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腦性麻痺로 因한 Swan-neck Deformity와 Thumb in Palm Deformity의 治驗 1例
白南仁,金德永,邊永壽,李弘鍵 최신의학사 1977 最新醫學 Vol.20 No.5
There is a small group of patients with cerebral palsy who can be benefited by reconstructive surgery on the upper extremity. In cerebral palsy long standing muscle imbalance, which can be improved only by surgical treatment, may prevent a hand from reaching its full potential for function. This case is a 18 yrs old girl had a flexed wrist, swan neck deformity of the fingers and a clasped thumb. She was treated by surgical measure of the tenodesis of the flexor sublimis tendon at the proximal interphalangeal joints of the index; transference of flexor carpi radialis to abductor pollicis brevis: and myotomy of adductor pollicis. We obtained very good result without other complication.
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식용식물자원으로부터 활성물질의 탐색-XXII. 사자발쑥 (Artemisia princeps PAMPANINI)의 지상부로부터 Triterpenoid의 분리
백남인,방면호,조진경,송명종,이대영,한민우,정해곤,정태숙,이경태,최명숙 한국응용생명화학회 2008 Journal of Applied Biological Chemistry (J. Appl. Vol.51 No.3
The aerial parts of Sajabalssuk (Artemisia princeps PAMPANINI, Sajabalssuk) was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H2O, successively. From the EtOAc fraction, three cycloartane-type triterpnoids and one ursanetype triterpenoid were isolated through the repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the results of physico-chemical data including NMR, MS and IR, the chemical structures of the triterpenoids were determined as wrightial (1), wrightial acetate (2), 27- norcycloart-20(21)-ene-25-al-3β-ol acetate (3) and ursolic acid (4). No report has been found for isolation of compound 3 in the literature so far, and compounds 1, 2 and 3 were the first to be isolated from Sajabalssuk (Artemisia princeps PAMPANINI, Sajabalssuk). Also, compound 1 showed Acyl-CoA:Cholesterol acyltransferase (hACAT-1) and hACAT-2 inhibitory activity with the IC50 values of 33.0 and 45.0 μg/ml, respectively. Compounds 2 and 3 inhibited hACAT-1 activity with the IC50 values of 12.0 and 16.0 μg/ml, respectively. The aerial parts of Sajabalssuk (Artemisia princeps PAMPANINI, Sajabalssuk) was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H2O, successively. From the EtOAc fraction, three cycloartane-type triterpnoids and one ursanetype triterpenoid were isolated through the repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the results of physico-chemical data including NMR, MS and IR, the chemical structures of the triterpenoids were determined as wrightial (1), wrightial acetate (2), 27- norcycloart-20(21)-ene-25-al-3β-ol acetate (3) and ursolic acid (4). No report has been found for isolation of compound 3 in the literature so far, and compounds 1, 2 and 3 were the first to be isolated from Sajabalssuk (Artemisia princeps PAMPANINI, Sajabalssuk). Also, compound 1 showed Acyl-CoA:Cholesterol acyltransferase (hACAT-1) and hACAT-2 inhibitory activity with the IC50 values of 33.0 and 45.0 μg/ml, respectively. Compounds 2 and 3 inhibited hACAT-1 activity with the IC50 values of 12.0 and 16.0 μg/ml, respectively.
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작약(Paeonia lactiflora) 뿌리로부터 항산화활성 물질의 분리
백남인,박남규,방면호,이상양,송정춘 한국농화학회 1999 Applied Biological Chemistry (Appl Biol Chem) Vol.42 No.2
On the purpose of development of novel antioxidative compounds from natural sources, 38 plants expected to show antioxidant activity have been examined concerning DPPH radical scavenging activity. Among them, thirteen plants, including Paeoniae radix, the root of Paeonia lactiflora, exhibited the activity. In order to isolate active component, the root was extracted in 80% aqueous MeOH and solvent fractionated with EtOAc, n-BuOH and water, successively. Silica gel column chromatographies of the EtOAc and n-BuOH fraction exhibiting antioxidant activity. were repeatedly carried out with monitoring by DPPH assay to afford three active compounds. On the basis of spectral data and the chemical characteristics, the structures of the compounds were determined as (+)-catechin, 1,2,3,4-tetragalloyl-6-digalloyl-β-D-glucose and 1,2,3,4,6-penta-galloyl-β-D-glucose.
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白南仁,邊永壽 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.1
The post-traumatic deformity resulting from the injury of the epiphyseal plate in the growing child is the matter of the great disaster in the orthopedic field and the prevention of those deformities is the important task for orthopedic surgeons. Several experimental studies on pathophysiology of bone bridge formation after growth plate injury have been reported but the prevention of ti has been controversial. To observe bone bridge formation after surgical manipulation for the injury of growing epiphyseal plated, forty-five rabbits weighing 700-1,000gm were divided into following 3 groups each group comprising of 15 rabbits. Group Ⅰ : Injuries to the epiphyseal plate with Kirschner wire. Group Ⅱ : Transplantation of autogenous fat tissue into the defect of the injured epiphyseal plate produced by K-wire. Group Ⅲ : Interposition of medical silicone rubber implant into the defect of the injured epiphyseal plate produced by K-wire. The animals were sacrificed at 2,4,6,8 and 12 weeks after the experimental procedures and the histological examination of the injured epiphyseal plated of distal femur were made. The results obtained are as follows: 1. In group Ⅰ, all fifteen cases started to form new osseous tissue from the fourth week, all of which developed to bone-bridge at the twelfth week between the metaphysis and the epiphysis. 2. In group Ⅱ, transplanted fat tissue was mostly necrotized at the second week which was replaced with fibrous tissue between the second to the twlfth week. And the bone bridge was observed one case each at the fourth, sixth, and eighth week and two cases at the twelfth week. 3. In group Ⅲ, thirteen out of fifteen cases did not from bone bridge up to the twelfth week. and only thin bone bridge was observed on case each at the eighth and twelfth week. 4. Prevention of bone bridge formation was ten out of fifteen cases (66.7%) in group Ⅱ and thirteen out of fifteen cases (86.7%) in group Ⅲ. The above mentioned results clearly show that implant of the medical silicone rubber is better than autogenous fat tissue in preventing the bone bridge formation across the traumatized epiphyseal plate.
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