http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
랫드에서 l-muscone의 급성독성 및 아급성독성시험 연구
오승민,연제덕,남혜운,박대규,조명행,정규혁 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
l-Muscone is synthesized for use as substitutive material of musk which is the active ingredient of woohwangchungsimwon. The objective of this investigation was to evaluate the acute and subacute toxicity of l-muscone in rats. In oral acute toxicity test, SPF Sprague-Dawley male and female rats were gavaged with l-muscone of two doses(0, 5.0g/㎏). No dead animal and abnormal autopsy findings were found in control and treated group. Body weights were slightly decreased in both sexes of rats treated with 5.0g/㎏. Therefore, oral LD_50 of l-muscone was consider to be higher than 5.0g/㎏ in male and female rats. In intraperitoneal acute toxicity test, rats were injected intraperitoneally with dosages of 0, 1,000, 1,316, 1,732, 2,279 and 3,000 ㎎/㎏. Decreased body weights and motor activities were observed at high dose group. Intraperitoneal LD_50 of l-muscone were 1,920 ㎎/㎏ in male and female rats. In the subacute study. l-muscone was administrated orally to both sexes of rats for 4 weeks as several doses(0, 10, 100 and 1,000 ㎎/㎏). There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, hematology, serum biochemical analysis, and other findings. Above data suggest that no observed adverse effect level of l-muscone in rats might be over 1,000 ㎎/㎏/day in this study.
오염된 토양으로부터 분리된 세균에 이한 2,4-Dinitrotoluene과 2,6-Dinitrotoluene의 생물학적 제거
오계현,조윤석,이명석 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.2
Dinitrotoluenes (e.g., 2.,4-Dinitrotoluene and 2,6-Dinitrotoluene) are the major impurity resulting from the manufacture of 2,4,6-trinitrotoluene(TNT) and are primary starting materials for the synthesis of toluenediisocyanate which are used in the production of polyurethane foam. Both 2,4-DNT(2,4-dinitro- toluene) and 2,6-DNT(2,6-dinitrotoluene) are recalcitrant and have been shown to be toxic to aquatic and terrestrial organisms in the environment. Because little information is available for the biological degradation of DNTs, they have has not been evaluated for the possible treatment processes of industrial waste streams where DNTs may represent a serious disposal problem. In the present work, we explored the feasibility using a bacterium for DNTs degradation, with the ultimate aim of application for the industrial treatment. A DNTs-degrading bacterium was isolated from soil samples collected from an explosive contaminated area. Complete degradation of 2,4-DNT at the initial concentration of 50 ㎎ 2,4-DNT per liter was achieved within 10 days of incubation in bench-scale bioreactors, whereas 2,6-DNT degraded completely within 14 days under the same conditions, respectively. The bacterium was able to utilize DNTs as the sole nitrogen source. Co-substrate was essential for the bacterial growth and DNTs degradation in the medium. Neither bacterial growth nor DNTs degradation were observed in the absence of co-substrate. The detection of the parent substrates and their intermediates were based on HPLC and GC-MS methodology.
오승민,남혜윤,김준수,연제덕,신대희,이진영,박대규,조명행,정규혁 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
The acute and subacute toxicity of New Woohwangchungsimwon(NWCH) which was used l-muscone as substitutive material of musk were investigated in S.D. rats. In intraperitoneal acute toxicity test, rats(Sprague-Dawley, SPF) were injected intraperitoneally with dosages of 0, 540, 750, 1,070, 1,500 and 3,000 ㎎/㎏. Body weights were significantly decreased at 540 ㎎/㎏ dose group in both sexes and abnormal autopsy findings were founded in both sexes at all treated groups. Intraperitoneal LD_50 of NWCH was 812.3 ㎎/㎏ in male and 872.3 ㎎/㎏ in female rats. In the subacute toxicity study, NWCH was administrated orally to both sexes of rats for 4 weeks as several doses(0, 320, 800 and 2,000 ㎎/㎏). There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, hematology, serum biochemical analysis, and other findings. Above data strongly suggest that no observed adverse effect level of NWCH might be over 2,000 ㎎/㎏/day in this study.
