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최병준,I-Wei Chen 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.12
The switching time-voltage dependence of electronic resistive switching was studied for understanding the switching dynamics in Pt-dispersed SiO2 thin film devices. Trapezoidal voltage pulses with opposite polarities were consecutively introduced and thereby transient on-switching and offswitching were examined. A prior on-switching voltage determines the off-switching voltage regardless of the sweeping rate of the pulse for the prior on-switching. However, the off-switching voltage was sensitive to the sweeping rate of the subsequent pulses for off-switching. The frequencydependent impedance of both the device and the surrounding circuit element are thought to result in the variation of the off-switching voltage; otherwise, the switching voltage is independent of time.
쥐의 시각피질절편에서 Pilocarpine으로 유도된 경련파 형성에 칼륨, Bicuculline 및 CNQX가 미치는 영향
최병준,김영인 대한신경과학회 2006 대한신경과학회지 Vol.24 No.6
Background: The purpose of this study was to investigate the effect of potassium, bicuculline (BIC) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) on epileptiform activity induced by pilocarpine in the rat visual cortex slices. Methods: In the rat visual cortex slices, we observed the change of pilocarpine-induced epileptiform discharges using extracellular recordings during perfusion of artificial cerebro-spinal fluid (ACSF) with various potassium concentrations ([K+], 2.5, 5, 7.5 and 10 mM) and ACSF with 10 μM BIC and 20 μM CNQX under 7.5 mM [K+]. Results: Spontaneous interictal epileptiform activity induced by pilocarpine was observed in 5 mM or higher [K+] and ictal discharge was only detected in 7.5 mM [K+]. Increase of [K+] from 2.5 to 7.5 mM not only resulted in the increase of frequency and amplitude of epileptiform activity but also favored the transformation of pilocarpine-induced interictal activity into ictal activity in the rat visual cortex. However, in 10 mM [K+], the ictal discharge was unprovoked and interictal activity was provoked with decreased frequency and amplitude. The spontaneous ictal discharge was blocked but interictal activity was maintained with increased frequency and amplitude by BIC. Interictal and ictal activities were completely blocked by CNQX. Conclusions: These results suggested that the extracellular potassium concentration, GABA system, and non- NMDA mechanism seemed to be involved in the development and maintenance of pilocarpine-induced epileptiform activity in the rat visual cortex.