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A Primary Extragonadal Teratoma of the Proximal Humerus
고재수,박종훈,강창호 대한의학회 2009 Journal of Korean medical science Vol.24 No.5
A extragonadal malignant teratoma of the extremity is a rare pheonemenon. We describe a extremely rare case of malignant teratoma of the left proximal humerus in a 14-yr-old female. Radiologic evaluations, including magnetic resonance imaging, suggested a malignant bone tumor, but a pathological examination revealed an immature bony teratoma. Bone scintigraphy and positron emission tomography computed tomography scan showed increased uptake of proximal humerus but no other abnormal lesion.
Novel isolate DC-DC converters with current circulating circuit for electronic/hybrid car and UPS
고재수,조은석,이용근 한국전시산업융합연구원 2015 한국과학예술융합학회 Vol.19 No.-
Full-bridge, Push-Pull, Flyback and Forwardconverters are generally used for electronic/hybridcar and UPS(Uninterrupted Power Supply). In thispaper, we proposed novel Full-bridge, Push-Pull,Flyback and Forward converters. In the designtopologies, the proper inductor was added in orderto make the circulating current even during deadtime period, so that we can achieve the betterproperties such as higher efficiency, cheaper price,with same output properties as the conventionalconverters. The proposed topologies simulated byPSpice.
고재수,Koh, Jae-Soo 대한세포병리학회 2008 대한세포병리학회지 Vol.19 No.1
The major categories of neuroendocrine tumors of lung are typical carcinoid, atypical carcinoid, large cell neuroendocrine carcinoma, and small cell carcinoma. The histologic classification criteria of neuroendocrine tumors are well documented in the "WHO Classification of Tumors" based on mitotic figures and necrosis. Cytologic characteristics of neuroendocrine tumors are trabecular, acinar, and solid arrangement of tumor cells and occasional rosette formation. Nuclear chromatin patterns are characteristically described as "salt and pepper chromatin pattern". Many of cytologic classifications documented in the literature are before the "WHO Classification". In this review, the cytologic features of pulmonary neuroendocrine tumors are documented according to the WHO classification, and recent concepts of neuroendocrine tumors of lung are discussed.
고재수,진민선,강신광,김민석,최희승,이정은,김길호,전대근 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.2
Background : The Src family kinases (SFKs) are involved in multiple aspects of tumorigenesis, such as, proliferation, migration, and angiogenesis, and are involved in the generation and progression of many types of tumors. Furthermore, dasatinib, a general SFKs inhibitor was recently approved for use in chronic myeloid leukemia. This study was performed to evaluate the expression of Lyn, a member of the SFKs, in osteosarcoma tissues. Methods : One hundred and sixteen patients with osteoblastic osteosarcoma were selected for Lyn expression analysis. The correlation between Lyn expression in tumor sections and patients’ clinicopathologic characteristics and the prognostic significance of Lyn expression were evaluated. Results : Lyn was found to be expressed in 52 of the 116 patients (44.8%), and Lyn positive tumor was found to be significantly associated with a lytic tumor pattern on plain radiographs (p = 0.04). Furthermore, those positive for Lyn showed longer metastasis free survival (5-year metastasis free survival, 65.2% for Lyn positive and 46.8% for Lyn negative; p = 0.06), though this was only marginally significant. Conclusions : Lyn was found to be overexpressed in osteosarcoma tissues, and this overexpression was found to be correlated with osteolysis.
고재수,하창원,조경자,장자준,Koh, Jae-Soo,Ha, Chang-Won,Cho, Kyung-Ja,Jang, Ja-June 대한세포병리학회 1992 대한세포병리학회지 Vol.3 No.2
A case of multiple myeloma with massive pleural effusion is reported. A 53 year-old previous known multiple myeloma patient vistited our hospital complaining of cough with sputum. Radiologic study revealed multiple osteolytic bony lesions and left side pleural effusion. The effusion were bloody exudates containing numerous atypical plasma cells. The tumor cells showed pleomorphism, eccentric nuclei, prominent nucleoli, perinuclear halo, multincleation, and chromatin patterns of occasional cart-wheel appearance. The cytological examination of pleural fluid established the malignant nature of the effusion with multiple myeloma.
