집적화된 실리콘 압력센서의 출력전압 보상파라미터 추출 및 그 특성

이보나,김건년,박효덕,신상모,이경탁,김찬,권혁채,이상조,박현주 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

An integrated silicon pressure sensor has been designed, fabricated and tested. The signal conditioning circuits were designed to include calibration and temperature compensation of output voltage through trimming of diffusion and ion-implanted resistors. Before trimming of resistors, the compensation parameters such as pressure sensitivity, temperature coefficient of pressure sensitivity, temperature coefficient of piezoresistors and pressure sensitivity of piezoresistors were measured. Then offset voltage, span, and temperature coefficients of offset voltage and span were calibrated by trimming of resistors. The measured output voltage met our design specification and simulation value above room temperature. But, the measured output voltage at -30°C deviated from our design specification and simulation value because the offset voltages were found to vary randomly as a function of temperature.

다산부에서 자간전증의 임상적 고찰

이주롱,이석민,한효상,이해혁,이임순,이권해 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

목적 : 전자간증 산모에서 초임신부와 다산부 각각의 임상적 특징을 조사하여 비교 분석하고자 하였다. 연구방법 : 1998년 1월부터 1999년 12월까지 2년간 순천향대학 서울병원에서 입원 분만한 임신성 고혈압성 질환 환자중 초임신부 106명과 다산부 50명, 총 150명을 대상으로 임상통계학적으로 조사 분석하였다. 결과 : 분만까지 임신기간의 비교시 초임신부에서는 33-36주에서 17.9%였고 다산부에서는 34.0%로, 다산부에서 조기분만의 예가 의의있게 많았다. 신생아 체중이 2500g 미만인 군이 초임신부군에서는 36.8%였고 다산부군에서는 62.0%로 다산부군에서 더 많았다. 임신성 고혈압성 질환의 중등도를 보면 중증자간전증의 초임신부에서 35.8%와 다산부에서는 44.0%로, 초임신부에 비해 다산부군의 중증 자간전증의 비율이 많았다. 결론 : 중증 임신성 고혈압성 질환이 다산부군에서 더 많았으며 적은 주수에서 제왕절개술을 시행해 출생아의 체중이 초임신부군에 비해 더 작았고 Apgar 점수도 더 낮았다. Objective : To study the clinical differences of primiparous and multiparous preeclamptic patients. Methods : We statistically analyzed 106 primiparous and 50 multiparous preeclamptic patients who were admitted to the Soonchunhyang University Hospital from January 1998 to December 1999. Results : It was statistically found that multiparae were more likely to give premature birth than primiparae: Thirty four percents of multiparae gave birth in the period between the 33rd and the 36th gestational weeks while 17.9% of primiparae did in the same period. Sixty two percents of the newborn babies of multiparae weighed less than 2500g. Among primiparae, the ratio was 36.8%. In addition, more multiparae(44.0% vs. 35.8%) suffered from severe preeclampsia. Conclusion : severe preeclampsia was found more frequently among multiparae. Since they gave birth earlier by cesarian section than primiparae, their babies weighed less and had lower apgar scores.

들잔디 성숙종자로부터 캘러스배양 및 식물체 재분화에 미치는 몇 가지 요인의 영향

이상훈,김범수,원성혜,조진기,김기용,박근제,성병렬,이효신,이병현 Plant molecular biology and biotechnology research 2004 Plant molecular biology and biotechnology research Vol.2004 No.-

In an effort to optimize tissue culture responses of zoysiagrass (Zoysia japonica Steud.) for genetic transformation, factors affecting callus induction and plant regeneration were investigated. MS medium containing 3 ㎎/L 2,4-D was optimal for embryogenic callus induction from mature seed. The plant regeneration frequency of 73.3% was observed when embryogenic calli induced in this medium were transferred to N6 medium supplemented with 0.1 ㎎/L 2,4-D and 5 ㎎/L BA. Among several basic media, MS and N6 medium were optimal for callus induction and plant regeneration, respectively. Regenerated plants were grown normally when shoots transplanted to the soil. A rapid and efficient plant regeneration system established in this study will be useful for molecular breeding of turfgrass through genetic transformation.

