http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
위축성 위염과 장상피화생의 호전에 영향을 미치는 인자에 대한 전향적 연구
황영재,김나영,윤창용,권민구,백성민,권영재,이혜승,이제봉,최윤진,윤혁,신철민,박영수,이동호 대한상부위장관ㆍ헬리코박터학회 2018 Korean Journal of Helicobacter Upper Gastrointesti Vol.18 No.3
Background/Aims: To investigate the predictive factors for improvement of atrophic gastritis (AG) and intestinal metaplasia (IM). Materials and Methods: A total of 778 subjects were prospectively enrolled and followed up for 10 years. Histological analysis of AG and IM was performed by using the updated Sydney system. To find the predictive factors for reversibility of AG and IM, 24 factors including genetic polymorphisms and bacterial and environmental factors were analyzed. Results: In all subjects, the predictive factor by multivariate analysis for improvement of both antral and corpus AG was successful eradication. The predictive factors for improvement of antral IM were age and successful eradication. The predictive factor for improvement of corpus IM was successful eradication. In patients with Helicobacter pylori infection, age and cagA were predictive factors for improvement of AG and IM. In patients with H. pylori eradication, monthly income and cagA were predictive factors for improvement of AG and IM. Conclusions: H. pylori eradication is an important predictive factor of regression of AG and IM and would be beneficial for the prevention of intestinal-type gastric cancer. Young age, high income, and cagA are additional predictive factors for improving AG and IM status. Thus, various factors affect the improvement of AG and IM. (Korean J Helicobacter Up Gastrointest Res 2018;18:-197)
황영재,김나영,윤창용,윤혁,신철민,박영수,손일태,오흥권,김덕우,강성범,이혜승,박선미,이동호 대한암예방학회 2018 Journal of cancer prevention Vol.23 No.4
Background: As the number of big-cohort studies increases, validation becomes increasingly more important. We aimed to validate administrative database categorized as colorectal cancer (CRC) by the International Classification of Disease (ICD) 10th code. Methods: Big-cohort was collected from Clinical Data Warehouse using ICD 10th codes from May 1, 2003 to November 30, 2016 at Seoul National University Bundang Hospital. The patients in the study group had been diagnosed with cancer and were recorded in the ICD 10th code of CRC by the National Health Insurance Service. Subjects with codes of inflammatory bowel disease or tuberculosis colitis were selected for the control group. For the accuracy of registered CRC codes (C18-21), the chart, imaging results, and pathologic findings were examined by two reviewers. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for CRC were calculated. Results: A total of 6,780 subjects with CRC and 1,899 control subjects were enrolled. Of these patients, 22 subjects did not have evidence of CRC by colonoscopy, computed tomography, magnetic resonance imaging, or positron emission tomography. The sensitivity and specificity of hospitalization data for identifying CRC were 100.00% and 98.86%, respectively. PPV and NPV were 99.68% and 100.00%, respectively. Conclusions: The big-cohort database using the ICD 10th code for CRC appears to be accurate. (J Cancer Prev 2018;23:183-190)
위축성 위염과 장상피화생의 유병률 변화 및 위험인자의 변화: 다기관 연구 비교
황영재,김나영,김성은,백광호,이주엽,박경식,주영은,명대성,김현주,송현주,김흥업,남광우,신정은,김현진,김광하,이종찬,임선희,서검석,최석채 대한상부위장관ㆍ헬리코박터학회 2018 Korean Journal of Helicobacter Upper Gastrointesti Vol.18 No.4
Background/Aims: The aim of this study was to analyze the trend of the prevalences of atrophic gastritis (AG) and intestinal metaplasia (IM) from 2011 to 2016∼2017 in Korea. And, the risk factors of AG and IM were compared between 2011 and 2016∼2017. Materials and Methods: A total of 4,023 subjects in 2011 and 2,506 subjects in 2016∼2017 were enrolled. AG and IM were diagnosed on the basis of endoscopic findings. Multivariate analysis was performed for risk factors of AG and IM. Seventeen factors were analyzed. Results: The seroprevalence of Helicobacter pylori decreased from 2011 (59.8%; 2,407/4,023) to 2016∼2017 (51.6%; 1,293/2,506; P<0.001). The prevalence of AG decreased from 2011 to 2016∼2017 (P=0.018), but that of IM increased (P<0.001). The risk factors of AG in 2011 were male sex, old age, H. pylori immuoglobulin G (IgG) positivity, family history of gastric cancer (GC), and high-salt diet. For IM in 2011, the risk factors were male sex, old age, H. pylori IgG positivity, and family history of GC. Risk factors of AG in 2016∼2017 were old age, H. pylori IgG positivity, and country of residence. For IM in 2016∼2017, the risk factors were male sex, old age, family history of GC, high fasting glucose level (≥126 mg/dL), H. pylori IgG positivity, and low income level. Conclusions: The difference in prevalence trends of AG and IM between 2016∼2017 and 2011 could be the result of the different risk factors of AG and IM, such as decreased prevalence of H. pylori infection. (Korean J Helicobacter Up Gastrointest Res 2018;18:247-257)
