청소년 수련시설 안전기준 제안을 위한 연구

洪榮均,鄭朱然 홍익대학교환경개발연구원 2001 환경개발연구논문집 Vol.6 No.-

Youth training facilities have been increased in terms of quantity since 1990s. Such a remarkable external growth should be foundation for youth training activities to build on. However, the disregard of growth in quality resulted in many problems to the safety management. The purpose of this research investigates the problems not in terms of programs but in terms of management for efficiency and safety, and proposes the alternative way for development.

광장공포증 동반유무에 따른 공황장애의 임상적 차이 연구

조주연,이길홍,이영식 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

To investigate certain differences in sociodemographic characteristics and clinical feature between panic disorder with agoraphobic patients and panic disorder without agoraphobic ones, this study was done. The subjects were 46 panic patients(27 were agoraphobic patients and 19 were without agoraphobic ones). Data was processed by computer using SAS program and was statisticaly analysed by Fisher's exact test, t-test Wilcoxon rank sum test. The results were as follows: 1) Agoraphobic group had more family pathology than without agoraphobic group. 2) Agoraphobic group had more frequent panic attack episodes and more severe step of panic disorder than without agoraphobic group. 3) In both group, the most frequent manifestation of panic symptom was palpitation. 4) IN comparison of two groups, the only symptom that were significantly different was dyspnea.

폐경전 여성에서 혈중 성호르몬결합글로불린 농도와 산화스트레스의 연관성

최영주,오지영,홍영선,성연아 대한내분비학회 2004 Endocrinology and metabolism Vol.19 No.1

연구배경: 여성에서 남성화의 간접적인 지표인 SHBG 농도는 인슐린저항성과 관련되며, 심혈관질환의 위험을 예측할 수 있는 지표로 보고되었다. 심혈관질환의 위험인자들이 산화스트레스의 증가와 관련되며, 최근 남성 호르몬의 증가와 인슐린저항성을 특징으로 하는 다낭성난소증후군 환자에서 성호르몬과 산화스트레스가 관련된다는 연구결과가 있다. 본 연구는 SHBG와 산화스트레스의 연관성을 규명하기 위하여 시행되었다. 방법: 당뇨병, 고혈압, 심혈관질환의 과거력 및 흡연력이 없는 폐경전 여성 46명을 대상으로 하여 방사 면역계수법으로 SHBG를 측정하였으며, ox-LDL은 효소면역측정법으로, TAS 및 MDA는 분광광도계로 측정하였고, SHBG와 산화스트레스를 나타내는 지표들간의 연관성을 관찰하였다. 결과: 1. 정상내당능군과 내당능장애군간에 SHBG와 MDA 농도는 유의한 차이가 없었으며, TAS는 내당능장애군에서 정상내당군에 비해 유의하게 높았다(1.41±0.15 mmol/L, 1.30±0.17 mmol/L, p=0.034). 2. SHBG 농도는 비만군에서 비비만군에 비해 유의하게 낮았다 (56.6±34.2 nmol/L, 76.0±23.8 nmol/L, p=0.036). 3. SHBG 농도는 체질량지수 (r=-0.394, p=0.007), 당부하후혈당(r=-0.326, p=0.027), 허리둘레(r=-0.323, p=0.029), 허리 대 허벅지둘레비 (r=-0.308, p=0.037), 공복인슐린 농도 (r=-0.387, p=0.008), 내장지방면적 (r=-0.339, p=0.021)과 유의한 음의 상관관계가 있었고, 인슐린 감수성지표와는 유의한 양의 상관관계(r=0.397, p=0.008)가 있었다. 4. SHBG 농도는 MDA 농도 (r=-0.357, p=0.015) 및 ox-LDL 농도 (r=-0.367, p=0.014)와 유의한 음의 상관관계가 있었다. 5. 다중회귀분석에서 연령, 체질량지수, 당부하후혈당, 허리둘레, 공복인슐린 농도, 수축기 혈압, 고밀도지 단백콜레스테롤, 중성지방을 보정한 후 SHBG 농도는 MDA 및 ox-LDL에 유의하게 독립적으로 영향을 주었다. TAS에 영항을 주는 인자로는 공복인슐린 농도와 당부하후 혈당이 통계학적으로 유의하였고, SHBG는 유의한 관련성이 없었다. 결론: 폐경전 여성에서 SHBG의 감소는 산화스트레스의 증가와 관련되어 심혈관질환의 위험을 예견할수 있는 지표로 생각된다. Background: Low levels of sex hormone-binding globulin (SHBG), an indirect index of androgenicity, are associated with insulin resistance and cardiovascular risk factors. The risk factors of the cardiovascular disease are known to be related to oxidative stress. In recent reports, sex hormones were associated with oxidative stress in women with polycystic ovarian syndrome (PCOS), which is characterized by increased androgenicity and insulin resistance. with NGT. Methods: To investigate the relationship between sex hormones and oxidative stress, we examined the association of malondialdehyde (MDA), total antioxidant status (TAS), oxidized low density lipoprotein cholesterol (ox-LDL), and SHBG in 46 Korean premenopausal women. Results: 1. SHBG and MDA levels were not significantly different among the women with NGT and IGT. But, TAS was significantly lower (p=0.034) in the subjects with IGT than in the subjects with NGT. 2. The SHBG level was significantly lower (p=0.036) in obese women than in non-obese women. 3. The SHBG level was significantly inversely correlated with BMI (r=-0.394, p=0.007), post challenge glucose (r=-0.326, p=0.027), waist size (r=-0.323, p=0.029), waist-to-thigh ratio (WTR) (r=-0.308, p=0.037), fasting insulin level (r=-0.387, p=0.008), visceral fat area (VFA)(r=-0.339, p=0.021), and was significantly positively correlated with SI (r=0.397, p=0.008). 4. The SHBG level was significantly inversely correlated with levels of MDA (r=-0.357, p=0.015) and ox-LDL (r=-0.367, p=0.014). 5. In a multiple linear regression analysis, the SHBG level was a significant and independent factor for both MDA and ox-LDL. For TAS, the fasting insulin level and post challenge glucose were significant and independent factors. Conclusion: Increased androgenicity assessed by the decrease in serum SHBG levels is associated with the increase in MDA and ox-LDL. These results suggest that increased androgenicity in premenopausal women can contribute to the development of cardiovascular diseases via increased oxidative stress (J Kor Soc Endocrinol 19:48∼57, 2004).

