순환기가감방(循環器加減方)이 고지혈증 유발 백서(白鼠)에 미치는 영향

김동현,임승민,안정조,조현경,유호룡,김윤식,설인찬,Kim, Dong-Hyun,Lim, Seung-Min,Ahn, Jung-Jo,Jo, Hyun-Kyung,Yoo, Ho-Ryong,Kim, Yoon-Sik,Seol, In-Chan 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.3

Objective : This study was performed to investigate the effect of Sunhwangigagambang(SHG) on hyperlipidemia in SD rats induced by high cholesterol diet. Method : After treatment with SHG, cytotoxicity, body weight, liver weight, AST, ALT, ALP, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, glucose, albumin, total protein in serum, malondialdehyde, and gene expression for ACAT and HMG-CoA reductase in hepatic tissue were analyzed. Result : 1. SHG didn't show any cytotoxicity in both human fibroblast cell line and SD rats. 2. SHG significantly inhibited the increase of liver weight by high cholesterol diet compared to the control group. 3. SHG significantly ameliorated the increase of total cholesterol, LDL-cholesterol, and triglyceride and reduction of HDL-cholesterol compared to the control group. 4. SHG significantly reduced glucose level in serum compared to the control group. 5. SHG significantly reduced malondialdehyde in hepatic tissue compared to the control group. 6. SHG significantly down-regulated gene expression of ACAT and HMG-CoA reductase compared to the control group. Conclusion : These results suggest that SHG might be effective in treatment and prevention of hyperlipidemia.

대체 비상탈출 조건을 고려한 초음속 전투기용 캐노피 작동부 구조해석

김동현,김동만,김영우,양건명,Kim, Dong-Hyun,Kim, Dong-Man,Kim, Young-Woo,Yang, Jian-Ming 한국군사과학기술학회 2007 한국군사과학기술학회지 Vol.10 No.4

In this study, analysis of structural design criteria for the canopy actuating device has been conducted considering the aerodynamic breakaway capabilities of jettisonable canopy system. Unsteady aerodynamic loads for the opened canopy configuration at passively controlled jettision mode were computed using CFD method. The general purpose multi-body finite element code, SAMCEF Mecano, is used in the implemented analyses for the passive jettision condition. The recommended altitude and speed of aircraft was suggested as design criteria of aerodynamic breakaway capability of jettisonable canopy system as a bakup egress method when normal canopy jettison sequence malfunctioned. Aerodynamic breakaway condition of jettisonable canopy was also simulated and the fracture load conditions of canopy actuator were investigated.

느타리 버섯류 ( Pleurotus spp. ) 의 생화학적 방법에 의한 품종구분

김동현,공원식,김경수,김영호,유창현,김영배 ( Dong Hyun Kim,Won Sik Kong,Kyung Soo Kim,Young Ho Kim,Chang Hyun You,Young Bae Kim ) 한국균학회 1998 韓國菌學會誌 Vol.26 No.2

Aceclofenac 경구제제인 에이서정의 생물학적동등성에 관한 연구

김동현,신경수,손동렬,Kim, Dong-Hyun,Shin, Kyung-Sue,Sohn, Dong-Ryul 대한임상약리학회 2001 臨床藥理學會誌 Vol.9 No.2

Background : The bioavailability of a generic preparation of aceclofenac(Acer from Kyungdong Pharmaceutical Company) was evaluated in comparison with a proprietary product(Airtal from Daewoong Pharmaceutical Company). Methods : Sixteen healthy male volunteers participated in the study conducted according to a two-way crossover, open-labeled Latin square design. The bioavailability was compared using the parameters total area under the plasma concentration-time curve$(AUC_{0-{\infty}})$, peak plasma concentration$(C_{max})$ and time to reach peak plasma concentration$(T_{max})$. Results : No statiscally significant difference was observed between the values of the two products in all three parameters. Moreover, the 90% confidence interval for the ratio of the logarithmic-transformed $AUC_{0-{\infty}}\;and\;C_{max}$ values of Acer over those of Airtal was found to lie between 0.94-1.03 and 0.94-1.06, respectively, being within the acceptable bioequivalence limit of 0.80-1.25. Conclusion : These findings indicate that the two preparations are comparable in the extent and rate of absorption.

