서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

국내 한의학 학술지에 발표된 동의보감 연구 현황 조사

한창현(Chang-hyun Han),박상영(Sang-young Park),권오민(Oh-min Kwon),안상영(Sang-young Ahn),안상우(Sang-woo Ahn) 한국의사학회 2009 한국의사학회지 Vol.22 No.2

Background : To understand Korean medicine it is crucial to first understand medical aspect of ‘DongUiBoGam’. It is also meaningful that it became one of the influential book even to posterity. Also based on the apprehension, we can take a view of development of Korean medicine led by ‘DongUiBoGam’. Objectives : This study aims to review the status, study field, specialist of DongUiBoGam. In the process, this review will grasp trends in this field of studies and will direct further researches into the right direction. Method : The computerized Korean databases were searched from their respective inceptions up to December 2008. The search terms used were ‘DongUiBoGam’ and random or Korean language terms related to DongUiBoGam. Several specialized journals were also manually searched for relevant articles. Result : Since the 2000s, DongUiBoGam papers in the Korean Literature is increased. Published 58 papers on The Korean Journal of Oriental Medical Prescription were more than the other journals. 58 papers published in The Korean Journal of Oriental Medical Prescription are the best in many areas related to Korean medicine. Most people have submitted papers related to DongUiBoGam was Woo-yeal Jeong. Conclusions : ‘DongUiBoGam’ research is conducted and current tendency and outlook for ‘DongUiBoGam’ is carried out focusing on several associations.

구리, 니켈 및 코발트를 함유한 염산용액으로부터 LIX84에 의한 구리의 용매추출

안종관,안재우,오영주,이만승 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.3

Solvent extraction experiments with LIX84 have been performed to separate copper from synthetic hydrochloric acid solutions containing copper, nickel and cobalt. Experimental conditions such as solution pH, the concentration of chloride ion and LIX84 and manganese ion, the volume ratio of organic to aqueous phase and pH of stripping solution have been investigated. The optimum conditions for the separation of copper from nickel and cobalt were obtained from the experimental results.

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

Matti-Russe술식을 이용한 주상골 불유합의 치료

안상로,정진선,박원,우영길 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

13 Cases of scaphoid nonunion had been treated by original Matti-Russe procedure and followed up more than 2 years, from September 1990 to September 1993, at the Department of Orthopedic Surgery, Chung Nam National University Hospital. The results were as follows ; 1. Scaphoid nonunion occurs between 21 to 40 years of age( 13 cases ) and 13 cases were all male. 2. Most commonly, the site of fracture were confined to middle one third in 9 cases( 69 %), and fracture line were transverse in 6 cases( 46% ). 3. Radiological union was obtained with DISI deformity correction and normalization of intrascaphoid angle in all cases. 4. The result of treatment were excellent in 8 cases( 61%), good in 4 cases( 31%) and fair in 1 case( 8%)

비완압형 어태치먼트의 위치에 따른 하악 가철성 국소위치의 지지조직에서의 저작압 분산 양태에 관한 3차원 유한요소적 연구

안원준,우순섭,이영수,심광섭,유광희 한양대학교 의과대학 1999 한양의대 학술지 Vol.19 No.1

The purpose of this study was to evaluate the stress patterns developed in supporting structures by removable partial denture with an extracoronal and an intracoronal rigid attachment. The mandibular removable partial dentures with Mini S-G (extracoronal) and C-M Box (intracoronal) attachment were constructed. Under 100N, 200N of vertical and 25N, 50N of lateral loads at the 1st and 2nd lower molar, stress distribution patterns and displacement were analyzed with three dimensional finite element method. The result were as follows: 1. There was no apparent difference in the patterns of stress distribution between rigid extracoronal and rigid intracironal attachments. 2. In case of the single abutment tooth with the rigid intracoronal attachment, it was not proper to preserve the abutment tooth. 3. With splinted abutments, the stress was distributed through all the root surface of both abutments. With single abutment, the stress was concentrated on the distal root surface of abutment. 4. With splinted abutments, there was not clear difference in the patterns of stress distribution with or without lingual bracing part. 5. In case of the single abutment tooth with the rigid intracoronal attachment and cantilever. More stress was concentrated around the abutment tooth with the lingual bracing part under loaded concentrated force and the abutment tooth without the lingual bracing part under loaded distributed force. 6. In case of the splinted abutments with the rigid extracoronal and intracoronal attachment, the denture base was displaced posteriorly and inferiorly when the force was applied. 7. In case of the single abutment tooth with the rigid intracoronal attachment, there was little displacement at the denture base.

