Comparison of controlled ovarian stimulation outcomes for fertility preservation in women with breast cancer according to KI-67, histologic grade, pathologic type, and cancer stage

( Eun Ji Oh ),( Yeon Hee Hong ),( Seul Ki Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: This study aims to analyze that specific prognostic factors such as Ki-67 value, histologic grade, pathology type, and cancer stage can affect controlled ovarian stimulation outcomes(COS) for fertility preservation in women with breast cancer. Methods: This retrospective cohort study included 92 patients with breast cancer aged 21-44 who underwent COS from August 2012 to April 2020, excluding patients with previous gonadotoxic therapy history. All COS cycles were conducted letrozole-combined random start GnRH antagonist protocol. COS outcomes were compared according to prognostic factors;Ki-67 (< 30% vs. ≥ 30%), histologic grade (low vs. high), and pathologic type (intraductal carcinoma(IDC) vs. triple-negative breast cancer(TNBC)), and cancer stage (early (I, II) vs. advanced (III, IV)). Multivariate analysis was also conducted to find any parameter that can impact over 10 mature oocytes acquisition. Results: Among the 92 patients, 42 were Ki-67≥30% compared to 49 of Ki-67<30%. The number of oocytes, and initial mature oocytes were comparable between Ki-67<30% and ≥30 group. The maturation rate was significantly higher in Ki-67≥30% group than Ki-67<30% group (57.4±36.8% vs. 44.8±28.3%, p=0.041). The same results were drawn when divided according to IDC or TNBC. The maturation rate was significantly higher in TNBC than the IDC group (73.0±17.6% vs. 47.0±28.1% p=0.001). However, the histologic grade or stage did not show any difference in COS outcomes between high and low grade or early and advanced stages. With multivariate analysis, age and AMH are parameters associated with the acquisition of over 10 mature oocytes (OR 0.863, 95% CI [0.755-0.987], OR 1.408, 95% CI [1.145-1.732], respectively). Conclusion: Either Ki-67 or pathologic type can be a potential reliable marker for predicting COS outcome, especially maturation rate. Further study with larger sample size with specific conditions is necessary to clarify the correlation between breast cancer prognostic factors and COS outcomes.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

通度寺 進入空間을 통해서 본 傳統景觀의 現代的 受容에 관한 考察

鄭基浩,韓炳權,全美璟 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.1

Traditional landscapes were effected on the characteristics of nature and culture and have created distinct landscapes, while todays such attributes are becoming obscure as technology. In aspect of the contermperary applications of traditional landscapes, the cognitive qualities of observers was researched, which is about the components of entrance space in Tongdo Teple by phenomenological approach. The results of this can be summarized as follows : 1. Old components were not perceived and effected on the behavior of observers. 2. Cognitive qualities were varied from the attributes of space in and out. 3. Artificial features that related to contemporary life were perceived easily. As there were old and contemporary features to gether, the existence of old things is to be obscure relatively.

실험동물에서의 내분비계 교란물질인 DEHP, DBP의 생체내 영향

정지윤,이성호,박영석,박병권,김병수,김상기,박창식,강경선,이영순 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

The major protocol features of the rodent uterotrophic assay have been evaluated using a range of reference chemicals. The protocol variables considered include the selection of the test species and route of chemical administration, the age of the test animals, the maintenance diet used, and the specificity of the assay for estrogens. The rodents were ovariectomized under general anesthesia via bilateral flank incisions and randomly assigned to groups of 5 animals. This study investigated the estrogenic effects of phthalates, which are DEHP and DBP, suspected as endocrine disruptors. It is concluded that three daily subcutaneous administration of test chemicals, which are di-ethylhexyl phthalate(DEHP) and di-n-butyl phthalate(DBP), to 9 week-old rodents. The results revealed that DEHP & DBP show similar uterotrophic activity in the rat and the mouse, using subcutaneous administration. DEHP and DBP failed to affect any of these parameters, which are body weight, mammary gland, vaginal and uterus histopathology. but, DBP increased uterus weight to only one rat of 1.0 g/kg group. The results conform the need for rigorous attention to experimental design and criteria for assessing estrogenic activity.

