비침습적 검사를 이용한 수술후 하지 심부 정맥 혈전증의 감시

김영욱,정한준,윤봉호,김신윤,이상국,변경환,김태헌 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

Deep vein thrombosis is recognized as a common complication in surgical patients in western countries especially in patients with high risk factors. The purposes of this study were to detect leg DVTs in early postoperative period by non-invasive surveillance and to analyze the risk factors of DVT. One hundred seventy one patients who underwent major operations(67 curative resection of colorectal cancer, 64 total hip replacement, 38 femur operation for fracture, and 2 colon resections for benign colon disease) were included for the prospective surveillance of leg DVT within 2 weeks after the operations. For the surveillance of leg DVT, strain gauge plethysmography(SPG) and Duplex scanning of both legs were completed for all patients except 10 patients. These 10 patients were examined in only one leg. The patients with past history of leg DVT or under prophylactic anticoagulant therapy were excluded from this study. To determine the risk factors related with leg DVT formation, age and sex of the patients, indication of surgery or surgical procedures, duration of operation, position during the operation, duration of postoperative immobilization, and preoperative serum level of antithrombin III (AT- III) were analyzed using Chi-square test. After performing SPG of 342 legs, 38 legs, showed abnormal on venous outflow/venous capacitance discriminant line chart, and 13 legs of 12 patients showed the finding(s) suggesting DVT on duplex scanning. Among the patients with abnormal duplex findings, 7 limbs(53.8%) were symptomatic, but the remaining 6 legs were silent. In 6 (15.8%) patients of 36 femur operations, 3(4.7%) of 64 total hip replacements and 3(4.5%) of 67 curative resections of colorectal cancer developed DVT by duplex scanning in the iliac(5), femoral-popliteal(6), and isolated calf(2) veins. After analyzing the risk factors, we could not find any statistically significant(p<0.05) factor related with leg DVT.

Disruption of rsmA Gene of Pectobacterium carotovorum subsp. carotovorum LY34 and Effect on Pathogenicity

Kim, Min Keun,Kang, Tae Ho,Kim, Sung Kyum,Jeong, Yu Seok,Yun, Han Dae,Kim, Hoon The Korean Society for Applied Biological Chemistr 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.6

The rsmA gene was cloned from soft-rot bacterium Pectobacterium carotovorum subsp. carotovorum LY34 (Pcc LY34), and its role in pathogenicity was investigated by marker exchange mutagenesis. From a cosmid library of Pcc LY34 genomic DNA, a positive clone carrying the rsmA gene was selected, and the gene was cloned by polymerase chain reaction (PCR) amplification. The gene is 186 bp in size and encodes a protein of 62 amino acids with a predicted molecular mass of 6,839 Da. The calculated pI of the RsmA is 8.16. The phylogenetic tree showed that the RsmA of Pcc LY34 appeared genetically identical to the CsrA of Pectobacterium atrosepticum SCRI1043 (100% identity) and similar to the CsrA of Yersinia pestis KIM10+(98.3%). The gene was disrupted by the $Km^r$ gene, and the cells became mutated (i.e., $RsmA^-$ mutant). The pathogenicity test revealed that the disease rating of the $RsmA^-$ mutant only differed slightly from that of the wild type on a slice of potato tuber and a Chinese cabbage stalk. These results suggest that RsmA is not an essential factor for the pathogenicity of Pcc LY34 and that the rsmA gene of Pcc LY34 is not completely derepressed in the $RsmA^-$ mutant for virulence-related genes, contrary to the results of Erwinia carotovora subsp. carotovora $RsmA^-$ mutant, which proved hypervirulent for celery petioles. These results showed that the microenvironmental conditions of the host and/or strain of pathogen are important for the coordination of virulence gene expression.

중증 미만성 뇌축색손상 환자의 MRI소견 및 임상적 고찰

김한겸,김성호,송시헌,김관태,김윤 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.1

The distribution and extent of traumatic lesions were evaluated with MRI in 31 patients with diffuse axonal injuries(DAI). Authors also analyzed patients with diffuse axonal injury, clinically. The patients with DAI showed statistically significant lower incidence of lucid interval, fracture of the skull and intracranial hematoma. Combined injuries, intracrnial hematomas and distribution of lisions were porved to be poor prognostic factors of DAI. Diffuse axonal injury is most commonly involved in the white matter of the frontal and temporal loves and the splenium of the corpus callosum. Patients with lisions in brainstem and cerebellum revealed worst prognoses. In our studies, the sensitivities of the imaging techniques for diffuse axonal injures were 7.3% with CT scan, 75.6% with T1WI, and with 97.6% in T2WI of MRI, respectively. The authors concluded that MRI has clear advantages over CT in evaluating diffuse axonal injuries.

