고중성지방혈증과 복부비만이 관상동맥 중재술을 시술받은 급성 심근경색증 환자의 임상경과에 미치는 영향

박종춘 ( Jong Chun Park ),강정채 ( Jung Chaee Kang ),한수경 ( Soo Gyoung Han ),정명호 ( Myung Ho Jeong ),이정애 ( Jung Ae Rhee ),최진수 ( Jin Su Choi ),이기홍 ( Kee Hong Lee ),박근호 ( Keun Ho Park ),심두선 ( Doo Sun Sim ),홍영준 대한내과학회 2014 대한내과학회지 Vol.86 No.2

Background/Aims: Dyslipidemia and obesity are risk factors for the development of acute myocardial infarction (AMI) that affect the clinical outcomes in patients. Methods: We analyzed 2,751 consecutive AMI patients who underwent percutaneous coronary intervention (PCI) (mean age, 63.7 ± 12.1 years). The patients were divided into four groups based on serum triglyceride levels and central obesity [Group Ia: triglycerides < 200 mg/dL and (-) central obesity; Group Ib: triglyceride < 200 mg/dL and (+) central obesity; Group IIa: triglyceride ≥ 200 mg/dL and (-) central obesity; Group IIb: triglyceride ≥ 200 mg/dL and (+) central obesity]. In-hospital outcome was defined as in-hospital mortality and complications. One-year clinical outcome was compared and defined as the composite of 1-year major adverse cardiac events (MACE), including death, recurrent MI, and target vessel revascularization. Results: Total MACE developed in 502 patients (18.2%), while 303 patients (11.0%) died prior to the 1-year follow-up visit. In-hospital complications and in-hospital mortality were not different among the four groups. One-year clinical outcomes based on triglyceride levels (Group I vs. Group II) were not different. In addition, there were no differences in clinical outcomes in patients with a triglyceride level < 200 mg/dL, regardless of central obesity. One-year MACE rates were not significantly different among the four groups. Conclusions: There was no significant difference in the 1-year MACE rate based on the triglyceride level and presence of central obesity in patients with AMI who underwent PCI. (Korean J Med 2014;86:169-178)

국소병변없이 거대한 종격동 종괴로만 재발된 자궁경부암

이준석 ( Jun Seok Lee ),공수정 ( Soo Jung Gong ),주종은 ( Jong Eun Joo ),이정애 ( Jung Ae Lee ),김정선 ( Jeong Seon Kim ),안영수 ( Young Soo Ahn ) 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.60 No.6

Uterine cervical cancer is the 5th most common malignancy in Korean women. With the development of new diagnostic and therapeutic modalities, earlier stage cancers are being diagnosed with longer survival rates being anticipated. Accordingly, recurrent cancers are being encountered more often in clinical practice. Most recurrent uterine cervical cancer patients, have intra-pelvic lesions and adjacent lymph node involvement, while a distant metastasis alone is extremely rare. A mediastinal recurrence of uterine cervical cancer is not common with most manifesting as small lymph node enlargements. We report a case of a 46-year-old woman with recurrent uterine cervical cancer presenting only as a huge mediastinal mass without a local recurrence. (Tuberc Respir Dis 2006; 60: 684-689)

연령 및 지역에 따른 한국인 혈 중 수은 분포 연구

정다영 ( Da Young Chung ),최종호 ( Jong Ho Choi ),이정애 ( Jeong Ae Lee ),박경수 ( Kyung Su Park ),윤혜정 ( Hae Jung Yoon ),표희수 ( Hee Soo Pyo ) 한국환경분석학회 2012 환경분석과 독성보건 Vol.15 No.4

The present study analyzed total mercury in whole blood from total of 4500 samples: adults = 2000, students = 1000 and infants = 800 (parents = 600), of Korean that were collected between 2010 and 2011 survey years using Gold Amalgamation-Direct Mercury Analyser (DMA-80). Geometric mean (GM) of adults, students and infants (parents) were 3.90 μg/L, 2.15 μg/L, 2.06 μg/L (3.23 μg/L), respectively, showing proportional relationship between age and total mercury concentration in whole blood. When the samples were analyzed in relation to gender, total mercury concentration was higher in male samples (3.11 μg/L) than female samples (2.76 μg/L). When the samples were analyzed in relation region, total mercury concentration was higher in coastal area samples (3.60 μg/L) than inland area samples (2.98 μg/L) with significance (p<0.05). Total mercury concentrations of 496 pairs of mother and infant showed low linearity with R^2=0.026. The above statistical analysis was performed using PASW Statistics 18 (Version 18.0, SPSS, Chicago, IL).