감기 치료 빈용 처방 구성 약물의 효능 연구

김동현,안현진,강순성,이범준,정승기,정희재,Kim, Dong-hyun,Ahn, Hyun-jin,Chiang, Shuen-cheng,Lee, Beom-joon,Jung, Sung-ki,Jung, Hee-jae 대한한방내과학회 2015 大韓韓方內科學會誌 Vol.36 No.3

Objectives: To investigate the anti-inflammatory, analgesic, anti-pyretic and anti-histamine activities of 20 herbal medicines to test their efficacy in common cold treatment. Methods: For all experiments, the herbal medicines were extracted with 80% ethanol and freeze-dried. To determine the anti-oxidative properties, we tested DPPH-free radical-scavenging activity and xanthine oxidase inhibitory activity. To determine anti-inflammatory and analgesic potential, we investigated acetic acid-induced vascular permeability and writhing test in ICR mice. For anti-pyretic activities, an LPS-induced pyrexia study was conducted in rabbits. To evaluate the anti-histamine activity, we examined compound 48/80-induced systemic anaphylaxis in ICR mice and the release of β-hexosaminidase on rat basophilic leukemia (RBL-2H3) cells. Results: Ephedrae herba, Forsythiae fructus, Cinnamomi ramulus, and Cimicifugae rhizome showed potent free-radical scavenging activities. Gentianae macrophyllae radix inhibited acetic acid-induced vascular permeability. Schizonepetae spica and Cimicifugae rhizome inhibited acetic acid. Cinnamomi ramulus and Angelicae decursivae radix inhibited LPS-induced pyrexia. Angeliace dahuricae radix and Asari radix inhibited compound 48/80. Scutellariae radix, Cinnamomi ramulus, Ephedrae herba, and Zingiberis rhizoma crudus potently inhibited the release of β-hexosaminidase. Conclusions: We examined the anti-inflammatory, analgesic, anti-pyretic and anti-histamine activities of 20 herbal medicines;We examined the anti-inflammatory, analgesic, anti-pyretic and anti-histamine activities of 20 herbal medicines Codonopsis pilosulae radix, Zingiberis rhizoma crudus, and Cinnamomi ramulus showed novel efficacy. These results suggest that some of herbal medicines may be very effective in treating common cold.

그린캠퍼스 운영체계에 대한 사례연구 - 미국 그린캠퍼스 지원기관 및 하버드대학을 중심으로 -

김동현,이현,전강은,김세용,Kim, Dong-Hyun,Lee, Hyun,Jeon, Kang-Eun,Kim, Sei-Yong 한국교육시설학회 2013 敎育施設 Vol.20 No.4

The concept of Green campus has recently become an issue with the fact that universities are classified as energy gluttons. This study clearly defines the meaning of domestic green campus, and explores the operating system of green campus and related associations. Then, it draws implications from the case of Harvard University. For the research, reports and research papers of the University are examined thoroughly, and detailed information were confirmed through visiting to the official home page and emails with authorities. The green campus support institutions of the United States are making efforts to integrate overlapping functions and create a synergy effect through internal interchange and information exchange, and substantive collaboration. Also, it is drawing active participation from students and faculties of American universities by publicizing and raising various methods of funding to manage them. The primary factors of Harvard University's success are: voluntary participation from all members, the coordinated operation of the administrative division to be the center of the green campus initiative and the cooperation of each department. Other critical factors of Harvard's success are their fundraising capability, and specialized management institution. The study has significance in that it draws applicable implications on domestic Green campus through in-depth analysis, which surpasses introduction of preceding studies.

일본뇌염 예방접종 후 면역원성 및 중화항체 지속률에 관한 조사: 전향적 다기관 코호트 연구

김동현,홍영진,이훈재,최보율,김창휘,박재옥,강진한,최병준,김종현,안영민,주영란,정영의,한명국,Kim, Dong Hyun,Hong, Young-Jin,Lee, Hoon-Jai,Choi, Bo-Yul,Kim, Chang Hwi,Park, Jae Ock,Kang, Jin Han,Choi, Byung Joon,Kim, Jong Hyun,Ahn, Young Min 대한소아감염학회 2013 Pediatric Infection and Vaccine Vol.20 No.3

