치료저항 만성 정신분열증 환자에서 Clozapine과 Haloperidol의 치료효과에 대한 비교

이홍식,김찬형,이희상,남궁기,송동호,이영문,한은선 大韓臨床藥理學會 1993 臨床藥理學會誌 Vol.1 No.2

폐외소세포암

선길홍,윤찬영,정춘해,박치영 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Background: Small cell carcinomas (SCC) are most commonly seen in the lung, approximately 2.5-4% of all SCC occur in extrapulmonary sites. This study aimed to review the clinical features, therapy and natural course of patients with extrapulmonary small cell carcinoma (EPSCC) in single-institution series. Methods: We retrospectively reviewed the medical records of patients with SCC between December 2002 and November 2005. Study eligibility required that patients had pathologically proven SCC in sites other than lung with normal radiological findings of the chest and normal sputum cytology or negative bronchoscopic findings. Result: Eight patients with EPSCC were identified and their primary sites were various such as esophagus (4 cases), kidney (1 case), thymus (1 case), stomach (1 case) and unknown primary supraclavicular lymph node (1 case). The 4 patients were classified as limited disease (LD) and 2 patients were as extended disease (ED) at initial staging work-up. But 2 patients were undetermined. The 3 patients with EPSCC of LD were treated with operation and adjuvant chemotherapy or chemotherapy and radiotherapy and one received only supportive care. They showed favorable clinical courses with a median overall survival of 23 months. EPSCC of ED and undetermined group received only supportive care. They had aggressive clinical courses with a median overall survival of 3 months, Conclusions: EPSCC was identified in various sites with the most common primary site being the esophagus, It was predominantly occurred in old male patients and associated with smoking like as SCC of the lung. Since EPSCC is a relalively rare disease that mimics SCC of the lung in its response to treatment and survival pattern, it would appear advisable to follow similar treatment guidelines. Although recurrence within short terms was observed, a significant survival benefit was obtained in EPSCC of LD received treatment (chemotherapy, operation and radiation therapy). Thus, EPSCC is usually a fatal disease with meidan overall survival of 18 months. 연구배경: 소세포암의 가장 흔한 발생부위는 폐이며, 폐외소세포암은 전체 소세포암의 2.5~4%를 차지하는 매우 드문질환이다. 본 연구의 목적은 단일 기관에서 진단된 폐외소세포암의 임상적 특징, 치료와 자연경과를 보고하고자 하였다. 방법: 조선대학교부속병원에서 2002년 12월 부터 2005년 11월 사이에 소세포암으로 진단된 66명의 의무기록을 검토하였다. 폐외소세포암은 흉부 단순 몇 전산화단층 촬영, 객담세포 검사, 기관지경 검사에서 폐병번이 없으면서 폐와 병변의 조직학적 생검에서 소세포암으로 증명된 경우로 하였으며, 총 8명이였다. 결과: 본 연구에서 식도가 전체 폐외소세포 암 환자의 50%(4례)로 가장 많은 원발병소를 보였으며 그 외 흉선, 신장, 위가 1례씩 있었으며 쇄곧상부 림프절에서 소세포암이 발견되었으나 원발 병소를 발견 못한 경우가 1례 관찰되었다. 4명의 환자는 제한 병기를 보였으며 2명은 광범위 병기를 보였지만 나머지 2명은 위내시경으로 식도에서 소세포암이 조직학적으로 진단되었으나 보전적 치료만을 받길 원하여 병기결정을 위한 검사는 시행할 수 없었다. 제한 병기의 폐외소세포암 환자는 4명이었다. 2명은 수술적 절제후 보조항암화학요법을 받았으며, 1명은 항암화학요법후 방사션치료를 받았고, 나머지 한명은 보전적 치료만 시행하였다. 제한 병기의 폐외소세포암 환자틀은 양호한 임상 경과를 보였으며 중앙 생존기간은 23개월이었다. 하지만 광범위 병기의 폐외소세포암 환자와 병기를 분류할 수 없던 환자에 대해서는 항암화학요법 등의 적극적 치료는 시행하지 않고 보존적 치료만 시행하였다. 그들의 임상경과는 빠르게 악화되었으며 중앙 생존 기간은 3개월이었다. 결론: 본 연구에서 폐외소세포암은 다양한 장기에서 발견될 수 있으나 가장 흔한 곳은 식도였다. 소세포폐암과 유사하게 고령, 남성 및 흡연과 관련을 보였었다. 제한 병기에서 국소 치료, 항암화학요법은 생존기간의 연장을 보였으나 쉽게 다른 장기로 전이가 되거나 재발하는 매우 치명적인 질환임을 확인할 수 있었다. 전체 중앙 생존기간은 18개월 이었고 항암 화학요법등의 치료를 받은 군이 보존적 치료를 받은 군에 비해 의미있는 생존기간 (p=0.040)의 연장을 보였다. 본 연구는 단일기관의 상대적으로 적은 수의 소규모 연구이지만 폐외소세포암의 제한 병기에서 국소치료 및 항암화학요법은 생존기간의 연장을 보였고 쉽게 다른 장기로 전이가 되거나 재발하는 매우 치명적인 질환임을 확인 할 수 있었다.