Novel Methylation Biomarker for Non-invasive Diagnostics in Lung Cancer

오태정,( Chang Hun Lee2 ),( Min Ki Lee ),( Yeul Hong Kim ),( Sang Yull Lee ),( Hyo Sung Jeon ),( Shin Yup Lee ),( Seung Soo Yoo ),( Jae Yong Park ),( Sung Whan An ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

To identify aberrantly hypermethylated DNA in lung cancer cells we established a genome-wide analysis for hypermethylation sites, namely Methyl DNA Isolation and Amplification (MeDIA) coupled-CpG microarray analysis. In the comprehensive methyaltion profiling analysis between human lung cancer, A549 cells and normal NHBE cells, we observed that several clusters of genes show a significant level of aberrancy in CpG island methylation pattern in cancer cells compared to normal cells. We further identified PCDHGA12 gene as a new marker of non-invasive diagnostics for lung cancer based on followings. 1) Transcription of PCDHGA12 gene is reactivated after treatment of A549 cells with demethylating agent. 2) Bisulfide clonal-sequencing reveals that CpG island of PCDHGA12 shows a distinctive differential methylation between two cell lines. 3) Pyrosequencing-based quantitative methylation assay for such region in tumor and non-tumorous tissues from lung cancer patients shows aberrant hypermethylation in 37 (92%) of the 40 tumor tissues. In clinical validation by pyrosequencingin induced-sputum of lung cancer patients (n=87) and healthy controls (n=51), we observed aberrant hypermethylation incident at significantly elevated level in samples derived from lung cancer patients. According to the optimal threshold calculated by ROC curve analysis, sensitivity and specificity of PCDHGA12 was 86.2% and 82.4%, respectively. PCDHGA12 methylation status could be a potential methylation biomarker alone or combined with others for the screen and the detection of relapse of lung cancer.

기계적 합금화에 의한 Cr-N계 합금분말의 합성연구

이충효,이상진 木浦大學校 應用科學硏究院 2001 應用科學硏究誌 Vol.1 No.-

Mechanical alloying(MA) by high energy ball mill of pure chromium powders was carried out under the nitrogen gas atmosphere. Cr-N amorphous alloy powders have been produced through the solid-gas reaction subjected to MA. The atomic structure during amorphization process was observed by X-ray and neutron diffractions. An advantage of the neutron diffraction technique allows us to observe the local structure surrounding a nitrogen atom because of a large coherent scattering length of the N atom in comparison with that of the Cr atom. The coordination number of metal atoms around a N atom approaches with 5.5 atoms. This implies that the nitrogen atom is located at both of centers of the tetrahedron, octahedron and/or trigonal prism formed by metal atoms to stabilize the amorphous structure.

표정인식을 위한 PCA와 템플릿 정합을 사용한 얼굴 요소 추출

우효정, 이슬기, 김동우, 류성필, 안재형 충북대학교 산업과학기술연구소 2013 산업과학기술연구 논문집 Vol.27 No.2

This paper proposed an extracting algorithm of human facial components for the recognition of facial expressions. First face image is acquired using the Haar-like feature mask from an input image. The face image is divided into two images. One is the upper image including eye and eyebrow. The other is the lower image including mouth and jaw. The extraction of facial components, such as eye and mouth, begins getting eye image and mouth image. Then eigenfaces are produced by the PCA training process with learning images. An eigeneye and an eigenmouth are produced from eigenfaces. Result eye image is obtained by template matching the upper image with the eigeneye, and the mouth image is obtained by template matching the lower image with the eigenmouth. The simulation results show that the proposed method has superior extraction ratio than previous method.

