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Jeon, Hye-Yeon,Kim, Na-Ri,Lee, Hye-Won,Choi, Hye-Jeong,Choung, Woo-Jae,Koo, Ye-Seul,Ko, Dam-Seul,Shim, Jae-Hoon American Chemical Society 2016 Journal of agricultural and food chemistry Vol.64 No.11
<P>A novel maltose (G2)-forming alpha-amylase from Lactobacillus plantarum subsp. plantarum ST-III was expressed in Escherichia coli and characterized. Analysis of conserved amino acid sequence alignments showed that L. plantarum maltose producing alpha-amylase (LpMA) belongs to glycoside hydrolase family 13. The recombinant enzyme (LpMA) was a novel G2 producing alpha-amylase. The properties of.purified LpMA were investigated following enzyme purification. LpMA exhibited optimal activity at 30 degrees C and pH 3.0. It produced only G2 from the hydrolysis of various substrates, including maltotriose (G3), maltopentaose (GS), maltosyl beta-cyclodextrin (G2-beta-CD), amylose, amylopectin, and starch. However, LpMA was unable to hydrolyze cyclodextrins. Reaction pattern analysis using 4-nitrophenyl-alpha-D-maltopentaoside (pNPGS) demonstrated that LpMA hydrolyzed pNPGS from the nonreducing end, indicating that LpMA is an exotype alpha-amylase. Kinetic analysis revealed that LpMA had the highest catalytic efficiency (k(cat)/K-m ratio) toward G2-beta-CD. Compared with beta-amylase, a well-known G2-producing enzyme, LpMA produced G2 more efficiently from liquefied corn starch due to its ability to hydrolyze G3.</P>
폐렴과 급성 호흡부전으로 나타난 흉막의 고립성 섬유성 종양
박혜선 ( Hye Sun Park ),곽현정 ( Hyun Jung Kwak ),박동원 ( Dong Won Park ),구태연 ( Tai Yeon Koo ),김혜영 ( Hye Young Kim ),박소연 ( So Yeon Park ),안성은 ( Seong Eun Ahn ),김상헌 ( Sang Heon Kim ),김태형 ( Tae Hyung Kim ),손장원 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.4
Solitary fibrous tumors of the pleura (SFTPs) are relatively rare tumors that originate from the mesenchymal cells of the submesothelial tissue of the pleura. Patients with SFTPs are often asymptomatic, while some patients experience pleuritic chest pain, cough and/or dyspnea. We report here on a case of SFTP, and the patient presented with septic shock and respiratory failure that required mechanical ventilation. A 68-year-old woman was admitted for the evaluation of her dyspnea and generalized edema. Chest imaging studies showed an 18 cm-sized voluminous mass occupying the right thoracic cavity with anterior displacement of hilar structures and atelectasis of the right lung. Immediately after admission, she developed pneumonia and septic shock that required antibiotics and mechanical ventilation. She displayed a partial response to medical treatment, and then complete excision of the tumor was performed and the pathologic examination revealed benign SFTP. Afterward, she fully improved without evidence of recurrence until now. (Tuberc Respir Dis 2008;65:334-338)
증례 : 혈액종양 ; 중추신경계와 폐를 침범한 말초 T세포 림프종 1예
구태연 ( Tai Yeon Koo ),박병배 ( Byeong Bae Park ),김혜영 ( Hye Young Kim ),김원준 ( Won Jun Kim ),최정혜 ( Jung Hye Choi ),김인순 ( In Soon Kim ),이영렬 ( Young Yeol Lee ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5
말초형 T세포 림프종은 B세포 림프종에 비해 림프절 외 침범이 많고 항암요법에 대한 반응이 낮아서 예후가 불량한 것으로 알려져 있다. 특히 비특정 말초 T세포 림프종은 폐나 신경계의 침범이 매우 드물고 표준 치료가 정립되어 있지 않다. 이 때문에 환자별로 치료자의 판단에 따라 적절한 치료전략이 세워져야 한다. 본 증례는 폐와 신경계를 침범한 비특정 말초 T세포 림프종의 1예로 IMEP 복합항암화학요법과 척추강 내 항암화학요법으로 관해 유도에 성공하였고, 관해 후 치료로써 고용량 항암화학요법 및 자가조혈모세포이식을 시도한 경우이다. Mature T-cell non-Hodgkin`s lymphoma (NHL) has more frequent extranodal involvement and is less sensitive to chemotherapy than B-cell lymphoma. Peripheral T-cell lymphoma unspecified (PTCL-U) is rarely combined with pulmonary or CNS involvement. We report a case of PTCL-U with lung and CNS involvement that was treated with high-dose chemotherapy followed by autologous stem cell transplantation (ASCT). A 62-year-old man was admitted with right-side weakness and paresthesias, and was diagnosed with PTCL-U after alung biopsy. Successful complete remission was achieved after threecycles of IMEP (ifosfamide, methotrexate, etoposide, and prednisone) chemotherapywith concurrent intrathecal chemotherapy and subsequent high-dose chemotherapy with ASCT to treat potential advanced stage PTCL-U. The non-anthracycline-containing IMEP regimen can be effective for PTCL-U, especially in cases with CNS involvement. (Korean J Med 77:643-648, 2009)
Original Articles : Clinical features of acute viral hepatitis B in Korea: a multi-center study
( Hye Jin Choi ),( Soon Young Ko ),( Won Hyeok Choe ),( Yeon Seok Seo ),( Ji Hoon Kim ),( Kwan Soo Byun ),( Young Seok Kim ),( Seung Up Kim ),( Soon Koo Baik ),( Jae Youn Cheong ),( Tae Yeob Kim ),( O 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.4
Background/Aims: The incidence of Hepatitis B has significantly declined since the introduction of an HBV vaccination program. The aim of this study was to investigate recent clinical features of acute viral hepatitis B (AVH-B) in Korea. Methods: A total of 2241 patients with acute viral hepatitis were enrolled and their data were collected from nine medical-centers between January 2006 and December 2009. Results: One hundred nineteen (5.3%) of the 2241 were diagnosed as AVH-B. Among 78 patients with AVH-B whose data were analyzed, 50 were male, and the mean age was 38.6 years. In an initial test, mean AST, ALT and total-bilirubin levels were 1296.2 IU/L, 2109.6 IU/L and 9.3 mg/dl, respectively. Positivity frequencies for HBeAg and anti-HBe were 55.1% and 67.9%, respectively, and the mean HBV DNA level was 5.2 log10 copies/ml. The mean length of hospitalization was 11.6 days. During follow-up, AST, ALT and total bilirubin levels were normalized or near-normalized in all patients without serious complications. Sixty-three of 66 (95.4%) patients showed HBsAg loss and 37 (56.1%) patients showed HBsAg seroconversion. Only 3 patients (4.5%) showed persistent hepatitis B viremia. There was no case of death or liver transplantation. Nine patients (11.3%) had received anti-viral agents and their clinical outcomes were not significantly different from those of patients treated without antiviral agents. Conclusions: The prevalence of AVH-B among acute hepatitis patients is relatively low in Korea. AVH-B infection can be cured without complications in almost all patients, regardless of antiviral treatment. (Korean J Hepatol 2011;17:307-312)