안와골절 수술 후 발생한 두 가지 상피세포를 가진 안와 점액낭종 1예

김미진,이민정,김찬중,김남주,정호경,곽상인,Mijin Kim,MD,Min Joung Lee,MD,Chan-Joong Kim,MD,Nam Ju Kim,MD,Ho-Kyung Choung,MD,Sang In Khwarg,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.7

Purpose: The authors report a case of orbital mucocele lined with two types of histological epithelial cells developed after repair of the orbital wall fractures. Case summary: A 53-year-old man presented with proptosis of the left eye for two years. The patient had a history of left orbital inferomedial wall fracture repair ten years earlier at a different hospital. Examination revealed 4 mm proptosis and superior globe displacement of the left eye. Restriction of left ocular movements on elevation, depression and adduction were observed. A computed tomography scan demonstrated a large, non-enhancing, cystic tumor in the left inferior orbit with the inferior and medial wall displaced toward the paranasal sinus. An orbital cystic tumor was excised with the removal of previously-inserted orbital implant via a transconjunctival and transcaruncular approach. The inferior, and medial orbital walls were reconstructed using a MEDPOR® TITANTM implant. The initial pathologic diagnosis was epidermal cyst. Histopathologic re-review revealed an orbital cyst lined with both stratified squamous epithelium and pseudostratified ciliated columnar epithelium, thus diagnosis was changed to orbital mucocele. Proptosis and restriction in ocular motility improved postoperatively. Conclusions: Mucocele formation should be considered in patients in whom a cyst developed after orbital fracture repair.

전층각막이식술 후 발생한 감염성 각막염의 임상양상 및 위험인자

김미진,오주연,김미금,한상범,이진학,위원량,Mijin Kim,Joo Youn Oh,Mee Kum Kim,Sang Beom Han,Jin Hak Lee,Won Ryang Wee 대한안과학회 2010 대한안과학회지 Vol.51 No.4

Purpose: To report the clinical manifestation, predisposing factors, microbiological profiles and treatment outcome of infectious keratitis following penetrating keratoplasty (PK). Methods: Medical records of the post-PK patients later diagnosed with culture-positive keratitis, between January 2003 and June 2008 at our hospital were retrospectively reviewed. Results: Among 228 eyes of 226 patients who previously had PK, 18 eyes (7.89%) of 16 patients developed microbial keratitis. Fifteen patients had a bacterial infection, of which a Streprococcus species was the most common causative microorganism (6 eyes, 33.3%). Three eyes had fungal infection; one case was co-infected with bacteria. Six eyes (33.3%) presented with a suture-related problem, and sixteen eyes (88.9%) had been using topical glaucoma medications. The suture-related problem and use of glaucoma medication were significantly associated with the development of infectious keratitis (p=0.040 and 0.013, respectively). Remission was achieved in all cases within the mean duration of 2.47 months after treatment initiation. However, visual improvement was not achieved in 11 eyes (68.7%) due to graft opacity. Conclusions: Early identification of predisposing factors and appropriate management at an early stage may prevent the occurrence of graft infection and improve graft survival. J Korean Ophthalmol Soc 2010;51(4):504-509

망막에서 기인한 기형성 수질상피종 1예

김미진,정호경,이민정,김영아,곽상인,Mijin Kim,Ho-Kyung Choung,Min Joung Lee,Young A Kim,Sang In Khwarg 대한안과학회 2010 대한안과학회지 Vol.51 No.12

Purpose: To report a rare case of medulloepithelioma originating from the retina. Case summary: A nine-year-old boy visited our clinic with conjunctival injection and decreased visual acuity in the left eye, which had developed two month previously. Slit lamp examination revealed a distorted pupil and an anteriorly protruding ciliary body displacing the peripheral iris toward the cornea on the inferonasal side. Funduscopic examination showed total retinal detachment accompanied by an inferior hypervascular mass. The examination of the right eye was unremarkable. On computer tomography imaging, a calcified mass was identified behind the iris of the left globe in the inferomedial aspect, and ultrasound biomicroscopy revealed a medium to high echogenic tumor with an uneven oval cystic cavity in the ciliary body. At the follow-up examination, the size of the mass was increased, so we performed enucleation of the left eye. Pathology demonstrated that the retrolental mass abutting the lens had arisen from the retina. Histological examination revealed that the tumor had originated from the retina and extended into the ciliary body, and most of the tumor was composed of hyaline cartilage with calicification. Tumor cells were identified in the periphery, forming elongated tubules and cord-like structures that were immunohistochemically positive for vimentin, neuron-specific enolase, and CD56 compatible with a teratoid medulloepithelioma. The patient was followed up for eight months without any metastasis in the orbit or elsewhere. Conclusions: Medulloepithelioma should be considered in the differential diagnosis of pediatric orbital mass accompanied by calcification. J Korean Ophthalmol Soc 2010;51(12):1665-1670

