한베이식 언어 설계 및 명령어 처리에 관한 연구

元裕憲,林海喆,朴道淳 弘益大學校 1983 弘大論叢 Vol.15 No.2

This papaer presents the design of programming language, named HAN-BASIC(HANgul BASIC), which is especially devised for the personal computer users who can't even understand English. This language gives the ability of programming with Korean language, permitting English variable names. In order to respond in real time, HAN-BASIC reserved-words is parrsed using hashing and finite automata method.

객체지향형 교육용프로그래밍언어 두리틀의 다중 예약어 지원 체계

최해심,권대용,김형신,염용철,유승욱,이원규 한국컴퓨터교육학회 2005 컴퓨터교육학회 논문지 Vol.8 No.2

산업보건관리자를 위한 소음성 난청 예방지침서의 개발

이원철,유경혜,장성실,이세훈,구정완,김현욱,노영만,이경재,김형아 가톨릭 대학 산업의학 쎈타 산업의학연구소 1996 韓國의 産業醫學 Vol.35 No.1

Occupational hearing loss became the leading occupational disease by constioution 56% of all work-related diseases in Korea. However, the prevalance rates showed wide variations among the specific medical examination providers and were very low(0.8-1.4%) compared with those 8.4% in Japan. The sources of these variations was regarded in the preview study as 1) Employee audometric estings were primarily conducted by nurses and nurse-aids who had no formal training for audiometry; 2) althought audiometric testing equipment used by the spedific medical examination providers, it should be periodically calibrated, a significant number of them were not properly calibrated : 3) Initial audiometric testings were conducted at any available spaces in workplace or at the testing room without considering bachground noise level. One of solutions that can be done for sloving surrent noise related problems is to provide a noise related manual for the occupational health managers including doctors, nurses and hyginests. This study was done to provide such a manual. The main core of the manual was hearing conservation program. And the contents of the manual was the same as the main frame of hearing conservation program such as noise survey, provided of the diagram showing the core contents of each factor of the hearing conservation program. Hopefully, this manual will be the references of the standardized performances of the specific medical examination providers.

cis-platin에 의한 급성구토예방의 Dexamethasone의 4가지 정주량의 비교

김원,강지은,서영선,이동민,서정균,신병철,정기영,박유환,정춘해 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

B5-hydroxytryptamine _3수용체(5-HT_3) 길항제와 dexamethasone의 동시투여가 cis-platin에 의한 급성 구토를 막는데 가장 효과적이다. 그러나 현재까지 가장 적절한 정주dexamethasone의 용량이 알려져 있지 않았다. 이에 dexamethasone의 4가지 다른 용량을 투여하여 그 효과를 비교하였다. 환자는 임의 추출되어 cis-platin 투여 45분전에 15분 동안 정주로 각각 dexamethasone 5, 10, 15, 20 mg을 투여 받았다. cis-platin 투여 30분전에는 ondansetron 8 mg이 부가하여 정주 되었다. 1999년 3월부터 2000년 2월까지 54명의 환자가 연구에 등록되어졌고 53명의 환자가 연구 대상으로 실험에 4군 (dexamethasone 5 mg 13명, 10 mg 14명, 15 mg 13명, 20 mg 13명)으로 나뉘어 평가 되어졌다. 급성구토와 구역질의 완전한 예방은 dexamethasone 5 mg을 투여 받은 환자에서 각각 69.2%, 60.9%, dexamethasone 10 mg을 투여 환자에서 69.1%, 61%, dexamethasone 15 mg 투여 환자에서 78.5%, 66.9%, dexamethasone 20 mg을 투여 환자에서 83.2%, 71.0%로 나타났다. 구토로부터 완전한 예방은 dexamethasone 20 mg을 투여 환자에서 5, 10 mg을 투여 환자와 비교하여 높았고, dexamethasone 15 mg을 투여 군에 비교하여서는 약간 우수한 효과만 있었다. 구역질으로부터의 완전한 예방도 월등한 것은 아닐지라도 20 mg을 받은 환자에서 높았다. 항 구토 치료는 특별한 불편 없이 조절되었고, 부작용의 발생에서 4가지그룹간에는 커다란 차이가 발견되지 않았다. Dexamethasone의 20 mg 정주양이 cis-platin으로 인한 급성구토를 예방하는데 가장 효과적인 예방량으로 사료되어진다. Background and objective: A 5-hydroxytryptamine _3(5-HT_3) receptor antagonist plus dexamethasone is the most efficacious antiemetic prophylactic treatment for the prevention of cis-platin induced acute emesis, but the optimal intraveous (Ⅳ) dose of dexamethasone is unknown. This prompted us to perform a randomized, double-blind, dose-finding study that compared four different doses of dexamethasone. Materials and Methods: Patients were randomized to receive dexamethasone, either 5, 10, 15, 20 mg, administered by 15-minute Ⅳ infusion 45 minutes before cis-platin. Ondansetron 8 mg was added to dexamethasone and was administered Ⅳ 30 minutes before cis-platin. From March 1999 to February 2000, 54 patients were enrolled onto the study and 53 were assessable according to the intention-to-treat principle (13 patients received 5 mg; 14 patients, 10 mg; 13 patients, 15 mg and 13 patients, 20 mg of dexamethasone). Results: Complete protection from acute vomiting and nausea was achieved by 69.2% and 60.9% of patients, respectively, who received 5 mg of dexamethasone, by 69.1% and 61.0% of those who received 10 mg, by 78.5% and 66.9% of those who received 15 mg, and by 83.2% and 71.0% of those who received 20 mg of dexamethasone. Complete protection from vomiting was significantly superior in patients who received 20 mg compared with those who received 5 and 10 mg of dexamethasone (P<05) and was superior, but not significantly, compared with those who received 15mg. Complete protection from nausea was superior, but not significantly, in patients who received 20 mg of dekamethasone. Multifactorial analysis confirmed these results. Antiemetic treatment was well tolerated, and no significant difference was found among the four groups in the incidence of adverse events. Conclusion: A 20mg single Ⅳ dose of dexamethasone should be considered the most efficacious prophylactic dose for the prevention of ois-platin induced acute amesis in treatment of cancer.