Capillary Column Gas Chromatography/Nitrogen Phosphorus Detector를 이용한 흥분제 및 마약성 진통제의 동시분석에 관한 연구

노동석,신호상,강보경,백형기,김승기,이정애,김영림,박종세,Lho, Dong-Seok,Shin, Ho-Sang,Kang, Bo-Kyung,Paek, Heang-Kee,Kim, Seung-Ki,Lee, Jeong-Ae,Kim, Young-Lim,Park, Jong-Sei 대한화학회 1991 대한화학회지 Vol.35 No.6

질소를 함유한 흥분제와 마약성 진통제 18종류의 약물들을 gas chromatography-nitrogen phosphorus detector(GC-NPD)를 사용하여 human urine으로부터 동시에 신속하게 분석할 수 있는 최적조건을 찾기 위하여 pH 변화와 추출용매 변화에 따른 회수율을 조사하였다. pH 8.5에서 에테르를 추출용매로 사용하였을 때 가장 적은 방해영향과 가장 좋은 회수율을 나타냈다. NPD에 대한 각 약물들의 상대 감응인자를 구하였고, 이 상대감응인자는 약물이 가지고 있는 질소원자의 갯수가 증가할수록 작은 값을 나타냈다. 생체시료 중의 약물들을 신속하게 검정하기 위하여 내부표준물질인 diphenylamine에 대한 relative retention time(RRT)을 작성하였다. 상대머무름 시간은 0.1% 이하의 정밀도를 나타냈다. A systematic analysis of 18 stimulants and narcotic analgesics containing nitrogen atom (s) in human urine by gas chromatography with nitrogen phosphorus detector (GC-NPD), is described. The urinary extract with diethyl ether at pH 8.5 showed good recoveries of the drugs and less interference peaks on GC chromatogram. Retention data were standardized by the calculation of relative retention times using diphenylamine as the internal standard. The relative standard deviations of retention times were less than 0.1% for the within-run analyses. The response factor (RRF) of a drug relative to the internal standard was calculated. RRF decreased with increasing number of nitrogen atoms. This technique can be adapted to various analytical toxicology problems.

다발성 폐종괴 및 기관지 점막으로 전이한 원발불명의 악성 흑색종

민영훈 ( Min Yeong Hun ),김성욱 ( Kim Seong Ug ),진희종 ( Jin Hui Jong ),이태유 ( Lee Tae Yu ),송헌호 ( Song Heon Ho ),이근석 ( Lee Geun Seog ),이정애 ( Lee Jeong Ae ),박영이 ( Park Yeong I ),현인규 ( Hyeon In Gyu ) 대한결핵 및 호흡기학회 2002 Tuberculosis and Respiratory Diseases Vol.53 No.2

치미센터 근무요원들의 노인의 의미에 대한 연구

박인숙 ( In Sook Park ),곽명순 ( Myung Soon Kwak ),이정애 ( Jong Ae Lee ) 한국정신간호학회 2004 정신간호학회지 Vol.13 No.3

N/A Purpose: The purpose of this study was to examine what senior citizens meant for medical personnels and volunteers who took care of those who suffered from dementia in a bid to help them provide a better care for them. Methods: The study was conducted from December 2003 to February 2004 by using Q-method. P sample consisted of 33 medical personnels and volunteers who took care of elderly people with dementia. The collected data were analyzed with Quanl computer program, and concerning Q-factors, principal component analysis was made. Results: There appeared five types: Denying, Pay back to society, Accepting, Caring and Self-accomplishing. Those five factors made a 75.35% prediction. Conclusions: The employees of dementia centers took a positive view of the elderly. They had an adaptive attitude toward old age or regarded elderly as those who could contribute to society and should be well cared. The workers who take care of elderly people should be educated about their significance and traits on elders in order to provide better nursing services to dementia elders.

