근저항 트레이닝이 20대 여성의 신체조성과 체력에 미치는 영향

이상우,김봉환,서해근,강신범,나재철 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effect of muscular resistance training on the body composition and the physical fitness. The subjects of study were 6 women in their twenties who had not taken will in ordinary days and had not gone through regular training. The above subjects were measured by body composition and physical fitness pre and post 8 weeks training. The frequence training was more than 4 times a week and the duration of training of each session was 70 miniutes. The results are as fallows: 1. In muscular resistance training for 8 weeks, % Fat 1.8%(7.76%), and Fat weigh 3.0kg(23.43%), wee decreased, while LBM 3.0kg(7.10%) was increased, However, there was no differences. 2. In muscular resistance training for 8 weeks, it was exposed to be increased a little in Left arm strength 2.65kg(9.60%), Fight arm strength 2.03kg(7.78%), Left leg extention strength 12.47kg(6.16%), Right leg extention strength 4.50kg(2.35%), Left leg flextion strength 13.67kg(13.01%), Right leg flextion strength 13.25kg(12.70%), Standing trunk flextion 3.25㎝(18.16%), Front split 2.67㎝(1.65%), Side step 3.83friq(11.16%), Vital capacity 5.02cc(0.22%).

토끼 콩팥에 대한 키토산 미세구의 색전 효과

이종익,곽병국,심형진,이종범,이용철,유재형,한상문 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.1

The aim of the study was to evaluate the possibility of therapeutic use of chitosan microspheres as a new embolic material. Twenty four New Zealand white rabbits were divided into four groups. Polyvinyl alhocol (PVA) particles (150-250 ㎛ ) was used in group 1. Chitosan microspheres were used in group 2 (150-250 ㎛ ), group 3 (250-355 ㎛) and group 4 (355-500 ㎛) respectively. Arteriography of right kidney was performed using 4 F cobra catheter. Embolization was continued until complete occlusion of the right renal artery was achieved. Catheters were tested whether the lumen is obstructed by embolic materials during and after embolization. One animal was sacrificed in each group on the 1st and 3rd day, 1st, 2nd, 4th, and 8th week respectively. Basic hematologic and blood chemisty were analyzed, and gross and microscopic pathologic findings were observed. Chitosan microspheres were round to oval shape, and had smooth surface and even size under the light microscope. Successful embolizations were achieved in all twenty four rabbits. On gross pathologic examination, all chitosan microsphere groups showed no differences from PVA particle group in renal contraction and discoloration. Histologically chitosan microsphere groups had a higher incidence of vasculitis. but did not show any recanalization in comparison with PVA particle group. Hematologic and blood chemisty showed no significant abnormal change in all groups. In conclusion, effective, technically easy and safe embolizations were achieved with chitosan microspheres in rabbit kidney. Chitosan microspheres might be a good embolic material.

男ㆍ女 中學生의 體格 GROUP別 發育樣相에 對한 縱斷的 硏究

이상우,신상근,안기영,강신범,나재철 東亞大學校附設스포츠科學硏究所 1996 스포츠科學硏究論文集 Vol.14 No.-

The purpose of this study was examine each group's growth type of the middle school syudents through three year's individual follow-measurement. Subject were 1110(male = 558, female = 552) who were living in Tea-gu. 1. In the whole means of each item the growth of rate of male for female in height and the sitting height was 2.9 and that of the weight and the girth of chest was 1.7. 2. The growth volume of the height, the sitting height was commonly anti-proportional in male and female. 3. The weight of male was revealed the similar growth between groups except 6,7 group. And that of female revealed the small decreasing phenomenon in 4 - 7 groups at 4,5 times. 4. The growth volume of the girth of chest was revealed highest in 2 group. Smallest in 6 group of male. And that was revealed the decreasing phenomenon in 6 group of female since 4 times.