Aptamer‑linked immobilized sorbent assay for detecting GMO marker, phosphinothricin acetyltransferase (PAT)

Woo‑Ri Shin,Mun‑Jong Lee,SEKHONSIMRANJEET SINGH,Ji Hun Kim,Sun Chang Kim,Byung‑Kwan Cho,Ji‑Young Ahn,Yang‑Hoon Kim 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3

Background Development of genetically modified crops has rapidly increased in last few years. The most widely grown GM crops express genes that confer herbicide tolerance and insect resistance. Detection system of GM crops is important for safety evaluation before its consumption. Objective The purpose of this research is to detect GM crops, especially PAT, in food-samples. Results The bar gene (PAT protein, herbicide resistant) was cloned in pGEX-4T-1 and expressed by E. coli. The high-affinity PAT-specific single-stranded DNA (ssDNA) aptamers were obtained from a random DNA library. MOE docking study was performed to identify the potential binding region of the selected aptamers on PAT. Aptamer-linked immobilized sorbent assay (ALISA) method was used to detect PAT. Conclusion We screened aptamer against PAT for developing an efficient detection method. The selected PAT specific aptamers, HRPA-05 and HRPA-07, showed the distinct target binding behaviors, and detected PAT protein by aptamer-linked immobilized sorbent assay method with high efficiency and selectivity.

알루미나-탄화티타늄 복합체 방전가공의 정상상태 수치해석

안영철,정영습,왕덕현,우정윤,윤존도,고철호 경남대학교 신소재연구소 1996 論文集 Vol.7 No.-

알루미나와 탄화티타늄이 혼합된 세라믹 복합체의 방전가공 현상에 대하여 방전열량이 연속적으로 공급되는 정상상태를 가정하여 갤러킨 방법으로 유한요소 해석을 수행하였다. 해석결과 방전열속이 3.710×10^(7) cal/s·㎡인 경우 반경 20㎛, 깊이 5㎛정도의 홈이 파일 것으로 예측되었다. 방전열속을 5,565×10^(7) cal/s·㎡로 1.5배 정도 높인 경우에는 관심영역 안의 모든 알루미나가 녹았으며 탄화티타늄도 반경 30㎛. 깊이 25㎛에 상당하는 범위까지 녹는 것을 알 수 있었고, 방전흔은 적어도 반경 30㎛ 이상이 될 것으로 예측되었다. 방전역속이 7,420×10^(7) cal/s·㎡ 이상이 되면 피가공물이 완전히 녹아 가공표면이 거칠어질 수 있으므로 방전열속을 이 값 이상 올리지 않는 것이 바람직하다. A finite element analysis has been performed for the electro-discharge machining of an alumina-titanium carbide(Al₂O₃-TiO₂) composite, assuming that the electro-discharge system is in steady-state. A discharge heat flux of 3.710X l0^{7} cal/s·m²is shown to possibly make a crater with radius of 20 μm and depth of 5 μm. When a discharge heat flux of 5.565× l0^{7} cal/s·m²is used, all of the alumina particles in the domain of intrest melts while the titanium carbide particles within the radius of 30 urn and the depth of 25 μm reach the melting point, thus the size of the crater formed becomes larger than 30 μm in radius. It is not recommended to use a discharge heat flux of greater than 7.42O×10^{7} cal/s·m², because it may deteriorate the surface roughness.

분편 인플루엔자백신(split influenza vaccine)의 임상효과 및 면역원성에 관한 연구

우흥정,김동림,정희진,천병철,이주연,안정배,김지희,박찬,신영규,김우주,김민자,박승철 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.1

