Case Reports : Basal Cell Carcinoma on the Pubic Area: Report of a Case and Review of 19 Korean Cases of BCC from Non-sun-exposed Areas

( Jin Park ),( Yong Sun Cho ),( Ki Hun Song ),( Jong Sun Lee ),( Seok Kweon Yun ),( Han Uk Kim ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.3

Basal cell carcinoma (BCC) is one of the most commonly diagnosed malignant skin tumors and develops characteristically on sun-exposed areas, such as the head and neck. Ultraviolet light exposure is an important etiologic factor in BCCs, and BCCs arising from non-sun- exposed areas are, therefore, very rare. In particular, the axilla, nipple, the genital and perianal areas are not likely to be exposed to ultraviolet light; thus, if BCC develops in these areas, other predisposing factors should be considered. Herein, we report a case of BCC arising on the pubic area in a 70-year-old man. We also performed a survey of the literature and discussed the 19 cases of BCC from non-sun-exposed areas reported to date in Korea.

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

태양돛 기술 동향

조형순(Hyeong-Sun Cho),김학인(Hak-In Kim),이수용(Soo-Yong Lee),노진호(Jin-Ho Roh) 한국항공우주학회 2014 韓國航空宇宙學會誌 Vol.42 No.6

태양돛은 태양 광자들의 운동량 변화를 이용하여 추력을 얻는 우주선이다. 매우 작지만 연속적인 가속도를 얻을 수 있어 태양돛은 다양한 임무를 수행할 수 있다. 효과적인 임무 개발을 위해서는 태양돛의 형상, 돛의 재료 그리고 전개 장치에 따른 구조/재료적 특성뿐만 아니라 위성의 임무 궤적에 따른 자세제어 방법들을 고려해야 한다. 본 논문에서는 태양돛의 기술발전, 태양돛 제작에 필요한 소요기술 그리고 태양돛을 이용한 향후 개발 가능한 위성 임무에 대하여 살펴보고자 한다. Solar sail spacecrafts can gain propulsion using the momentum change through reflecting the photon packets of energy from the Sun. The sail slowly but continuously accelerates to accomplish a wide-range of potential missions. To develop the potential mission of the solar sail, the configuration, the film characteristics and the deployment devices should be carefully considered. In this paper, recent development and activities of the solar sail are introduced and design technology of the sail subsystem is investigated.

Modeling of CO₂ Emission from Soil in Greenhouse

Lee, Dong-Hoon,Lee, Kyou-Seung,Choi, Chang-Hyun,Cho, Yong-Jin,Choi, Jong-Myoung,Chung, Sun-Ok Korean Society of Horticultural Science 2012 원예과학기술지 Vol.30 No.3

Greenhouse industry has been growing in many countries due to both the advantage of stable year-round crop production and increased demand for fresh vegetables. In greenhouse cultivation, $CO_2$ concentration plays an essential role in the photosynthesis process of crops. Continuous and accurate monitoring of $CO_2$ level in the greenhouse would improve profitability and reduce environmental impact, through optimum control of greenhouse $CO_2$ enrichment and efficient crop production, as compared with the conventional management practices without monitoring and control of $CO_2$ level. In this study, a mathematical model was developed to estimate the $CO_2$ emission from soil as affected by environmental factors in greenhouses. Among various model types evaluated, a linear regression model provided the best coefficient of determination. Selected predictor variables were solar radiation and relative humidity and exponential transformation of both. As a response variable in the model, the difference between $CO_2$ concentrations at the soil surface and 5-cm depth showed are latively strong relationship with the predictor variables. Segmented regression analysis showed that better models were obtained when the entire daily dataset was divided into segments of shorter time ranges, and best models were obtained for segmented data where more variability in solar radiation and humidity were present (i.e., after sun-rise, before sun-set) than other segments. To consider time delay in the response of $CO_2$ concentration, concept of time lag was implemented in the regression analysis. As a result, there was an improvement in the performance of the models as the coefficients of determination were 0.93 and 0.87 with segmented time frames for sun-rise and sun-set periods, respectively. Validation tests of the models to predict $CO_2$ emission from soil showed that the developed empirical model would be applicable to real-time monitoring and diagnosis of significant factors for $CO_2$ enrichment in a soil-based greenhouse.

Modeling of CO₂ Emission from Soil in Greenhouse

Dong Hoon Lee,Kyou Seung Lee,Chang Hyun Choi,Yong Jin Cho,Jong-Myoung Choi,Sun-Ok Chung 한국원예학회 2012 원예과학기술지 Vol.30 No.3

