노인의 성격과 죽음태도에 관한 탐색적 연구

유경원,박상하,김혜숙,정경인 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Background and Objectives: The purpose of this study was to analyze how the personality of elderly people affects their attitude toward death. Method: For this study, we investigated 86 old men and women with over the age of 60 in C and J nursing home for the old at Gwang ju city during January 5 to March 31, 2003. As a research tool, the total 20 questions of modified Shanans assorted survey method to measure personality style were used and the reliability of this study was Cronbach's α= 0.7507. For determination of attitude of death, the total 36 questions of FODS, which has been used by Suh, Hye-Kyung were used and the reliability of this study was Cronbach's α= 0.60. Using SPSS program, the collected data were analyzed by Frequency, ANOVA and Pearson correlation coefficient, respectively. Results: In the analyze of the results of personality complying with general characteristics, there were statistically significant differences in age. It was shown that the personality of the old with the age of 61-65 is positive. There were no significant differences in thee attitude toward death complying with general characteristics. The hypothesis in this study, the correlation that the more positive personality of the old, the more positive attitude toward death was supported. Conclusion: Since the elderly people with more positive personality may have more positive attitude toward death, it is considered that the old themselves, their family and workers might help to haw positive personality for the positive attitude toward death.

암 환자의 불안과 우울에 관한 연구

하혜경 大韓神經精神醫學會 1982 신경정신의학 Vol.21 No.4

The author studied the emotional status, especially, anxiety and depression and their influential factors of the hospitalized cancer patients by means of the semistructured interview and psychological tests(SAS, MMPI, BDI). The results were as follows; 1. Among the total 102 inpatients, considerable anxiety was noticed in 40% of them by SAS, and depression in 40% by MMPI and 60% by BDI. 2. Sex differences were noted with statistical significance, the female patients are more anxious than the male patients. (p<0.05) The older the patients, the more anxious and depressed, and maximum anxiety and depression were noticed in the 6th decade group. (p<0.05) 3. The anxiety scores lower in the Protestant and Catholic group than the Buddhists and other religions group. (p<0.05) 4. The patients who had been surgically operated was more anxious and depressed than those who had not been operated though the differences were not statistically significance. 5. The patients who had been informed about the diagnosis, had less anxiety and depression than those who had not been informed on the diagnosis, but as the time went on, the informed patients became increasingly anxious and depressed. 6. The depression was more severe in the group who had neurotic symptom in the past than those who did not. 7. According to the affected organs, the patients having the genital organ cancer(uterine cervical cancer, breast cancer) were more anxious and depressed than the other organ cancer patients. (p<0.05). 8. Anxiety and depression of the cancer patients were positively correlated each other: The more anxious the patients, the more depressed and vice versa.

Whole-genome resequencing analysis of 20 Micro-pigs

Da‑Hye Son,Nam‑Hyun Hwang,Won‑Hyong Chung,Ha‑Seung Seong,Hyungbum Lim,Eun‑Seok Cho,Jung‑Woo Choi,Kyung‑Soo Kang,Yong‑Min Kim 한국유전학회 2020 Genes & Genomics Vol.42 No.3

Background Miniature pigs have been increasingly used as mammalian model animals for biomedical research because of their similarity to human beings in terms of their metabolic features and proportional organ sizes. However, despite their importance, there is a severe lack of genome-wide studies on miniature pigs. Objective In this study, we performed whole-genome sequencing analysis of 20 Micro-pigs obtained from Medi Kinetics to elucidate their genomic characteristics. Results Approximately 595 gigabase pairs (Gb) of sequence reads were generated to be mapped to the swine reference genome assembly (Sus scrofa 10.2); on average, the sequence reads covered 99.15% of the reference genome at an average of 9.6-fold coverage. We detected a total of 19,518,548 SNPs, of which 8.7% were found to be novel. With further annotation of all of the SNPs, we retrieved 144,507 nonsynonymous SNPs (nsSNPs); of these, 5968 were found in all 20 individuals used in this study. SIFT prediction for these SNPs identified that 812 nsSNPs in 402 genes were deleterious. Among these 402 genes, we identified some genes that could potentially affect traits of interest in Micro-pigs, such as RHEB and FRAS1. Furthermore, we performed runs of homozygosity analysis to locate potential selection signatures in the genome, detecting several loci that might be involved in phenotypic characteristics in Micro-pigs, such as MSTN, GDF5, and GDF11. Conclusion In this study, we identified numerous nsSNPs that could be used as candidate genetic markers with involvement in traits of interest. Furthermore, we detected putative selection footprints that might be associated with recent selection applied to miniature pigs.

