VP-16으로 성공적으로 치료된 위 Kaposi 육종 1예

양웅석,송근암,조몽,이재승,송철수,김형욱,김영민,이수봉,김태오,이성훈 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.4

The skin is an uncommon site of distant metastasis from any internal malignancy, and the incidence of metastatic skin lesions as the first symptom of disease is only 0.8% in patients with all systemic malignancies. Furthermore, cutaneous metastasis from adenocarcinoma of the stomach has been found to be extremely rare. A 35-year-old female patient was admitted due to multiple cutaneous nodules in her chest, abdomen, and back. A gastroendoscopic examination and biopsy was made according to the results of skin pathologic findings. Stomach and skin biopsy results revealed a signet ring cell type of adenocarcinoma. A case of gastric adenocarcinoma in which metastatic skin nodules appeared as the first sign of disease, is here in reported with a review of related literature.

A comparison of survival outcome of open, total laparoscopic and laparoscopy-assisted vaginal radical hysterectomy in patients with early cervical cancer of stage IB2

( Sul Lee ),( Hyung Joon Yoon ),( Eun Hye Jeon ),( Juseok Yang ),( Yong Jung Song ),( Hyun Jin Roh ),( Sang Hun Lee ),( Byung Su Kwon ),( Ki Hyung Kim ),( Dong Soo Suh ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: The aim of this study is to evaluate oncologic outcomes of total abdominal radical hysterectomy (TARH), total laparoscopic radical hysterectomy (TLRH) and laparoscopic-assisted radical vaginal hysterectomy (LARVH) in early cervical cancer patients (stage IB2-3, tumor size≥2cm), analyzing the risk factors that may affect the clinical results. Methods: A total of 756 patients underwent radical hysterectomy between 2000 and 2019 from three university hospitals (Pusan National University Hospital, Yang-san Pusan National University Hospital, Ulsan University Hospital) were enrolled. Among them, 172 patients with stage IB2-3 were analyzed retrospectively. Results: Seventy-seven patients were treated with TARH, and 95 were managed via minimally invasive surgery (MIS), consisting of 35 with TLRH and 60 with LARVH. TARH group had better disease five-year disease free survival (DFS) and overall survival (OS) compared with MIS group (86.4% vs. 73.4 for DFS and 91.7 vs. 82.2 for OS), but not statistically significant in both (p=0.058 for DFS and p=0.119 for OS). When TARH and the LARVH group were compared, both five-year DFS and OS were not significant different (86.4 vs 82.2%; p=0.288 for DFS and 91.7 vs 84.4%; p=0.206 for OS). However, when TARH and the TLRH group were compared, TLRH group had significantly worse five-year DFS than TARH (86.4 vs 54.5%; p=0.008), but five-year OS was not significant different (91.7 vs 77.5%; p=0.127). Multivariate analysis showed that LN metastasis and TLRH surgical approaches were an independent prognostic factor for DFS in IB2-3 cervical cancers. Conclusion: Our findings provided the evidence that TLRH surgical approach was associated with worse DFS in IB2-3 cervical cancers but that of LARVH was not. Such results may have important implications of colpotomy method for MIS in cervical cancer.

Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예

백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy

진공포장 수준이 돈육포의 품질에 미치는 영향

양철영,채수규,이수한 凡石學術奬學財團 1998 凡石學術論文集 Vol.2 No.1

돈육 등심부위(Longissimus dorsi)를 이용하여 산업적으로 제조된 건조육포의 효율적인 저장, 유통에 관한 자료를 얻고자 진공수준, 저장온도, 저장기간에 따른 품질에 미치는 영향을 분석·고찰하였다 . 1. 진공수준과 저장온도에 따른 중량변화는 20℃의 76cmHg 진공수준에서 적었고. 40℃의 60일 후에 감소율이 증가하였으며, 진공수준은 76cmHg < non-vacuum < 60cmHg 순으로 중량감소의 영향이 높았다 . 함유수분의 변화는 저장온도 20℃와 40℃의 non-vacuum상태에서 저장기간에 따라 감소를 나타내고, 60cmHg 진공수준과 76cmHg 진공수준에서 저장기간에 따라 증가함을 나타내며 120일에서 감소를 보였고, 40℃ 저장시 수분의 변화가 보다 높았다. 2. TBA가에 미쳐는 진공수준의 영향은 20℃저장에서 60cmHg < 76cmHg < non-vacuum 순으로 증가함을 보이고, 40℃ 저장시에는 non -vacuum < 76cmHg < 60cmHg 순으로 증가치가 높으나 유의성은 인정되지 않았다. 3. 수분활성도에 미치는 영향은 저장온도 40℃에서 보다 컸으며, 저장기간 120일에서 initial 보다 감소하였고, 저장기간 사이에서 유의성이 인정되지 않았다. 4. 경도(hardness)는 진공수준, 저장온도 및 저장기간에 따라 큰 차이를 보이며, 저장온도 20℃와 40℃에서 120일후 경도값이 높게 나타내고, 저장기간 30일 이후부터 저장기간 사이에서 상관성이 유의있게 보였다. 저장온도, 저장기간, 진공수준에 의한 강도(strength)의 영향이 컸으며, 저장온도 20℃보다 40℃에서 120일후 강도값이 높게 나타내고, 저장기간 30 일 이후부터 저장기간 사이에서 상관성이 유의있게 보였다. 5. L값은 20℃, 40℃의 진공수준별에서 저장기간이 연장됨에 따라 감소폭이 비슷하였으며, a값은 각 저장온도에서 120일후 큰 차이를 나타내고, b값은 40℃가 20℃보다 진공수준 사이에서 큰 차이를 보였다. 6. 전체적인 기호평가는 저장온도 20℃, 진공 수준별에서 120일후 color, flavor 및 overall acceptance가 4.35~4.50이었으며, 저장온도 40℃에서 1.14~1.64 사이였다. Experiments were carried out to investigate the quality of the dried pork jerky according to vacuum packaging level on the during storage 120 days at 20℃ and 40℃. 1. The change of weight was decreased on vacuum level 76cmHg at 2℃, and the during storage at 40℃ was decreased as the follows: 76cmHg < non-vacuum < 60cmHg. in order. 2. TEA values was increased as the follows: 60cmHg < 76cmHg < non-vacuum. in order at 20℃. and the during storage at 40℃ were increase as the follows: 76cmHg < non-vacuum < 60cmHg, in order with an increase at stroage periods. Also. there is no significant difference among the various vacuum level, storage periods and storage temperature. 3. The effect of water activity at 40℃ were higher than during storage at 20℃, as the water activity were decreased at storage period 120 days after than initial period, also there is no significant difference among the storage periods. 4. Hardness showed remarkably different according to vacuum packaging level, storage temperature and storage periods. Strength were remarkably influenced according to various storage conditions. and as the strength value at 40℃ were higher than 20℃ in storage periods 120 days. 5. The lightness(L) tended to decrease according to an increase in storage periods at 20℃ and 40℃, redness(a) showed remarkably different according to the various storage temperature from storage period 120 days after, yellowness(b) were influenced highly at 40℃ than 20℃ on the vacuum packaging level. 6. Sensery score of overall acceptance for the vacuum packaging level to dried pork jerky were 4.35~4.50 ranges at storage temperature 20℃, and the storage temperature 40℃ were 1.14-1.64 ranges.

경부외측종괴의 감별진단 및 접근에 대한 고찰

이경호,박현진,강지연,최희원,조용석,김경원,양수남 大韓顎顔面成形再建外科學會 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.6

Most neck masses of specific cause occur in rather predictable locations within typical age groups. This allows a systematic approach to developing a working diagnosis and a differential diagnosis and management plan for the patient presenting with a neck mass. Pathologic masses of the neck will be divided into the following segment: 1. Masses of nonspecific location. 2. Masses in the submandibular region, 3. Masses in the parotid region, 4. Masses in the median-paramedian region, 5. Masses in the lateral neck region. The lateral neck region is the area posterior to the hyolaryngotracheal conduit, below the posterior belly of the digastric muscle and tip of the parotid gland, and extends down to the clavicle. The contents of this region include the large vessels, nerves and greatest number of lymph nodes of the neck, and lymph node metastasis in this region is usually from a primary lesion at the base of the tongue or elsewhere in the oropharynx. Common lateral neck masses include branchial cleft cyst, carotid body tumor, neurogenic tumor, pan-neck infection, cystic hygroma, hemangioma, lipoma and lymphoma. Especially lymphosarcoma. Hodgkin's disease, cystic hygroma, hemangioma and branchial cleft cyst and more common and often manifest in the young patients. Many head and neck disease processes manifest as neck masses. These conditions are treated by surgical excision, except for some inflammatory masses, and often those also must be excised before a diagnosis can be made. We retrospectively reviewed 5-year experiences in the treatment of lateral neck masses at our department to define better clinical characteristics of the masses and the optimal diagnostic and therapeutic approaches to these rare diseases.

불평형을 고려한 절삭력 모델에 관한 연구

양완석,이수훈 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.1

This paper is on a new cutting force model which includes the force caused by unbalance. The cutting forces under the different additional masses are measured with the spindle speed changed. The model is justified through correlation between simulation and experimental result.

