정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Ti-3Al-2.5V 합금의 피로특성 : 온도, 미세조직의 영향을 중심으로 The Effects of Temperature and Microstructure

박동준,김현철,임병수 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.2

Ti alloys, with the advantageous tensile strength/density ratio and the chemical stability, have been used widely in the aerospace and chemical engineering industries and their usages are still expanding in various industrial areas. In the automotive industry, because of their superior merits of weight reduction and fuel saving, Ti alloys are expected to be used as various part materials including connecting rods, engine valves, springs and retainers, which are all subjected to the fatigue loads. In this study, using Ti-3A1-2.5V alloy, the effects of temperature and microstructure change on fatigue crack propagation have been investigated.

雙補丸이 卵巢摘出로 骨多孔症을 誘發한 흰쥐에 미치는 영향

朴鍾元,崔相淳,金哲源,朴炳烈 한국전통의학연구소 2000 한국전통의학지 Vol.10 No.1

Aging is characterized by an age-dependent reduction in bone density. Pronounced bone loss by postmenopausal estrogen deficiency induces a bad effect on dynamic balance of bone metabolism. The purpose of this study is to examine what are the effects of the Ssangbohwan(SBH) on the ovariectomized rat model of postmenopausal osteoporosis. The results were summarized as follows : 1. Body weight in control group showed significant increase in comparison with sham, but that in SBH-treated showed no change in comparison with control. 2. The level of serum albumin in control group showed significant decrease in comparison with sham. That in SBH-treated was slightly decreased in comparison with control, which showed no efficacy. 3. The level of serum ALP activity in control group showed significant increase in comparison with sham, but that in SBH-treated was slightly decreased in comparison with control, which showed no efficacy. 4. The level of serum phosphorous in control group showed significant increase in comparison with sham, but that in SBH-treated showed no change in comparison with control. 5. The level of serum calcium in control group showed no change in comparison with sham, but that in SBH-treated was significantly decreased in comparison with control. 6. The level of serum T3 in control group showed no change in comparison with sham, but that SBH-treated showed significant decrease in comparison with control. 7. The level of serum T4 in control group showed significant increase in comparison with sham, and that in SBH-treated showed significant decrease in comparison with control. 8. Trabecular tibia strength in control group showed significant decrease in comparison with sham, but that in SBH-treated was slightly imcreased in comparison with control, which showed no efficacy. According to the above these results, SBH has shown to be capable of preventing and curing osteoporosis caused by old-aged and postmenopause

前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

구강내 접근방식에 의한 하악골절의 정복술

박병윤,이영호,이명철 大韓成形外科學會 1987 Archives of Plastic Surgery Vol.14 No.1

There are two approach methods in reduction of mandibular fracture, one is external approach and the other is intraoral approach. Most surgeon have been used external approach but intraoral approach gives many benefits. The authors performed interosseous fixation of various sites of 10 cases of mandibular fracture through intraoral approach and concluded that advantages of this method are; 1. no external scar 2. complete reduction (alignment) 3. decreased rate of malunion, maloclusion 4. fewer possibility of facial nerve injury 5. shorter operation time.

超高周波 領域에서 에폭시 기판의 相對誘電常數의 測定

朴東徹,朴炳權 충남대학교 공업교육연구소 1981 論文集 Vol.4 No.2

The relative dielectric constant of epoxy fiber glass was indirectly measured by using a simple method developed by Napoli and Hughes. Theoretical resonant frequencies of open-edged rectangular cavity were calculated and compare with the measured resonant frequencies. Modes could be identified through this comparison. Relative dielectric constant could be indirectly obtained from both measured frequencies and mode informations.

