人蔘 Saponin成分이 흰쥐 膽膵液 分泌에 미치는 效果에 관한 硏究

愼鏞會,李炫實,朴鍾大,趙台淳 成均館大學校 科學技術硏究所 1990 論文集 Vol.41 No.2

The effect of saponins including water extract of Panax Ginseng was studied on the pancreaticobiliary secretion and cholate output and amylase activity in rats. The saponins tested were crude saponin, panaxadiol (PDS), panaxatriol (PTS). After single or two weeks administration of the samples, pancreaticobiliary juice of rats were collected for 8 hrs and the results obtained were summarized as follows. (1) In animals with single administration, pancreaticobiliary juice volume(PJV) was not significanty increased as compared to the control group. However, there was a significant increase in PJV of animals from 4 to 6 hrs after two weeks administration of water extract (500mg / kg / day) or crude saponin(50mg / kg / day). (2) Cholate output was increased dose-dependently from 1 to 5 hrs after the single administration of PDS, PTS. On the other hand, after two weeks administration of crude saponin (50mg/kg/day), the cholate output of the animals was increased significantly. (3) amylase activity in the juice were intermittently increased in single administration of water extract, crude saponin and PTS(100mg / kg). After two weeks administration, there was a significant increase in amylase activity of animals treated with PTS as compared to the control group.

건강성인자원자에 있어서 Theophylline과 β_(2)-adrenergicagonists (Procaterol 및 Albuterol)의 약동학적 상호작용

신현택,권현명,김호순 숙명여자대학교 약학연구소 1998 약학논문집-숙명여자대학교 Vol.14 No.-

Theophylline and adrenergic β₂ -agonists are frequently used together in bronchial asthma and chronic obstructive pulmonary disease(COPD). Among the adrenergic β₂ -agonists, procaterol and albuterol are most frequently used with theophylline in Korean hospitals. The effect of procaterol and albuterol administration on pharmacokinetics of theophylline was studied in 11 normal healthy volunteers(6 males, 5 females). The theophylline clearances with and without /J-adrenergic agonist (procaterol) were 38.76 + 9.53 ml/kg/hr and 32.46 + 8.46 ml/kg/hr respectively, which were not statistically significant. Similar result was seen with albuterol. The values of AUC, T_(1/2), Ke and Vdss were not influenced by either procaterol or albuterol. Also, there was no significant change in cardiac output and heart rate. In conclusion, adrenergic β₂ -agonists (procaterol and albuterol) do not alter theophylline pharmacokinetics.