초음파 수침법을 이용한 터빈베어링 Babbitt 금속 박리 검사 기술

정계조,박상기,조용상,박병철,길두송 한국비파괴검사학회 2004 한국비파괴검사학회지 Vol.24 No.4

이 연구는 터빈베어링의 신뢰성을 평가하기 위하여 초음파 C-Scan 방법을 적용한 기술이다. 수침법에 관한 연구는 실험실과 현장검사 적용에 광범위하게 사용되는 기술이다. 여기에서는 C-Scan 방법을 이용하여 베어링의 모재와 Babbitt 금속간 경계부의 상태를 평가하였다. 수침법 C-Scan 방법에 의한 초음파 영상은 베어링 경계부의 상태를 확인하는데 효과적인 방법으로 사용될 수 있었다. 초음파 영상의 분해능을 높이기 위하여 집속형 탐촉지를 사용하고, Babbitt 금속과 베어링 모재간의 접합경계면에서 발생하는 초음파 음압 반사율을 측정하여 결함의 검출과 면적을 추정할 수 있었다. 초음파 수침법은 베어링 접합부의 박리위치와 박리면적의 경계면을 결정하여 크기를 계산하는데 아주 유용하게 사용될 수 있는 기술이며, 이 연구에서 개발된 기술은 화력발전소에서 사용되고 있는 터빈베어링의 건전성을 확보하는데 적용되었다. This study is aimed for the implementation of ultrasonic method to assess the reliability of turbine bearings. A modified ultrasonic immersion technique was carried out in both laboratory experiment and field application. From the laboratory results, we confirmed that the condition of interface layer between the babbitt and base metal be monitored by the C-Scan. The C-Scan image by the ultrasonic immersion test can be used successfully to observe the condition of interface layer. The testing with a focused transducer provides a promising approach for estimating the extent of the damaged region and observing the interface layer effectively. The difference of the ultrasonic reflection ratio between the bonding and debonding area at the interface layer is one of the key parameters for assessing the extent of the damaged area; additionally, the reflection amplitude exhibits a favorable correlation with the overall damage level. The technique developed in this study was applied to the inspection of the turbine bearings at several power plants in Korea whereby the applicability in the filed can be ascertained.

24시간 혈압 감시를 통한 만성 뇌졸중 환자에서의 야간 혈압 강하 현상의 연구

정산,이병철,유경호,정승철,김성민,권기한,황성희 대한신경과학회 1996 대한신경과학회지 Vol.14 No.4

Ti 鎔接材의 機械的 特性 및 疲勞크랙 進展擧動에 關한 硏究

최병기,장경천,정장만 朝鮮大學校 機械技術硏究所 2001 機械技術硏究 Vol.4 No.2

Ti 용접재 시험편을 통하여 용접조건에 따른 기계적 성질 및 피로크랙 진전거동을 각각 비교·검토한 결과 다음과 같은 결론을 얻을 수 있었다. 동일한 용접조건에서 패스 수에 따라 4패스는 7패스와 비교하였을 경우 인장강도가 10%정도 높게 나타났고, 연신율은 30%종도 감소함을 알 수 있었다. 또한 실딩가스량이 많고, 용접 후 자연냉각 시간간격이 길수록 인장강도는 높게 나타났고, 연신율은 감소하였다. 충격 흡수에너지값은 4패스는 7패스에 비해 50%정도 감소하였으나, 실딩가스량이 많을수록 높게 나타났다. 또한 경도값은 패스 수가 적을수록 높게 나타났으며, 용접 후 자연냉각 시간간격에는 비슷하였으나 용접 후 자연냉각 시간간격이 적은 것은 조금 감소하였다. 초기크랙 진전속도는 Bond부, 용착부, HAZ, 온도영향부 순으로 느리게 나타났으나, 피로수명은 Bond부, HAZ부, 용착부, 온도영향부 순으로 높게 나타났다. The purpose of this thesis was to investigate the welding characteristics and the fatigue crack propagation behavior of titanium commonly using power station, aircraft and ship. The experimented material was TIG welded in order to look over the characteristics according to the notch position and compare with other materials. We compared and reviewed the fatigue crack propagation behavior of nonwelded base metal and welded specimens having different notch position to evaluate the fatigue crack propagation behavior by welding condition. The tensile strength and elongation of the 4 pass welded specimens was shown about 10% and 30% higher than those of the 7 pass welded specimens at the same welding conditions. Also, the more shield gas and the lower natural cooling time, the higher tensile strength but the lower elongation. The absorption energy of the 4 pass welded specimens, was decreased about 50% more than that of the 7 pass welded specimens, and the more shield gas, the higher impact absorption energy value. The higher hardness, the lower pass, but the natural cooling time almost had no relation to the hardness. The fatigue life was shown higher as following the order, boundary zone > HAZ > welding zone > base metal. Especially the fatigue life of boundary zone notched specimen was shown 700% higher than that of base metal.

