소아에서 발생한 Calcaneal Petechiae (Black Heel) 1예

이호섭,우상혁,유화정,유동수,송해준 대한피부과학회 2004 대한피부과학회지 Vol.42 No.1

Calcaneal petechias (black heel) is a traumatic lesion affecting the back of posterolateral aspect of the heel. An asymptomatic, pigmented, macular lesion is found on one or both heels immediately above the hyperkeratotic border of the foot. It is caused by any sport, such as basketball, tennis, or football, that leads to slamming of the foot against the shoe. Calcaneal petechilae is probably more common than is realized. As it is usually symptomless, it may be disregarded or only observed by chance. The importance of the lesion lies in its clinical resemblance to a malignant melanoma. We report a case of calcaneal petechiae which was confused clinically with a melanoma. (Korean J Dermatol 2004;42(1):84~86)

자동차용 컨트롤 링크 업셋 용접부의 용접성 및 피로강도 향상에 관한 유한요소 해석

조해용,권혁홍,이봉규 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.6

This study is concerned with Finite Element Analysis on welded part of control link for automobile. For analysis, control link was modeled into two parts, ring and rod. Heating condition, temperature distributions and fatigue fracture strength were analyzed using "HEAT Ⅲ" and "ENDURE" module of NISA Ⅱ. Metal flow in the process of welding was simulated by DEFORM^TM 2D. The analyzed results were compared with experimental inspection. Quality of welded part was able to be improved by controlling metal flow in the process of welding by increase the friction constant of ring part. Heat transfer analysis and flow simulations were in good agreement with welding experiments.

한국의 지역문화정책과 그 발전과정에 관한 연구

박혜자,이기혁 朝鮮大學校 社會科學硏究所 1999 社會科學硏究 Vol.20 No.2

離婚家庭 靑少年을 위한 仲裁프로그램의 開發

張赫杓,李成海,金得星 부산대학교 과학교육연구소 1987 교사교육연구 Vol.15 No.-

The divorce rates are increasing and children of divorced parents are exposed to various social, phychological problems compared to those children living together with their own parents. The main purpose of this research project lies in developing intervention programs for counseling children of families having divorced parents. The study is mainly composed of two parts. The first part deals with the investigation of psychological characteristics of children of divorce-parents families. The second part documents the effect and actual status of intervention programs for counseling those children of divorce-parents families in order to reduce the level of negative psychological features(such as anxiety, aggression, depression, self-esteem and achievement motivation). A total of 1,082 middle school students from 11 boy's middle schools and 7 girl's middle schools are the object of the survey research of the first part of the research project. In this sample are included 605 students of normal family(362 boys and 243 girls), 256 families with one or both parents deceased(159 boys and 97 girls) and 221 students of divorce-parents families(140 boys and 81 girls). In the second part of the research, we provided intervention programs for counseling children of divorce-parents families. A total of 15 students (7 boys and 8 girls) participated in this program in which every student was given two intervention sessions in a four-night-five-day schedule. This intervention program consists of 15 stages and is characteristic of a group counseling program. All of the 15 students participating in this intervention program were given guestionnaires measuring levels of children's attitudes and self-perception(CASP) on divorce before and after the intervention program activity, this trying to figure out whether there were any significant differences in their CASP between before and after the program. One of the findings were there were some differences between boy students an girl students. For boy students, it was found that there are significant differences between before and after the program with the exception of anxiety, aggression, social self-esteem and family self-esteem. For girl students, there existed significant differences except family self-esteem. Judging from these findings it is concluded that the intervention program developed for this research works effective as we originally designed to work. However, further researches should be done in order to elaborate the reasons of the differences between boy and girl students.

조직공학적 연골생성에 있어서 연골막의 필요성

오경석,김해진,이동준,정재호,최준혁 大韓成形外科學會 2001 Archives of Plastic Surgery Vol.28 No.4

일측성 질폐쇄 및 동측 신장 무발생을 동반한 중복자궁 2예

윤일영,여소진,김형문,김정식,김태희,이해혁,남계현,이권해,김준모,김민의 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Uterus didelphys with unilateral obstructed hemivagina and ipsilateral renal agenesis usually presents after menarch with progressive abdominal pain during menses secondary to hematocolpos, and indeed a very rare congenital anomaly due to Mullerian duct malformation. An accurate and prompt diagnosis is of importance to permit treatment and to assure the future fertility of the patient. Pelvic ultrasound, physical examination and pelvic MRI established a diagnosis of hematometracolpos secondary to uterus didelphys with unilateral imperforate hemivagina. An incision in the vaginal septum allowed drainage of the hematocolpos, providing relief of the patients symptoms. We report two case of uterus didelphys with obstructed hemivagina with brief review of the literature.