두경부 암환자의 항암화학요법에 따른 삶의 질 변화

신혜숙,박혜자,박명희,연기순,김훈교,문한림,송혜향 가톨릭대학교 가톨릭대학교 간호대학 호스피스 교육연구소 1999 호스피스논집 Vol.4 No.-

The purpose of this study was to assess the changes in quality of life wish elapse of chemotherapy in head and neck cancer patients. This study was a longitudinal descriptive design. The subjects were 9 patients who had stage III and stage IV head and neck cancer and received neoadjuvant cisplatin and 5-fluorouracil chemotherapy. Linear Analogue Self Assessment Scale (LASA) of the QOL which it includes eleven items(seven physical items appetite, nausea/vomiting, physical well-being, vigor activity, energy, sleepiness, fatigue and four mental items anger, anxiety, depression & vital power) were used to assess the quality of life eleven times(once in the prechemotherapy period and from the 1st day to 10th day postchemotherapy). The means of scores at each time were analyzed by repealed measures of ANOVA and Bonferroni multiple comparison method. The results are as follows : 1. The degree of appetites decreased significantly on the period between third and sixth day compared with that of appetites on the prechemotherapy day (p<0.001). 2. The degree of physical well-being decreased significantly on the period between first and fifth day compared with that of physical well-being on the prechemotherapy day (p<0.001). 3. The degree of nausea/vomiting decreased significantly on the period between first and fourth day compared with that of appetites on the prechemotherapy day (p<0.001). 4. The degree of anger decreased significantly on the second, fourth, eighth and ninth day after chemotherapy compared with that of anger on the prechemotherapy day(p<0.001). 5. The degree of fatigue decreased significantly on the fourth day compared with that of fatigue on the prechemotherapy day(p<0.001). 6. The increment of nausea/vomiting and poor appetite started on the 2.89th day and 3.67th day after chemotherapy, respectively. 7. The increment of sleepiness started on the 2.56th day after chemotherapy. 8. The increment of depression and anxiety started on the 2.33th day and 3.33th day after chemotherapy, respectively. 9. The lowest degrees of nausea/vomiting and poor appetite were 37.00±17.9 % and 28.64±14.94 % after chemotherapy compared with those of nausea/vomiting and poor appetite on the prechemotherapy day, respectively. 10. The lowest degrees of anger and vigor activity were 48.12±28.3 % and 39.83±24.9 % after chemotherapy compared with those of anger and vigor activity on the prechemotherapy day, respectively. 11. The recovery rates of eight items of quality of life (appetite, vigor activity, energy, fatigue, anger, anxiety, depression & vital power) were shown to reach a peak on the tenth day after chemotherapy and be reached to almost 84 % compared with those of quality of life on the prechemotherapy day. 12. The recovery rates of physical well-being and sleepiness were shown to reach to 67.75 % and 95.68 % on the 10th day after chemotherapy compared with those of physical well-belong and sleepiness on the prechemotherapy day. 13. The recovery rates of seven physical items were faster than those of four mental items on the 10th day after chemotherapy. In conclusion, it is suggested that nursing care strategies to improve the quality of life in patients with chemotherapy would be established both physically and mentally, and be extended at least ten days when patients stayed their home after chemotherapy.

치과용 실험 레진에서 광 기시제와 중합억제제 함량이 광중합에 주는 영향

신현철,임범순,최재윤,이용근 大韓齒科器材學會 2004 대한치과재료학회지 Vol.31 No.4

The purpose of this study was to evaluate the effect of fraction of photo-initiator and inhibitor in the experimental resins on the degree of polymerization using a FT-IR and dynamic mechanical analyzer (DMA). Eight experimental dental resins, four different concentrations of photo-initiator (EXP-A, EXP-B, EXP-C, EXP-D) and four different concentrations of inhibitor (EXP-E, EXP-F, EXP-G, EXP-H), were tested. Storage modulus was measured by using DMA (StressTech Rheometer, Rheologica Instrument, Sweden) with fast oscillation mode (1 Hz). After disk-typed (4 ㎜×1 ㎜) samples were irradiated with Halogen light curing unit at 500 ㎽/㎠ for 30 sec, the storage modulus was recorded continuously for 60 min. The degree of conversion was also measured using the FT-IR spectroscopy (FTS-165, Biorad Win-IR, Perkin-Elmer, USA) at 1 hr and 24 hrs after irradiation with the same curing condition as DMA test. The average of results for five specimens was analyzed using Tukey multiple comparison test (p=0.05). From the results, the minimum concentration of photo-initiator was 0.35 wt.% and the maximum concentration of inhibitor was 0.15-0.20 wt.% to obtain the proper polymerization. To enhance the biocompatibility, the concentration of photo-initiator should be added to dental resins as low as possible. To prolong the shelf-life, the concentration of inhibitor should be added to dental resins as much as possible, but biocompatibility due to the inhibitor should be considered to determine the optimum concentration.

