정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

조선대학교 의과대학 의학과 학사편입제도의 전향적 검토

임성철,박상기,도남용,박상학,이승일,송창훈,박종 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

There are many advantages and disadvantages under the limited bachelor's admission system. To diminish the demerits and to increase the merits of this system, the authors posed questions to the faculties and students of the Department of Medicine. Chosun University College of Medicine and other colleges in Korea. The questionnaire was made according to trends and feelings in this system. We received a lot of information and suggestions as to how to improve the system, in the following paper we discuss and report the prospective aspects of the bachelor's admission system.

방사선에 노출된 환자에 발생한 갑상선결절의 세침흡인세포학적 소견

임성철,구자봉 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

배경 : 두경부의 각종 질환치료에 사응되는 방사선 조사는 갑상선암종의 발생위험을 높이고, 여러 가지 세포학적 변화를 초래한다고 잘 알려져 있다. 그러나, 대부분의 보고는 임상적, 방사선학적 및 병리학적 소견에 집중되고 세침흡인 세포학적 소견의 보고는 없는 실정이다. 이에 저자들은 세포학적소견을 절제생검된 조직과 연계하여 문헌고찰과함께 보고한다. 방법 : 세침흡인 세포검사는 초음파 유도하에 이루어졌고, 이어 시행된 절제 생검조직을 세침흡인 세포학적 소견에 바탕하여 고찰하였다. 결과 : 환자는 55세 여자로 21개월전에 진단된 혀의 편평세포암종으로 화학요법과 방사선요법을 받았으며, 내원 14개월전에 치료를 마쳤다. 또한 환자는 영아기에 흉선비데가 있어 방사선치료를 받은 과거력이 있다. 환자는 화학요법후 최근에 발생된 갑상선 기능저하증을 제외하고는 특별한 이상소견 없이 잘 지내왔다. 최근 갑상선 좌엽의 결절이 발견되어 세침흡인검사를 시행하였으며, 도말상 군집을 이루거나, 산재된 갑상선 여포세포들이 심한 세포학적 이형성을 보이며 관찰되었으나, 유사분열이나, 괴사의 소견은 없었다. 결론 : 세포학적 소견이 방사선조사에 의한 것에 부합되지만 여포병변의 가능성을 배제할 수 없어서 갑상선 전절제술을 시행하였는데, 피막에 잘 싸여진 여포선종이 관찰되었다. 그리고, 갑상선 전체에서 관찰되는 상피세포의 이형성은 악성변화와는 무관하며 방사선조사효과에 부합된다고 판단하였다. BACKGROUND. It is well known that any kind of radiation used to treat benign or malignant conditions in the head and neck area results in an increased risk of thyroid cancer and a cytomorphologic changes. Most of the reports have been described the clinical, radiological, and pathological features, but cytology of FNA has not. In the current study the authors report the cytologic findings in FNA specimens with literature review and attempt to correlate the cytologic features with the excisional biopsy findings. METHODS. FNA was performed with ultrasound guidance. Corresponding subsequent excisional biopsy tissue was reviewed in conjunction with the cytologic findings. RESULTS. A case of FNA cytologic atypia of the thyroid gland in radiation exposed patient. She is 55-year-old with history of a squamous cell carcinoma of the tongue, diagnosed in 21 months ago, and underwent chemotherapy, followed by radiation therapy, which was completed in 14 months ago. She also has a history of thymus enlargement in infancy, which was treated with radiation therapy. She has done well since chemotherapy except most recently developed hypothyroidism. She was found to have a left lobe thyroid nodule for which she has undergone fine needle aspiration. Smears showed clusters as well as scattered thyroid follicular cells with marked cytologic atypia. Areas with microfollicular arrangement and colloid were present. There was no evidence of mitosis or necrosis. CONCLUSION. Although the findings were compatible with radiation changes, the possibility of an underlying follicular lesion could not be excluded. She underwent total thyroidectomy and showed well-encapsulated follicular adenoma. The entire thyroid contained epithelial atypia consistent with radiation therapy effect.

NDRG2 is one of novel intrinsic factors for regulation of lL-10 production in human myeloid cell

최승철,김광동,김종태,오상석,윤선영,송은영,이희구,조영경,최인표,임종석,김재화 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

복숭아나무 揷穗의 크기와 저장양분의 發根과 圃場活着에 미치는 影響

林敬鎬,金炳三,黃仁澤,金月洙,金光秀,金相喆 全南大學校 農業科學技術硏究所 1998 農業科學技術硏究 Vol.33 No.-

복숭아나무 경지삽목 번식에 있어서 삽수 굵기와 길이 및 삽수내 저장 양분 함량이 발근과 포장활착에 미치는 영향을 구명하였다. 삽수 굵기는 直徑 5∼8㎜의 삽수가 발근율이나 발근수, 발근장 등 뿌리 발달이 좋았으나 포장 활착율은 삽수재 저장양분이 많은 직경 8∼11㎜가 좋았다. 삽수 길이는 20∼30㎝ 처리가 발근율, 발근수, 발근장 등 발근력이 좋았으나 포장 활착율은 삽수재 잔존 저장 양분이 많은 30㎝ 길이가 좋았다. 삽목용 적정삽수는 8㎜ 굵기에 30㎝ 길이가 가장 효과적이었으며 포장에서 활착후 묘고, 간경 등 생육은 모든 처리에서 116㎝ 이상, 20.4㎜ 이상으로 삽목 당년에 우량묘가 생산되었다. This experiment was studied to examine the effect of cutting size and storage nutrient on rooting and survival in field using hardwood cutting of 'Sunaga Wase' peach to establish mass production system of rooted cutting. Cuttings having 5 to 8㎜ in stem diameter showed the best rooting percentage, root number and root length. In the survival in field, the stem diameter of 8 to 11㎜ showed the highest survival rate and less consumption of storage nutrient during cutting. Those hardwood cuttings of 20 to 30㎝ in stem length showed the best rooting, and higher survival in field was obtained in 30㎝ long cuttings. After transplanting rooted cuttings to field, tree height and trunk diameter of 'Sunaga Wase' peach was 116㎝ and 20.4㎜, respectively.

