백서 심근경색모델에서 시간경과와 경색의 크기에 따른 심자도의 변화

김미성(Mi Sung Kim),박영선(Young Sun Park),권순길(Sun Gil Kwon),지정훈(Jeong Hoon Ji),신종성(Jong Sung Shin),오광식(Kwang Sik Oh),양용모(Yong Mo Yang),연태진(Tae Jin Youn),김동운(Dong Woon Kim),조명찬(Myeong Chan Cho),이용호(Yong Ho 대한내과학회 2002 대한내과학회지 Vol.62 No.1

N/A Background: Magnetocardiogram (MCG), which records the changes of magnetic fields generated by the heart`s electrical activity, theoritically can provide unique data for clinical application. To date, MCG has been investigated only at a single time point after myocardial infarction (MI) with severe left ventricular dysfunction in rats. The purpose of the present study was to investigate sequential changes of MCG after MI and to evaluate effects of infarct size on MCG. Methods: Acute MI were induced by the permanent ligation of left coronary artery in 22 rats. Magnetic fields were recorded just above a rat with Nb Superconducting Quantum Interference Device (SQUID) gradiometer inside a magnetically shielded room. MCG was measured before and immediately after surgery and it was subsequently recorded at the time points of 1, 4 and 6 hours post operatively. MCG was also measured at 1, 3, 7 and 21 days after surgery. Results: Elevation of ST segment and appearance of pathological Q wave on the MCG were evident immediately after the ligation of coronary artery and persisted to 6 hours after MI. On MCG, ST segment was depressed and T wave was inverted from 1 day after MI. In rats with small-and moderate- sized MI (infarct size〈30%), ST depression returned to near the isoelectric level and Q wave disappeared from 7 days after MI. However, ST depression and Q wave were still present in rats with larger infarct (infarct size≥30%). Conclusion: Evolutional changes of MCG were well-recognized up to 21 days after MI. Furthermore, the infarct size can be expressed by the extent of Q wave and ST segment depression on MCG. Taken together, these data indicate that MCG is a helpful modality for the diagnosis, evaluation of infarct size and follow up after MI.(Korean J Med 62:42-48, 2002)

의약분업 전후의 의약정보서비스의 질의응답과 질의자의 만족도 분석

신정인,김미애,허경희,김미정,신현택,오정미 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Drug Information Centers(DICs) are responsible for providing updated and relevant drug information on the efficacy, safety and quality of drugs to health-care practitioners and finally to patients. After the establishment of new prescription law(Bunup)' on August 2000, the future direction for DICs is strongly needed to provide specified, appropriate and rapid information to health-card practitioners and patients. This project was undertaken to provide a future direction of DICs via comparing differences of Q&A before and after Bunup, based on the analysis of Q&A worksheets that were conducted from August 1999 to July 2001 at Drug Information Research Institute(DIRI) of Sookmyung Women's University. In addition, feedback sheets were collected from the users of DIRI from April 2001 to August 2001, to evaluate the satisfaction scores by '5-point Likert scale' on the response. The number of inquiries responded by DIRI was increase from 201 to 574 and the most frequently asked inquirers were pharmacists, specifically community pharmacists. The mean time to respond before and after Bunup was 5.35 and 4.68 hours, respectively. The method of inquiry utilized the most was electronic mailing system followed by telephone both before and after Bunup(66.2% vs. 65.7% via e-mail, from 32.8% vs. 32.4% via telephone). The most frequently asked category of question was on the 'clinical drug' category both before and after Bunup (79% vs. 73.6%). The tertiary literature was the most frequently used reference to answer the inquiries. Mean feedback result via questionnaires was good. That included accuracy, quality of information, time to respond, attitude of provider, accessibility, etc. The most increased inquirer after Bunup was general person, compared with before. Therefore DICs should provide separate responds according to inquirers, develop the systemic program to improve the response for each request, have systemic Q&A worksheet, and develop the educational program for drug information providers. DICs should continuously provide more appropriate and rapid information to health-care practitioners and patients.

Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

OSP 투자지능화 시스템의 고찰

오구영,임미숙,정재우,조용환 충북대학교 컴퓨터 정보통신 연구소 2000 컴퓨터정보통신연구 Vol.8 No.1

본 논문은 OSP(Outside Plant) 투자지능화 시스템개발을 위해서 국내외에서 개발하여 사용하고 있는 선로투자공급 시스템들에 대하여 관심을 두고, 관련된 시스템들을 조사하여 각각의 시스템의 특징 및 구성에 대하여 분석하였다. 이러한 분석결과를 토대로 국내 통신 사업체에서 통신망 계획 및 분석을 위해 앞으로 개발하여야 할 선로투자공급 모형에 대한 기준을 제시한다. This paper analysed systems that are developed as relevant systems for OSP. We focused their distinction and composition of each system which are developed and used to interior and overseas. This result is able to propose the standard model of a Intelligent System for OSP model which have to develop system for plan and analysis of communication network to telecommunication operator.