산업 근로자의 구강건강실태 및 구강질환 관련요인에 관한 연구

김혜진,박천만,우극현,이은숙,이종렬,하은경 대한보건협회 2002 대한보건연구 Vol.28 No.2

To maintain and improve workers' oral health, I investigated and analyzed the oral health status of workers, who are working at companies located in Koomi City. The results of the investigation and analysis are as follows. 1. Regarding the general properties of investigated objects, the male ratio of whole objects(1299 persons) occupied 86.6% the larger percentage, the persons from 20ages to 29ages in terms of age distribution occupied 35.6%, and the high school graduators in the respect of education occupied 75.3%. As for the property of duties, technical workers occupied 83.6% the larger percentage. In the drinking frequency of habits, one or two times drinking per week occupied 34.1% in case of male, and no drinking occupied 62.9% in case of female. 2. In the existence and nonexistence of oral disease depends on the general property of each objects, many females have an oral disease in comparison with males(p<.05), many persons with low education level have an oral disease(p<.001), and lots of self-boarding persons have an oral disease compared to the persons stayed at own home or dormitory(p<.05). In the existence and nonexistence of oral disease depends on living habits, the more male has a drinking capacity, the more has an oral disease(p<.05). And, the more male is smoking, the more has an oral disease(p<.05). When examine oral disease in accordance with cubjective healthy condition, there were many respondents answered that I have a decayed tooth or periodontitis in comparison with respondents did that I' m healthy(p<.001). In the existence and nonexistence of oral disease depends on oral health control practices and recognition, the persons received scaling for the latest one year had show a few of oral diseases significantly(p<.001). 3. As a result of Logistics Regression Analysis by putting oral disease as a dependent variable, the person who does not receive scaling, does smoking, has a low education level, does work at company for a short time, experiences lots of subjective symptoms, and does drinking, has a possibility that he/she can be infected easily with oral disease. As a whole of the above results, regular oral checkup every year shall be strengthen in its quality and quantity. In particular, the activation of oral health education to prevent oral disease may make workers' oral health and their life quality to be improved. Accordingly, in oral health education for workers, the more systematic and effective program shall be developed and the supports in government policy shall be needed.

컴포머 충전과정에 따른 상아질 투과도의 변화

조혜진,이경하,이세준,이광원 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.4

Compomer is composed of matrix and filler; matrix is made of the combination of resins and polycarboxylic molecules that are light-cured. and a filler is a glass component which is capable of ion-release. The resin content of compomers produces polymerization shrinkage which can adversely affect marginal adaptation. Pretreatment is a fundamental step which is treated with conditioner or primer in the use of these materials. Microleakage of restorative materials has been investigated mostly by dye penetration method. Dye penetration method was not quantitative and not measured repeatedly. Fluid filtration method. introduced and developed by Pashley's group, has been extensively used for 20 years for research purpose to understand the physiology of dentin, as well as the effects of various restorative treatments on dentin permeability. It permits quantitative, nondestructive measurment of microleakage in a longitudinal manner. The purpose of this study was to evaluate the change the change of dentin permeability according to the process of compomer restoration. In this study, CI Ⅴ cavities were prepared on buccal surface of thirty extracted human molars. The prepared cavities were etched by 37% phosphoric acid. The experimental teeth were randomly divided into three groups. Each group was treated with following materials; Group 1 : Prime & Bond NT/Dyract AP, Group 2: Single Bond/F2000 compomer, Group 3 : Syntac Single Component/Compoglass. The bonding agent and compomer were applied for each group following manufactures information. Dentin permeability of each group was measured at each process by fluid filtration method; Step 1 : preparation(smear layer), Step 2 : etching(smear layer removal), Step 3 : applying the bonding agent, Step 4 : filling the compomer. Dentin permeability was expressed by hydraulic conductance(㎕ min^-1cmH_2O^-1). The data were analysed statistically using One-way ANOVA and Sheffe's method. The results were as follows : 1. Dentin permeability differences between each process were significant except between step 1 and step 2(p<0.01). 2. Dentin permeability after removal of smear layer was highly increased(p<0.01). 3. In most case, decrease of dentin permeability was obtained by applying bonding agent(p<0.01). 4. Dentin permeability differences among the experimental groups were not significant(p>0.05). 5. None of compomers used in this study showed perfect seal at the interface.