목적: 일본뇌염 백신의 면역원성 및 중화항체 지속률을 평가하여 일본뇌염 예방 사업을 위한 토대를 제공하고자 하였다. 방법: 국내 6개 대학병원에 입원한 2-6세의 어린이 중 기초접종력이 확인된 170명을 대상으로 기초접종 완료 경과 기간에 따른 중화항체가를 조사하였다. 결과: 총 170명 중 불활성화 백신 접종군 103명, 생백신 접종군 64명, 교차접종군 3명이었다. 항체검사까지의 기간은 불활성화 백신 17.5개월, 생백신 21.0개월이었고 모두 일본뇌염 방어가 가능한 항체가를 보여 불활성화 백신 322, 생백신 266이었다. 추가접종 후 항체역가 변화는 1-4개월에 가장 높았고 이후 서서히 떨어지는 경향을 보였다. 결론: 불활성화 백신과 생백신의 면역원성과 중화항체 지속률에는 차이가 없고 두 백신 모두 일본뇌염 예방을 위한 적절한 수준의 면역원성을 갖고 있었다. 향후 대규모 표본을 대상으로 더 많은 연구가 필요하다. Purpose: This study aimed to study the antibody response of Japanese encephalitis vaccination in children using different kinds of vaccines (inactivated vaccine, live attenuated vaccine or interchanged) and evaluate the effectiveness of the vaccines to provide the basis of efficient immunization schedule of Japanese encephalitis. Methods: Measurement of the neutralization antibody (NTAb) titers following Japanese encephalitis vaccination using different vaccines for 170 children, 2-6 year of age, who visited six university hospitals and are confirmed by immunization records. Results: Among 170 children who were given primary immunization on Japanese encephalitis, 103 children were given inactivated vaccine, 64 children were given live attenuated vaccine and 3 children were given interchangeably. NTAb titers were more than 1:10 in all children of three groups. The geographic mean antibody titer was 322 in inactivated vaccine group and 266 in live attenuated vaccine group. However, there was no significant difference between two groups. In both groups, the NTAb titer showed the peak at 1-4 months after the third immunization and declined. The NTAb titers of three children who were given two kinds of vaccines alternately were 1:135, 1:632, and 1:2511, respectively. Conclusion: According to the results of this study in children younger than 6 years old, there is no significant difference in effectiveness between inactivated and live attenuated vaccines. However, further studies for the changes of antibody titers for a longer period of time on larger population are required.

ICT 기반의 인삼 공정 육묘 시 질소 형태와 게르마늄(Ge) 유무가 생장에 미치는 영향

김동현,김연복,구현정,백현진,이수빈,최지혜,홍의기,장광진,Dong Hyun, Kim,Yeon Bok, Kim,Hyun Jung, Koo,Hyun Jin, Baek,Su Bin, Lee,Jeei Hye, Choi,Eui Gi, Hong,Kwang Jin, Chang 국립한국농수산대학교 교육개발센터 2022 현장농업연구지 = Journal of practical agricultural resear Vol.24 No.4

Ginseng hydroponic cultivation was cultivated as a nutrient solution and the growth was investigated 60 days later. The length(cm) increased from EC1.0 and EC2.0 concentrations to 5.47cm before, followed by EC0.5, 2.5, 1.5, and 0.0. The weight(g) increased from EC1.0 concentration to 2.39g before, followed by EC1.5, 2.5, 0.5, 0.0 and 2.0. The width(mm) increased from EC1.0 concentration to 1.9mm than before, followed by EC2.5, 0.5, 1.5, 2.0, and 0.0. In the ginseng growth experiment according to nutritional components, the average length of NO₃-N mixed experiment increased to 0.33cm, the average weight of 0.04g, and the average width of 0.35mm. In the experiment in which NH₄-N was mixed without NO₃-N, the growth was reduced to 0.37cm in average length, 0.03g in average weight, and 0.22mm in average width. In an experiment in which germanium(Ge) is mixed with a nutrient component, the average length is increased to 0.33cm, the average weight is increased to 0.04g, and the average width is increased to 0.35mm, but in an experiment excluding germanium(Ge), the growth is reduced to 0.11cm, the average weight is 0.04g, and the average width is 0.03mm.