경남지역 건강검진자에서의 혈청지질에 관한 연구

정준훈,박현모,류재오,조동자,표미순,오은경 한국건강관리협회 2000 건협 Report Vol.3 No.-

선박수리업무에 종사하는 군무원들의 작업환경에 대한 인식이 직업만족도에 미치는 영향

오경재,모영하,윤한,김명선,이정미,권근상 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

This study was carried out to evaluate the relations among working environments, health behaviors and satisfaction with their duty in a group of 200 ship-repair workers in the ROK navy. The results were as following; Age of workers was 40 years and over(83%) and working duration was 10 years and over (71.5%). Most of them were married and had studied beyond high school. The 69.5% of workers satisfied with their job, whereas. about 59.5% of workers had satisfaction with their working condition. There were current drinkers, 78.5%, current exercising workers, 43.5%, obese workers, 28.0%, and salted food intakers, 18.5% in the workers. The major harmful environmental factors in the ship-repair workplace are noise, vibration, dust and chemicals. Most of workers are exposed to above harmful factors and complained about exposure of noise and dust. The consumption of cigarette or alcohol in people who exposed to noise was much higher than in people who did not, but the difference was not statistically significant. Prevalence of obesity and hypertension were not significantly different between the exposure with noise and dust. Noise or dust exposure was significant relation to satisfaction with their duty and working condition. The affective factors for satisfaction with their duty were people who worked for 10 years or more(OR= 4.53), exercisers(OR=4.78) and dust(OR=3.05) in Logistic regression analysis.

無等山 標高에 따른 季節別 昆蟲相에 關한 硏究(Ⅰ) : -春季分布相-

丁聖淑,金美蓮,金奎眞,吳貞子 全南大學校 農漁村開發硏究所 1992 農業科學技術硏究 Vol.27 No.-

無等山 標高에 따른 季節別 昆蟲相을 調査하기 위해 1991-1992年 2個年에 걸쳐 調査한 結果를 要約하면 다음과 같다. 1. 無等山의 봄에 分布하는 昆蟲種類는 總 10目 39科 120種이 調査되었다. 2. 標高別 調査에서는 100-500M에서 10目 37科 110種이, 500-900m에서는 9目 35科 101種이, 900-1200m에서는 5目 12科 18種이 調査되었다. 3. 표고에 따른 출현빈도가 높고 발생량이 많은 種은 100-500m 에서는 흰나비科의 줄흰나비(Artogeia napi), 배추흰나비 (Artogeia rapae), 배추흰나비 (Artogeia rapae), 네발나비科의 청띠신선나비 (kanisha canace), 애기세줄나비 (Neptis dsppho), 풍뎅이科의 검정풍뎅이 (Holotrichia kiotensis), 꿀벌科의 꿀벌(Apis melica), 뒤영벌科의 어리호박벌(Xylocopa appendiculata)로 밝혀졌고, 500-900m 사이에서는 네발나비科의 애기세줄나비(Neptis dssppho), 허리노린재科의 큰허리노린재(Molipteryz fulignosa), 집게벌레科의 노란다리민집게벌리(Euborellia pallopes), 꿀벌科의 꿀벌(Apis melifica)이었고 900-1200m에서는 부전나비科의 부전나비(Pelbejus angus), 꿀벌科의 꿀벌 Apis melifica), 길앞잡이科의 아이누길앞잡이(Cicindela gemmata)等이었다. 4. 무등산 정상인 1,000-1,200m 지대에서 봄에만 볼수있는 종으로서 호랑나비科의 이른봄애호랑나비(Luehdorfia puzilor), 흰나비과의 갈고리나비(Anthocharis scolymus) 2種이 관찰되었다. This study was carried out to investigate the insects fauna of Mt. Mudeung in spring season from 1991 to 1992. The results obtain summaries as follows. 1. The total of 120 species belongs to 39 families of 10 orders were investigated. 2. In different sea levels,10 orders 37 families 110 species at 100-500m. 9 orders 35 families 101 species at 500-900m and 5 orders 12 families 18 species at 900-1200m in sea level investigated respectively. 3. High grequency and population density of Insects by sea level were investigated : Artogeia rapae, Kanisha canace, Neotis dspho, Holotrichia kiotensis, Apis melifica and Xylocopa appendiculata in 100-500m. Plebejus angus, Apis melifica and Cicinedela gemmata in 900-1200m above sea level. 4. Both species of Luehdorfia puzilor and Anthocharis solymus were observed at 1000-1200m of Mt.Mudeung as species appeared only spring season.

