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제약조건과 사전확률이 고려된 선형비용모형의 수정검사정책
이도경 國立金烏工科大學校附設生産技術硏究所 1991 産業技術開發硏究 Vol.7 No.-
Various linear cost models have been proposed that can be used to determine a sampling plan by attributes. This paper is concerned with this sampling cost model when the probability that the number of nonconforming items is smaller than the bread-even quality level is known. In addition to this situation, a constraint by AOQL is considered. Under these conditions, optimal sampling plan which minimize the average cost per lot is suggested.
이도경 金烏工科大學校 1999 論文集 Vol.20 No.-
In this paper, a new process capability index 'Multivariate Process Capability Mean(MPCM)' is proposed. The existing process capability indices are concerned with the single variable. In many cases, a quality characteristic is composed with several factors. In that case, we want to know the integrated process capability of a quality characteristic not those of each factor. We induced the concept of process capability mean to the number of multivariates. For the concept of MPCM, we illustrated an example. Sensitivity analysis is done for the MPCM and the number of variables.
이도경 金烏工科大學校 1991 論文集 Vol.12 No.-
This paper is concerned with redundancy allocation problem to maximize system reliability of multiconstraints mixed parallel-series system. The constraints need not be linear. This paper propose a modification of the Narasimhalu et al. model by introducing an initial solution which has a new criterion and is near to the optimal solution. This criterion accounts for the relative unreliability versus the relative resources for each subsystem. To show the efficiency of this method, numerical example and comparison with Narasimhalu et al. is illustrated in chaper 4.
이도경,Nam Joo Ha,Mi-Jin Kim,Ji-Wook Ham,Hyang-Mi An,Min-Kyung Cha,Si-Won Lee,박철인,신선희,Kang-Oh Lee,김경제 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.6
The objective of this study was to evaluate the antibacterial and anti-inflammatory effect of Bifidobacterium spp. In the first part of the study, the antibacterial activities of live and sonicated cells, from a total of 23 Bifidobacterium species, on the growth of 5 different strain of Staphylococcus aureus. Six strains, of sonicated Bifidobacterium, exhibited antibacterial activity against staphylococci samples, and seven Bifidobacterium strains exhibited antibacterial activity on the growth of S. aureus S.P.-N2. In the second part of the study, we tested the antimicrobial activity, of Bifidobacterium against Propionibacterium acne KCTC3320, using the co-culture method. The loss of P. acnes viability, caused by B. adolescentis SPM0308 and B. longum SPM1207, was 84% and 75%, respectively (*p < 0.05). In the third part of the study, the anti-inflammatory activity of B. adolescentis SPM0308 and B. longum SPM1207 were assessed; nitric oxide (NO), and tumor necrosis factor-α (TNF-α), production were tested using the murine macrophage RAW 264.7 cell line. Treatment of RAW 264.7 cells, with Bifidobacterium, decreased production of NO and TNF-α rather than LPS (100 ng/mL) treatment. The results suggest that B. adolescentis SPM0308 could be used as an effective control for P. acnes KCTC3320, and S. aureus, and reduce the risk of acne vulgaris development. We suggest that B. adolescentis SPM0308 may be a useful probiotic microorganism, for prevention of acne vulgaris, without adverse effects.
이도경,하남주,Shin Young Park,Seok Jang,Eun Hye Baek,Mi Jin Kim,Sun Min Huh,최경순,정명준,Jin Eung Kim,이강오 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.1
Probiotics such as lactic acid bacteria (LAB) and prebiotics such as fiber are generally considered beneficial for health. These affect the microflora composition and fermentation metabolites and consequently contribute to local and systemic effects in humans. The beneficial effects of probiotics can be improved when combined with prebiotics. Here we investigated the effects of a mixed LAB supplement combined with dietary fiber on the population of LAB in the gut, as well as on serum cholesterol levels, fecal water content and microbial harmful enzyme activities. For animal studies, 0.2 mL of mixed LAB (Bifidobacterium longum SPM1205, Lactobacillus acidophilus, and SAFELAC isolated from Pediococcus pentosaceus)supplement (10^7 ~ 10^8 colony forming units per day) was orally administered to male Sprague-Dawley rats every day for 2 weeks along with a diet containing 5% or 10% cellulose. The mixed LAB supplement combined with dietary cellulose significantly (p < 0.05) reduced serum total cholesterol and LDL levels. This combination also significantly (p < 0.05) increased the population of LAB and the fecal water content and significantly (p < 0.05) reduced microbial harmful enzyme (β-glucosidase, β-glucuronidase and tryptophanase) activities. These effects of LAB were particularly improved by its combination with 5% cellulose compared to the control (a diet without cellulose), and the 5% cellulose combination was more effective than the 10%cellulose combination. In conclusion, the incorporation of a fibrous diet such as cellulose with lactic acid bacteria improved the population of LAB, and daily consumption of this combination could reduce the serum cholesterol levels and activities of harmful enzymes such as β-glucosidase,β-glucuronidase, tryptophanase, urease in rats.
Antiviral activity of Bifidobacterium adolescentis SPM0212 against Hepatitis B virus
이도경,강주연,신혜순,박일호,하남주 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.12
Bifidobacteria are considered one of the mostbeneficial probiotics and have been widely studied for theireffects in preventing and treating specific pathologicalconditions. The present study explored the antiviral activityof Bifidobacterium adolescentis SPM0212 isolated fromhealthy Koreans against hepatitis B virus (HBV) and itsmechanism of action. To determine the effect of B. adolescentis SPM0212 against HBV, the level of HBVsurface antigen (HBsAg) in the culture medium and thelevels of viral transcripts in HepG2.2.15 cells were measuredby enzyme-linked immunosorbent assay and reversetranscription-quantitative PCR (RT-qPCR), respectively. To clarify the mechanism, we performed RT-qPCR usingspecific primers for genes encoding Interferon (IFN)-signalingcomponents and IFN-inducible antiviral effectors. The cell extract of B. adolescentis SPM0212 dose-dependentlydecreased the extracellular HBsAg level by up to50 %. Its gene expression in HepG2.2.15 cells was alsoinhibited by 40 %. This extract significantly increased theexpression level of myxovirus resistance A, which is anIFN-inducible antiviral effector. Furthermore, the antiviralactivity was observed in the fraction of compound(s) withmolecular weights under 30 kDa. Thus, the cell extract ofB. adolescentis SPM0212 inhibits HBV and its antiviralmechanism is associated with the Mx GTPase pathway.