식용 식물자원으로부터 활성물질의 탐색 -XIII. 개망초(Erigeron annuus L.) 꽃으로부터 triterpenoid의 분리-

김동현,정성제,방명호,정인식,김성훈,권병목,김대근,박미현,백남인,Kim, Dong-Hyun,Jung, Sung-Je,Bang, Myun-Ho,Chung, In-Sik,Kim, Sung-Hoon,Kwon, Byoung-Mog,Kim, Dae-Keun,Park, Mi-Hyun,Baek, Nam-In 한국응용생명화학회 2004 Applied Biological Chemistry (Appl Biol Chem) Vol.47 No.4

개망초의 꽃을 80% MeOH 용액으로 추출하고, 추출물을 EtOAc, n-BuOH 및 물로 분배, 추출하였다. 이 중 EtOAc 분획을 silica gel, octadecylsilica gel(ODS) column chromatography 및 high performance liquid chromatography(HPLC)로 정제하여 3종의 화합물을 분리하였다. 각 화합물의 화학구조는 NMR, MS 및 IR 등의 스펙트럼 데이터를 해석하여, ${\alpha}-amyrenone(1),\;{\alpha}-amyrin(2)$ 및 ${\beta}-amyrin(3)$으로 동정하였다. 이들 3종의 triterpenoid는 개망초에서는 처음 분리되었다. The flower of Erigeron annuus L. was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and $H_2O$, successively. From the EtOAc fraction, three compounds were isolated through the repeated silica gel, ODS column and high performance liquid chromatographies. From the result of physico-chemical data including NMR, MS and IR, the chemical structures of the compounds were determined as ${\alpha}-amyrenone,\;{\alpha}-amyrin\;and\;{\beta}-amyrin$. These three compounds were isolated for the first time from the flower of Erigeron annuus L.

기업조직 내 소셜 미디어 서비스 활용의 가치 제고 및 활성화 방안

김동현,서현식,김형준,이봉규,Kim, Dong-Hyun,Seo, Hyun-Shik,Kim, Hyung-Joon,Lee, Bong-Gyou 한국정보처리학회 2011 정보처리학회논문지D Vol.18 No.4

본 연구의 목적은 조직 내 소셜 미디어를 활용하여 기업의 성과에 도움이 되는 방안을 찾고자 함에 있다. 최근 들어 기업들도 소셜 미디어를 다양한 분야에 활용하는 방안을 모색하고 있음에도 이에 대한 연구는 극히 미흡한 실정이다. 이에 본 연구는 소셜 미디어 서비스 사용자 간의 커뮤니케이션이 증가하게 되면 다양한 인간관계 형성 및 확장이 발생되고, 이것은 다시 정보공유, 자아추구, 사회참여, 유희(오락) 등의 성과로 이어지는 연구모형을 설정하였다. 연구의 효과를 극대화하기위해 연구대상을 소셜 미디어 서비스를 이용하는 직장인과 비직장인들로 분류하여 조사 및 분석하였다. 연구 결과, 직장인들은 모르는 사람들과 지식을 공유한 후, 습득된 지식을 바탕으로 자신의 이미지를 지인들에게 어필하는 것으로 나타났다. 또한, 소셜 미디어 기능에 유희(오락)성을 포함시키면 조직 내 소셜 미디어의 사용이 활성화되어 경영참여로 이어질 수 있는 것으로 분석되었다. 본 연구는 향후 조직 내 소셜 미디어 서비스를 활용할 경우 유용한 가이드라인으로 사용될 수 있을 것이다. The purpose of this study is to find the beneficial plan for business success by the advantage of social media service in the business organization. There is few research for applying social media on a variety of fields in business organization although many companies are trying to find the way for its application. Hence, this study identifies the possibility for the utilization of social media services, and it also finds the plan for their effective application. The social relationship is created by increasing communications between users of social media service. The research model is established on the basis of the hypothesis that the social relationship affects knowledge share, pursuit of ego, social participation, amusement. To maximize the impact of results, the research was conducted on the basis of the target on two groups including the business men and non-business men who use social media services. As results of the research, the business men tend to appeal their impression based on sharing knowledge with anonymous people. Also, it is necessary to make a social participation to a management participation, and to utilize the social media in the organization by including amusement to its function. This research is expected to have significant implication to companies which wants to apply social media services in the future.