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The vaccine is biological pretreatment that improves immunity to a particular disease. We can get immunity from producing antibody with injection antigen which has ability to defense against the disease. The ELISA is the most widely used method to measure antibody titer. We have developed and performed validation of ELISA according to the guideline of KFDA and ICH. In this paper, we have verified ELISA method is an excellent method to measure the titer of anti-PA antibody. We have constructed recombinant protective antigen among anthrax toxins and used as antigen of ELISA. In this validation, we have evaluated precision (repeatability, interlaboratory precision), specificity, linearity(range) and LOD, which are validation articles suggested by guideline. Inter-person precision was replaced with inter-laboratory precision. From the results, we have confirmed high precision in all experiments with CV under 20%.
This paper is a part of developing a computer code that can be used to generate IR images of a naval ship by considering the emitted and reflected infrared signals. The spectral radiance received by an IR sensor is consisted of the self-emitted component from the ship surface, the reflected component of the solar/sky irradiance at the ship surface, the emitted radiance from the ship surface and the exhaust plume gas, and the scattered radiance by the atmosphere. The plume gas radiance occupies a large part of the emitted radiance from a naval ship in operation. Therefore plume gas radiance must be taken into account when calculating the radiance from a naval ship for reliable IR images. In this paper, IR images of a naval ship with the exhaust gas effect in various environmental conditions are generated by using an exhaust gas prediction model called the JPL model. The contrast radiance (CR) values of the IR images are calculated to analyze the effect of the exhaust gas radiance quantitatively. The results obtained by quantitative analysis show that the IR signatures with the exhaust plume gas are 2.26 times larger than those neglecting the plume gas effect. The effect of the exhaust plume gas is shown to be more eminent in winter than in summer in the daytime.
This research is to develop a simulation framework to gauge the mission effectiveness of the rotorcraft system that will be a part of Korean future combat system. The rotorcraft system comprises of many subsystems that are very time-consuming and tedious to model. Each subsystem and its characteristics have been modeled using component-based modeling techniques, which enhances its reusability. The entire system is then constructed from the individually modeled component, which significantly reduces the modelling time. The mission effectiveness of the rotorcraft system is simulated using the developed models, and the output indicates that the methodology proposed in this study is useful, which will be suitable for the modeling and simulation of Korean future combat system.
This paper presented here contains development of variable stability system(VSS) control laws for the KIFS (Korean In-Flight Simulator) aircraft to simulate the dynamics of F-16 aircraft. Development of VSS Control law for pitch rate, roll rate, yaw rate simulation for three specified flight conditions using Model Following Technique with rate feedback autopilot for stability provision. The direct lift force controller was also added to the developed VSS control law to simulate the pitch rate and normal g-load simultaneously. The simulation results show high accuracy of F-16 aircraft's pitch, roll, yaw rate and g-load simulation.
For effective development in consideration of the maintainability of the weapon system, it is necessary to understand whether the maintainability design requirements are satisfied at the early phase of development. This requires the application of an early design phase maintainability prediction process to provide opportunities for improvement. By defining the ambiguity group definition, fault isolation level, fault isolation probability, and countermeasures for faults, it was possible to predict early phase development. The MTTR of the initial design phase applying Procedure V to the artillery system was 3.46H, which is about 16 % higher than 2.98H, the MTTR using Procedure II. This is a result of system design ambiguity that has not been specified in the early phase of development.
The counter-fire operation system performs its mission exchanging information with other related systems such as command & control systems and military information systems. In the process of exchanging information, the counter-fire operation system uses a type of data message which contains exchange data information in the format of KMTF. The requirement of data exchange of count-fire operation will continue to evolve. But the EDX(External Data eXchange) configuration item of the current counter-fire operation system can not effectively cope with the variation of data exchange requirements due to its fixed software structure. In the paper, a solution for improving flexibility of external data exchange in counter-fire operation system is proposed.
The low-altitude PAC-2 Patriot missile system is the backbone of ROK air defense for intercepting enemy aircraft. Currently there is no missile interceptor which can defend against the relatively high velocity ballistic missile from North Korea which may carry nuclear, biological or chemical warheads. For ballistic missile defense, Korea's air defense systems are being evaluated. In attempting to intercept ballistic missiles at high altitude the most effective means is through a multi-layered missile defense system. The missile defense problem has been studied considering a single interception system or any additional capability. In this study, we seek to establish a mathematical model that's available for multi-layered missile defense and minimize total interception fail probability and proposes a solution based on genetic algorithms. We perform computational tests to evaluate the relative speed and solution of our GA algorithm in comparison with the commercial optimization tool GAMS.
This paper describes the wireless communication test environment for the Link-K system and shows the performance analysis of multiple access protocols. The test environment consists of data generator, modem, radio sets, attenuators, and antennas. In case of both CSMA and Roll-Call protocols, throughput performance and delay are measured. And test results are analyzed. The test results would be used for communication performance analysis and network design of Link-K system.
It is obvious that understanding the effects of shallow water environment of Korea is very important to guarantee the optimal performance of active sonar such as monostatic and bistatic sonar. For this reason, in this paper, we analyzed the detection performance characteristics for various depth deployments of sonar in summer, winter and water temperature inversion environments, which environments are frequently observed in shallow water of Korea such as the Yellow sea. To analyze only effects of water temperature structures on target detection performance, we applied range independent conditions for bottom, sea surface and water temperature characteristics. To understand the characteristics of detection performance, we conducted transmission loss and signal excess modeling. From the results, we were able to confirm the characteristics of detection performance of active sonar. In addition, we verified that operation depth of transmitter and receiver affects the detection performance. Especially in the water temperature inversion environment, it was confirmed that the shadow zone could be minimized and the detection range could be increased through bistatic operation.
In this paper, we analyze the standards of the bolts for maintaining the products. The maintainer don't know the detail information of bolts by seeing the shape of bolts when they repair the products. So they waste much time and cost. To solve the these problem, we propose the new systematical discrimination of bolts. To propose the discrimination code, we divide the shapes of the bolts into four classes(head, internal drive, shank and end). User can fine preferentially similar standards by just the shapes of bolts under the this discrimination code. And, User can find the standards of bolts that they want by using the additional information such as measurements. We will reduce the cost and time for the maintaining the products by using the proposed discrimination code.