고재수,하창원,명나혜,조경자,장자준,Koh, Jae-Soo,Ha, Chang-Won,Myong, Na-Hye,Cho, Kyung-Ja,Jang, Ja-June 대한세포병리학회 1991 대한세포병리학회지 Vol.2 No.2
A total of 362 bile samples from 104 patients with evidence of biliary tract obstruction were submitted for diagnostic cytology from January, 1989 to April, 1991. The patients were classified based on the obstructive cause, and the cytologic results were reviewed. 298 of the specimens were from patients with intrabiliary malignant structure, and 17 were from patients with extrabiliary malignant compression or benign biliary obstruction. Bile cytology was positive for carcinoma in 42 samples from patients with intrabiliary malignant stricture, and the diagnostic sensitivity was 14%. There were no false positive cases. We concluded that the cause of low sensitivity was degenerative change of cell due to prolonged sampling time. What is noteworthy was the high prevalence of Clonorchis sinensis eggs, being detected in 25 patients with intrabiliary malignancy, supporting the association between clonorchiasis and biliary tree malignancy.
고재수,조은석,이용근 한국전시산업융합연구원 2014 한국과학예술융합학회 Vol.18 No.-
A step-down non-isolated Buck converter is acommon and basic topology in the field. Weanalyzed the Characteristic of Multiphase InterleavedBuck Converter in DCM(Discontinuous CurrentMode) and CCM(Continuous Current Mode) for lawripple and high efficiency1). Multiphase buckconverter has more advantages than other topology. Input current of converter is divided into eachconverters because of the structure. it has featuresof decreasing input current ripple and increasingefficiency of converter. So we can reduce the sizeof Capacitor and Inductor2). It means that the sizeof system is also reduced3). The Time ReverseRecovery loss of diode was also affected4)5), theTRR loss was confirmed to be negligible in the120kHz 8 Phase case despite the CCM situation. Inthis study, the effects of the loss factors wereanalyzed on the efficiency of the multiphaseinterleaving buck converter in DCM and CCM, andit would be helpful to design a more efficientconverter by effectively controlling the factors ofeach loss. At least, we tested the performance ofthe analyzed system with PSpice.
"Atypical Squamous Cells of Undetermined Significance"의 질적 분류와 조직 소견과의 비교
고재수,정진행,이승숙,조경자,Koh, Jae-Soo,Chung, Jin-Haeng,Lee, Seung-Sook,Cho, Kyung-Ja 대한세포병리학회 1999 대한세포병리학회지 Vol.10 No.1
To evaluate whether different qualifications of a cytologic diagnosis of "atypical squamous cells of undetermined significance(ASCUS)" predict a greater or lesser likelihood of tissue diagnosis of uterine cervix, we compared different cytologic qualifications of ASCUS with the tissue diagnosis. One hundred twenty-two consecutive Papanicolaou smears showing ASCUS in women who had undergone cervical biopsy within nearest 30 days were collected. The 122 smears were qualified as "favor reactive"(25%), "favor low grade squamous intraepithelial lesion (LSIL)"(24%), "favor squamous intraepithelial lesion(SIL)"(16%), "favor high grade squamous intraepithelial lesion(HSIL)"(16%), and "not otherwise specified"(19%). Squamous intraepithelial or invasive lesion was pathologically confirmed by cervical biopsy in 13%, of the "favor reactive", 27% in "favor LSIL", 70% in "favor SIL", 75%, in "favor HSIL", and 35% in "not otherwise specified" smears. There were significant associations between the favor reactive smear and the benign biopsy finding and between the favor SIL smear and the biopsy shewing a squamous intraepithelial or more severe lesion. Nevertheless, most of favor LSIL smears exhibit reactive process in tissue biopsy. Conclusively, qualified ASCUS stratifies women Into different risk groups for SIL. The cytopathologist should make the cytologic diagnosis of "ASCUS, favor LSIL" circumspectly.