심한 낙타혹(Hump)의 형성을 동반한 제 2 형 막증식성 사구체신염(Dense Deposit Disease) 1예

오희정,유민아,이영숙,김미연,김승정,강덕희,윤견일,최규복,성순희 이화여자대학교 의과대학 2004 EMJ (Ewha medical journal) Vol.27 No.1

Dense deposit disease (DDD), known as type Ⅱ MPGN, is an uncommon form of glomerulonephritis. It is an acquired primary glomerular disease, characterised by electron microscopic evidence of a continous, dense membrane deposition replacing the lamina densa. There is associated alternative pathway complement activation and a C3 nephritic factor maybe present. Patients with dense deposit disease tend to be young at clincal onset and more commonly have persistent nephrotic syndrome, gross hematuria, and acute nephritis episode and persistent depression of the serum complement level. The prognosis of dense deposit disease is worse than that of typeⅠMPGN. We experienced a patient with dense deposit disease that presenting persistent nephrotic syndrome, gross hematuria and having subepithelial hump. It is a first report of dense deposit disease having subepithelial hump in Korea, therefore we report this case with the review of relevant literatures.

과산화수소의 농도와 적용시간이 상아질의 깊이에 따라 레진 수복물의 미세인장결합강도에 미치는 영향

손정룡,이계영,강유미,오영택,이광원,김태균 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.5

본 연구의 목적은 심부 상아질과 치수실 상아질에 H₂O₂를 각기 다른 적용시간과 농도로 적용하였을 때, 레진수복물과의 미세인장결합강도에 미치는 영향을 평가하는 것이다. 준비된 각각의 치아에 전형적인 근관와동을 형성하고 다음과 같이 무작위로 1개의 대조군과, 4개의 실험군으로 나누었다: 1군, 전처리를 시행하지 않았다; 2군, 20% H₂O₂를 20분, 10분, 5분간 적용하였다; 3군, 10% 를 20분, 10분, 5분간 적용하였다; 4군 5% H₂O₂를 20분, 10분, 5분간 적용하였다; 5군, 2.5% H₂O₂를 20분, 10분, 5분간 적용하였다. 위와 같이 처리한 후 와동 내를 Superbond C&B(Sunmedical, Co., Shiga, Japan)로 충전하였다. 각 치아는 증류수에 24시간 저장한 뒤 심부 상아질과 치수실 상아질로 잘라 미세인장결합강도 시험을 시행하였다. 각 군에서 측정된 미세인장결합강도를 3-way ANOVA와 Tukey post hoc test로 통계 처리하였다(p < 0.05). 실험 결과 모든 군에서 심부 상아질(D1)의 미세인장 결합강도가 치수실 상아질(D2)보다 높게 나타났다. 평균 결합강도는 H₂O₂의 농도와 적용 시간이 증가할수록 감소하였다. 통계분석에서 상아질의 깊이, H₂O₂농도와 적용 시간이라는 세 가지 변수간의 교호작용 효과는 없으나(p > 0.05). 상아질의 깊이와 H₂O₂농도 사이, H₂O₂농도와 적용 시간 사이에서는 교호작용 효과가 있었다(p < 0.05). SEM 관찰에서는 H₂O₂의 농도가 증가할수록 상아세관이 좀 더 개방된 양상을 보였다. The purpose of this study was to examine the effect of hydrogen peroxide at different application time and concentrations on the microtensile bond strength of resin restorations to the deep and the pulp chamber dentin. A conventional endodontic access cavity was prepared in each tooth, and then the teeth were randomly divided into 1 control group and 4 experimental groups as follows: Group 1, non treated; Group 2, with 20% Hydrogen peroxide (H₂O₂); Group 3, with 10% H₂O₂; Group 4, with 5% H₂O₂; Group 5, with 2.5% H₂O₂; the teeth of all groups except group 1 were treated for 20, 10, and 5min. The treated teeth were filled using a Superbond C&B (Sun medical Co., Shiga, Japan). Thereafter, the specimens were stored in distilled water at for 24-hours and then sectioned into the deep and the chamber dentin. The microtensile bond strength values of each group were analyzed by 3-way ANOVA and Tukey post hoc test(p < 0.05). In this study, the microtensile bond strength of the deep dentin (D1) was significantly greater than that of the pulp chamber dentin (D2) in the all groups tested. The average of microtensile bond strength was decreased as the concentration and the application time of H₂O₂ were increased. Analysis showed significant correlation effect not only between the depth of the dentin and the concentration of H₂O₂ but also between the concentration of H₂O₂ and the application time(p < 0.05), while no significant difference existed among these three variables(p > 0.05). The higher H₂O₂ concentration, the more opened dentinal tubules under a scanning electron microscope(SEM) examination.