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Invasive Squamous cell carcinoma of Vagina with Cerebellar Metastasis
민경진,오영택,소경아,이상훈,김재원,홍진화,송재윤,이낙우,이재관 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
Primary vaginal cancer is an uncommon tumor, representing only 1% to 2% of malignant neoplasms of the female genital tract. Due to early diagnosis and technical advances of brachytherapy in radiotherapy, the outcome for patients has improved over the past several decades. Distant metastases occur most commonly to lungs and liver. We describe a case of a 72-year-old woman with an invasive vaginal squamous carcinoma, who underwent chemo-radiation initially. Initially, there was no evidence of distant metastasis. However, the patient exhibited nausea, vomiting, slurred speech, and dizziness for several days at 1-year follow-up. Brain MRI was performed to check the lesion, and the suspected metastases were found in right cerebellum. Multiple lung metastases were found in chest x-ray. Conservative management was executed due to the patient`s poor general condition, such as Karnofsky performance status scale (KPS) 50, and refusal to treatment. Cerebellar metastasis should be considered in patients with neurological symptoms despite its rareness in vaginal carcinoma. Patients with multiple brain metastases and poor performance status as in our patient may not benefit from any type of therapy. The treatment plan for CNS metastases should be made on an individual basis, with careful consideration of the ultimate purpose of the treatment.