꽃꽂이시 절화조합이 장미의 절화수명과 미생물 증식에 미치는 영향

박윤점,정주연,장홍기,허북구 한국화훼연구회 2001 화훼연구 Vol.9 No.2

Various combinations of cut rose and other cut flowers were accomplished to provide basic data for vase life extension of cut rose. The vase life of cut rose combined with other cut flowers was as follows ;rose (8 days) > rose + gladiolus (6 days) > rose + calla (4 days) > rose + chrysanthemum (4 days) > rose + carnation (3 days) > rose + gerbera (2 days). The vase solution of cut rose without other cut flowers had the lowest concentration (1.2×105 CFU/mL) of bacterial cells. On the other hand, The vase solution of cut rose with gerbera had the highest concentration (9.3×106 CFU/mL) of bacterial cells. From the above results, it is concluded that vase life of cut rose is extended by reducing the bacterial cells in the vase solution though the proper combination with effective cut flowers.

한국인의 간과 콩팥조직 내 수은 함유량의 참고치

최병선,박영주,권일훈,홍연표,박정덕 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.2

This study was conducted to investigate the reference value of mercury (Hg) in liver and kidney of Korean population. The mercury concentration in 244 'sudden and unexpected death' autopsies (male: 180, female: 64) aged from 0 to87 years was analyzed. The concentration of mercury was measured by atomic absorption spec(Perkin -Elmer Model 5100) with mercury/hydride generating system (FIAS 400). The contents of mercury in liver and kidney fitted well the log-normal distribution rather than normal distribution. Geometric mean concentration of mercury in liver and kidney was 0.115 ㎍/g wet weight and 0.149 μg/g wet weight, respectively. Geometric mean concentration of mercury in female was higher than in male (p<0.01). The mercury content in liver and kidney increased with age up to the forties and slightly decreased there-after, The regression model of mercury deposit in liver and kidney by age was predicted as the following equation : Log KHg=-1.0576+0.0045·Age -0.0001·Age²+0.0873·Sex, Log KHg=-1.0576+0.0152·Age-0.0002·Age²+0.1935·Sex. The liver burden of mercury was estimated to be 158.3~161.3μg in male and 163.0-166.9 ㎍ in female. The kidney burden of mercury was estimated to be 42.0~42.9 ㎍ in male and 55.5 ∼57.1 μg in female.

항결핵 6개월 단기요법의 성과 고찰

서지원,정연채,김남재,홍석철,김주옥,김선영,노흥규 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

To evaluate the effect of 6-month short term antituberculosis chemotherapy with INH, Rifampin, Ethambutol, and Pyrazinamide(2HREZ/4HRE) in the patients with pulmonary and/or extrapulmonary tuberculosis, the authors prescribed 2HREZ/4HRE regimen in 79 tuberculosis patients for 6 months with measuring the sputum staining for AFB, chest X-ray findings, recurrence rates and possible side reactions of the treatment. The result were as follow; 1. Pulmonary Tuberculosis 1) Among the 56 pulmonary tuberculosis patients who had taken 2HREZ/4HRE regimen. 32 patients showed initial positivity in sputum AFB smear stain(57.2%). Negative conversion occurred usually within 2 months after initiation of chemotherapy and the mean period of negative conversion was 1.4 months. 2) Among the 56 pulmonary tuberculosis patients, chest X-ray finding changed in 41 patients (37.21%). From these 41 patients 39 patients showed continuous improvements in chest X-ray finding, though 3 patients showed initial aggravation in spite of continuous medication. The remainder 2 cases aggravated due to the failure of treatment. 3) Treatment failure occurred in 2 patients (3.57%) during the chemotherapy among 56 patients of pulmonary tuberculosis and they were infected with secondary drug-resistant strains of M. tuberculosis. 2. Extrapulmonary tuberculosis. Among 8 patients with tuberculous pleurisy and 15 patients with superficial tuberculous lymphadenitis, there were no evidence of treatment failure after completion of antituberculosis chemotherapy for 6 months with 2HREZ/4HRE regimen. 3. Follow-up study was performed from 6 months to 50 months after completion of antituberculosis chemotherapy and the relapse was not noted in both pulmonary and extrapulmonary tuberculosis patients group during this period. 4. Serum AST/ALT elevated in 9 patients(11.4%) during the treatment and this occurred usually within 3 months after the initiation of antituberculosis chemotherapy. However treatment interruption occurred in 2 patients (2.5%) due to the development of hepatitisone due to drug-induced hapatitis and the other due to type B viral hepatitis. In conclusion, we could find this 2HREZ/4HRE 6-months short-term antituberculosis regimen is effective and could be recommanded as a promising regimen for the treatment of tuberculosis.