Compensation(보정), Positioning accuracy(위치 정밀도)

홍성오,홍순남,조규재,전언찬 東亞大學校 1997 東亞論叢 Vol.34 No.-

Thermal expension of the ball screw in semi-closed loop type CNC lathe directly introduced positioning errors along the travel axis In this paper the thermal displacement of the ball screw is estimated by using macro variables. The estimated displacementes of the ball screw are given to the NC in the form of pitch error compensation data into time interval.The thermal behaviour of the ball screw of the CNC lathe under the constant driving conditions was measured to examine the effectiveness of this compensation method. The results showed that thermal displacements of the ball screw were the positioning accuracy could be maintained to better than 6μm which using this compensation.

혼합형 자가면역성용혈성빈혈과 동반된 Evans 증후군 1례

선길홍,윤찬영,박상곤,박경희,우정주,한경택,김진화,김영훈,정춘해,박치영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Evans syndrome is defined as a simultaneous or sequential occurrence of autoimmune hemolytic anemia and autoimmune thrombocytopenia. Autoimmune hemolytic anemia (AIHA) is usually induced by IgG warm autoantibody or cold-active IgM antibodies reacting specifically with antigens associated with a patient's RBC. AIHA is a fairly uncommon disorder, with estimates of the incidence at 1 to 3 cases per 100,000 per year. Mixed-type AIHA is a relatively uncommon form of AIHA, with studies noting the incidence of 7-8% among cases of AIHA. We experienced a patient, 46-year-old woman who was diagnosed having a very rare clinical presentation of mixed warm and cold antibody mediated Evans syndrome. She was treated with corticosteroid therapy only and has been maintaining a complete response for 15 weeks. 저자들은 혼합형의 자가면역성 용혈성 빈혈과 자가면역성 혈소판 감소증이 동시에 발생한 혼합형 Evans 증후군으로 진단하고 스테로이드 요법 후 혈액학적으로 회복된 상태로 15주가 지난 현재 steroid 5 mg/일 까지 감량한 상태에서 추적 관찰 치료중인 46세 여자 환자를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

지역사회 정신의학 전공의 교육과정 실태조사

홍진표,황순찬,이영문,이선형,신나리,이종일,박종익,장동원,정인원 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.1

Objectives : There is a increasing need to recruit and retain more psychiatrists who can plan and implement organized programs to work with chronic mentally ill patients in community settings. The aim of study is to discover what training is currently in place to prepare psychiatrist for work in "community" or "public" settings. Methods : Survey questionnaires were mailed to 85 residency training directors and 10 leaders of community mental health in 2005. Response rate was 75%. Results : Academic seminar about community mental health were not administered to residents in 63% of training hospitals. Forty one out of 64 training hospitals had community mental health rotation programs, Community mental health center (50%) and day hospital (36%) were the most common type of programs. Few general hospital had affiliation with community mental health programs. The amount of time for clinical rotation varied from less than three months part time to 6 months fulltime, with most frequent form of one day per week for three month in second or third year of psychiatry residents. Conclusion : Further steps are needed to improve residency training curricula and to encourage well qualified psychiatrist to choose careers in community psychiatry.

인공지반의 조경적 활용에 관한 국내 연구동향 : 옥상녹화를 중심으로

김동찬,서주환,김옥경,승지현,김홍균,최선주,박선영 경희대학교 부설 디자인연구원 2007 예술· 디자인학연구 Vol.10 No.1

This study aims at understanding the trend of researches carried out on the subject of rooftop afforestation. The issue of rooftop afforestation is receiving attention as one of the plans to secure green zones in urban area. While the actual execution of rooftop afforestation in Korea in only in the initial state, thus in not activated, studies on this subject have been actively carried out particularly in terms of the methods of rooftop afforestation. Recently, studies are being actively performed on the creation and effect of rooftop afforestation. However, these studies tend to focus on specific areas. This leads to the necessity to approach the issue of rooftop afforestation with a wider perspective. Therefore, in the study, the previous studies on rooftop afforestation carried out both in and outside the country are categorized as the study on the methods, effect and activation plans of rooftop afforestation, thus are examined to understand the recent trend in the study of rooftop afforestation. The results indicate that domestic studies. which was centered on the methods to promote rooftop afforestation. have been expanding into the study on the methods to establish eco-habit at on rooftop as well as on the environmental and economic effect rooftop afforestation.