혼합형 뇌졸중의 임상적 의의 : 비색전성 뇌경색 환자를 중심으로

이병철,유경호,도화범,권기한,황성희,김형철,강익원 대한신경과학회 1996 대한신경과학회지 Vol.14 No.1

근력 트레이닝의 효과와 디트레이닝시 근력의 변화

이상우,강신범,안기영,김우규 東亞大學校 附設 스포츠科學硏究所 1995 스포츠科學硏究論文集 Vol.13 No.-

We gat a result after testing for weight training for 6 weeks and then we found how changed fitness with 14 students, a group of Isokinetic training(7), a group of Isotonic training(7). 1. In Peak Torque changing, after training 6 weeks laters, a group of Isokinetic(increase 20.3%) is higher than a group of Isotonic(increase 13.1%) When we compare with before training and after Detraing 6 weeks. It showed that a group of Isokinetic(increase 12.3%) was higher than a group of Isotonic(increase 2.2%) 2. In Total Work changing, after trainig 6 weeks laters, a group of Isokinetic(increase 22.8%) is higher than a group of Isotonic(increase 12.4%) When we compare whth before training and after Detraing 6 weeks. It showed that a group of Isokinetic(increase 11.8%) was higher than a group of Isotonic(increase 6.6%) 3. In AVG·Power changing after trainig 6 weeks laters,a group of Isokinetic(increase 32.5%) is higher than a group of Isotonic(increase 16.5%) When we compare with before training and after Detraining 6 weeks. It showed that a group of Isokinetic(increase 13.1%) was higher than a group of Isotonic(increase 8.6%) 4. A result of after training 6 weeks later and Detraining 6 Weeks later. It showed that a group of Isokinetic is more decrease than a group of Isotonic in Total Work, AVG·Power and a group of Isotonic is more decrease than a group of Isokinetic in Peak Torque.

점증적 최대운동이 항산화 효소의 혈중 농도에 미치는 영향

강신범,이상우,김상권,서해근,김준모 東亞大學校附設스포츠科學硏究所 1999 스포츠科學硏究論文集 Vol.17 No.-

The purpose of this study is to examine how exercise stimulus effects on the boold concentration of antioxidant enzymes. And then, the results of analysing the boold concentration of antioxidant enzymes before and after graded maximal exercise based on high school's 7 males, are as follows: 1. The blood concentration of SOD is found to have a significant increase before and after graded maximal exercise. 2. The blood concentration of CAT is found to have a significant increase before and after graded maximal exercise. 3. The blood concentration of CAT is found to have a significant change. As the above results, the severe exercise of short time is found to increase the blood concentration of SOD as well as CAT. And then, the blood concentration of GPX is found not to have a significant exchange. To examine the mechanism of the above results manifestly, it is considered that the deep study based on exercise style, duration time and exercise intensity, should be continued.

흰쥐에서의 카르복시메칠셀룰로오스나트륨과 겔란검 혼합겔의 유착방지 효과

권윤환,이시범,이정권,박용덕,박정숙,황성주 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.6

The aim of the present study was to investigate the efficacy of a mixed gel formulation composed of sodium carboxymethyl cellulose and gellan gum (Na-CMC gel) for the prevention of adhesions after laminectomv. The anti-adhesive effect of the Na-CMC gel was tested in a controlled randomized study using an animal model of lumbar laminectomv. The animals (60 female Sprague-Dawlev rats) were randomly allocated into two treatment groups to receive the Na-CMC gel on the injured area or no gel (control). The incidence of adhesions and their grade were blindly evaluated at 4. 8 and 12 weeks after surgery. The amount of scar tissue and tenacity were grossly reduced by the Na-CMC gel at postoperative 4. 8. and 12 weeks. The mean adhesion scores were 0.75. 125. and 1.38 at 4. 8. and 12 weeks in the gel-treated group. respectively. No significant inflammatory reaction was observed and the healing of wound was not affected by the Na-CMC gel. The Na-CMC gel reduced the amount of scar formation and tenacity in rat laminectomv model without affecting the healing of operation wound and other complications. Therefore. the Na-CMC gel may be the potential to prevent postsurgical adhesions in clinical state.

레보프라이드 정 (레보설피리드 25 mg)에 대한 레보셀 정의 생물학적동등성

김민수,김정수,이시범,박정숙,황성주 충남대학교 약학대학 의약품개발연구소 2007 藥學論文集 Vol.22 No.-

The aim of the present study was to evaluate the bioequivalence of two levosulpiride tablets, Levopride (SK Pharmaceutical Co., Ltd.) and Revocel (Kwang Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty four healthy male volunteers, 23.7±1.8 year in age and 66.8±7.6 kg in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After three tablets containing 75 mg of levosulpiride were orally administered, blood was taken at predetermined time intervals and the concentrations of levosulpiride in plasma were determined using HPLC with fluorescence detector. The dissolution profiles of two levosulpiride tablets were not significantly different at all dissolution media. Pharmacokinetic parameters such as AUC_(t), C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), and C_(max). The results showed that the differences between two formulations were 2.59%, -2.04% and 8.94% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log0.8 to log1.25 (e.g., log0.95~log1.13 and log0.91~log1.06 for AUC_(t) and C_(max)). Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Levopride tablet and Revocel tablet are bioequivalent.

