바터 팽대부에 생긴 유암종 1예

강명주,지삼룡,박석주,이재익,조영완,김준영,박성재,박은택,이연재,이상혁,설상영,배상균 인제대학교 2006 仁濟醫學 Vol.27 No.-

Carcinoid tumors have been reported in a wide range of organs but most commonly involve the lungs, bronchi and gastrointestinal tract. Within the gastrointestinal tract, appendix is the most common location for carcinoid, followed by the distal small intestine, the rectum, and the stomach. Among these, primary involvement of the ampulla of Vater is extremely rare. We report a case of carcinoid tumor of ampulla of Vater. A 62-year-old man presented with epigastric soreness. Gastroduodenal endoscopy showed hyperemic bulging mass on ampulla of Vater and diagnosed as carcinoid tumor by histologic finding, with immunohistochemical study. In ^(111)In-octreoscan, tumor had regional lymph node metastasis, but no evidence of distant metastasis. Pancreatoduodenectomy with lymph node dissection was performed.

Caffeine이 지구성 운동 수행능력에 미치는 영향과 억제성 아미노산에 의하여 활성화되는 이온통로의 조절작용

김은경,김영표,천병옥,이계영,김연정,임백빈,조영욱,김창주,김성수 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

To investigate the effect and mechanism of caffeine on endurance exercise, two experiments were performed. First, to test caffeine effect on aerobic exercise, 200-300g Sprague-Dawley rats were used and three groups, control group, low caffeine injection group and high caffeine injection group, were divided. Blood smpling by heart puncture were done at rest, after 30 min treadmill exercise, and after maximal exercise. Blood glucose, free fatty acid concentration were detected and following results were obtained. Glucose concentration showed significant difference between groups(p=0.0305) and also significant changes were exhibited between time(p=0.0004). Free fatty acid concentration had no difference between groups. but had significance between times(p=0.00065). Exercise endurance performance time showed significant difference(p=0.02350 in high caffeine injection group compared to control group. In this experiments, endurance exercise capacity was increased by caffeine injection. Therefore, second experiment was performed to investigate the effect of caffeine on ion current induced inhibitory amino acid neurotransmitter. GABA and glycine. Single periaqueductal gray neuron was acutely dissociated and nystatin perforated patch clamp was performed under voltage clamping condition. Caffeine evoked outward current in PAG neuron dose dependent manner. 1mM of caffeine application had no response. but 3mM caffeine evoked about 32.5±8.539pA outward ion current and 10mM caffeine evoked about 215.46±19.4pA outward current. 10^-2mM GABA activated Cl￣current and recorded by inward current. Caffeine inhibited GABA activated Cl￣ current concentration dependent manner. 10^-2mM of caffeine had no effect on 1-^-2mM of GABA response. but 10^-1mM caffeine inhibited GABA activated Cl￣ current about 5.74±2.13%, 1mM caffeine inhibited about 17.25±2.70%, 10mM caffeine inhibited GABA response about 45.31±7.71%. 10^-1mM of glycine activated Cl￣ current and also recorded by inward current. Caffeine inhibited glycine activated Cl￣ current concentration dependent manner. 10^-2mM caffeine decreased glycine activated Cl￣ current about 4.61±1.650%, 10^-1mM caffeine decreased about 6.49±2.24%, 1mM caffeine decreased about 26.82±4.27%, and 10mM caffeine decreased glycine response about 94.47±1.39%. These results suggest that caffeine inhibite inhibitory amino acid, GABA and glycine, this response causes excitation of CNS and this seems to be the basic mechanism of increasing effect to aerobic exercise performance by caffeine.

학교평생교육에 대한 현직교사의 인식 조사 연구 : 서울시 초등학교 교사를 중심으로

전주성,유은수,한수연,이현주,임희연,이희송 한국성인교육학회 2007 Andragogy Today : International Journal of Adult & Vol.10 No.3

인터넷 상의 다중공격에 대비한 침입탐지시스템 모델 설계

최주영,최은정,이지윤,윤세안,김명주 서울여자대학교 자연과학연구소 2000 자연과학연구논문집 Vol.12 No.-

Since modern attacks against information system utilize large-scale and distributed network, they become more versatile and complicated. We propose a new model of intrusion detection system, IDSS that can effectively detect multiple resource attack from to the inter-system and intra-system. IDSS (Intrusion Detection System for Seoul women's university) is optimized in agent unit to detect multiple attacks on network effectively and designed to and respond to them in real time.

