백서 간재생중 H2B Histone 유전자 발현에 대한 Octamer Binding Transcription Factor의 역할

임규,방재웅,최두식,손미영,이영철,박청,김태동,김영래,박종일,윤완희,박승길,황병두 한국노화학회 2001 한국노화학회지 Vol.11 No.1

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

가상 상점(Cyber Shopping Mall)의 서비스품질 측정

박정훈,강기두,주희엽 한국경영과학회 2000 經營 科學 Vol.17 No.3

With the explosion of internet users, there are many enterprises and organizations that regard the internet as the great marketing superhighway. Although fascination and speculation surrounds the impact of the cyber shopping mall on consumer shopping behavior, there is little empirical evidence underlying all this speculation. This article reports on the critical issues that consumers found salient as they browsed through cyber shopping malls. We gathered consumers' reactions via open-ended survey. We related the reactions to the factors of tangibility, assurance, responsibility, empathy, and reliability which we had identified from the existing literature on service quality. Two additional questionnaires were administered to translate these factors to the cyber shopping mall context and to explore their relative salience. We also evaluated SERVQUAL and SERVPERF as service quality measures for cyber shopping malls. The results show that SERVPERF seems more promising than SERVQUAL. The results also suggest that cyber shopping mall merchants need to think more about how they perform on the issues known to affect customers' decision making for purchasing. We offer advice for enhancing the design of cyber shopping mall.

정보화사회와 미래의 과학 교육에 대한 고찰

박재호,김학수,이두희 부산대학교 사범대학 과학교육연구소 1996 科學敎育硏究報 Vol.23 No.-

We discuss the concept of imformation society and the middle school science education for the future information society. The discussions can be summarized as the followings ; 1. The information society can be realized by the renovation of informational techniques such as computer and electric communication. And the society will be heavily dependent on the various services, informations, and knowledges. 2. The educational curricula, educational method, and educational contents in the information society will be drastically different from today's and developed into the information-oriented ones.

Mn-X-Bi系 薄膜의 磁氣-光學的 特性

朴愛珠,金斗姬,李章魯 淑明女子大學校 1980 論文集 Vol.20 No.-

Magnetic and mageto-optic properties of the ferromagnetic compound Mn_5Ni_2Bi_4 thin films are studied. The films are prepared by vacuum evaporation. Bi, Ni and Mn films are evaporated successively onto glass substrates at room temperature. The experimental conditions of the evaporatina process and thermal treatment of thin films of the Mn-Ni-Bi tennary system are examined. The specific conditions required are obtained to be more than ten hours of annealing at 350℃ in vacuum of 10^-5∼10^-6 Torr. The formation of compound Mn_5Ni_2Bi_4 films was confirmed by X-ray diffraction. The magnetic hysteresis loop of Mn_5Ni_2Bi_4 films of the thickness 800 A˘ measured by a magneto-optical method are rectangular, that is, the remnant magnetization equals the saturation magnetization. The magneto-optic Kerr effect of the films are inverstigated by measuring the rotation angle of the polarization and the ellipticity of the reflected light from the film surface using an ellipsometer. The state of polarization is analytically represented by using the poincare' sphere. The optical indices such as the refractive index, the index of absorption, the magneto-optic amplitude, its phase are obtained by analyzing the measured rotation angles and ellipticities in terms of the reflection coefficient derived by Voigt. The absorption coefficient, the figure of merit, the electric conductivity, and the electric polarizability are also calculated using the above quantities. The dependence of the magneto-optic constants upon the wave length of the light have also been investigated. The largest value of kerr rotation, magneto-optic amplitude and figure of merit obtained near the wave length 5000∼5200A˚are attributed to the resonance of the electric conductivity term and polarizability term of off-diagonal elements of the dielectric tensor. It is found that the center of the dispersion of magneto-optic constants is at the above region of the wave length showing that the magneto-optic transition occurs around this wave length. The figures of merit Mn_5Ni_2Bi_4 film are smaller than those of MnBi. The films are very resistant to oxidation by the surrounding atmosphere. The Mn_5Ni_2Bi_4 film seems promising as a magneto-optic memory medium

2-Hydroxy-5-(3-phenethylthiocarbamoyloxypentyl)benzoic acid methyl eater의 합성 및 바닐로이드 수용체 길항효과

박주현,김희두 숙명여자대학교 약학연구소 2005 약학논문집-숙명여자대학교 Vol.22 No.-

2-Hydroxy-5-(3-phenethylthiocarbamoyloxypentyl)benzoic acid methyl ester(2) was designed, synthesized and evaluated as a vanilloid receptor antagonist. Compound 2 did not show an antagonist activity up to 30 μM concentration in ^(45)Ca^(2+) -influx assay.