불응성 자가면역질환에서의 자가조혈모세포이식

민도준,양동원,민창기,김완욱,이상헌,박성환,김동욱,이종욱,조철수,민우성,김범생,김호연,김춘추 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.1

배경: 기존의 치료에 불응하고 예후가 불량한 자가면역질환 환자들에게 최근 고용량 면역억제 및 조혈모 세포이식이 새로운 치료방법으로 대두되고 있다. 저자들은 다발성 경화증(multiple sclerosis, MS) 및 류마티스 관절염(rheumatoid arthritis, RA) 등 2명의 자가면역질환 환자들에서 자가조혈모세포 이식을 시행하였다. 방법: 말초혈액 조혈모세포 가동화를 위하여 cyclophosphamide (4 g/㎡) 및 granulocyte colony stimulating factor (10 g/kg/day)를 투여하였고, CD34+ 세포를 분리·채집 하였다, 이식 전처치로 MS 환자에서 BEAM 및 antihymocyte globulin (ATG) (3.75 mg/kg), RA 환자에서 fludarabine (180 mg/㎡), ATG (10 mg/kg)와 busulfan (8 mg/kg)을 투여하였다. 결과: 호중구 수가 500/㎕ 이상으로 회복되는 기간은 MS 환자에서 9일, RA 환자에서 15일이었다. 혈소판이 20.000/㎕ 이상으로 회복되는 가간은 RA 환자에서 9일 이었고, MS 환자에서는 혈소판 감소증이 발생하지 않았다. 비혈액학적 독성으로 MS 환자에서 WHO 1도의 오심 및 점막염이 관찰되었다. MS 환자는 이식 6개월 후까지 시력감소가 남아있었으나, 이식전에 관찰되던 감각이상 및 운동장애 등의 신경학적 이상 소견은 더 이상 관찰되지 않았다. RA 환자는 이식 1개월 후 관절 증상 및 검사소견의 호전을 보였다. 결론: 불응성 자가면역질환 환자에서 고용량 면역억제 및 조혈모세포이식은 적은 독성으로 높은 치료효과를 기대할수 있으며, 향후 이 시술의 임상적 의의를 규명하기 위하여 전향적이고 장기적인 연구가 필요할 것으로 사료된다. Background: High-dose immunosuppressive therapy followed by autologous hemathpoietic stem cell transplantation (HSCT) has been proposed as a new approach to treat severe, refractory autoimmune diseases. We describe two patients with refractory autoimmune diseases (one multiple sclerosis 〔MS〕and one rheumatoid arthritis〔RA〕) who underwent T-cell-depleted autologous peripheral bleed stem cell transplantation for the first time in Korea. Methods: We mobilized autologous stem cells with cyclophisphamide (4 g/㎡) and granulocyte colony-stimulating factor (10 ㎍/kg/day). Stem cells were enriched ex vivo using CD34-positive immunoselection and reinfused after high-dose chemotherapy with BEAM and antithymocyte globulin (ATG) (3.75 mg/kg) in MS, or fludarabine (180 mg/㎡), ATG (10 mg/kg) and busulfan (8 mg/kg) in RA. Results: The engraftment with an absolute nerutrophil count greater than 500㎕ occurred on day 9 in MS and 15 in RA, respectively. The time to nontransfused platelet count greater than 2.000/㎕ was 9 day in RA. MS patient did not show ant episode of thrombocytopenia. Regimen-related non-hematopoietic toxicity was minimal. For 6 months since HSCT, them patient with MS had been free from previously existed sensory and motor abnormalities except decreased visual acuity. Then patient with RA and only one tender joint and two mildly swollen joints with improvement in laboratory parameters at one month after HSCT. Conclusion: These results underscore the feasibility and potential efficacy of intensive immunosuppression followed by autologous HSCT for treatment of intractable autoimmune diseases. The durability of remission, however, remains to be clarified.

Cover Picture: Biomimetic Artificial Photosynthesis by Light-Harvesting Synthetic Wood (ChemSusChem 5/2011)

Lee, Minah,Kim, Jae Hong,Lee, Sang Hyun,Lee, Sahng Ha,Park, Chan Beum Wiley (John WileySons) 2011 ChemSusChem Vol.4 No.5