위암의 진행에 따른 Fas관련 아포프토시스 유도의 상관성

임성철,황철기,오서진 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Background and Objectives : The purpose of this study is to determine whether human gastric adenocarcinomas express Fas-L, sFas-L or Fas , whether serum sFas-L leyel is changed in gastric cancer patients after gastrectomy, whether Fas-L expression is associated with increased apoptotic induction, especially, tumor-infiltrating Iymphocytes(TIL) and whether apoptotic induction is associated with the tumor stage and histologic type. Materials and Methods : The author analysed 38 cases of early gastric carcinoma(EGC) and 61 cases of advanced gastric carcinoma (AGC) which received gastric resection from 1997 to 1998. Of them, the number of diffuse type is 38 cases and the number of intestinal type is 61 cases. The author used immunohistochemical staining for Fas, Fas L and CD45, TACS^TM in situ apoptosis detection kit, and sFas ligand ELISA kit. Results : Fas-L was localized to neoplastic cells in 23 cases (23/38; 61%) of EGC group and 40cases (40/61; 66%) of AGC group. The extent of Fas-L expression was variable, with both Fas-L was localized to neoplastic cells in 23 cases (23/38; 61%) of EGC group and 40 cases(40/61; 66%) of group. The extent of Fas-L expression was variable, with both FasL-positive and negative neoplastic region cccuring within. TIL were detected by co-expression of CD4S and TACS on serial histologic sections. TIL adjacent to Fas-L erxressing tumor regions were decreased in number and TIL adjacent to FasL-negative tumor regions were increased in number; apoptotic induction of TIL showed the opposite pattern (p<05). Fas expression was found essentially homogeneously throughout the tumor mass independent of tumor stage. Fas expression showed 39 cases (39/61; 64%) of intestinal type and 26 cases (26/38; 68%) of diffuse type. Labeling indces for tumoral apoptosis in EGC and AGC were 6.72% and 7.13%, respectively and this difference was statistically insignificant. Co-expression of Fas-L and Fas, which occurred over large areas of the tumors, did not result in an enhanced rate of tumor cell apoptosis. The mean serum sFas-L level was significantly higher in patients before treatment compared with controls, whereas in post-gastrectomy patients, it was significantly lower, In addition, tumor stage and other prognostic factors were not associated with Fas and Fas-L expression, serum sFas-L level, number of TIL and apoptotic induction. Conclusion: 'The author demonstrates a statistically significant reduction of TIL concomitant with significantly increased TIL apoptosis adjacent to FasL-expressing regions of gastric adenocarcinomas. Also an elevated level of ·serum sFas-L in the gastric adenocarcinoma group was noted. These findings suggest Fas-mediated apoptotic depletion of TIL in response to Fas-L expression by stomach cancers, and provide the evidence to support the Fas counter-attack as a mechanism of immune escape in gastric cancer. And These findings indicate that the serum sFas-L level is a useful indicator in evaluating postoperative follow-up. In addition, gastric carcinoma cells of the intestinal and diffuse type did not differ in their expression of the Fas-apoptotic system.

기관내삽관에 의한 후두손상

임상철,이준규,이동훈,윤태미 全南大醫大 2004 전남의대학술지 Vol.40 No.1

회전축계의 진동제어용 ER 유체 댐퍼의 설계 및 반능동 비례제어

임승철,채정재,박상민 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

This paper is concerned with the design and application of an Electro-Rheological(ER) fluid damper to suppress vibration of rotor systems. The example system at hand is flexible with a slender shaft and a thin disk, being su pported by two ball bearings. In addition, to investigate the system performances also in the high speed range, the driving torque is made to transmit through a speed increasing gear train. Along with the experiments, to predict and compare the ER damper effect, the rotor system is simulated as to its free and forced vibration characteristics. Such simulations are done by means of a finite element analysis code, which includes the mathematical model of the designed ER damper.

공업화부재의 생산/운반/양중관리를 위한 정보가시화 시스템 개발에 관한 연구

임형철,송영석,김창덕,송성진 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

Recently, The construction field in the urban area is short of working space and securing processing place because it is surrounded by adjacent buildings and nearby roads and have difficulties in rising labor costs. The insufficient space causes problems of interference and conflicts in transporting materials and working at the site. Therefore, Construction Manager find many alternative method and select industrialized method. The objective of this paper is to develop and give a method of information visualization system for manufacturing, delivering and lifting these materials in construction project stakeholders, using tools visualizing informations. The tools supports to stakeholders so many informations in material manufacturing, delivering, lifting in construction site. That is, order information, manufacture information in factory, sending information, carrying information, unloading and lifting in Site, and so on. Case studies are performed to evaluate the feasibility and applicability of the proposed method.

백서 간재생중 H2B Histone 유전자 발현에 대한 Octamer Binding Transcription Factor의 역할

임규,방재웅,최두식,손미영,이영철,박청,김태동,김영래,박종일,윤완희,박승길,황병두 한국노화학회 2001 한국노화학회지 Vol.11 No.1