CT 유도하의 경피적 폐생검 : 임상적 의의 및 합병증에 관한 연구 A Study of Clinical Significance and Complication

박재성,백상현,차장규,홍현숙,김대호,박성진,조준희,임한혁,이혜경 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Purpose : To determine the diagnostic accuracy and predicting factor of pneumothorax on CT-guided percutaneous transthoracic needle biopsy. Materials and Methods : Using automated biopsy devices, 107 CT-guided percutaneous needle biopsies of pulmonary lesions were performed. Final diagnosis was made with operation or other methods. We retrospectively analyzed the frequency of complications and diagnostic yields of 107 biopsies. The clinical features, treatment, and courses of complications were reviewed, and risk factors of pneumothorax such as depth and size of lesion, CT emphysema score of whole lung and pathway of needle, and the result of pulmonary function test were analyzed. Result : 96 biopsies(89.7%) yielded sufficient tissue for pathologic evaluation. For cases of malignant and benign disease, sensitivity was 91.5% and 87.5% respectively; the corresponding figures for diagnostic accuracy were 88.1% and 77.1%. So, sensitivity and diagnostic accuracy of percutaneous transthoracic needle biopsy was 89.7% and 83.2%. Eighteen(16.8%) of 107 patients developed pneumothorax and 3 of these required application of chest tube or percutaneous catheter drainage. In the group with pneumonthorax, the lesion was significantly smaller(p=0.029) and higher CT emphysema score of pathway of needle(p=0.032). But there were no significant difference between two groups(with or without pneumothorax) for depth of lesion, pulmonary function test(% predictive value of FEV1 and FEV1/FVC) and CT emphysema score of whole lung. Conclusion : CT-guided transthoracic needle biopsy of the pulmonary lesions is safe and easy method of obtaining specimens of good quality and quantity. It may be an useful procedure in the diagnosis of localized pulmonary lesions. For the prediction of pneumothorax, size of lesion and CT emphysema score of pathway of a needle are significant risk factors.

Mitochondrial Respiratory Dysfunction Induces Claudin-1 Expression via Reactive Oxygen Species-mediated Heat Shock Factor 1 Activation, Leading to Hepatoma Cell Invasiveness

Lee, Jong-Hyuk,Lee, Young-Kyoung,Lim, Jin J.,Byun, Hae-Ok,Park, Imkyong,Kim, Gyeong-Hyeon,Xu, Wei Guang,Wang, Hee-Jung,Yoon, Gyesoon American Society for Biochemistry and Molecular Bi 2015 The Journal of biological chemistry Vol.290 No.35

<P>Although mitochondrial dysfunction has been implicated in tumor metastasis, it is unclear how it regulates tumor cell aggressiveness. We have reported previously that human hepatoma cells harboring mitochondrial defects have high tumor cell invasion activity via increased claudin-1 (Cln-1) expression. In this study, we demonstrated that mitochondrial respiratory defects induced Cln-1 transcription via reactive oxygen species (ROS)-mediated heat shock factor 1 (HSF1) activation, which contributed to hepatoma invasiveness. We first confirmed the inverse relationship between mitochondrial defects and Cln-1 induction in SNU hepatoma cells and hepatocellular carcinoma tissues. We then examined five different respiratory complex inhibitors, and complex I inhibition by rotenone most effectively induced Cln-1 at the transcriptional level. Rotenone increased both mitochondrial and cytosolic ROS. In addition, rotenone-induced Cln-1 expression was attenuated by <I>N</I>-acetylcysteine, an antioxidant, and exogenous H<SUB>2</SUB>O<SUB>2</SUB> treatment was enough to increase Cln-1 transcription, implying the involvement of ROS. Next we found that ROS-mediated HSF1 activation via hyperphosphorylation was the key event for Cln-1 transcription. Moreover, the Cln-1 promoter region (from −529 to +53) possesses several HSF1 binding elements, and this region showed increased promoter activity and HSF1 binding affinity in response to rotenone treatment. Finally, we demonstrated that the invasion activity of SNU449 cells, which harbor mitochondrial defects, was blocked by siRNA-mediated HSF1 knockdown. Taken together, these results indicate that mitochondrial respiratory defects enhance Cln-1-mediated hepatoma cell invasiveness via mitochondrial ROS-mediated HSF1 activation, presenting a potential role for HSF1 as a novel mitochondrial retrograde signal-responsive transcription factor to control hepatoma cell invasiveness.</P>