여성 요실금에서 Kontinence™와 Compact Elite™의 치료효과 비교

양상국,정상원,오미희,노용수,김홍섭,우응제,박승훈,이수열 건국대학교 의과학연구소 1999 건국의과학학술지 Vol.9 No.-

Biofeedback and pelvic floor electrical stimulation are new modalities that have been advocated for the treatment of female urinary incontinence. The aim of this study was to compare prospectively the therapeutic effect of Kontinence™(HMT Co., Korea) with Compact Elite™(ECL Co., France) in female urinary incontinence. All patients were evaluated with a complete history, physical examination, urinalysis, urine culture and urodynamic study. Eighteen patients were treated with Compact Elite™, and thirteen patients with Kontinence™. Enrolled patients had completed 8 office sessions consisting of biofeedback and intravaginal electrical stimulation according to the program of each machines. Overall treatment response was graded by patients on a scale of complete cure to aggravation. At two weeks after last session, overall improvement rate was 78% in Compact Elite™group and 92% in Kontinence™group(p>0.05). Overall patients' acceptability during treatment course was greater than 80% in both machines(p>0.05). There were no unexpected clinical findings during Kontinence™ treatment. After Kontinence™treatment, there were no laboratory changes including electrocardiography, complete blood count, liver function profile, and chest PA. These results showed that the biofeedback and electrical stimulation with Kontinence™was safe and moderately effective for female urinary incontinence comparable to Compact Elite™. However, long-term results of a larger patients are needed to ensure the therapeutic effect of Kontinence™.

조세순응성향과 조세회피행위에 관한 연구 : 봉급생활자와 자영업자를 중심으로 Focus on salaried employees and self-employed business people

李良玄,崔林洙 중앙대학교 산업경영연구소 1997 산업경영연구 Vol.6 No.1

The purpose of this study was to analyze factors influencing taxpayers'propensity to comply tax and tax evasion behavior, and to test if taxpayers' propensity to comply tax influences taxpayers' tax evasion behavior as a mediating variable. Pearson Correlation Analysis showed that almost tax ethical variable and taxpayer knowledge variable were significantly and positively related to tax propensity to comply tax, but on the contrary almost tax institutional variable and socio-cultural variable were significantly and negatively related to tax propensity to comply tax. Multiple Regression Analyses revealed that almost tax ethical variable and taxpayer knowledge variable emerged as significant positive predictors for propensity to comply tax, however almost tax institutional variable and socio-cultural variable were significant negative ones for propensity to comply tax. Logistic Regression Analyses showed almost tax ethical variable, tax psychological variable and propensity to comply tax variable to be significant negative predictors of taxpayer' tax evasion behavior, but almost tax institutional variable and taxpayer knowledge variable to be significant positive predictors of taxpayers' tax evasion behavior. And Logistic Regression Analyses also revealed that propensity to comply tax variable acted as a mediator variable between tax ethical variable, tax institutional variable, tax psychological variable, taxpayer knowledge variable, and socio-cultural variable and taxpayers' tax evasion behavior.

Methazolamide와 Acetazolamide 복용 후 유발된 천식 1예

이건화,이영목,김양기,김기업,어수택,박춘식 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

足三里의 電鍼刺戟이 흰쥐의 中樞神經系에서 Interleukin-6의 活性에 미치는 影響 - 求心性 體感覺 情報傳達을 中心으로- : 求心性 體感覺 情保傳達을 중심으로

이혜정,신형철,진수희,손양선,윤동학,임사비나 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Objectives : Acupuncture is expected to have somewhat like the efficacy parallel increasing activity of immune system in Western modern medicine. There, already, are many animal researches on activating effect of acupuncture for the immune system in peripheral organs. So, we carried out this experiment to see whether acupuncture has controlling effect on interleukin-6(IL-6) activity in rat's brain. Methods and Results : We had topical application of IL-6(1U-1pg, 10㎕) on brain of rat. It reduced afferent sensory transmission to the primary somatosensory(SI) cortex from periphery. Whereas, electrical stimulation(ES, 2Hz, 1.5V, 15min) of ST36(足三里) with application of IL-6 prominently activated afferent sensory transmission. ES of non-acupoint(proximal tail) with IL-6 showed suppression of afferent transmission. ES of ST36 without IL-6 application also exerted facilitation of afferent transmission to the SI cortex. Conclusions : Electoacupuncture(EA) on ST36 has noticeable influences on modulating activation of IL-6 in central nervous system, which do major role in immune system.