2지역 연계 전력시스템의 뉴로-퍼지제어기 설계

이오걸,이용길,김상효 동의공업대학 2001 論文集 Vol.27 No.1

This paper proposed a optimal scale factors technique of a neuro-fuzzy controller for a load frequency control of two areas power system. The optimal scale factors control technique is optimize from an initial fuzzy logic control rule, and then is learned with an error back propagation learning algorithm of the neuro-fuzzy controller. In application two areas the load frequency control of the power system, it hopes to have response characteristic better than the conventional control technique.

Mid-Span Spectral Inversion 기법을 채택한 장거리 광 전송시스템에서의 비트 에러율 평가

이성렬,김남성,방효창 한국항행학회 2002 韓國航行學會論文誌 Vol.6 No.3

본 논문에서는 MSSI 보상 기법을 채택한 2,000km 광 전송 시스템의 수신 성능 평가를 위해 신호간의 간섭 영향을 고려한 직접 검파 수신단 에서의 잡음 전력과 비트 에러율을 도출하고, 비트율에 따른 수신 감도를 계산해 보았다. 본 논문에서 제안한 BER 계산이 실제 시스템에 적용될 수 있는 방법이라는 것을 확인할 수 있었고, 전송 링크에 MSSI 보상 기법이 적용된 시스템에서 신호 파형의 색 분산과 비선형 효과에 의한 왜곡이 보상되지만, 결국 비트율이 높아질수록 좁아지는 비트 간격에 따른 ISI에 의해 평균 수신 전력의 감소를 가져오고 궁극적으로 수신 감도를 감소시켜 준다는 것을 확인할 수 있어다. In this paper, we induced that the noise powers and bit error rate of direct detection receiver taking account of ISI (intersymbol interference) in the 2,000 km optical transmission system. And we evaluated the sensitivity in the vrious bit rate system. We verified that the proposed calculation method is applicable to the exact optical system. And we confirmed that the signal distortion due to both chromatic dispersion and nonlinear effects compensated by using of MSSI(Mid-Span Spectral Inversion) method, and yet the sensitivity of a higher bit rate system is reduced, because of the increase of ISI and then the decrease of the average receiving power, compared with a the lower bit rate system.