그룹홈과 아동양육시설의 운영성과에 영향을 미치는 요인

정익중(Ick Joong Chung),우석진(Seok Jin Woo),강현아(Hyun Ah Kang),전종설(Jong Serl Chun),이정애(Jung Ae Lee) 한국아동학회 2012 아동학회지 Vol.33 No.4

This study investigates the factors influencing service outcomes of group homes and residential care centers, as well as the factors causing any differences between the two service outcomes. 119 and 137 5-6th graders were selected from group homes and residential care centers respectively, using the cluster sampling method. Multiple regression and Blinder-Oaxaca decomposition were used in this study. The results revealed that ``stigma``, ``school adjustment``, and ``social support`` were significant factors influencing service outcomes among children in group homes, while ``stigma``, ``primary caregivers`` attitude``, and ``peer relations`` were identified as significant factors among children in residential care centers. The study also found that the mean service outcome score for group homes was higher than that of residential care centers. The 74 percent of this difference in the mean scores was due to the difference in children` characteristics of the two out-of-home care service types. The remaining 26 percent of this difference was due to unobserved characteristics. Finally, the implications of this study in child welfare practices were also discussed.

만성골수성백혈병에서의 동종골수이식 : 국내 경험의 후향적 분석 Retrospective Analysis of Korean Experience

이규형,이제환,이정신,김상희,김우건,김춘추,이종욱,김병국,박선양,이홍기,윤성수,김효철,남동기,한지숙,민유홍,현명수,황태주,정익주,박영석,이정애 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.2

연구방법: 국내에서 시행된 만성골수백혈병의 치료를 위한 가족간 동종골수이식의 임상적 특징을 후향적으로 분석하였다. 9개의 병원에서 1986년 9월부터 1997년 6월까지 시행한 137예의 가족간 동종골수이식을 보고하였다. 결과: 전체 환자 중 62%인 85예가 남자였고 연령은 15세에서 50세까지 분포하였다(중앙치 30세). 95예(71%)의 환자는 이식 당시 만성골수성백혈병 만성기의 상태였고 38예(28%)는 가속기 또는 모세포성발증기의 상태였다. 70예(51%)의 환자는 이식전처치로 busulfan+cyclophosphamide (BuCy) 치료를 받았고 42예(31%)의 환자는 cyclophosphamide+전신방사선 조사(Cy-TBI)를 받았다. 환자에게 이식된 단핵구의 수는 0.06-9.5×10^(8)/kg(중앙치 1.2×10^*/kg)였다. 1 예를 제외한 모든 환자에서 이식 후 8-100일(중앙치 17일)에 중성구 500/㎕ 이상의 착상이 관찰되었다. 급성 및 만성이식편대숙주질환은 각각 46%와 43%의 환자에서 관찰되었다. 중앙추적기간 20개월(범위 3-135개월) 경과 후 137예의 환자 중 52예의 환자가 사망하였다. 사망 원인은 감염(27%), 백혈병의 지속 또는 재발(23%), 이식편대숙주질환(21%), 치료독성(15%), 그리고 이식편거부(8%) 등이었다. 환자들의 event-free survival에 영향을 주는 인자로는 이식전 병의 상태(p<0.001)와 환자의 혈청 HBsAg 양성여부(p=0.012)가 중요하였다. Overall survival에 영향을 주는 인자도 이식전 병의 상태와 환자 혈청 HBsAg 양성여부로 나타났다. 결론: 본 연구에서 국내 만성골수성백혈병에 대한 동종골수이식술은 그 시행 예가 급격히 증가하고 있음을 보여주었다. 환자들의 임상 특성과 생존 성적은 외국의 성적과 유사하였다. B형 간염 감염환자의 경우 예후가 유의하게 불량하였고, 이는 추후의 임상연구에서 확인이 필요한 소견으로 사료된다. Background and Methods: Clinical features of allogeneic bone marrow transplantation (BMT) performed for patients with chronic myelocytic leukemia (CML) in Korea were analyzed retrospectively. Nine hospitals reported a total of 137 cases of allogeneic BMT performed between September, 1986 and June, 1997. Results: There were 85 male (62%) and 52 female patients with median age of 30 years (range 15-50). Ninety five patients (71%) were in chronic phase and 38 patients (28 %) were in accelerated/blastic phase of the disease. Seventy patients (51%) received busulfan-cyclophosphamide (BuCy) regimen for preparation and 42 patients (31%) received cyclophosphamide-total body irradiation (Cy-TBI) regimen. The median mononuclear cell dose given to patients was 1.2×10^(8)/kg (range, 0.06-9.5×10^(8)/kg). All but one patient achieved absolute neutrophil count of 500/μl after median 17 days after BMT (range, 8-100 days). Acute and chronic graft-versus-host disease (GVHD) were reported in 61/133 (46%) and in 57/134 (43%) patients, respectively. The median follow-up time of survivors was 20 months (range, 3-135 months). There were 52 deaths (38%). The causes of death were infection (14 patients, 27%), recurrent/persistent disease (12 patients, 23%), GVHD (11 patients, 21%), regimen related toxicity (8 patients, 15%), graft rejection/failure (4 patients, 8%), and unknown (3 patients, 6%). The factors influencing event free survival of the patients were disease status before BMT (p<0.001, by log-rank test) and serum hepatitis B surface antigen status (p=0.012). Longer duration of disease before BMT showed poorer outcome but the difference did not reach statistical significance. The factors affecting overall survival of the patients were disease status before BMT (p=0.009) and hepatitis B surface antigen status (p=0.036). The donor hepatitis B antigen status did not influence event free survival or overall survival of the patients. Conclusion: Clinical features and survival patterns of patients with CML treated with allogeneic BMT in Korea were similar to historical data from other countries. Further data analyses are warranted for the role of hepatitis B virus infection influencing the outcome of allogeneic BMT for CML.