우리나라 지역 직업성질환 감시체계의 현황과 전망

임종한,장성실,김성아,문재동,채창호,홍윤철,김수영,김진석,김영욱,한상환,이혜숙,원종욱,송동빈,하은희,강성규 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

기존의 특수건강진단과 작업환경측정을 통한 직업병 관리가 진폐증, 소음성난청 등의 소수 특정질환에 국한되고 실제 직업병 발생 규모 파악이나 신종 직업병의 발견에 한계를 보인다는 사실은 산업의학전문가들 사이에서도 공감을 이루고 있다. 미국과 영국 등에서의 직업성질환 감시체계에 대한 경험은 우리 나라의 직업성질환 감시체계 구축에도 새로운 자극제가 되면서, 1998년이후 인천, 대전, 여천, 구미, 부울경 지역에서 지역 직업성질환감시체계를 산업보건관리의 중요한 시스템으로 구축하려는 노력이 확산되고 있다. 새로이 구축되어지는 이들 지역 직업성질환 감시체계는 감시하고자 하는 대상질환, 활용 가능한 인적자원 및 자료원, 지역 의료체계의 특수성 등에 따라서 목적과 방법을 달리하면서 독특한 형태로 발전을 하고 있다. 각 지역단위 감시체계들이 그 상황에 맞게 독특한 목적과 전략들을 발전 시키면서도, 향후 발전할 국가적인 차원의 직업성질환 감시체계 구축을 위하여 직업성질환 감시의 기본 전략 등을 공유하는 등의 노력이 필요하다. 환례 정의 및 기본적인 등록 서식의 공유, 직업성질환 감시 자료원의 발굴, 공동의 정보 네트워크 및 직업성질환 감시 데이터베이스 구축 등 직업성질환 감시활동을 지원하기 위한 여러 기초 인프라 구축에 힘을 모아야 할 것이다. 우리 나라에서 직업성질환 감시체계를 성공적으로 구축하기 위해서는 수집된 자료의 질 관리를 위한 직업성질환 감시의 원칙 제정과 감시 전략의 공유 등이 필요하며, 전국적인 직업성질환 감시체계의 하부구조라고 할 수 있는 지역감시체계의 기초 토대 마련과 강화작업이 절실하게 필요하다.

텅그스텐鋼에 形成된 炭化物의 Ostwald ripening에 대한 定量組織學的 分析

金漢軍,李相允,崔鎭源 東亞大學校 大學院 1987 大學院論文集 Vol.12 No.-

This study has been carried out to determine the structural characteristics and growth kinetics in thungsten steels. the results obtained from the the experiment are summerized as follows; 1. Microstructure of carbide particles spheroidization treated after quenching has been finely dispersed along grain boundary when tungsten content is increased. 2. The value obtained by mean redius of carbide particle and spherodizing treatment analysis has been calculated to be 0.27 and the growth of these carbide particles occurs by diffusion-controlled mechanism. 3. The value of activation energy obtained by particle number measurements and spherodizing time analysis has been calculated to be 69.6Kcal/mole and the coarsening phenomina of these carbide particles in tungstem steels occurs by the interdiffusion mechanism of iron, tungsten and carbon atoms. 4. The tungsten carbides in which W : C atomic ratio is 0.12 change to M₃C+MC but tungsten steels in which atomic ratio is 0.25 and 0.36 change to the stable M₃C+MC type caride after the process of the metastable M?C?+M?C type carbide. 5. Hardness measurements have revelaed that hardness during the spheroidization of tungsten steels varies as the Hall-Petch type relation, impact value has increased with th increasing of W content in range of 125 hours spheroidizing treatment time and 3% tungsten content.