부산·경남지방의 외과적 갑상선 질환에 대한 통계적 고찰

박희두 부산의대 1983 부산의대잡지 - 부산대학교 의과대학 Vol.23 No.2

조증과 유사한 갑상선기능항진증 1례

박두병,김용희,기백석,이재광 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.2

The psychiatric symptoms produced by hyperthyroidism are less clearly defined than those occured with myxedema. The typical psychiatric syndrome of hyperthyroidism is reported by most authors to simulate a bipolar disorder. Other forms reported were simple, catatonic and paranoid schixophrenia; psychotic depression; functional psychosis; organic brain syndrome; and atypical psychosis. No clear picture, however, exists concerning any fixed psychotic syndrome. Sometimes the patient become delirious while other times experience of hyperexcitability simulating mania that is quite confusing for the clinician to differentiate from bipolar disorder. The authors experienced a case of hyperthyroidism simulating bipolar disorder. The case was a 49-year-old male patient who developed a episode of delirium and manic symptoms during treatment of hyperthyroidism. Although mania is directly associated with thyroid hormone level, this case is not considered primary bipolar disorder because of close proximity between onset of hyperthyroidism and manic episode. Absence of past history and family loading for the bipolar disorder further support its relationship with hyperthyroidism. We considered that this patient's course of illness is embarrassing for there is a episode of delirium as well as manic symptoms. Psychiatrists should be aware of psychiatric syndromes including bipolar disorders associated with hyperthyroidism.

주요 우울 장애 환자의 면역기능에 관한 연구

김용희,이재광,박두병 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.3

주요 우울 질환 환자에서 전반적인 면역상태를 알아보고 연령, 성별, 우울증의 심도와의 상관성을 검토해보기 위해 저자들은 30명의 주요 우울장애 환자군과 32명의 정상 대조군을 비교하여 다음의 결과를 얻었다. 1) 환자군과 대조군 간의 면역지표 중 총백혈구 수, 총임파구 수와 백분률, 자연 살 세포 수와 백분률, T 임파구의 수와 백분률, B 임파구의 수와 백분률, helper T 임파구의 수, supressor T 임파구의 수, helper T임파구/supressor T 임파구 비에 있어 통계적으로 의미있는 차이를 보이지 않았고 supressor T 임파구 백분률만 의미있게 감소되어 있었다. 혈청 면역글로블린은 환자군과 대조군 간에 IgG와 IgM은 통계적으로 의미있는 차이는 없었지만 IgA는 환자군이 대조군에 비해 의미있게 증가되어 있었다. 2) 환자군에서 임파구 총 수, B 임파구 수와 백분률, IgA가 남자가 여자보다 감소되어 있었다. 연령에 따른 비교에서 환자군에서 연령과 임파구 백분률 사이에 정적 상관 관계를 보였고 대조군에서는 T 임파구 백분률, helper T 임파구의 수와 백분률에서 정적 상관 관계를 보였다. 환자군에서 HDRS로 평가된 증상의 심각도에 따라 IgM이 부적 상관 관계를 보였다. The authors compared 30 depressive patients with 32 normal controls to see the change of immunity in major depressive disorder and study the relationship between altered immunity and variables such as sex, age, and symptom severity. The results of this study were as follows : 1) Percent of suppressor T cell in depressive patients was significantly lower than that of normal controls and IgA concentration of depressive patients was significantly higher than that of normal controls. 2) In the depressive patient group, male patients showed significantly lower number in total lymphocyte, number and percentage of B cell, and IgA concentration than in the female patients. 3) In depressive patient group, a positive correlation was found between percentage in lymphocyte and age and in control group, positive correlations were found among percent of T lymphocyte, number and percentage of helper T cell and age. Negative correlation between IgM and the symptom severity assessed by HDRS was observed in depressive patient group.

프로테오믹스 연구의 최근 동향 및 전망

이도희,박성구,박병철,명평근 충남대학교 생물공학연구소 2006 생물공학연구지 Vol.12 No.-

Proteomics is the study of the "proteome" or the entire protein complement of a genome. It is now well-established that proteomics is far more complex than simply cataloguing all the proteins present in a cell or organism at a given time. Proteomics now includes not only the identification of proteins or the study of protein expression pattern but also the understanding of post-translational processing of proteins or protein-protein interaction, which often result in the alteration of protein stability, localization and/or function. Here we briefly summarize how proteomics has been evolved during the last decade and review a few crucial techniques widely used in the proteomic studies, such as 2-DE and mass spectrometry. Moreover, we discuss the applications of proteomic tools in related research areas and its potentials in drug discovery and the study of diseases.