Thin 실리콘 기판을 이용한 MEMS 소자의 패키징

박윤권,김용국,김훈,이윤희,김철주,주병권 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

婦人科領域에서 應用된 鍼灸治療에 關한 文獻的 考察

金哲源,柳深根,朴炳烈 圓光大學校 韓醫學硏究所 1991 원광한의학 Vol.1 No.1

Bibliographic study on the acupuncture and moxibustion treatment applied to gynecological diseases divided into 9 Parts. And the results are as follows. 1. Total numbers of meridian-point used in the JO-KYUNG Part(調經門) were 54. Kidney-Meridian, Liver-Meridian, Conception Vessel-Meridian were used with high frequency and Joong-Kuk (CV_3), Sam-Um-Kyo(SP_6), Ki-Hai(CV_6) were frequently used. Also Yin-Meridian was chiefly used. 2. Total numbers of meridian-point used in the BUNG-ROO Part(崩漏門) were 36. Liver-Meridian, Kidney-Meridian, Bladder-Meridian were used with high frequency and Tai-choong(LIV_3), Hyul Hae(SP_10) Um-Gok(K_10) were frequently used. Also Yin-Meridian was chiefly used. 3. Total numbers of meridian-point used in the DE-HA Part(帶下門) were 46. Bladder-Meridian, Conception Vessel-Meridian, Kidney-Meridian were used with high frequency and God-Gol(CV_2), Jook-Kuk(CV_3), Di-Hai(CV_6) were frequently used. Also Yin and Yang-Meridian showed same frequency. 4. Total numbers of meridian-point used in the JING-HA Part(징하문) were 51. Spleen-Meridian, Kidney-Meridian, Conception Vessel-Meridian were used with high frequency and Sa-Man(K_14), Suk-Kwan(K_18), Kok-Chun(LIV_8) were frequently used. Also Yin-Meridian was chiefly used. 5. Total number of meridian-point used in the KOO-SA Part(求嗣門) were 38. Kidney-Meridian, Conception Vessel-Meridian, Bladder-Meridian were used with high frequency and Kwan-Won(CV_4), Joong-Kuk(CV_3), Yeun-Gok(K_2) were used with high frequently used. Also Yin-Meridian was chiefly used. 6. Total numbers of meridian-point used in the IM-SIN Part(姙娠門) were 58. Conception Vessel-Meridian, Spleen-Meridian, Kidney-Meridian were used with high frequency and Sam-Um-Kyo(SP_6), Kwan-Won(CV_4), Kyum Jung(G_21) were frequently used. Also Yin-Meridian was chiefly used. 7. Total numbers of meridian-point used in the SAN-HOO Part(産後門) were 43. Conception Vessel-Meridian, Spleen-Meridian, Liver-Meridian were used with high frequency and Ki-Hai(CV_6), Sam-Um-Kyo(SP_6), Kwan-Won(CV_4) were frequently used. Also Yin-Meridian was chiefly used. 8. Total numbers of meridian-point used in the YOU-BYONG Part(乳病門) were 47. Kidney-Meridian, Stomach-Meridian, Conception Vssel-Meridian were used with high frequency and Jok-Sam-Lee(S_36), Ha-Lyum(S_39), Jun-Jung(CV_17) were frequently used. Also Yin and Yang-Meridian showed same frequency. 9. Total numbers of meridian-point used in the JUN-UM Part(前陰門) were 35. Liver-Meridian, Heart-Meridian, Kidney-Meridian were used with high frequency and Kok-Chun(LIV_8), Sho-Boo(H_8), Dai-Don(LIV_1) were frequently used. Also Yin-Meridian was chiefly used.

제주자생 해조류의 세포성장 억제효과

김상철,박수영,김병석,강희경 제주대학교 생명과학연구소 2002 제주생명과학연구 Vol.5 No.6

The purpose of the present study is to examine the inhibitory effect of extracts of marine algae growing in Jeju on the growth of leukemia cells, adenocarcinoma cells, normal cell. The effect was observed by measurement of metabolic activity using colorimetric MTT assay. The methanol extracts on 36 species of marine algae growing in Jeju were screened for cytotoxic activity against HL-60 cells was found in 5 specices of Marine algae. In particular, Scytosiphon lomentaria, Lithophyllum okamurae. Hydroclathrus clathratus, Dictyopteris undulata, also showing similar cytotoxity to KG-1 cells. But, they did not show similar cytotoxicity to SNU-16 cells, HCT-15 cells. Lithophyllum okamurae, Dictyopteris undulata markedly inhibited the growth of CCD-25Lu normal cell.

[논문]보육실습에서 프로젝트접근법에 대한 예비보육교사의 관심수준 변화 연구

유병민,박수홍,강문숙,박철수,정경훈 교육혁신학술위원회 2011 교육혁신연구 Vol.21 No.1

본 연구는 예비보육교사가 보육실습이라는 과정에서 프로젝트 접근법에 대한 관심은 어떠하며, 관심변화 여부를 사례중심으로 살펴보는 것을 목적으로 하였다. 이를 위하여 예비보육교사를 대상으로 보육실습 사전과 사후검사를 실시하였으며, 자세하고 구체적인 사실과 연구의 질적인 부분을 찾아보고자 인터뷰하였다. 그 결과, 첫째, 프로젝트에 대한 예비보육교사들의 관심은 전반적으로 무관심으로 나타났다. 둘째, 사전․사후검사 결과, 프로젝트 접근법에 대한 관심수준의 변화가 있었던 사례에서는 관심변화의 패턴도 다양하게 나타났으며, 관심변화가 크게 없었던 사례에서는 개인, 정보관심이 높게 나타났다. 이러한 결과는 프로젝트에 대한 예비보육교사의 관심수준은 보육환경, 보육과정, 실습지도 교사, 예비보육교사의 지각력, 프로젝트에 대한 사전지식이나 교육정도에 따라 다양하게 변할 수 있음을 알게 되었다. The purpose of this study is to analyze the case in which we can identify how the SoC of prospective child care teachers about the project approach changes and why these change appears during the child care practice when we assumpt that for prospective child care teachers to implement the project approach is that they participate in change during child care practice. In Case K, the SoC of the prospective child care teacher moves from Stage 0 awareness to Stage 2, Stage 3, Stage 4, and In Case M, the SoC moves from Stage 0 to Stage 1. In Case P, the SoC moves from Stage 1 to Stage 2, Stage 3, and in Case S, the SoC isn't changed. Above this, we identify the SoC of prospective child care teachers. Case K, M, and P changes SoC after child care practice, but Case S doesn't change. the reason why there is a difference is the mindset of prospective child care teachers. Anyone who wants to accomplish specific purposes can deal with diverse changes with flexibility, but others can easily have an effect on the changes. We suggest that instructor in organization for prospective child care teachers’ education need to have a class for prospective child care teachers to put theory into practice, give direct facilitation and intervention in the field to prospective child care teachers, make a learning environment for prospective child care teachers to make good use of teaching materials and instrument, develop guidebook for project approach and give support to prospective child care teachers.