Exposure to mercury induced early apoptotic signals in human placental BeWo cells through alteration of cell cycle regulation

김미진,김철홍,An Mi-Jin,Shin Geun-Seup,Lee Hyun-Min,김지영,Hwang Jae Yoon,이주현,Kim Jung-Woong 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.4

Backgrounds Heavy metals are environmental pollutants and their breakdown is regarded as a serious risk to human health. Despite increasing evidence that heavy metals have adverse efects in vivo and in vitro, there is no evidence of the efect of heavy metals during placental formation. Objective We determined the efect of heavy metals on cell viability of BeWo human placental cells using MTS assay and live and dead assay. We also evaluated cell proliferation, cell cycle, and apoptosis by heavy metal treatment using FACS analysis. Results Mercury chloride induces severe cell cycle arrest at the sub-G1 phase by the accumulation of cyclin B. Furthermore, we identifed that mercury chloride induces apoptosis by enhancing the activity of caspase-3. However, we were unable to confrm the deleterious efect of lead in BeWo cells. Conclusion Our results suggested that exposure to heavy metals, specifcally mercury chloride, induced cytotoxic efects in BeWo cells through cell cycle arrest and apoptosis.

생명과학 분야 연구자들의 연구 성과 분석 연구 - K 대학교를 중심으로 -

김미진,Kim, Mee-Jean 한국도서관정보학회 2020 한국도서관정보학회지 Vol.51 No.2

본 연구의 목적은 정부로부터 많은 연구개발비의 지원과 더불어 연구역량 및 국제적 연구네트워크를 갖추고 있는 K대학교 생명과학과 교수진이 발표한 14년간(2004년-2017년)의 학술지 논문을 대상으로 연구개발비 재원별, 주제 영역별, 발표 주요 학술지, 연구 유형별로 조사함으로써 국내 생명과학 분야 선도 연구자들의 연구 발행 패턴의 특성을 파악하였다. 또한 교수진이 발표한 논문의 발행 패턴에 따른 15년간(2004년-2018년) 즉시 피인용 빈도 및 피인용 빈도, 주제 영역 학술지 영향계수(IF) 4분위 수 등 피인용도와의 관계를 분석하였다. 연구개발비 지원 유형에 따른 논문 1편당 즉시 피인용 빈도를 Welch 검증 분석 결과, 세 가지 유형 중 해외기관 재원에 의한 연구 논문이 1.8회로 가장 높았으며 통계적으로 유의미한 차이가 있는 것으로 나타났다(F = 10.467, p < .000***). 또한 공동연구 유형별로 논문 1편당 즉시 피인용 빈도 및 논문 1편당 피인용 빈도에서 해외 기관과의 국제 공동연구 논문이 다른 세 가지 공동연구 유형에 의한 논문과 비교해 더 많이 인용된 것으로 분석되었다. The purpose of this study is to provide an in-depth analysis on the publication patterns of the 1,029 journal articles by the Life Sciences' faculty at the K University, for the years 2004-2017 and to investigate any difference between their publication patterns and the citedness for the years 2004-2018. Among the three funding agency types, the research publications supported by foreign funding received the more citations than publications by other types of funding, and the study also found a statistical difference in the citedness (F = 10.467, p < .000***). In addition, the internationally co-authored publications received more citations than three other types of co-authored publications in terms of the immediacy index per publication and the average citations per publication.

당뇨교육실 - 당뇨인의 올바른 간식 섭취법

김미진,Kim, Mi-Jin 사단법인 한국당뇨협회 2008 당뇨 Vol.219 No.--

2007년 서울 지역에서 판매되고 있는 반찬류의 세균 오염과 항생제 내성실태

김미진,이도경,장석,양환진,안향미,백은혜,하남주,Kim, Mi-Jin,Lee, Do-Kyung,Jang, Seok,Yang, Hwan-Jin,An, Hyang-Mi,Baek, Eun-Hye,Ha, Nam-Joo 대한약학회 2008 약학회지 Vol.52 No.6

The purpose of this research was to investigate the microbiological quality and antimicrobial susceptibilities of the ready-to-eat side dishes, which are were collected from the grocery stores, big markets, and department stores in Seoul throughout November, 2007. Of total 124 samples, presence of staphylococci and enteric bacilli was observed in 38 samples (31%) and 53 samples (43%), respectively. And 30 samples (24%) were shown to be of unsatisfactory quality for total bacterial count (>$10^5$). Antimicrobial susceptibilities of the staphylococci isolated from the side dishes were tested for six different antimicrobial agents, which are in widespread clinical use in Korea, as well as four new antimicrobials, daptomycin, linezolid, quinupristin/dalfopristin and tigecycline. As a result, the staphylococcal isolates were found to be resistant to oxacillin (${MIC}_{90}$, >128 ${\mu}g$/ml), teicoplanin (${MIC}_{90}$, >128 ${\mu}g$/ml), mupirocin (${MIC}_{90}$, >128 ${\mu}g$/ml), linezolid (${MIC}_{90}$, 128 ${\mu}g$/ ml) and quinupristin/dalfopristin (${MIC}_{90}$, 32 ${\mu}g$/ml). Especially, some of the staphylococcal isolates exhibited high level and multi-drug resistance. Moreover, these bacteria were also resistant to new antimicrobials, except tigecycline.