좌측흉수로 발현된 Boerhaave 증후군 1예

이준,변유미,조민근,조주연,원경준,김영대,박찬국,김만우,유재근,서홍주,이석기 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

구토 후 발생한 토혈을 주소로 내원한 환자에서 좌측 늑막 삼출 동반 시 식도 파열의 가능성을 고려하여 흉수 천자 및 지속적인 흉부 단순 촬영의 추적관찰이 필요하며 식도 파열이 배제된 후 환자의 생체 징후 및 토혈 양을 파악하여 내시경 검사 시기를 신중히 결정하는 것이 좋을 것으로 생각된다. 본 증례는 토혈을 주소로 내원하여 Mallory-Weiss 증후군 의심 하에 내시경을 통한 치료 시행 후 추적 관찰에 의해 진단된 Boerhaave 증후군을 경험하였기에 보고하는 바이다. Boerhaave's syndrome is a spontaneous perforation of the esophagus most commonly resulting from a sudden increase in intraesophageal pressure combined with negative intrathoracic pressure caused by straining or vomiting. Surgery should generally be performed within 24 hours because mortality approached 30 to 50 percent in which surgery was delayed. Therefore, early diagnosis and prompt surgical repair are critical for survival. We have experienced a case of Boerhaave's syndrome in a patient presenting with hematemesis with left pleural effusion without any signs or symptoms of pneumomediastinum or pneumothorax.

혈우병 환자에 동반된 자발성 후복막강 출혈

김광일,김동호,우상민,이석주,김홍성,조인성,윤환중,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

Spontaneous retroperitoneal hemorrhage due to hemophilia A with impaired coagulopathy is very rare. Spontaneous retroperitoneal hemorrhage has been recorded as having originated from many retroperitoneal organs and blood vessels, and it may be due to local and/or systemic factors. In the majority of the patients, kidney and adrenal gland were the major site of hemorrhage. The systemic causes of spontaneous retroperitoneal hemorrhage are anticoagulation therapy and chronic hemodialysis. During the course of these treatments, hemorrhagic complications may occur at many site, including the retroperitoneal space. Blood dyscrasias including leukemia, polycythemia, sickle cell trait and hemophilia have been reported associated with spontaneous retroperitoneal hemorrhage. We report a case of spontaneous retroperitoneal hemorrhage occurred in a gemophilia A patient with brief review of literature

전북 익산지역에서의 묘화 이용실태 조사

박윤점,이일병,정주연,장흥기,허북구 한국식물인간환경학회 2001 인간식물환경학회지 Vol.4 No.1

This study was surveyed to know utilization of the in graveyard the military and the police(MP), the catholic graveyard(CG) and graveyard of mausoleum(GM). The items of investigation were the ratio, kinds of flower, color of cut flower and form of offering a bunch of flowers. The time of investigation were New Year's day, Chusok(the korean thanksgiving day) and a weekday. On a week day, the ratio of offering a bunch of flowers was 6.3 perrcent in GM. CG and GM were 2 and 6 percent, respectively, On Chusok MP was 9 percent, CG was 25 percent and GM was 55.9 percent. On New Year's Day MP was 17.9 percent, CG was 43.3 percent and GM was 49.8 percent. Except for GM, when we compared the chusok with a week day, they were offered 12-24 times. Of the kinds of cut flower offered a bunch of flowers, chrysanthemum was 60 percent or more without regard to MP, CG and GM. About color of cut flower, white was 39.2 percent or more and yellow was 8.8 percent or more. Most of used colors were white and yellow. And they were 48 percent or more. That of on a week day was low remarkably. The form of offered flower on a graveyard were various: a flower, a basket of flower, a potflower, a flower in a case of glass, and a flower in a vase. Of that, a bunch of flowers were 33 percent or more in GC, MP and CG. KEY WORDS : flower, graveyard, new year's day, chusok, chrysanthemum

국가예방접종전산등록체계 개발을 위한 민간의료 기관 하부구조 및 환경 조사연구

이무식,김은영,이건세,이석구,홍지영,김건엽,김대경,신의철,이연경,기몽서,나백주,김영택 한국모자보건학회 2003 한국모자보건학회지 Vol.7 No.2