initially performed conventional MLR for this purpose. However, anti-PD-1 blocking Abs could not increase the proliferation of allo-reactive T cells in conventional MLR because PD-L1+ and PD-L2+ cells disappeared gradually during MLR. Therefore, we re-applied the same stimulator PBMCs to the allo-stimulated responder cells as a second-round MLR on day 6 when anti-PD-1 or immunomodulators were also added. In this two-round MLR, the proliferation of allo-reactive T cells was enhanced by anti-PD-1 in a dose-dependent manner or by immunomodulators, such as lenalidomide and galunisertib, a TGF-β receptor-1 inhibitor. Proliferation was further increased by the combination of immunomodulators with anti-PD-1. Here, we established a modified two-round MLR method with human PBMCs for evaluation of the functional activities of anti-PD-1 and immunomodulators.
권민석,박규범,홍동표,박용재,한승용,강대식,고제성 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.4
Conventional industrial grippers that grip a flat object generally hold objects by using suction or electrostatic force. However, these grippers have limitations when gripping thin, flat, and flexible objects, such as films and flexible printed circuit boards (FPCBs), due to their undefined shape and high flexibility. This paper proposes a soft gripper that can grip flexible and thin objects by utilizing directional adhesives and a compliant mechanism. The directional adhesive pad is fabricated by a three-dimensional (3D) printing process for cost-effective and environment-friendly manufacturing. However, fabrication by 3D printing has disadvantages in terms of the quality of the adhesive surface. An additional coating process presented in this study compensates for the low resolution of 3D printing by improving smoothness. Moreover, an additional coating process is a simple approach for developing directional adhesives with enhanced adhesion strength by deforming the tip shape without a sophisticated fabrication process. The adhesion of adhesives with curved pillars is enhanced compared to adhesives with simple wedge-shaped pillars. The maximum normal adhesion force of the gripper is measured to be 0.47 N (1.57 kPa), and 95% of the initial adhesion is retained after ten thousand attachment/detachment cycles. The adhesion force can be recovered by the cleaning process when the contaminant is attached to the adhesive. The final demonstration shows that the gripper can handle various objects for potential applications such as in green-environmental industries.
열광학 장주기 격자를 유도하는 히터 배열의 인자들이 파워 소모에 미치는 영향
권민석,Kwon, Min-Suk 한국광학회 2008 한국광학회지 Vol.19 No.4
열광학 장주기 격자를 이용한 노치 필터의 파워 소모를 이론적으로 살펴 보았다. 여기서 열광학 장주기 격자는 주기적인 히터들과 패드들로 구성된 히터 배열에 의해 유발된다. 히터 배열에서 소모되는 파워는 열광학 장주기 격자를 유발하는 줄(joule) 열로 전환되기 때문에, 그 파워를 조절함으로써 노치 필터의 특성을 동적으로 제어할 수 있다. 적절한 결합 효율을 얻기 위해 히터 배열에 가하는 파워는 히터 배열의 인자들에 의존하는데, 이 인자들은 히터의 폭과 길이, 패드의 폭, 그리고 히터 배열을 구성하는 금속 박막의 두께이다. 이 인자들이 파워 소모에 미치는 영향을 이론적으로 해석하는 근사적인 방법을 설명하고, 설명한 방법을 사용하여 인자들의 변화에 따른 파워 소모의 변화를 해석한다. 해석 결과로부터 파워 소모를 줄이기 위해 필요한 인자 선택의 기준을 도출한다. We investigate theoretically the power consumption of a notch filter using a thermo-optic long-period grating, which is induced by a heater array consisting of periodic heaters and pads made of metal thin-film. Since the power consumed by the heater array is converted to joule heat that generates the thermo-optic long-period grating, the characteristics of the notch filter are dynamically controlled by adjusting it. The power necessary for appropriate coupling efficiency depends on the parameters of the heater array, which are the width and length of a heater, pad width, and the thickness of the thin-film. We explain an approximate method of analyzing the influence of the parameters on the consumed power. Using the analysis method, we simulate the change of the power depending on the parameters. From the simulation, we suggest a few guidelines on the parameters required to reduce the power.