광주광역시 치매의 유병률과 위험인자의 도시-농촌 지역 비교

신일선,김재민,윤진상,김석재,양수진,김웅장,이승현,강순아,곽지영,이형영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 본 연구의 목적은 광주광역시의 도시 및 농촌 지역에 거주하는 노인에서 치매의 유병률과 위험인자를 조사하고자 하였다. 부가적으로 이 두 지역간에 치매의 유병률과 위험인자를 비교하고자 하였다. 방 법 : 광주광역시의 전형적인 도시와 농촌지역의 65세 이상의 노인(N=1,598)을 대상으로, 2단계의 역학연구를 수행하였다. 1차 선별 단계에서는 38명의 훈련된 연구보조원이 대상노인을 면담하여, 사회인구학적 특징을 조사하고 한국판 간이정신상태검사(Korean version of Mini-Mental State Examination ; MMSE-K)로 평가하였다. 2차 임상 진단 단계에서는 1차 단계에서 MMSE-K 점수가 24점 이하인 노인(N=431)을 대상으로, 전문연구팀의 임상적 평가를 통해 치매를 진단하고 원인질환별로 알쯔하이머병(Alzheimer's disease ; AD), 혈관성 치매(vascular dementia ; VaD) 및 기타 치매로 분류하였다. 대상노인에서 치매의 유병률을 측정한 후, 광주광역시 전체 노인의 연령보정 유병률을 산출하였다. 전체 대상에서 AD의 위험인자를 조사한 후, 도시와 농촌군으로 나누어 분석을 다시 시행하였다. 결 과 : 1차 및 2차 단계의 참가율은 각각 71.0%(N=1,134) 및 83.2%(N=410) 였다. 연구 참여 노인(N=1,134)에서 전체 치매, AD 및 VaD의 유병률은 최소 각각 9.7%, 5.2%, 1.8%였다. 광주광역시 전체 노인의 연령 보정 유병률은 각각 10.7%, 5.7%, 1.9%인 것으로 산출되었다. AD의 독립 위험인자는 고령, 여성, 무학이었다. 도시와 농촌에 따른 유병률의 차이는 파악되지 않았다. 그러나 AD의 위험인자는 지역에 따라 차이가 있었다. 도시 노인에게는 무학만이, 농촌 노인에게는 고령과 여성인 경우가 독립 위험인자였다. 결 론 : 광주광역시 노인에서 치매의 유병률은 높았고, 이는 국내 다른 지역에서 수행된 선행연구 결과와 유사하였다. 알쯔하이머형 치매의 위험인자는 도시와 농촌에 따라 다른 결과를 보였다. 본 연구 결과는 한국에서의 치매의 실태를 반영하며, 치매의 적절한 관리와 예방을 위해서는 지역성 특성이 고려되어야 함을 시사한다. Objectives : The purpose of this study was to investigate the prevalence rate and risk factors of dementia in an urban and a rural sample of older persons in the metropolitan Kwangju area, Republic of Korea. In addition, the prevalence rate and risk factors of dementia between the two samples were compared. Methods : A two-phase epidemiological study of residents aged 65 or over(N=1,598) was conducted in a highly developed, urban and a non-contiguous, poorly developed, rural area of metropolitan Kwangju. In the first(screening) phase, 38 trained research assistants collectively peformed in-home interviews for all participants. Detailed sociodemographic characteristics were gathered and the Korean version of Mini-Mental State Examination (MMSE-K) was administered. In the second (diagnosing) phase, diagnosis of dementia was established for those scoring 24 or less on the MMSE-K in the screening phase(N=431), and etiological types of dementia were classified to Alzheimer's disease(AD), vascular dementia(VaD) or miscellanous type by two teams of experts. Prevalence rate of dementia was determined in the participants, and age-standardized prevalence rate adjusted by age distribution in metropolitan Kwangju was estimated. For AD, the risk factors were investigated in all participants, and analyses were repeated for the urban and rural samples separately. Results : The participating rates in the first and second phases were 71.0%(N=1,134) and 83.2%(N=410), respectively. In the participants, the prevalence rates of dementia(all types), AD and VaD were 9.7%, 5.2% and 1.8%, respectively. The age-standardized prevalence rates were 10.7%, 5.7% and 1.9%, respectively. Aging, female gender and no education(complete lack of formal education) were identified as independent risk factors for AD. No difference between the urban and rural samples was observed in the prevalence rates of dementia(all types), AD and YaD. However, risk factors for AD differed between these areas. In the urban sample, no education was the only significant factor ; whereas, aging and female gender were identified as risk factors in the rural sample. Conclusion : A high prevalence rate of dementia was observed among old persons in metropolitan Kwangju, consistent with previous studies conducted in other Korean areas. The risk factor profi1es for AD differed between urban and rural settings. The results of this study reflect the current status of dementia in Korea and suggests that appropriate management and prevention strategies for dementia should be tailored toward the geographic settings.