새터민의 기초직업능력 진단

이찬,이용환,이윤조,신재호,홍윤선,최홍주 한국농업교육학회 2007 농업교육과 인적자원개발 Vol.39 No.3

이 연구는 새터민의 고용현황 및 문제점을 고찰하고 새터민의 기초직업능력을 진단하여 직업능력개발 방향에 있어 시사점을 제공하는데 그 목적이 있었다. 새터민의 기초직업능력 진단을 위한 도구는 관련 문헌 고찰과 pilot test 및 새터민 교육ㆍ지원 담당자의 안면타당도 검증 등을 통하여 개발되었다. 연구의 목적을 달성하기 위하여 현재 하나원에서 사회 적응교육 및 직업교육을 받고 있는 새터민의 기초직업능력을 진단함으로써 우리나라에 거주하는 새터민의 기초직업능력을 파악하였다. 주요 결과는 다음과 같다. 첫째,새터민들의 기초직업능력 중에서 직업윤리능력은 상당히 갖추어져 있는 것으로 인식하고 있으며,정보능력,즉 컴퓨터 사용능력은 상대적으로 낮은 수준으로 평가하고 있다. 둘째,성별에 따라서는 기초직업능력에 있어서 통계적으로 유의미한 차이를 보이지 않았다. 연령에 따라서는 정보능력과 수리 능력,조직이해능력 영역에 있어서 통계적으로 유의미한 차이를 보였다. 셋째,학력에 따라서는 문제해결능력과 의사소통능력,수리능력,대인관계 영역에 있어서 통계적으로 유의미한 차이를 보였다. 넷째,새터민의 취업을 위한 기초직업능력 개발에 있어 정보능력,수리능력,의사소통능력의 비중 확대,수준별ㆍ맞춤형 교육프로그램개발,새터민을 위한 취업 및 사업정보 제공 등을 제시하였다. The purpose of this study was to explore the current employment status and HRD issues of North Korean refugees and to assess their level of the basic vocational competencies. The assessment tool for the basic vocational competencies was developed based on literature reviews and pilot tests from the North Korean refugees. The face validity was verified by educators and counselors for the North Korean refugees. The major findings in this study were as follows: First, among the basic vocational competencies of the North Korean refugees, the level of vocational ethics was the highest and the level of information teachnology competency was the lowest. Second, the North Korean refugees' basic vocational competencies showed no statistical differences by gender. Territories of information competency, mathematical competency, and communication competency showed statistical differences by age. Third, territories of problem-solving competency, communication competency, mathematical competency, mathematical competency, and communication competency showed statistical differences by education level. Fourth, to develop the basic vocational competencies for North Korean refugees, the following suggestions were presented.; 1) extend the importance of information technology, mathematical, and communication competencies,; 2) develop the customized training programs by competency level,; and 3) offer the employment information for North Korean refugees.

경부에 발생한 2새열낭종 2례

박홍주,박세찬,손영휘,윤천주,유선열 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.4

Developmental anomalies arising from the branchial apparatus include cysts, external sinuses, internal sinuses, and complete fistulas. Second branchial cleft cysts are by far the most common among these anomalies. It may occur at any age, being most common in the third decade, and more frequent in the male than in the female. It usually presents a smooth, round, nontender fluctuant mass located between the level of the tragus and the clavicle along the anteromedial border of the sternocleidomastoid muscle. It is lined by respiratory or squamous epithelium unless inflammation is present. The considerable amount of lymphoid tissue may be found beneath the epithelium. The treatment of choice of branchial cleft cyst is surgical excision. If the lesion is acutely infected, however, it is essential to relieve the infection prior to the surgery This report deals with two cases of second branchial cleft cyst. In case 1, the cyst had rapidly increased in size over pregnant period. In case 2, the patient presented the swelling in the left neck, and had the history of incision and drainage because of misdiagnosis as submandibular space abscess. The infection was treated by antibiotic therapy in the first place, and then complete surgical excision was made. There was no evidence of any recurrence or complications for these 3∼4 years.

방광질루 치험

황선태,이종찬,양상국,김홍섭,노용수 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

Vesicovaginal fistula is a distressing complication which may follow hysterectomy, prolonged labor, chemical cauterization due to uterine prolapse, radiation therapy and cervix cancer. The management of vesicovaginal fistula still remains controversial in regard to the type of approach and timing of repair but the classic opinion is to wait 3 to 6 months to allow the surgical inflammatory reaction to subside. We experienced 4 cases of vesicovaginal fistula which were as follows; Case 1: 51-year-old The vesicovaginal fistula, about 3.0cm in diameter, after laparascopic hysterectomy 15 days ago was repaired with interposition of a gracilis muscle flap via the transvaginal route. Case 2: 38-year-old The vesicovagianl fistula, about 2.5cm in diameter, after Cesarean section 5 years ago was repaired with interposition of the omental flap via the transabdominal route because she had been accompanied by an overian cyst. Case 3: 46-year-old The vesicovaginal fistula, about 2.5cm in diameter, after manual self abortion at home 30 years ago was repaired with interposition of fibro-fatty tissue in labia via the transvaginal route. Case 4: 43-year-old The vesicovaginal fistula, about 2.0cm in diameter, after prolonged labor 12 years ago was repaired with interposition of the fibro-fatty tissue in labia via the transvaginal route. There noted no complications or recurrence during the minimal 1 year follow-up.

주사 전자현미경에서 프르브 전류의 측정

임선종,이찬홍 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

Measurement of probe current is used to align the column and to check proper current for image. The data is compared with data of other system and could be standard data for developing the system. In the measurement for aligning the column, scanning control signal is only utilized. The current for image is changed by aperture size. Faraday cup is one of tools for doing this and is used in this paper. It is composed of mesh and a cup to be connected to signal line. The current is measured by a pico-amperemeter.