Greenhouse industry has been growing in many countries due to both the advantage of stable year-round crop production and increased demand for fresh vegetables. In greenhouse cultivation, CO₂ concentration plays an essential role in the photosynthesis process of crops. Continuous and accurate monitoring of CO₂ level in the greenhouse would improve profitability and reduce environmental impact, through optimum control of greenhouse CO₂ enrichment and efficient crop production, as compared with the conventional management practices without monitoring and control of CO₂ level. In this study, a mathematical model was developed to estimate the CO₂ emission from soil as affected by environmental factors in greenhouses. Among various model types evaluated, a linear regression model provided the best coefficient of determination. Selected predictor variables were solar radiation and relative humidity and exponential transformation of both. As a response variable in the model, the difference between CO₂ concentrations at the soil surface and 5-㎝ depth showed are latively strong relationship with the predictor variables. Segmented regression analysis showed that better models were obtained when the entire daily dataset was divided into segments of shorter time ranges, and best models were obtained for segmented data where more variability in solar radiation and humidity were present (i.e., after sun-rise, before sun-set) than other segments. To consider time delay in the response of CO₂ concentration, concept of time lag was implemented in the regression analysis. As a result, there was an improvement in the performance of the models as the coefficients of determination were 0.93 and 0.87 with segmented time frames for sun-rise and sun-set periods, respectively. Validation tests of the models to predict CO₂ emission from soil showed that the developed empirical model would be applicable to real-time monitoring and diagnosis of significant factors for CO₂ enrichment in a soil-based greenhouse.

인트라넷 기반 복합운송 정보시스템 개발

조용준,박윤선 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

Until now, in overseas trading, shipper, export[import] agents and airways have communicated with each other by exchanging documents through off-line or by fax or e-mail. But it causes repetition of paper-work, delay and complexity. In this study, we solved these problems using Internet technique. We also offer environments that can strengthen the competitiveness. It is called Cargonet System. It constructs not only the necessary information system but also the corresponding network among agents, forwaders, airways, Client users use only Web-Brwoser. Therefore, it enables to update rapidly for system extension.

농아에서의 측두골 전산화 단층촬영 소견과 다른검사 요인과의 연관성

조태환,이상흔,권대구,엄규상,성창섭,김용선,한기원 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1

Temporal bone high resolution computed tomogram(TBHRCT)is a essential diagnostic tool in considering for cochlear implantation in patients with profound sensorineural hearing loss. This study was designed for an effort to provide and efficacy of TBHRCT in determination of inner ear malformations for the patients who have profound sensorineural hearing loss and to examine the relationships between TBHRCT findings and other preoperative evalutions for cochlear implantation in that patients. Authors examined 68 deaf patients to provide fundamental data for cochlear implantation. Inner ear abnormalities were founded in 13(19%) patients, among which 10(14.7%) patients had Mondini'dysplasia in which 5 patients were hypoplastic type and 5 patients were hydrops type. Other inner ear abnormalities were as follows : lateral semicircular canal hypoplasia ; internal auditory canal abnormality ; cochlear aqueduct widening ; vestibular aqueduct widening. No relationships were found between TBHRCT findings and other test results. : promontory test, K-WISC cognitive test etc.(Korean J Otolaryngol 39 : 8, 1996)

體重 및 無脂肪體重과 背筋力과의 相關에 관한 硏究

曺容善,黃甫淵 漢陽大學校 體育科學硏究所 1986 體育科學 Vol.6 No.6

The Purpose of this study was to investigate the influence of percent of Body Fat on Back Muscle Strength 150 Subjects(50=Physical Education department Students, (=P.E.D.S.), 50=General Students(=G.S), 50=Excellent Players (=E.P)) were Selected to measure the percent of Body fat at the Subscapular and Thigh with a skinfolder. Percent of Body fat was then Calculated with Sloan & Wire's formula and Brozek, et als formula. The Back Muscle Strength was Calculated through investigating the difference between the percent of Body fat and Static Back muscle Strength among the 3 groups. The results of this study are as follows: 1) The difference of Mean of Percent of Body fat, (1) There are significant differences among the 3 groups. (P<0.05, G.S., E.P., P.E.D.S.) (2) There is a Significant difference between G.S. and P.E.D.S. (P<0.01, G.S., P.E.D.S.) (3) There is no Significant difference between the P.E.D.S. and E.P. (P>0.05) (4) There is a Significant difference between the G.S. and E.P. (P <0.05, G.S., E.P.) :2) The difference of Means of Back Muscle Strength, (1) There are significant differences among the 3 groups (P<0.01, E.P., P.E.D.S., G.S.) (2) There is a significant difference between the G.S. and P.E.D.S. (P<0.01, P.E.D.S., G.S.) (3) There is a significant difference between the P. E. D. S. and E.P. (P<0.01, P.E.D.S., E.P.) (4) There is a high significant difference between the G.S. and E.P. (P<0.01, G.S., E.P.) 3) The correlation between the Back Muscle Strength and Weight, (1) There is no correlation in the G.S. (r=0.10) (2) There is a little correlation in the P.E.D.S. (r=0.23) (3) There is a high significant correlation in the E.P. (r=0.91) 4) The correlation between the Back Muscle Strength and Lean Body Weight (1) There is a small Negative Correlation in the G.S. (r=-0.22) (2) There is a negation Correlation in the P.E.D.S. (r=-0.32) (3) There is a significant positive correlation in the E.P. (r=0. 55)

신경증적 증상 환자들의 자기- 불일치와 정신병리의 관계 : 자기-불일치 이론의 임상적 적용가능성에 관한 탐색적 연구 An Exploratory Study on the Clinical Applicability of Self-Discrepancy Theory