상사근기능항진에서 상사근힘줄절제술 및 상사근뒤쪽힘줄절제술의 교정 효과

김미진,김성준,유영석.Mijin Kim. MD. Sung Jun Kim. MD.. Young-Suk Yu. MD. 대한안과학회 2012 대한안과학회지 Vol.53 No.6

Purpose: The authors of the present study compared the effects of tenectomy and posterior tenectomy of the superior oblique for treating superior oblique overaction (SOOA). Methods: The records of 30 eyes of 19 patients who underwent tenectomy or posterior tenectomy of the superior oblique alone or in combination with surgery on other horizontal rectus muscles from April 2005 through November 2010 were reviewed. The review was performed in 3 patients who underwent unilateral superior oblique tenectomy, 5 patients who underwent unilateral superior oblique posterior tenectomy, 3 patients who underwent bilateral superior oblique tenectomy, 6 patients who underwent bilateral superior oblique posterior tenectomy, and 2 patients who underwent superior oblique posterior tenectomy and tenectomy. Results: The mean age of the patients was 14.2 years, and the mean follow-up period was 20 months. Through superior oblique tenectomy (11 eyes) and superior oblique posterior tenectomy (19 eyes), the amount of SOOA decreased from +2.27 to +0.09 and from +1.84 to +0.93, respectively. Except for 1 out of 11 eyes with superior oblique tenectomy, SOOA was completely corrected, although SOOA remained in 6 eyes after posterior tenectomy. Therefore, the correctional effects of the 2 methods differed; both procedures showed insignificant correctional effects on vertical strabismus. Conclusions: Superior oblique tenectomy has a superior long-term weakening effect; however, posterior tenectomy showed a comparable effect in the patient with moderate to severe SOOA. Both of these methods had few complications and are considered to be effective superior oblique weakening procedures. J Korean Ophthalmol Soc 2012;53(6):813-818

이소성 췌장과 위점막을 가진 멕켈 게실에 의한 장중첩증 1예

김미진,김재영,설지영,강대영,Kim, Mi Jin,Kim, Jae Young,Sul, Ji Young,Kang, Dae Young 대한소아소화기영양학회 2006 Pediatric gastroenterology, hepatology & nutrition Vol.9 No.1

저자들은 장중첩증의 관장 정복 후 입원 관찰 기간 동안에 2차례 더 재발한 장중첩증을 가진 5세여 아에서 복부 CT 촬영으로 선두를 확인하고 복강경으로 치료한 이소성위점막과 췌조직을 동시에 가진 멕켈 게실에 의한 장중첩증 1예를 경험하였기에 문헌 고찰과 함께 보고한다. Intussusception is a frequent cause of intestinal obstruction in early childhood and most are idiopathic in origin. In a minority of cases a definite pathological lead point is identified by imaging studying or during surgery. As the pathologic lead point of intussusception, Meckel's diverticulum is the most common lesion. In symptomatic patients, 40~60% of Meckel's diverticulum contain ectopic tissue, with gastric mucosa being far the most common type. A few Meckel's diverticulum contain pancreatic tissue. Combined heterotopic pancreatic and gastric tissues in the Meckel's diverticulum especially causing intussusception is extremely rare. We report the case of 5-year-old girl with an intussusception caused by Meckel's diverticulum containing both heterotopic gastric and pancreatic tissues.

한냉(寒冷)증상과 냉대하(冷帶下)를 겸한 여고생 월경통(月經痛)에 대한 주자당귀환(酒煮當歸丸)의 효능에 관한 임상적 연구

김미진,문덕빈,엄윤경,배경미,이인선,Kim, Mi-Jin,Mun, Deok-Bin,Eom, Yun-Kyung,Bae, Kyung-Mi,Lee, In-Seon 대한한방체열의학회 2005 대한한방체열의학회지 Vol.4 No.1

The purpose of this study is to identify the clinical effects of Jujadanggui-hwan in the treatment of dysmenorrhea with cold hypersensitivity. Jujadanggui-hwan mentioned in Dongeuibogam has an effect on leucorrhea and cold hypersensitivity of hands and feet, lower abdomen and lumbus. Jujadanggui-hwan were prescribed to 24 dysmenorrhea patients with cold hypersensitivity of hands and feet or with leucorrhea three times a day for 13 weeks. After the treatment, numerical index for the pain was obviously reduced 'tot' point 2.12. It means that pain index as the patient can't do everyday occurrences reduce to 3 grad enough to do ordinary experience. So this study shows that Jujadanggui-hwan has remarkable effects on dysmenorrhea with cold hypersensitivity.