식도-대장-위 연결술 후 연결한 대장에서 발생한 샘종폴립 1예 간추린 제목: 식도-대장-위 연결술 후 발생한 샘종폴립
황영재 ( Young Jae Hwang ),이종수 ( Jong Soo Lee ),이재민 ( Seung Han Kim ),김승한 ( Jae Min Lee ),안젬마 ( Jem Ma Ahn ),이범재 ( Beom Jae Lee ),박영태 ( Young Tae Bak ) 전북대학교 의과학연구소 2012 全北醫大論文集 Vol.36 No.1
식도-대장-위 연결술에서 연결한 대장에 서 샘종폴립이 발견된 위의 증례로 보아서 대장암에 대한 선별검사가 필요하다. 대장 샘종폴립은 내시경적으로 절제하여서 대장 암을 예방할 수 있으므로 식도-대장-위 연 결술을 시행한 환자에서 내시경을 시행할 때 연결한 대장에 폴립이 생길 수 있음을 염두에 두어야 한다. 저자들은 식도-대장-위 연결술을 시행 받은 환자에서 연결한 대장 에서 폴립을 발견 하였고 내시경으로 절제 하였기에 이를 보고하는 바이다. The colonic adenomatous polyp is a pre-malignant lesion which may progress to colon cancer. Early detection and removal of the adenomatous polyp is important to prevent it from malignant change. An interposed colon is used for esophageal replacement in esophageal diseases like strictures or cancers. The exact incidence of adenomatous polyps in the interposed colons is not known, although it seems to be low, and whether cancer screening in these cases is necessary is not clear. We report a case of adenomatous polyp found in an interposed colon. We propose that an interposed colon should be examined carefully to detect a possible existence of adenomatous polyps during an upper gastrointestinal endoscopy.
요양시설에 입소한 치매환자의 사망과 관련된 임상적 변인에 관한 고찰
황영재(Youngjae Hwang),조경형(Kyeonghyeong Jho),최진숙(Jinsook Choi),신영민(Youngmin Shin) 대한노인정신의학회 2002 노인정신의학 Vol.6 No.2
저자들은 치매와 비치매 환자, 알쯔하이머형 치매와 혈관성 치매 환자의 사망과 관련된 변인들을 조사하였다. 특정 요양시설의 6년간 사망자 421명 중 부적합자 70명을 제외한 351명(치매 283명, 비치매가 68명)을 대상으로 하였다. 치매 환자는 알쯔하이머형 치매 환자 146명, 혈관성 치매 환자 101명, 비특이성 치매 36명으로 구성되었는데, 본 연구에서는 알쯔하이머형 치매와 혈관성 치매를 비교 연구하였다. 결과는 다음과 같다. 1) 치매 환자의 평균사망연령이 비치매 환자보다 높았고 알쯔하이머형 치매의 평균 사망 연령이 혈관성 치매보다 높았다. 2) 입소 후 사망 시까지의 기간은 치매와 비치매 군간 및 알쯔하이머형 치매와 혈관성 치매군간에 차이를 보이지 않았다. 남자 알쯔하이머형 치매는 기간이 유의 하게 짧았으나 여자 환자의 수보다 절대적으로 적어서 전체 통계에 큰 영향을 미치지 못 하였다. 3) 선행질환에서 알쯔하이머형 치매에 비하여 혈관성 치매에서 고혈압, 뇌혈관 질환, 당뇨병이 유의하게 높았다. 4) 사망원인은 감염, 전신대사성 질환이 공통적으로 많았다. 알쯔하이머형 치매에서는 전신대사성 질환이 유의미하게 많았고 혈관성 치매에서는 뇌혈관 질환이 유의하게 많았다. 앞으로 좀더 장기간에 걸쳐 생존율 분석 등을 추가하고 체계적 연구가 필요하다고 생각된다. Objective:This study was designed to evaluate the cause of mortality in patients with dementia, including Alzheimer's disease and multi-infarct dementia, and those without dementia. Method:Hospital records of geriatric patients (≥65) in nursing home having dementia were reviewed retrospectively for 6 years. The total number of patients was 351 (the number of demented patients was 146 and those without dementia was 68). Of the ones with dementia, 146 had dementia of Alzheimer's type, 101 patients had vascular dementia, and 36 patients had non-specific dementia. This study focused on the different complications associated with Alzheimer's disease and cerebrovascular dementia. Result:1) The average age at death of demented patient is higher than the non-demented population; however, there is no difference in age between Alzheimer's disease and vascular dementia. 2) There is no difference in time spent in the nursing home among the non-demented group, Alzheimer's disease and vascular dementia group from admission to death. The life expectancy of male patients with Alzheimer's disease after admission to the nursing home is significant shorter than their female counterpart. 3) Patients with vascular dementia have a higher incidence of hypertension, atherosclerotic disease, and diabetes than the Alzheimer's patients. 4) The main overall causes of the death (in nursing home patients) are infection and sepsis. In Alzheimer's disease's, sepsis is the major cause of death, while in vascular dementia, atherosclerotic disease is the number one cause. Conclusion:Knowledge of the causes of the death in demented patients may help the management of the possible complications associated with the different types of dementia. However, long-term research is then needed to analyze the survival rates of demented nursing home patients.