하악의 교정용 미니 임플랜트 식립 부위에서의 피질골 두께와 치근간 거리 : 3차원으로 재구성한 CT 영상을 이용한 연구

임주은,임원희,전윤식 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.6

교정용 미니 임플랜트의 식립 부위에 대한 연구는 주로 구치부 치근사이 공간에 집중되어 왔다. 본 연구의 목적은 전치에서 구치에 이르는 치아간의 피질골 두께와 치근간 거리를 측정함으로써 교정용 미니 임플랜트 식립 시에 참고 할 수 있는 임상적 지침을 제공하는 것이다. 연구를 위해 성인 28명(남자 14명, 여자 14명)의 CT를 V-works 4.0 을 이용하여 3차원 영상으로 전환하였다. 중절치에서 제2대구치에 이르는 모든 치아 사이를 치간 접촉점을 지나면서 교합 평면에 수직이 되도록 잘라 90° 단면을 형성한 후 치조정으로부터 높이를 달리하여 0, 15, 30, 45° 의 각도를 주어 피질골의 두께를 측정하였다. 또한 치조정으로부터 2, 4, 6 mm 높이에서 교합 평면에 평행하게 잘라 90° 단면을 만든 후 치근간 거리를 측정하였다. 피질골의 두께는 전치부에서 구치부로 갈수록 두꺼워지는 경향을 보였으며, 5-6과 1-1 사이, 6-7과 1-1, 1-2, 2-3 사이에서는 유의한 차이를 보였다 (p < 0.05). 치조정으로부터 2 mm 높이를 제외한 대부분의 위치에서 각도가 증가함에 따라 피질골의 두께가 급격히 증가하는 경향을 보였고, 4 - 6 mm 높이에 식립시 30 - 45˚ 이상의 각도를 부여해야 피질골 보유량(engage 양)에 유의한 차이를 보였다. 치근간 거리 측정 결과 4-5, 5-6, 6-7 사이가 치근 손상 없이 미니 임플랜트를 식립하기에 적절한 위치라고 볼 수 있었고, 1-1과 1-2 사이는 미니 임플랜트 식립을 위한 충분한 치근간 거리를 제공하지 못하는 것으로 나타났다. 본 실험의 결과로 볼 때 피질골과 미니임플랜트의 접촉면을 증가시키기 위해서는 치조정에서 치근단부로 4와 6 mm 되는 부위에서 30˚ 또는 45˚ 로 식립하는 것이 유리할 것으로 보인다. The purpose of this study was to provide clinical guidelines to indicate the best location for mini-implants as it relates to the cortical bone thickness and root proximity. Methods: CT images from 14 men and 14 women were used to evaluate the buccal interradicular cortical bone thickness and root proximity from mesial to the central incisor to the 2nd molar. Cortical bone thickness was measured at 4 different angles including 0°, 15°, 30°, and 45°. Results: There was a statistically significant difference in cortical bone thickness between the second premolar/ first permanent molar site, central incisor/central incisor site, between the first/second permanent molar site and in the anterior region. A statistically significant difference in cortical bone thickness was also found when the angulation of placement was increased except for the 2 mm level from the alveolar crest. Interradicular spaces at the 1st/2nd premolar, 2nd premolar/1st permanent molar and 1st/2nd permanent molar sites are considered to be wide enough for mini-implant placement without root damage. Conclusions: Given the limits of this study, mini-implants for orthodontic anchorage may be well placed at the 4 and 6 mm level from the alveolar crest in the posterior region with a 30° and 45° angulation upon placement.

Cisplatin이 1차 감작된 마우스의 IgM 용혈반 형성 세포수와 임파구 증식능에 미치는 영향

표명윤,강명옥,윤희은,주은영 숙명여자대학교 약학연구소 1996 약학논문집-숙명여자대학교 Vol.12 No.-

The effects of cisplatin on the IgM plaque forming cells and the lymphocyte proliferation in primarily sensitized mice were investigated. Cisplatin was i.p. injected with a single low does (0.825, 1.65, 3.3mg/kg, which is 5, 10, 20% of LD_50) to mice. The splenic IgM antibody plaque forming cell (PEC) was assayed after ICR mice had been treated in vivo with a combination of three different doses of Cisplatin at different time (day-2, day+2) plus SRBC(day 0). IgM PFC was significantly increased when drug was injected prior to immunization with SRBC, but it was decreased when administered after SRBC antigen. Splenocytes from mice injected with Cisplation(1.65, 3.3mg/kg) on the 2nd day before the test day were cultured with Con A and LPS. The splenocyte proliferation to Con A mitogen was slightly increased, but to LPS was significantly and markedly increased. It was found that Cisplatin at low dose showed either immunosuppression or immunostimulation, depending on the time of drug-application in relation to antigenic treatment.