웹과 MUG를 활용한 협동적이고 통합적인 교육용 코스웨어의 설계

허균,이정애 한국컴퓨터교육학회 1999 컴퓨터교육학회 논문지 Vol.2 No.2

최근의 코스웨어를 위한 환경은 멀티미디어 CD타이틀 제작에서 온라인 환경으로 이동해 가면서 다중의 사용자가 동시 접속하여 양질의 교육을 받을 수 있는 클라이언트/서버 구조인 인터넷 환경으로 급변하고 있다. 또, 이제까지의 학습용 소프트웨어의 대부분은 주로 디스크나 CD-ROM등을 이용한 일대일 학습이었으며 최근 WBI에 기반을 둔 학습 프로그램이 개발되고 있지만 학습자의 다양한 관심과 반응을 이끌어 내기에 역부족이다. 이에 본 논문에서는 컴퓨터를 이용한 교육에서 기존의 학습용 소프트웨어의 문제점을 해결하고 다양한 교육 효과 및 새로운 교육 방법의 가능성으로 웹기반 협동학습 시스템과 MUG를 적용한 학습용 시스템을 설계하였다.

항 내인자 및 항 벽측 세포 항체 양성을 보인 악성 빈혈 1 예

박영석,이정애,정지영,강승식,이재명,조성태,한태호,박수종,이록윤,선덕재,박찬정,최조영 대한내과학회 1997 대한내과학회지 Vol.52 No.4

We present a case of pernicious anemia without history of operation in 52 year old female. She suffered from oral ulcer, gum bleeding, nausea, vomiting, and beefy tongue. She had dysesthesia on the both arm and foot, and hypesthesia of global and stocking type by neurologic examination. Laboratory findings were as follows: serum cobalamin 9.1 pg/mL (normal range: 180-710pg/mL), anti intrinsic factor antibody (strong positive), antiparietal cell Antibody 1:10 (positive), first stage of Schilling test (1.4%). The findings of peripheral blood and bone marrow were compatible with megaloblastic anemia. We report a case of pemicious anemia with positive anti intrinsic factor antibody and antiparietal cell antibody.