서울지역 여대생들의 떡에 대한 인식 및 섭취 실태 조사

김영순,오순덕,김향미,신지홍,김현경,배유미,조규영,조성환 高麗大學校 倂設 保健大學 保健科學硏究所 2003 保健科學論集 Vol.29 No.1

This study conducted a survey of the improvement and popularization for Korea Rice Cakes, a Korean traditional food, on two hundred women students in five colleges in Seoul, Korea. It was investigated to get the information of the recognition, preference, and consumption patterns for the succession and improvement of Korean Rice Cakes. The results are as follows: 1. A portion of 41.5% among responders knows from three to six kinds of Korean Rice Cakes, and of 28% can make at least one among the kinds of Korean Rice Cakes. 2. A portion of 91% recognizes that Korean Rice Cakes are one of well-nourished food, but of 42% answers that Korean Rice Cakes cannot be replaced with the principle food. Also, there are no significant differences in the recognition of Korean Rice Cakes as the kinds of religions. 3. The frequency of purchase is about one or twice in a month (35.5%). Consumers (36.5%) intend to purchase Korean Rice Cakes for the commemoration of national holidays or anniversaries. 4. The reasons for the preference of other foods more than Korean Rice Cakes are the easiness of purchase (36.0%), the deliciousness (21.5%), the diverse kindness (17.5%), and the proper package (9.5%). It is important that constant and particular school / home education is need to improve and success Korean Rice Cakes.

Hirschsprung 씨 질환에서 항문직장계측검사의 진단적 의의

최순옥,강중신,백태원,박우현 啓明大學校 醫科大學 1987 계명의대학술지 Vol.6 No.2

It is well known that stimulation of rectum by balloon distention results in the reflex relaxation of the internal anal sphincter in the normally innervated bowel. and this rectosphincteric reflex is absent in Hirschsprung's disease. It's the first report in Korea to evaluate diagnostic reliability of anorectal pressure study in Hirschsprung's disease using anorectal manometry, Model 003 developed by professor Holschneider. This investigation was performed on 21 consecutive children who complained of acute intestinal obstruction especially in infants and chronic constipation during the period February 1986 to September 1987. The ages of the children ranged from 8 days to 15 years, and 8 patients including the 4 neonates were examined within 1 year old. The 7 patients were proved to have Hirschsprung's disease who revealed no rectosphincteric reflex on anorectal pressure study, and Hirschsprung's disease was ruled out in 14 patients who reveales rectosphincteric reflex. In 2 out of 14 patients who showed no rectosphincteric reflex, Hirschsprung's disease was ruled out by rectal suction biopsy and clinical course. With the above results, this study shows an over-all diagnostic accuracy 90% along with sensitivity 100% and specificity 86%. In conclusion, anorectal pressure study is a reliable, diagnostic procedure for Hirschsprung's disease, and it has the advantage of simple , non-invasive and safe procedure without general anesthesia and is of particular value as a screening test in inpatients as well as outpatients.

상악골과 비사골동에 이환된 백악질 골화성 섬유종(cemento-ssifying fibroma)의 치험례

권대현,김신유,남정순,구명숙,이봉서,권대근,김종배 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

The cemento-ossifying fibroma is a benign fibro-osseous tumor that may behave in an aggressive pattern. Although found predominantly in the mandible, most of these unusual tumors may arise in the maxilla and paranasal sinuses. Especially these lesion in the maxilla and sinuses behave more aggressively and are more prone to recur compared to mandibular counterparts. Therefore, more radical approach may be recommended than expectant observation or curettage in the initial management of this neoplasm. This is a case report of cemento-ossifying fibroma extended to maxillary sinus and naso-ethmoidal area treated by wide surgical excision after repeated conservative treatments.