PTT단위를 갖는 액정중합체의 합성 및 블렌드

김원,최유성,이태양,최재곤,홍완해,조병욱 조선대학교 생산기술연구소 2003 生産技術硏究 Vol.25 No.1

This study explores the potential of improving the physical properties of poly(trimethylene terephthalate) (PTT) by inducing thermotropic liquid crystalline polymers. The TLCP was synthesized by polycondensation reaction of terephthaloyl chloride with corresponding diols. The TLCP used was copolymers containing random PTT groups on the polymer backbone. The PTT moieties were used to increse compatibility between the PTT and the TLCP. The TLCP showed the nematic phase above those melting temperature(T_m) The TLCP seems to act as plasticizers and nucleating agents in the matrix polymers Liquid crystalline phase did not reaveal any significant macrophase separation and thermal degradaton under the temperature of processing condition.

마산연안지역의 국지풍 순환 및 대기오염물질 확산에 관한 연구

김유근,이화운,문윤섭,김해동,원경미,정우식,오인보 부산대학교 환경문제연구소 1997 環境硏究報 Vol.15 No.1

To investigate a horizontal windrose and the mixing height in Masan coastal area, a local atmospheric flow and the concentration of air pollutants were analyzed by abserved data from AWS, airsonde and air sampler. The land-sea breeze model and the ISCST2 model of U. S. EPA(Environmental Protection Agency) were used to predict the concentration of air pollutants such as SO2 and TSP. As a result, during spring the principal wind direction in the Masan region is mainly represented by windrose of the WNW and NW, which can be induced by land breeze and the SE and SSW of sea breeze even if weak wind speed. The mixing height during the measurement was marked with the range from 400 m(0900 LST) to 1450 m(1500 LST), and the height of an inverse layer was presented as the range from 30 m(2100 LST) to 150 m(0300 LST). It is very important to cosider the local wind field for the accurate diffusion and movement of air pollutants in coastal urban area. The atmospheric flow was simulated by the two-dimensional local wind model upon considering the orographic characteristics such as land-sea contrast, mountain valley and urban building. The result of air quality simulated by ISCST2 support that the dispersion pattern of the pollutants in that area was followed as local circulation system in coastal urban area.

참돌꽃 근경의 항산화작용

류광열,강원식,김영호,장해동,홍진태,유환수,윤여표 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

The purpose of this study was to determine the antioxidative effects of Rhodiola sachalinensis Rhodiola methanol extract was fractionated sequentially with dichloromethane and butanol. Each Rhodiola fraction (water, MeOH, BuOH and CH_2Cl_2 fractions) showed the potent superoxide dismutase (SOD) activity, and had inhibitory effets on peroxide value of linoleic acid (40~57%) and lipid peroxidation (47~70%) in FE^2+/ascorbate system-induced rat liver microsome. Rhodiola methanol extract also recovered carbon tetrachloride-induced decrease in SOD by 42% and catalase activities by 50%, and had inhibitory effects (54%) on carbon tetrachloride-induced lipid peroxidation in rat liver microsome. These results suggest that Rhodiola sachalinensis has the antioxidative effects.

진행성 골화성 섬유 이형성증의 1예

임태영,조영신,정춘해,박유환,하상호,유재원 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

진행성 골화성 섬유 이형성증은 2 백만명 중에 1명 발생하는 매우 드문 유전질환이다. 저자들은 2차례의 외상후 심해진 진행성 섬유 이형성증환자에서 최근 다시 발생된 외상후 생긴 병변부위에 biphosphonate와 steroid 투여로 최근수상부위의 근육 골화와 경화를 현저한 호전을 보였으나, 기존의 골화가 이미 진행된 병변에서는 잘 반응하지 않음을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Fibrodysplasia ossificans progressiva(FOP) is an extremely rare hereditary disorder characterised by progressive heterotopic ossification of the soft tissue. The resulting progressive immobilization of the limbs, jaw and chest wall generally leads to severe disability. We present an 20-rear-old man with advanced FOP. He had two operative interventions by prior traffic accident and recent biopsy. It resulted abnormal ossification. Treatment for this disorder is avoidance of exacerbating factors and medical strategies is biphosphonate and steroid. We observed the course of ossification and muscle atrophy during biphosphonate and steroid therapy in advanced FOP.