Anthracene을 이용한 allyl alcohol의 합성

김윤영,한 훈,정대일 東亞大學校 1994 東亞論叢 Vol.31 No.1

To synthesize biochemically important GPP(Geranyl pyrophosphate) (15), allyl alcohol (24) (33) as starting material of our strategy was prepared by anthracene. Methyl propiolate(27) was syntliesized by esterification of propionic acid and methyl alcohol. [4+2] Diels-Alder reaction of methyl propiolate (27) and anthracene gave methyl 9, 10-ethenoanthracene-ll-carboxylate(28). Methyl 9, 10-ethenoanthracene-ll-carboxylate(28) was reduced with H2/Pd-CaCO3 to give methyl 9. 10-ethanoanthracene-11-carboxlate(29). 9, 10-Ethanoanthracene-11-methanol(30) was synthesized by the treatment of LiAlH4 to methyl 9, 10-ethanoanthracene-11-carboxlate(29). 2-Propenol(24) was synthesized by pyrrolysis of 9, 10-Ethanoanthracene-ll-methanol(30) with Wood's metal bath at 330℃. And also, 9, 10-ethanoanthracene-11-carboxylate-cis-11, 12-d2(31), 9,10-Ethanoanthracene-11-methanol-cis-11, 12-d2(32) and propen-3-ol-cis-l, 2-d2(33) containing deuterium were synthesized in same methods. Chemical analysis of all products was executed by UV, TLC, mp, IR, NMR, and MASS.

산전 태아사망 환자에서의 Mycoplasma hominis와 Virdans streptococcus감염 1예

김윤숙,문성택,전섭,김종수,최승도,선우재근,배동한 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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男女 中學生들의 傳統 飮食에 대한 意識과 嗜好度 調査硏究 : 서울과 전주를 중심으로

김윤신,한용봉 한국 가정과 교육 학회 1994 한국가정과교육학회지 Vol.6 No.2

The purpose of this study is to investigate understanding and preferance in 28 kinds of traditional korean food of middle school boys and girls. The data for this study were collected in a survey conducted from 25th August to 8th September in 1993 in Seoul and Jeonju. Questionnaires were completed by 409 students: The results are as follow. The students have preception(75.8%) and favor(82%) about traditional korean food, And they do not take very often without ceremonial and traditional-holyday, because the cooking method and process are sophiscate and difficult(76.5%). However, they want that korean traditional food should success, keep and develope the cooking apparatus and simplifing cooking method.

지연유합과 불유합에서 저신호 강도 초음파의 유용성

윤여헌,김종오,고영도,유재두,정준모,오종건,방한천,최창호,신명철 대한골절학회 2003 대한골절학회지 Vol.16 No.1

목 적 : 저 신호 강도 초음파를 이용한 지연유합과 불유합의 치료에 대한 유용성을 알아보고자 하였다. 대상 및 방법 : 2001년 7월부터 2002년 5월까지 본원에 내원한 지연유합 7례와 불유합 8례를 대상으로 5개월간 저 신호 강도 초음파로 치료하여 5개월후 골유합 여부를 알아 보았다. 결 과 : 총 15례 중 대퇴골 간부 2례, 경골 간부 1례, 상완골 간부 1례, 요골 1례의 지연유합에서 골유합을 얻었고 대퇴골 간부 불유합 3례에서 유합을 얻었다. 지연주합은 71%의 유합율을, 불유합은 37.5%의 유합율을 보였다. 결 론 : 저 신호 강도 초음파는 골유합을 촉진 시킬 수 있으며 지연유합에서 시도해 볼 만 하나 불유합 치료를 위해서는 보다 많은 연구가 필요 하다. Purpose : To evaluation of usefulness of low-intensity ultrasound for nonunion and delayed union. Materials and Methods : For 5 months, we treated 7 delayed union and 8 nonunion using low-intensity ultrasound. After 5 months, in checked X-ray AP and Lateral view, when cortical bridge formation was done, we through union. Results : In 7 delayed union, 5 cases-2 femur, tibia, humerus, radius were healed. In 8 nonunion, 3 femur nonunion were healed. Union rate was 71% in delayed union 37.5% in nonunion. Conclusion : we thought that the low-intensity ultrasound has capacity of induction of union and was considered as the method of treatment for delayed union.

電氣抵抗探針法에 의한 氣泡塔內의 氣泡特性에 관한 硏究

金相烈,金瀅翰,睦演洙 동아대학교 공과대학 부설 한국자원개발연구소 1988 硏究報告 Vol.12 No.1

The bubble behavior in a bubble column was observed, and its size and velocity were determined using two sets of probes measuring the resistance. From the measurement a local gas holdup was also obtained. Since the local gas holdup could be measured, the distribution of bubbles in the radial direction was able to find from the experiment. As a result, a correlation between gas holdup and the operating condition of the column, represented as Reynolds number, and the physical property, expressed as Galilei number, was made from the experimental data.