LiNbO₃기판을 사용한 광 도파로의 설계 및 분석

강기성,채기병,소대화,박정철 明知大學校 産業技術硏究所 1991 産業技術硏究所論文集 Vol.10 No.-

In this paper, we calculate refractive index change of optical waveguide and electric field to simulate y-cut LiNbO₃optical waveguide at He-Ne laser (λ=0.6328[㎛]) by BPM mechanism. At waveguide width of 4[㎛], buffer layer of 0.02[㎛] of LiNbO₃ substrate (XI 55[㎛] x ZI 5000[㎛], we observed electric field Ex, Ey in x, y-direction. By applying these parameters of single waveguide to simulate a X-switch, we have chosen index change of 0.002, width of 3[㎛] and angle of 0.4。∼0.6°of optical waveguide and under these conditions, optical beam propagates cross-side at 0.4° When applied switching vlotage of 25[V], optical beam of X-switch turns cross-side to bar-side at intersection angle 0.4° index change of 0.002, wavegulde width of 3[㎛], electrode gap 2[㎛]. By the above results, we can obtain the basis design conditions of X-switch optical modulator. And optical single waveguide is fabricated on the y-cut LiNbO₃ single crystal substrate by Ti-indiffusion method. The line-width of the waveguide was made from 4[㎛] to 6[㎛]that observed single mode at 4[㎛] as a result of propagation of He-Ne(0.6328[㎛]) laser beam.

온도상승에 따른 마감재의 세공구조 특성에 관한 연구 : 석고보드를 중심으로 Focusing on Gypsum Boards

김광기,박선길,김근허,송병창,정상진 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

On fire, the most significant materials influencing the rise of temperature are finishing materials, and highly combustible materials become the reason of magnifying fires compared to incombustible materials. Recently, gypsum boards are widely used as interior finishing boards for constructions because of their features of absorbing heats and little temperature rising at the early stage of fire. Therefore, in this research, basic data were suggested to secure fireproof stability by investigating interior processing features, which change together with the backside temperature of test materials from Flash Over(within 30 minutes after firing), at which temperature reaches its highest point, to survey the features of materials due to rising temperature in the chase of gypsum boards (general and fireproof gypsum board)

제놈 분석용 계산 Web 서버의 구성

박기정,이병욱,박용하 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

국내 제놈 프로젝트와 생물학 연구자들을 지원하기 위한 GINet 서버에서 분석 프로그램들을 Web을 통해 사용할 수 있도록 GINet 분석계산용 Web 서버를 구성하였다. 각 분석 프로그램의 구조를 분석하여 필요한 데이타와 옵션의 종류 및 사용 형태를 정리한 후, 사용자가 이들을 입력할 수 있는 입력 form을 HTML로 작성하였다. 입력된 옵션과 데이터는 Web 서버에 전송되는데, 이들을 분석하여 해당 실행 프로그램을 실행한 후 분석 결과를 Web 사용자에게 전송해 주도록 CGI 프로그램들을 작성하였다. 특히 분석 프로그램의 형태를 2가지로 나눠 각 경우 CGI 프로그램을 구현하는 공통적인 절차를 구성하였고, 여기에 각 분석 프로그램마다 개별적으로 다른 부분은 개별적으로 보완하는 방식으로 각 CGI 프로그램을 구현하였다. 현재 이 서버에서 직접 지원하는 분석 프로그램은 사용 빈도가 가장 높은 프로그램들과 자체 개발한 프로그램들을 포함한 것이고, 추후 설치되거나 자체 개발되는 프로그램들의 대부분도 이 계산 Web 서버에서 제공될 수 있도록 시스템이 구성될 것이다. A computation server is needed to provide analysis programs to Korean biologists, especially genome researchers, on GINet. For each analysis program, we implmented an input form with HTML and a CGI program of interface between an input form and an analysis program with C language on GINet computation Web server. We made two construction methods of CGI programs for analysis programs, and implemented all CGI programs based on the methods followd by modifying each CGI program for specific processing of each analysis program. On the server ten programs are available now, which include most frequently used ones and those developed by our team, and most programs which will be ported or developed by our team will be available on the Web server.