조용래,김선태,표경식 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.3

본 연구는 우리나라 임상장면에서 Higgins(1987)의 자기-불일치 이론의 적용가능성을 탐색하기 위하여 신경증적 증상 환자들의 자기-불일치와 정신병리의 관계를 경험적으로 알아보고자 하는 것이 주목적이다. DSM-Ⅳ의 기분부전장애, 불안장애, 신체형 장애, 적응장애, 섭식장애의 진단기준에 부합되는 환자 총 71명(남:45명, 여:26명)을 연구대상으로 자기 질문지로 자기개념을 측정한 후 Higgins(1987)의 방법에 따라 각 종류별 자기-불일치 점수를 채점하였으며, 정신병리는 Beck의 우울척도(BDI), Beck의 불안척도(BAI) 및 간이 정신진단 검사(SCL-90-R)의 하위척도 등으로 측정하여 다음과 같은 결과를 얻었다. 1) 네가지 유형의 자기-불일치 모두에서 채점자간 일치도가 매우 높았으며(r=0.96∼0.98), 자기-불일치 유형들간의 상관계수(r)의 범위는 0.41∼0.59로서 모두 유의하였다. 2) 전체 자기-불일치는 대부분의 정신병리와 유의상관(r=0.24∼0.40)이 있었으므로, 전체 자기-불일치와 정신병리 전반의 관계에 대한 일반성 가설이 지지되었다. 3) 단순상관 분석에서, 실제적-이상적 불일치는 일반적인 불안과는 유의한 상관을 보이지 않았으나, 우울 외에 대인불안 및 강박증상과도 유의한 상관이 있었으며, 실제적-이상적/자신 및 타인 불일치의 경우에도 거의 비슷한 양상을 보였다. 그러나, 편상관 분석에서는 실제적-이상적 불일치의 어떤 유형도 특정한 정신병리와 유의한 상관을 보이지 않았으므로, 실제적-이상적 불일치와 우울의 관계에 대한 특정성 가설은 부분적으로 지지되었다고 하겠다. 4) 실제적-의무적/자신 불일치의 경우 우울과는 유의한 편상관을 보이지 않았으나, 일반적인 불안 및 대인 불안과는 유의한 편상관이 있었다. 하지만 실제적-의무적 불일치 및 실제적-의무적/타인 불일치 양자 모두 공포불안을 제외하고는 거의 모든 유형의 정신병리와 유의한 편상관을 보였다. 따라서 실제적-의무적 불일치와 불안의 관계에 대한 특정성 가설은 각 유형에 따라 혼합되게 지지되었다고 할 수 있겠다. 결론적으로, 본 연구의 결과들은 자기-불일치 이론을 대체로 지자하고 있으며, 우리나라 신경증적 증상 환자들의 정신병리를 이해하고 치료적으로 도와주는데 있어 자기-불일치 이론의 임상적 적용가능성을 시사한다고 하겠다. Objectives : The main purpose of this study is to investigate the relationship between self-discrepancy and psychopathology in patients with neurotic symptoms in order to explore th clinical applicability of Higgins'(1987) self-discrepancy theory. Methods : Subjects were 71(male : 45, female : 26) patients with dysthymic disorder, anxiety disorder, somatoform disorder, adjustment disorder, or eating disorder diagnosed with DSM-Ⅳ. After all the subjects' different self-cocepts were measured with the Selves questionnaire, their different kinds of self-discrepancy scores were scored according to the method of Higgins'(1987), and their various psychiatric symptom dimensions(psychopathology) were measured with BAI, BDI, and SCL-90-R. Results : 1) All of the interscorer agreements for four different kinds of self-discrepancies were very high, and the intercorrelations among these were all significant. 2) Total self-discrepancy was significantly associated with most of psychiatric symptom dimensions, and thus this result supports the generality hypothesis about the relationship between total self-discrepancy and psychopathology. 3) In simple correlation analysis, whereas overall actual-ideal discrepancy was not significantly related to anxiety, it was significantly related to interpersonal anxiety and obsessive-compulsive symptom dimension as well as depression. These patterns of correlations were also identified in both actual-ideal/own discrepancy and actual-ideal/other discrepancy, but partial correlations between all of the actual-ideal self-discrepancies and psychopathology were not significant. Therefore, these results partly support the specificity hypothesis about the relationship between actual-ideal discrepancy and depression. 4) In partial correlation analyses, actual-ought/own discrepancy was significantly associated with both general and interpersonal anxiety, but was not associated with depression. However, both overall actual-ought discrepancy and actual-ought/other discrepancy were significantly associated with most of psychiatric symptom dimensions except phobic anxiety. Thus, these results provide mixed support for the specificity hypothesis about the relationship between actual-ought discrepancy and anxiety. Conclusion : The results of this study provide general support for self-discrepancy theory, and provide suggestions for its clinical applicability in understanding and treating patients with neurotic symptoms.

니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,김은아,정현철,심영순,임동구,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetiler^TM (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^TM (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07 7.98㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 94.87% and 87.17%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_max, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^TM tablet is bioequivalent to Nicetile^TM tablet.