Fabrication of an rhBMP-2 loaded porous β-TCP microsphere-hyaluronic acid-based powder gel composite and evaluation of implant osseointegration

Lee, Jae Hyup,Kim, Jungju,Baek, Hae-Ri,Lee, Kyung Mee,Seo, Jun-Hyuk,Lee, Hyun-Kyung,Lee, A-Young,Zheng, Guang Bin,Chang, Bong-Soon,Lee, Choon-Ki Springer US 2014 Journal of materials science, Materials in medicin Vol.25 No.9

<P>Methods to improve osseointegration that include implantation of rhBMP-2 with various kinds of carriers are currently of considerable interest. The present study was conducted to evaluate if the rhBMP-2 loaded β-TCP microsphere-hyaluronic acid-based powder-like hydrogel composite (powder gel) can act as an effective rhBMP-2 carrier for implantation in host bone with a bone defect or poor bone quality. The release pattern for rhBMP-2 was then evaluated against an rhBMP-2-loaded collagen sponge as a control group. Dental implants were also inserted into the tibias of three groups of rabbits: an rhBMP-2 (200 µg) loaded powder gel composite implanted group, an implant only group, and a powder gel implanted group. Micro-CT and histology of the implanted areas were carried out four weeks later. The rhBMP-2 powder gel released less rhBMP-2 than the collagen sponge, but it continued a slow release for more than 7 days. The rhBMP-2 powder gel composite improved osseointegration of the dental implant by increasing the amount of new bone formation in the implant pitch and it improved the bone quality and bone quantity of new bone. The histology results indicated that the rhBMP-2 powder gel composite improved the osseointegration in the cortical bone as well as the marrow space along the fixture. The bone-to-implant contact ratio of the rhBMP-2 (200 µg) loaded powder gel composite implanted group was significantly higher than those of the implant only group and the powder gel implanted group. The powder gel appeared to be a good carrier and could release rhBMP-2 slowly to promote the formation of new bone following implantation in a bone defect, thereby improving implant osseointegration.</P>

Three-Headed 99mTc-RBC SPECT를 이용한 간혈관종의 진단

이승규,정영화,민영일,이영상,문대혁,이문규,이명혜,양석균,성규보 대한소화기학회 1992 대한소화기학회지 Vol.24 No.6

We evaluated the role of three-headed single-photon emission computed tomography (SPECT) in ^(99m)Tc-RBC scintigraphy for the diagnesis of cavernous hemangioma of the liver. A total of 76 patients, including 55 patients with 62 hemangiomas and 21 patients with 27 non- hemangiomas (20 hepatocellular carcinomas, 5 hepatic metastases, 2 other benign lesions), underwent planar RBC imaging followed by blood-pool SPECT scanning. The sensitivity of RBC scintigraphy for detecting hemengiomas was improved with the addition of SPECT; from 0% to 16.7% for hemangiomas smaller than 1.0 cm in diameter (n=6), from 20.0% to 76.0% for lesions between 1.0-1.9 cm (n =25), from 64.3% to 100% for lesions between 2.0-2.9 cm (n=14), and from 94.1% to 100% for lesions ≥3.0 cm (n = 17). None of 27 non-hemangiomas showed increase in delayed blood-pool with either planar or SPECT image. In conclusion, ^(99m)Tc-RBC scintigraphy is highly specific in the diagnosis of hepatic hemangiomas and, with the addition of three-headed SPECT, the sensitivity of RBC scintigraphy for the detection of small hemangiomas is considerably improved.