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Eupatilin Inhibits Gastric Cancer Cell Growth by Blocking STAT3-Mediated VEGF Expression
정재호,Sung Yi Hong,젠얀준,노성훈 대한위암학회 2011 Journal of gastric cancer Vol.11 No.1
Purpose: Eupatilin is an antioxidative flavone and a phytopharmaceutical derived from Artemisia asiatica. It has been reported to possess anti-tumor activity in some types of cancer including gastric cancer. Eupatilin may modulate the angiogenesis pathway which is part of anti-inflammatory effect demonstrated in gastric mucosal injury models. Here we investigated the anti-tumor effects of eupatilin on gastric cancer cells and elucidated the potential underlying mechanism whereby eupatilin suppresses angiogenesis and tumor growth. Materials and Methods: The impact of eupatilin on the expression of angiogenesis pathway proteins was assessed using western blots in MKN45 cells. Using a chromatin immunoprecipitation assay, we tested whether eupatilin affects the recruitment of signal transducer and activator of transcription 3 (STAT3), aryl hydrocarbon receptor nuclear translocator (ARNT) and hypoxia-inducible factor-1Ձ (HIF-1Ձ) to the human VEGF promoter. To investigate the effect of eupatilin on vasculogenesis, tube formation assays were conducted using human umbilical vein endothelial cells (HUVECs). The effect of eupatilin on tumor suppression in mouse xenografts was assessed. Results: Eupatilin significantly reduced VEGF, ARNT and STAT3 expression prominently under hypoxic conditions. The recruitment of STAT3, ARNT and HIF-1Ձ to the VEGF promoter was inhibited by eupatilin treatment. HUVECs produced much foreshortened and severely broken tubes with eupatilin treatment. In addition, eupatilin effectively reduced tumor growth in a mouse xenograft model. Conclusions: Our results indicate that eupatilin inhibits angiogenesis in gastric cancer cells by blocking STAT3 and VEGF expression, suggesting its therapeutic potential in the treatment of gastric cancer.
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지방자치단체장의 개인적 특성이 민간이전경비에 미치는 영향에 관한 연구
정재호,이성우 한국지역개발학회 2016 韓國地域開發學會誌 Vol.28 No.3
본 연구는 지방자치단체장의 개인적 특성과 민간이전경비와의 관계에 대해 실증분석 하였다. 민간이전경비는 대표적인 선심성 예산으로 지적받고 있으며 최근 증가속도가 뚜렷하고 통제장치 또한 미흡하여 낭비적 지방재정 운영의 대표적인 사례로 지적받고 있어 문제점에 대한 검토와 시사점의 검토가 필요하다. 분석을 위하여 종속변수는 기초지방자치단체의 주민 1인당 민간이전경비 예산액으로 하였고, 독립변수는 지방자치단체장의 연령, 교육수준, 전직 직업, 재선(연임, 중임)여부 및 소속정당을 선택하여 모형을 구축하였다. 또한 설명력을 높이기 위하여 지방선거 투표율, 재정자립도, 65세 이상 노인인구비율, 지자체 유형을 통제변수로서 모형에 포함하였다. 분석자료는 2003년에서 2013년까지의 자료를 패널데이터로 작성하였고, 분석방법은 고정효과 모형에 의한 패널회귀분석 방법을 적용하였다. 분석 결과 행정가형 지방자치단체장은 경영가형 지방자치단체장에 비하여 주민 1인당 민간이전경비 예산액을 증가시키는 것으로 확인되었고, 지방자치단체장의 소속 정당이 민주당(열린우리당)과 무소속 또는 기타 정당인 경우가 한나라당(새누리당) 소속 지방자치단체장에 비하여 민간이전경비 예산편성에 적극적인 것으로 나타났다. 또한, 초선 지방자치단체장일수록 연임․중임 지방자치단체장에 비하여 지방자치단체의 1인당 민간이전경비를 증가하는 방향으로 영향을 미치는 것을 확인할 수 있었다. This study analyzes the relevance of local government heads and local governments' transfer expenses to private sector. Local governments' transfer expenses to private sector have been pointed out the rapid increase and inadequate control mechanism. For models of this study, there are five independent variables which are related to the characteristics of local government heads and four control variables which fall into categories of Political Factor, Financial Factor and Social Factor. The dependent variable of this study is local governments' transfer expenses to private sector per municipal people. And regression analyses(fixed-effects model) with panel data of fiscal year 2003-2013 are conducted to determine whether they are statistically significant. The results of analysis show that if he/she is a former administrator, local governments' transfer expenses to private sector is likely to increase significantly in statistics. And if a head of local government is affiliated to Hannara(Saenuri) party, there is a relative tendency to decrease local governments' transfer expenses to private sector. Also it is confirmed that a newly elected local government head inclines to increase local governments' transfer expenses to private sector than a re-elected local government head.
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피부사상균 의한 Majocchi's granuloma 4예
정재호,유민영,윤석권,김한욱 대한의진균학회 2001 대한의진균학회지 Vol.6 No.1
Dermatophytes usually do not invade beyond the epidermis. However mechanical breakage of the skin resulting from scratching or trauma and immunocompromised state, such as diabetes mellitus, lymphoma, and long-term steroid use may allow penetration of the fungi into reticular dermis. Cutaneous granulomas produced by infection with superficial fungi are infrequently recognized. We report four cases of dermatophytic granuloma on the lower extremities. Histopathologic examinations of the skin lesions of flour patients showed chronic granulomatous inflammation with fungal elements. Cultures of Sabouraud's media with excised tissue revealed Trichophyton(T.) rubrum in two patients and T. mentagrophytes in one patient. The patients were treated with oral administration of terbinafine or itraconazole for 2-4 weeks. [Kor J Med Mycol 6(1): 37-41]
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정재호,김현근,김향희,전태보 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.A
Simulation analysis for an auto body manufacturing system has been performed in this study. The major goal is to figure out the condition yielding the production rate, 70 per hour. It is, however, very difficult to maintain this rate due to inherent system factors such as machine failure rates, machine repair rates, number of carriers between manufacturing lines(shops), carrier speed etc. We first carefully examined the system and developed a simulation model using ARENA. We then applied statistical experimental design concepts for performance analysis. Our results indicate that the buffer size of 30 and quick repair of failed robots are required for the desired production rate. Other factors, on the other hand, are seen to have minor effects on the throughput. The approach taken in this study and the results obtained may provide a practical guideline for performance analysis and thus be applied without trepidation for similar cases.
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