기관지천식 환자의 정신신체의학적 특성 : Focused on Alexithymia 감정표현불능증을 중심으로

이종명,김상헌,임효덕 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.1

본 연구는 감정표현불능증적 성격 경향이 정신신체질환을 가진 환자들의 고유한 성격적 특성인지를 알아보기위해, 단일 신체 질환인 기관지천식 환자군에서 지금까지 알려진 여러 가지 도구들을 사용하여 감정표현 불능증을 중심으로 한 정신신체의학적 특성들을 확인해보고자 하였다. 정상군(30명), 기관지천식 환자(30명), 정신분열증 환자(30명) 그리고 신경증 환자(33명)를 대상으로 하여 각 장애를 가진 환자들의 감정표현불능증적 경향을 알아보기 위하여 정신의학적 면담과 BIQ, MMPI-A, TAS, 주제통각검사를 실시하였고, 각 군의 특징적인 성격 경향 그리고 내재하는 정신병리를 확인하기 위하여 MMPI와 SCL-90-R을 시행하였다. MMPI와 SCL-90-R에서 각 군은 정상 범위안에 있었는데, 신경증 환자군의 정신병리의 수준이 가장 높았고 정상군이 가장 낮았다. 기관지천식 환자군과 정신분열증 환자군은 양 극단 사이의 중간 수준을 보여주었다. BIQ 평균점수에서 기관지천식 환자군이 정상군에 비해 유의하게 높았으며(p<0.05), 다른 군간에는 유의한 차이가 없었다. MMPI-A 평균점수 및 TAS 전체 합산 점수 모두에서 각 군은 정상군과 유의한 차이가 없었다. 주제통각검사에서 신경증 환자군은 가장 많은 정동 어휘를 기록하였지만 정상군과는 유의한 차이가 없었는데 비해, 기관지천식 환자군과 정신분열증군 환자군보다 유의하게 많은 정동 어휘 수를 기록하였다(p<0.0001). 즉 기관지천식 환자군은 감정표현불능증적 경향이 주제통각검사에서는 신경증 환자군에 비해서 유의하게 많고(p<0.001), BIQ에서는 정상군에 비해서 유의하게 많은 것으로 나타났으나(p<0.05), TAS, MMPI-A 검사 상에서는 정상군을 포함한 다른 대조군들과 유의하게 구분되지 않았다. 이러한 소견에 따라 본 연구는 감정표현불능증이 기관지천식 환자군만의 특징적 성격 특성이라는 추정에 대한 확실한 답을 얻지는 못하였지만, BIQ는 정상군과 정신신체질환군을 변별하는 데, 그리고 주제통각검사는 신경증군과 정신신체질환군간의 관계를 변별하는 데에는 유용함을 확인하였다. 본 연구는 대상의 수가 적고 보다 다양한 정신신체질환을 대상으로 하지 못하였다는 제한점을 가지고 있지만, 다음과 같은 4가지 연구 방향을 결론 내릴 수 있을 것이다. 첫째 향후 정신신체의학 연구에 있어서 다양한 집단 속에 존재하는 감정표현불능증을 감별해내는 데 있어서 각 도구들이 가진 특정한 변별 특이성을 고려하여 단일 도구가 아닌 각 도구들의 집합체를 종합적으로 이용해야 할 필요성, 둘째 향후의 연구로서 대규모 임상연구에 의한 정신신체질환과 정신병적 상태와의 관련성에 관한 연구, 셋째 외국 검사 도구들의 국내 임상에의 적용 과정에서 보다 철저한 신뢰도 및 타당도 검증과 한국화에 대한 연구 그리고 국내 독창적인 도구의 개발, 넷째 감정표현불능증적 경향이 실재로 정신신체질환에만 특정적으로 존재하는 성격적 소인이 아닐 가능성과 이런 방향으로의 국내 정신신체의학 연구 등이 그것이다. 앞으로 다양한 정신신체질환에서 감정표현불능증과 다른 정신과적 질환과의 관계에 대한 다각도의 연구와 함께 한국적인 상황에서 감정표현불능증을 평가하는 보다 신뢰성 있고 타당성 있는 도구의 개발이 필요할 것으로 생각된다. This study is designed to evaluate psychosomatic characteristics, especially alexithymic tendency, of the patients with bronchial asthma and to determine whether alexithymia is a unique personality characteristic of the patient with classical psychosomatic disorder, using various methods developed for measurement of alexithymia. Thirty normal healthy persons, thirty patients with extrinsic bronchial asthma, thirty schizophrenic patients, and thirty-three neurotic patients were studied to assess differences in alexithymic tendency using the methods of thirty minute psychiatric interview, BIQ, MMPI-A, TAS and TAT. They were also assessed by MMPI and SCL-90-R to evaluate general personality traits and underlying psychopathology. All the groups were in the normal range of the scores of MMPI and SCL-90-R. The neurotic patients showed the highest level of psychopathology, and the normal group the lowest in both inventories. Bronchial asthma and schizophrenic patients, were between the highest and the lowest extremes of the scores. The mean score of BIQ in the bronchial asthma group was significantly higher than that in the normal group(p<0.05) and no difference was found among the other groups. The mean scores of MMPI_A and the total scores of TAS showed no difference among all the groups. In TAT the neurotic patients scored the highest in affect word counts and showed significantly higher counts than ther bronchial asthma patients and schizophrenic patients(p<0.0001), while they showed no significant difference with normal persons. That is, in TAT the group of bronchial asthma had more alexithymic tendency than that of the neurotic patients(p<0.0001), and in BIQ it had more alexithymic tendency than that of normal(p<0.05). Bronchial asthma patients were found to express less emotional words than normal persons and neurotic patients, but were not differentiated any more from groups of the schizophrenic, neurotic, and normal by TAS and MMPI-A. The authors with the inconsistent results of this study, could not confirm the assumption that alexithymia is the personality characteristic of patients with classical psychosomatic disease. But we found that BIQ was useful in discriminating between the groups of normal and psychosomatic disease, and TAT was useful in discriminating between the groups of neurosis and psychosomatic disease with alexithymia construct. This study has some limitations in the number of subjects and the diversity of psychosomatic diseases, but in spite of those limitations the findings of this study suggest some considerations are needed for further investigation. They are as follows: First of all, a study on the need of the combination of multiple tools in consideration of the specific discriminating ability of each tool ; secondly, a clinical study on the relationship between pychosomatic diseases and the psychotic state in a large population ; thirdly, a study on the applications of foreign tools in the Korean culture and on the problem of the validity and reliability of such tools ; and a study is needed on the possibilities that alexithymic tendecy is not a specific predisposing factor of personalities with psychosomatic disorder. It is thought that more variegated studies on the relationships between diverse psychosomatic diseases and alexithymia, and on the development of reliable tools with validity in the measurement of alexithymia in the context of the Korean culture should be taken in further investigations.