Two-dimensional shear wave elastography for assessing liver fibrosis in patients with chronic liver disease: a prospective cohort study

( Hae Won Yoo ),( Sang Gyune Kim ),( Jae Young Jang ),( Jeong-ju Yoo ),( Soung Won Jeong ),( Young Seok Kim ),( Boo Sung Kim ) 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.2

Background/Aims: The objective of this study was to determine whether the newly developed two-dimensional shear wave elastography (2D-SWE, RS85, Samsung-shearwave imaging) was more valid and reliable than transient elastography (TE) for predicting the stage of liver fibrosis. Methods: The study prospectively enrolled a total of 116 patients with chronic liver disease who underwent 2D-SWE, TE, laboratory testing, and liver biopsy on the same day from two tertiary care hospitals. One patient with unreliable measurement was excluded. The measurement of 2D-SWE was considered acceptable when a homogenous color pattern in a region of interest of at least 10 mm was detected at 10 different sites. Diagnostic performance was calculated using area under the receiver operating characteristic curve (AUROC). Results: Liver fibrosis stages included F0 (18%), F1 (19%), F2 (24%), F3 (22%), and F4 (17%). Interclass correlation coefficient for inter-observer agreement in 2D-SWE was 0.994 (95% confidence interval [CI], 0.988 to 0.997). Overall, the results of 2D-SWE and stages of histological fibrosis were significantly correlated (r = 0.601, p < 0.001). For The 2D-SWE showed good diagnostic ability (AUROC, 0.851; 95% CI, 0.773 to 0.911) comparable to TE (AUROC, 0.859; 95% CI, 0.781 to 0.916) for the diagnosis of significant fibrosis (≥ F2), and the cut-off value was 5.8 kPa. AUROC and optimal cut-off of 2D-SWE for the diagnosis of liver cirrhosis were 0.889 (95% CI, 0.817 to 0.940) and 9.6 kPa, respectively. TE showed similar diagnostic performance in distinguishing cirrhosis (AUROC, 0.938; 95% CI, 0.877 to 0.974; p = 0.08). Conclusions: 2D-SWE is comparable to TE in diagnosing significant fibrosis and liver cirrhosis with high reliability.

The Prediction of Liver Decompensation Using Hepatic Collagen Deposition Assessed by Computer-Assisted Image Analysis with Masson-Trichrome Stain

( Hae Won Yoo ),( Jae Woo Park ),( Jeong-ju Yoo ),( Sang-gyune Kim ),( Young Seok Kim ),( Young Chang ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Hong Soo Kim ),( Baekgyu Jun ),( Young 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: METAVIR staging classifies structural deformation caused by hepatic fibrosis semi-quantitatively. However, there could be disagreement of fibrosis staging by METAVIR among pathologists. Quantification of fibrosis using computer-assisted image analysis can offer relative objective information for liver fibrosis. We measured hepatic fibrosis quantitatively using collagen proportionate area (CPA) and assessed its impact on predicting the development of liver decompensation (which was defined as the presence of ascites, variceal bleeding and hepatic encephalopathy). Methods: During January 2010 to June 2018, we assessed 582 patients who got liver biopsy and computer assisted image analysis (ZEN 2.3 lite software by ZEISS) were available. Clinical and laboratory data were collected at baseline and at the time of the last follow-up or progression to liver decompensation (LD). Forty-two patients with acute hepatitis who had no underlying chronic liver disease were excluded. Results: The mean age was 45.3±13.7 years, and most common etiology of liver disease was chronic hepatitis B (28.6%) and followed by fatty liver disease (26.9%). Median follow-up duration was 37 months during which 28 out of 540 patients experienced LD. Mean analyzed dimension of collagen was 5653362±2423925 μm2 and included portal tract was 8.9±3.9. Mean CPA was 8.91±7.10%. A positive correlation between CPA and liver fibrosis stage was observed (r=0.553, P<0.001) (Figure 1). Albumin at baseline (HR: 0.257, 95% CI: 0.094- 0.701, P=0.008), CPA (HR: 1.107 per 1% increase, 95% CI: 1.059-1.157, P<0.001), presence of diabetes mellitus (HR: 4.315, 95% CI: 1.063-17.510, P=0.041), and presence of alcoholic hepatitis (reference : chronic hepatitis B) (HR : 5.811, CI : 1.351-24.987, P=0.018) were independent predictors of liver decompensation on multivariate Cox-regression analysis. The concordance indices of CPA and METAVIR stage for progression to LD were 0.803±0.044 and 0.758±0.041, respectively, without significant difference. When dividing patients with calculating cut-point with maximally selected rank difference, higher CPA (≥16.6%) predicts LD better than lower CPA (Logrank test: P<0.001) (Figure 2). Conclusions: The CPA correlates very well with the METAVIR stage of liver fibrosis and also is an independent predictor of clinical outcomes in liver disease. It is expected to be useful quantitative determination of liver fibrosis and prognosis.