베체트병에서 비스테로이드성 소염진통제에 의해 발생한 대량 소장출혈 1예

강인숙,류연주,장지은,정성애,이지수,조영주,이경은,이지희 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

Bechet's disease(BD) is a chronic inflammatoroy condition involving several organs inclu-ding gastrointestinal tract. Gastrointestinal tracts involvement in BD has been identified throughout the entire alimentary tract and commonly accompanies ulcerative lesions in the small and large bowel. It is debatable whether BD could be included among seronegative spondyloarthropathy (SPA).SPA usually occurs without overt sign of intestinal inflammation, but significant number of patients have asymptomatic intestinal inflammation, usually affecting ileum. Since most patients with SPA in-cluding BD are treated with NSAIDS. However, NSAID may play a role in aggravation or provo-cation of intestinal inflammation. Special attention to asymptomatic intestinal inflammation is needed, especially when NSAIDs are used for management of arthritic symptom in SpA. We experienced a case of BD which was complicated by a massive small bowel bleeding precipitated by NSAID use. 저자들은 베체트병 환자에서 비스테로이드성 소염진통제 사용 후 발생한 대량 소장 출혈의 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

의미 분석 단계에서의 정보 흐름 제어

조현욱,김명수,정은환,유재휘,윤병주 명지대학교 공학기술연구소 1986 공학기술연구소 논문집 Vol.1 No.-

One of protection methods for computer internal data is to pursue data flow in program and to control its flow. In this thesis, we propose a mechanism which guarantees secure information flow in a program. By investigating security classes of all the variables in a statement and judging necessary condition for secure information flow, proposed model descriminates the program whether it is secure or not. Out model can be implemnted at language translation time, particularly semantic analysis phase, by pursuing security class transfer of each statement.

Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model

Youn, Ju Ho,Kwak, Man Sup,Wu, Jie,Kim, Eun Sook,Ji, Yeounjung,Min, Hyun Jin,Yoo, Ji-Ho,Choi, Ji Eun,Cho, Hyun-Soo,Shin, Jeon-Soo WILEY-VCH Verlag 2011 European journal of immunology Vol.41 No.9

<P>Lipopolysaccharide (LPS) triggers deleterious systemic inflammatory responses when released into the circulation. LPS-binding protein (LBP) in the serum plays an important role in modifying LPS toxicity by facilitating its interaction with LPS signaling receptors, which are expressed on the surface of LPS-responsive cells. We have previously demonstrated that high mobility group box 1 (HMGB1) can bind to and transfer LPS, consequently increasing LPS-induced TNF-α production in human peripheral blood mononuclear cells (PBMCs). We report here on the identification of two LPS-binding domains within HMGB1. Furthermore, using 12 synthetic HMGB1 peptides, we define the LPS-binding regions within each domain. Among them, synthetic peptides HPep1 and HPep6, which are located in the A and B box domains of HMGB1, bind to the polysaccharide and lipid A moieties of LPS respectively. Both HPep1 and HPep6 peptides inhibited binding of LPS to LBP and HMGB1, LBP-mediated LPS transfer to CD14, and cellular uptake of LPS in RAW264.7 cells. These peptides also inhibited LPS-induced TNF-α release in human PBMCs and induced lower levels of TNF-α in the serum in a subclinical endotoxemia mouse model. These results indicate that HMGB1 has two LPS-binding peptide regions that can be utilized to design anti-sepsis or LPS-neutralizing therapeutics.</P>

QTL-seq analysis of flowering time in radish

Youn-Sung Kim,Chan-Sup Ko,Eun-Ju Lee,Jeong-Pal Suh,Jae-Yong Lee,Hye-Sun Cho 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

To develop molecular markers for late flowering time in radish we performed QTL-seq analysis in which whole genomes are sequenced and SNPs between two groups showing opposite phenotypes in F2 population are analyzed to find regions or QTLs involved in a trait of interest. Two inbred lines (NH-JS1 and NH-JS2) showing opposite phenotypes of flowering time were selected to generate F2 population for the analysis. NH-JS1 showed late flowering time whereas NH-JS2 early flowering time. Genomic DNA from the two lines were extracted and sequenced. In addition F2 population from F1 between NH-JS1 and NH-JS2 was generated and flowering time phenotypes of 180 F2 plants were analyzed. We selected 11 plants with late flowering time and 12 plants showing early flowering time. We extracted DNA from each individuals from the two groups and bulked them to generate two bulked DNA samples that are subject to whole genome resequencing. Preliminary analysis of SNP data from the resequencing showed that there may be several QTLs involved in flowering time control in radish.