소규모사업장 보건관리기술지원사업 지원여부에 따른 사업장내 의사소통 비교

정최경희,박혜숙,김정연,이경용,현성민,오지영,김수근,김현주,하은희 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

목적: 소규모사업장 보건관리기술지원사업 지원여부에 따라 사업장내 위험의사소통채널이 마련되었는지와 이 채널이 기능을 하는지, 그리고 의사소통채널마련과 사업장내 위험의사소통 활성화의 기본적이고 중요한 배경이 되는 사업주의 산업보건에 대한 관심이 차이가 있는지에 대해 살펴보고자 하였다. 방법: 서울, 안산, 대전, 광주, 포항 지역에서 보건관리기술지원사업을 받은 사업장과 받지 않은 사업장을 대상으로 비례층화무작위표본추출법을 사용하여 추출한 후 1991년 12월 6일부터 10일간 우편설문조사를 실시하였다. 설문대상은 각 사업장의 남녀 각 1명, 보건업무담당자, 사업주였으며, 설문내용은 사업장 및 응답자의 일반적 특성 및 사업장내 위험의사소통이었다. 설문에 응답이 온 463개 사업장의 자료를 자료처리하여 총 228개 사업장(단해년도지원 사업장 189개, 연속2년지원 사업장 13개, 비지원사업장 26개)을 대상으로 분석하였다. 결과: 사업장내 의사소통에 대한 단변량분석에서는 보건업무 담당자의 선정여부만이 통계적으로 유의한 차이가 있었다. 소규모사업장 보건관리기술지원사업을 지원받지 않은 사업장과 지원받은 사업장의 사업장내 위험의사소통을 비교하기 위한 로지스틱회귀분석 결과, 모든 항목에서 통계적으로는 유의한 차이를 보여주지 않았다. 그러나 사업주의 관심(OR ; 1.63, 95% CI ; 0.38~7.01)과 보건업무담당자의 선정(OR ; 3.67, 95% CI ; 1.00~13.44) 및 결정권한(OR ; 1.48, 95% CI ; 0.25~8.91), 사업주의 산업보건문제 소통(OR ; 3.07, 95% CI ; 0.81~11.71), 보건업무담당자의 정보요청경험(OR; 4.48, 95% CI ; 0.97~20.57)에서는 지원받지 않은 사업장에 비해 지원받은 사업장에서 교차비가 증가하는 양상을 보여주었다. 반면 노동자의 산업보건문제 소통가능성여부는 오히려 교차비가 0.53(95% CI ; 0.11~2.44)로 감소하는 경향을 보여주었다. 결론: 소규모사업장 보건관리기술지원사업을 의사소통의 측면에서 평가해보면, 사업주나 보건업무담당자에게는 다소 효과가 있었지만 노동자가 지속적으로 참여할 수 있도록 의사소통문화를 바꾸어내는 데에는 한계가 있었다. 개선을 위해서는 노동자 중심의 접근 프로그램의 개발 및 시행이 시급하다 할 수 있다. Objectives :This study was to evaluate the effectiveness of the government-funded subsidized occupational health program for small-scale enterprises(GSOHP_SSE) by occupational health com-munication in workplace. Methods : We sampled the 1,835 enterprises of study by proportional stratified random sampling among industries of supported and not supported by GSOHP_SSE in Seoul, Ansan, Daejeon, Kwang-joo and Pohang. Information on the general characteristics of enterprises and respondants and occupational health communication in the workplace was collected on self-reported questionnaires by post-survey between December 6 and 15 in 2001. We received answers from 463 enterprises and analyzed 228 enterprises through data-cleaning by logistic regression to evaluate effectiveness of GSOHP-SSE about occupational health communication in the workplace. Results : By multiple logistic regression analysis, GSOHP_SSE turned out not to be statistically significant factor in all dependent variables about occupational health communication in the work-place. The concern of owner(odds ratio (below OR) ; 1.63, 95% confidence interval(below 95% CI) ; 0.38-7.01), formation(OR ; 3.67, 95% CI ; 1.00-13.44) and empowerment(OR ; 1.48, 95% CI ; 0.25-8.91) of health manager, request about occupational health problem of health manager(OR ;4.48, 95% CI ; 0.97-20.57) and occupational health communication of owner (OR ; 3.07, 95% CI ; 0.81-11.71) had the trend increasing OR in the industries supported GS-OHP_SSE relative to the industries not supported. But in recognition of possibility on occupational health communication of laborers, OR of GSOHP_SSE was decreased in 0.53(95% CI ; 0.11-2.44). Conclusions: This study found that the GSOHP_SSE was some effective to the side of employer and health manager, but had a limitation about change of communication culture useful to the laborers. We suggested the laborer-centered health training programs or the empowerment-based health training programs for effective occupational health management in the workplace.