Self-etching primer/adhesive를 사용한 교정용 브라켓의 접착시 오염이 전단결합강도에 미치는 영향

김유신,이형순,이현정,전영미,김정기 대한치과교정학회 2004 대한치과교정학회지 Vol.34 No.5

이 연구는 self-etching primer와 adhesive를 사용하여 법랑질 표면에 교정용 브라켓을 접착할 때 수분과 타액, 그리고 혈액에 의한 오염이 브라켓의 전단결합강도에 어떤 영향을 미치는지 알아보고자 시행되었다. 96개의 발거된 치아를 4개의 군으로 나누어서 self-etching primer와 adhesive를 사용하여 다음의 4가지 방법에 따라 교정용 브라켓을 접착하였다. 첫 번째 군은 치면을 건조시킨 상태에서 부착하였고, 두 번째, 세 번째, 네 번째 군은 각각 증류수, 인공타액, 혈액을 적용한 후 브라켓을 접착하였다. 각 시편의 전단결합강도를 측정하였고 debonding 후에 브라켓과 치아 표면은 stereomicroscope을 사용하여 관찰하였다. 각 군에서 4개씩의 시편을 선택하여 표면처리된 법랑질 표면과 접착계면을 주사전자 현미경으로 관찰하여 다음과 같은 결과를 얻었다. 건조군과 증류수군의 전단결합강도는 각각 15.22 ± 2.86 MPa과 16.20±3.85 MPa로 혈액군의 전단결합강도(12.56 ± 2.94 MPa)보다 높았다(p<0.05). 건조군과 증류수군, 그리고 인공타액군간에는 전단결합강도에 통계적 차이가 없었다(p>0.05). 혈액군은 다른군에 비해서 debonding 후 법랑질 표면에 잔류한 레진의 양이 더 적었다(p<0.05). self-etching primer로 처리된 치면의 주사전자현미경 소견에서 건조군과 증류수군의 치면에서는 인공타액군과 혈액군에 비해서 더욱 뚜렷한 산부식 구조를 볼수 있었다. 이상의 결과로서 self-etching primer/adhesive를 사용한 교정용 브라켓의 접착시 수분이나 타액의 오염은 결합력에 거의 영향을 미치지 않음을 알수 있으며, 혈액으로 오염시에는 결합력에 영향을 미치지만, 임상적으로 유용한 최소 결합강도(5.9-7.8 MPa) 이상을 보이고 있음을 알 수 있었다. The purpose of this study was to investigate the influence of water, saliva, and blood contamination on the bonding strenght of metal brackets with a self-etching primer/adhesive to enamel. Ninety-six extracted human teeth were divided into four groups. The brackets were bonded to enamel with a self- etching primer (3M/Unitek Dental Products, Monorovia, California) according to one of four protocols. The teeth were bonded in a dry condition (group D) or in contamination with distilled water (group W), artificial saliva (group S), or fresh human blood (group B). Shear bond strengths were tested using an Instron Universal testing machine. After debonding, bracket and tooth surfaces were examined with a stereomicroscope. In each group, four samples were selected and examined with a Scanning electron microscope of the prepared enamel surface and resin-enamel interface. The results obtained were summarized as follows: Shear bond strength in group D (15.22 ± 2.86 MPa) and W (16.20 ± 3.85 MPa) were higher than in group B (12.56 ± 2.94 MPa) (p<0.05). There were no statistical differences in the shear bond strengths between groups D, W and S (p>0.05). There was a tendency to have less residual adhesive remaining on the enamel surfaces of group B than group D. The SEM morphology of group D and W showed a more roughened etching pattern than group S and B. Water or saliva contamination on bonding of orthodontic brackets with Transbond plus self etching primer had almost no influence on bond strength. In this study, the blood contaminated group showed the lowest bond strength, but it was above the clinically acceptable bond strength (5.9-7.8 MPa, Reynold, 1975). The results of this study suggest that acceptable clinical bond strengths can be obtained in wet conditions when self-etching adhesives are used.

교원 근무성적 평정제도 개선에 관한 연구

박천순,신현석 고려대학교 교육문제연구소 1996 敎育問題硏究 Vol.8 No.-