한국 재래식 된장과 고추장의 숙성 중 미생물, 효소활성 및 주요 성분의 변화

이종수,권수진,정성원,최영준,유진영,정동효 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

재래식 된장과 고추장의 가스 발생을 억제하여 저장성을 향상시키기 위한 생물공학적 방법을 개발하고자 먼저 재래식 된장(봄메주 된장과 가을메주 된장)과 고추장(순천식)을 제조하여 4개월간 숙성시키면서 미생물과 효소활성 및 주요 성분의 변화를 조사하였다. 호기성 세균은 된장과 고추장 모두 숙성 60일까지 증가한 후 큰 변화가 없었고 혐기성 세균은 숙성기간 동안 된장에서는 10^7~10^8/g, 고추장에서는 10^5~10^6/g이었으며 효모는 된장에서는 숙성 15일까지 급격히 증가한 후 변화가 없었으나 고추장에서는 숙성 15일에 출현하여 60일까지 10^6/g으로 증가하였다. α-amylase 활성은 가을메주 된장에서, glucoamylase는 고추장에서 숙성기간 전반에 걸쳐 제일 높았고 산성 protease와 중성 protease 활성은 대체로 숙성 15일~30일경에 최대를 보였다. pH는 된장에서는 숙성 60일까지 7.0까지 높아졌지만 고추장은 숙성기간 내내 pH 5.0으로 낮아졌다. 수분은 봄메주 된장과 고추장에서 숙성이 진행됨에 따라 낮아져서 숙성 120일 후 40%이었으며 환원당은 고추장에서 숙성 15일까지 19.9%로 증가한 후 감소하는 경향이었다. Changes in microorganisms, enzyme activities and major components of two types of Doenjang prepared with spring Meju and autumn Meju and Kochujang were investigated during 5 months of fermentation. The viable cell counts of aerobic bacteria in Doenjang and Kochujang were increased up to 60 days of fermentation, but viable cell counts of anaerobic bacteria did not show remarkable changes during fermentation. Viable cell count of yeast showed a rapid increase up to 15 days of fermentation in Doenjang and 60 days in Kochujang. It was found that α-amylase activity of autumn Meju Doenjang and glucoamylase activity of Kochujang were higher than the other. Acidic and neutral protease showed the highest activity during 15~30 days of fermentation. The pH of Doenjang was increased up to pH 7.0 until 60 days of fermentation, but pH of Kochujang gradually decreased during fermentation. Moisture content of spring Meju Doenjang and Kochujang decreased to 40% during fermentation and reducing sugar content of Kochujang increased up to 15 days of fermentation, but decreased after that.