난소의 호산성 투명세포암종 - 1예의 보고 -

하창원,고재수,명나혜,조경자,박상윤,김미경,장자준 대한병리학회 1992 Journal of Pathology and Translational Medicine Vol.26 No.5

황사 기간 동안에 어린이, 성인, 노인에서의 자각증상과 예방행동에 대한 조사연구

이보은,하은희,박혜숙,권지숙,신경림 韓國學校保健學會 2005 韓國學校保健學會誌 Vol.18 No.1

Purpose: Recently there are scientific evidences for the health effects of Asian dust-storms. Particularly in 2002, the daily average of PM_(10) exceeded 600 and 700 ㎍/㎥ in March and April respectively. We examined the effects of Asian dust-storms on perceived symptoms and preventive behaviors among children, adults, and elders. Method: The subjects of this study were 425 children, 444 adults and 60 elders. A questionnaire survey was carried out on the children and the adults by teachers and on the elders by interviewers to obtain information on demographic variables, perceived symptoms and preventive behaviors, previous respiratory disease, environmental tobacco smoke, and proximity between the house and the road during Asian dust-storms. We analyzed using descriptive statistics, X_(2) test and multiple logistic regression models. After adjustment for potential confounders, we estimated the odds ratios and 95% confidence intervals of the children and the elders for perceived symptoms and preventive behaviors. Result: The elders had a significantly higher prevalence of respiratory symptoms than the other groups. The children had a significantly higher prevalence than the adults in getting URI (1.51), coughing (1.68), rhinorrhea (1.46), fever (2.39) and medication for allergy or asthma (1.90). The children had better behaviors than the elders in closing windows (3.57), taking less outdoor recreational activity (2.59) and staying home (2.60).

부산 일부 대학교 학생들의 니코틴 의존도와 구취의 연관성

김유린(외 5명) 신라대학교 자연과학연구소 2012 自然科學論文集 Vol.22 No.-

The purpose of this study is to examine the association of bad breath and nicotine dependency. By use of the findings from this study, This study conducted the survey of 53 smoker who visited dental hygiene lab for delivery from October to November 2012 with structured questionnaires(Fagerstrom Tolerance Questionnaire FTQ) and equipment(CO measuring instrument, Oral Chroma etc). The data were analyzed by using SPSS 20.0 program for χ2-test, ANOVA. Smokers' average age was 23 years old. The more higher nicotine dependence the more the average age was higher. The more higher nicotine dependence the less to nque brushing. No association of nicotine dependence and self-bad breath level. CO State was Significant differences(ND1(M=2.58), ND2(M=3.98), ND3(M=7.41), ND4(M=4.19), ND5(M=13.14))(F=2.616, p=.047). Dimethyl Sulfide was Significant differences(F=3.026, p=.026).

만성해수 치료제의 개발 연구

김연태,하혜경,김정숙 한국한의학연구원 1999 한국한의학연구원논문집 Vol.5 No.1

Chronic asthma is considered as an incurable disease in modern society. This study focused on development of an animal model for the chronic asthma to investigate new drugs from traditional herbal medicine. And we tested the animal model with a typical prescription. Chungsnagboha-tang and tried to find biochemical markers such as catecholaminers and cAMP in serum and as desities of beta-receptor in lung tissue. SD rats were actively sensitized by exposure to ovalbumine (OA). Ten days after sensitization, rats were challenged with OA aerosol by nebulizer six times every three days. Mucin was increased in bronchoalveolar lavages (BALs) after antigen (OA) challenge. Serum concentration of epinephrine was decreased significantly although there were not changed much in serum concentration of cAMP and the densities of beta-raceptor in lung tissue. Chungsnagboha-tang (5g/kg/day) was given orally to ovalbumin-sensitized rats (n=8) for 15days. Mucin in bronchoalveolar lavages (BALs) was increased significantly after treatment of Chungsnagboha-tang although concentrations of epinephrine and cAMP were not changed significantly. The densities of beta-receptor in lung tissues were not different from those of controls. These results suggest that the ovalbumin-sensitized rats can be a good animal model of chronic asthma and Chungsnagboha-tang is a possible drug in the treatment of chronic asthma.