TNT-분해세균인 Stenotrophomonas maltophilia에 의한 s-Triazine계 제초제인 Atrazine의 미생물학적 분해
오계헌,조윤석,이명석 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.2
The agricultural use and relative persistence of s-triazine herbicide such as atrazine have led to increasing concern about environmental contamination. Stenotrophomonas maltophilia capable of utilizing TNT as sole nitrogen source has been isolated from contaminated soils and the bacterium showed excellent degradability for several-triazine herbicides including atrazine. Complete depletion of atrazine was achieved within 30 hours of incubation. Atrazine was catabolized in the presence of different supplemented carbons. Among the co-substrates used in this experiment (e.g., glucose, fructose, starch, succinate, acetate), fructose was the best co-substrate. However, no atrazine degradation was monitored without the supplemented co-substrates in the cultures. The relationships between atrazine degradation by S. maltophilia and several relevant physicochemical parameters (e.g., N-sources, yeast extract) were examined. High performance liquid chromatographic methodology was used to measure this substrate and it also resolved unknown intermediates.
선박수리업무에 종사하는 군무원들의 작업환경에 대한 인식이 직업만족도에 미치는 영향
오경재,모영하,윤한,김명선,이정미,권근상 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1
This study was carried out to evaluate the relations among working environments, health behaviors and satisfaction with their duty in a group of 200 ship-repair workers in the ROK navy. The results were as following; Age of workers was 40 years and over(83%) and working duration was 10 years and over (71.5%). Most of them were married and had studied beyond high school. The 69.5% of workers satisfied with their job, whereas. about 59.5% of workers had satisfaction with their working condition. There were current drinkers, 78.5%, current exercising workers, 43.5%, obese workers, 28.0%, and salted food intakers, 18.5% in the workers. The major harmful environmental factors in the ship-repair workplace are noise, vibration, dust and chemicals. Most of workers are exposed to above harmful factors and complained about exposure of noise and dust. The consumption of cigarette or alcohol in people who exposed to noise was much higher than in people who did not, but the difference was not statistically significant. Prevalence of obesity and hypertension were not significantly different between the exposure with noise and dust. Noise or dust exposure was significant relation to satisfaction with their duty and working condition. The affective factors for satisfaction with their duty were people who worked for 10 years or more(OR= 4.53), exercisers(OR=4.78) and dust(OR=3.05) in Logistic regression analysis.
홍성진,윤석중,김성우,조형구,오명호,김기혁,이인성 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-
Myelodysplastic syndrome(MDS) is a group of acquired conditions characterized by progressive bone marrow failure associated with normocellular or hypercellular bone marrow that cannot be attributed to nutritional deficiency, chronic infection, or other chronic systemic illness, and cannot be reversed by the successful treatment of those conditions. Whereas the cases of secondary MDS occur at all ages, primary MDS is essentially a disease of elderly, though no age group is exempt and predomonant in men. The MDS is fundamentally clonal disorders at the level of the haemopoietic totipotent stem cell. Clinically, they are characterized by varing degrees of peripheral cytopenia(s) with morphological and functional abnormalities of blood elements. We have experienced two unrelated pediatric cases, who showed pancytopenia on admission and the characteristic marrow findings of MDS. The first case, a 12 months-old girl, showed increased reticulin with abnormal localization of immature precursor cells(ALIP) in her bone marrow, in addition to dysplastic features such as bi-and multi-nucleation of late normoblasts and internuclear bridging. She also showed 22% of blasts in her bone marrow cells thus classified in the category of RAEB-t after FAB classification. Also found were a chromosomal abnormality namely 46 XX t(14q21q), which was an unusual one. Her family brought her home and, 4 month later, she deceased. The second case, a 12 year-old boy, showed pancytopenia with Pseudo-Pelger-Huet anomaly in neutrophils but no blasts in the peripheral blood. Bone marrow of this case also showed the picture of dyserythropoiesis with binuclearity, internuclear bridging, nuclear fragments, multinuclearity of late normoblasts, in addition to megaloblastoid change in the normoblasts and increased mitosis in granulocytic series. No chromosomal abnormality was found. Classified as RA after FAB classification of MDS. Showed good response to conservative management for anemia for more than one year.