목적 : 아단위 인플루엔자 백신 접종 후 백신의 인플루엔자 예방효과, 인플루엔자 방어 항체형성, 인플루엔자 백신의 안전성을 조사하고자 하였다. 방법 : 총 571명을 대상으로 인플루엔자 백신 접종을 하였고, 이들 접종자에서 인플루엔자 양질환의 이환을 조사하여 인플루엔자 백신의 인플루엔자예방효과를 알아보았고, 백신의 접종 전 및 접종 4주 후 혈청에서 혈구응집억제물(Hemagglutination Inhibition : HAI) 항체 검사를 실시하여 백신의 방어항체생성을 조사하였고, 백신의 안전성을 알아보기 위해 백신접종 후 1주일 이내의 부작용을 조사하였다. 결과 :백신 접종군과 백신 비접종군에서 인플루엔자 양 질환의 이환을 조사한 결과 접종군 28.35%, 비접종군 35.88%으로 나왔으며, p 값이 0.001로 통계적으로 접종군에서 유의하게 낮았고, 인플루엔자 양 질환의 예방 효과는 20.97%를 보였다. 백신의 방어항체 형성의 평가를 위해 유럽의 인플루엔자 백신 허가 기준을 조사하였는데 B/Guangdong/5/94균주의 백신접종 후 항체가 40이상의 비율을 제외한 다른 기준은 모두 만족 시켰다. 부작용은 전체 조사자 521명중 149명(29%)으로 주로 접종 부위의 국소 부작용을 호소했고, 전신 부작용은 2% 내외였으며 특별히 심각한 부작용은 발견되지 않았다. 결론 : 분편 인플루엔자 백신은 인플루엔자양질환의 예방과 방어항체생성에 효과 있으며 안전한 것으로 사료된다. Background : The safety and effectiveness of influenza vaccine are well known in developed country. The influenza vaccination has been recommended as one of the tentative immunization schedule for indicated persons since 1997 in Korea. But there are still no available data about them, even though nearly 5 million doses of influenza vaccine were used in 1997-1998 season. So it is immediately needed to investigate the safety. efficacy and immunogenicity of influenza vaccine among Korean. Methods : We studied the clinical efficacy of influenza vaccine by monitoring Occurrence of influenza-like illness in influenza risk group(vaccination ; 300, non-vaccination; 215) from December in 1997 to March in 1998. We used the split quadrivalent influenza vaccine containing 15 microgram of hemagglutinin of A/Beijing/262/95(HlNl), A/Wuhan/359/95(H3N2), B/Mie/1/93 and B/Guangdong/5/94. Hemagglutination inhibition(HA1) antibody titers were determined before immunization and 1 months after vaccination And we evaluated adverse effect of influenza vaccination at 7 days after vaccination. Results : Influenza vaccination was associated with si@icant reductions in influenza-like spptoms(vaccination group; 28.35%, non-vaccination group, 35.88%, p=0.001). The preventive effect of influenza-like i3lne.s among influenza risk goup was 20.97%. And immunogenicity of influenza A and B exceeded all of the European licensure criteria for immunogenicity except postvaccination proportion of titers 240 of B/Guangdong/5/94 strain. And the adverse effects were mainly local injection site problem and no serious adverse effect was noted. Conclusion : Split influenza vaccine is safe, inmunogenic and eff'tive in influenza risk group in Korea.

폴리카보네이트와 폴리메틸메타크릴레이트 혼합물의 상거동 특성 연구

안영철,천우종 慶南大學校 附設 工業技術硏究所 1998 硏究論文集 Vol.15 No.3

본 연구에서는 비스페놀-A계 폴리카보네이트와, 폴리메틸메타크릴레이트 혼합물의 상거동을 미분주사 열량계를 사용하여 조사하였다. 용매 메틸렌클로라이드, 테트라하이드로푸란과 비용매 헵탄을 사용한 용액 캐스팅법으로 높은 분자량의 폴리카보네이트와 폴리메틸메타크릴레이트 혼합물을 만들었다. 메틸렌클로라이드와 테트라하이드로푸란을 용매로 사용한 용액캐스팅법으로는 단상의 혼합물을 만들지 못하지만, 비용매 헵탄에 의한 침전법은 폴리카보네이트의 분자량이 작을 때 단상의 블렌드가 생긴다는 기존의 학설과는 달리 분자량이 큰 폴리카보네이트와 폴리메틸메타크릴레이트의 블렌드가 단상의 혼합물을 형성할 수 있다는 것을 확인하였다. The phase behavior of the blends of bisphenol-A polycarbonate(PC) and polymethyl methacrylate(PMMA) has been investigated by a differential scanning calorimetry. Using methylene chloride and tetrahydrofuran as solvents and heptane as non-solvent, a blend of high molecular weight PC and PMMA was made and examined. Differently from the generally accepted theory that a blend obtained by precipitation from its solution using non-solvent heptane forms a homogeneous phase only for the low-molecular weight PC, it was shown that a high molecular weight PC is able to from a homogeneous phase blend with PMMA by the precipitation technique using heptane as the non-solvent.