Time-Related Changes in Detrusor Overactivity in Awake Rats with Spinal Cord Injury Observed by Simultaneous Registrations of Intravesical and Intraabdominal Pressures

Jin, Long-Hu,Shin, Hwa-Yoan,Yoon, Seung-Hwan,Seong, Do-Hwan,Park, Chang-Shin,Lee, Tack,Yoon, Sang-Min Korean Continence Society 2011 International Neurourology Journal Vol.15 No.1

<P><B>Purpose</B></P><P>To compare the physical characteristics of detrusor overactivity (DO) induced by intravesical infusion of saline in awake, sham rats and rats with chronic spinal cord injury (SCI), by simultaneous registrations of intravesical and intraabdominal pressures.</P><P><B>Methods</B></P><P>Male Sprague-Dawley rats, normal or with a spinal vascular clip at the level of Th9, were investigated cystometrically 1 and 4 weeks after SCI. Intravesical pressure (IVP) and intraabdominal pressure (IAP) were recorded simultaneously to evaluate true DO. During the filling phase, the event of IVP rises, defined as increments that exceeded 2 cmH<SUB>2</SUB>O from baseline, were determined as DO according to the absence of simultaneous changes in IAP.</P><P><B>Results</B></P><P>All SCI rats exhibited DO during the filling phase, which was not shown in sham rats. The frequency and pressure of DO had a tendency to decrease with time. The DO frequency of SCI rats after 4 weeks (0.9±0.2 min<SUP>-1</SUP>) was decreased compared with that after 1 week (2.1±0.4 min<SUP>-1</SUP>; P<0.05). The DO pressure of SCI rats after 4 weeks (8.4±1.9 cmH<SUB>2</SUB>O) was decreased compared with that after 1 week (11.6±2.9 cmH<SUB>2</SUB>O; P>0.05).</P><P><B>Conclusions</B></P><P>Cystometric studies in awake male SCI rats showed some significant changes in bladder function after SCI. All SCI rats exhibited DO during the filling phase, and showed different physical characteristics of DO over the course of time. The neurological basis of these time-related changes remains poorly understood, but may provide important prognostic information about long-term urological management in SCI patients.</P>

Algal bioassay 에 의한 조류생장 제한영양염류 결정

오희목(Hee Mock Oh),이석준(Seog June Lee),김성빈(Seong Bin Kim),박미경(Mi Kyung Park),윤병대(Byung Dae Yoon),김도한(Do Han Kim) 한국하천호수학회 1998 생태와 환경 Vol.31 No.2

Determination of Limiting Nutrient for Algal Growth by Algal Bioassay. Oh, Hee-Mock, Seog June Lee, Seong-Bin Kim, Mi- Kyung Park, Byung-Dae Yoon and Do-Han Kim (Environmental Microbiology Research Unit, Korea Research Institute of Bioscience and Biotechnology, Taejon 305-333, Korea and Water Resources Research Institute, Korea Water Resources Corporation, Taejon 305-390, Korea) Water quaiity and algal growth potential (AGP) using Microcystis aeruginosa were investigated from April to September 1997 in Daechung Reservoir. Secchi disk transparency was 1.1 m in August. Chlorophyll-a concentrations were higher than 10㎍/l at all samples. Total phosphorus concentration was in a range of 0.020∼0.027mg/l which is at the approximate value of 0.03 mg/l, the general critical level of eutrophication. These results indicate that Daechung Reservoir is in an eutrophic state except some temporary times and restricted sites. Phosphorus uptake rate of M. aeruginosa was higher in the water from the epilimnion than in the hypolimnion and also higher under light condition than under dark condition. Therefore, phosphorus uptake rate appears to depend on cellular phosphorous content and light condition, a meaning of endergonic process. Phosphorus was the most frequently limiting nutrient: phosphorus was limiting algal gowth in April and May, nitrogen, phosphorus and trace elements were the limiting factors for algae in August, and trace elements in September. If a fast growing alga, M, aeruginosa, is used as a test organism for assaying AGP, in vivo fluorescence instead of dry weight can be measured for algal biomass and incubation period can be reduced from traditional 14 days to 7 days.

iTECH 바닥 슬래브의 시공단계별 진동특성에 관한 연구

이윤경,주영규,윤성원,김도현,김상대 대한건축학회 2005 大韓建築學會論文集 : 構造系 Vol.21 No.3

The story height of the tall buildings is the significant factor due to the limited construction area within the central city such as Seoul. Therefore we developed iTECH(Innovative Technical Economical & Convenient Hybrid) system to reduce story height. Since the top flange of the proposed beam is within the slab, the vibrational characteristics have to be verified by the test. The purpose of this paper is to study on vibration characteristics of floor with iTECH composite system and to evaluate the serviceability. In this research, natural frequency, damping ratio and peak acceleration were measured at experiments for each construction step such as steel erection stage, concrete casting stage and finishing stage. The test results are compared with that of the code. As a result, the proposed composite slab showed enough vibrational characteristics.

폴리머콘크리트 제조 방법

이민수,정홍석,임성팔,안도희,김광락,이성호,백승우,민병윤 한국공업화학회 2003 응용화학 Vol.7 No.2

In this paper, the foaming method of polymer concrete was studied. The pre-composition of polymer concrete consisted of unsaturated polyester as a binder material 15∼50wt%, sand 0∼80 wt%, filler 5-50 wt%, and foaming agent 0.1∼1.5 wt%. The pre-composition was heated at 100∼200℃ for 30∼120 minutes, which thermal treatment caused hardening of unsaturated polyester and cracking of foaming agent. The foamed polymer concrete showed low thermal transfer coefficent together with good mechanical properties.

日本現代建築의 共通的 特性에 관한 硏究

尹道根,李一珩 弘益大學校 1992 弘大論叢 Vol.24 No.2

Contemporary architecture in Japan is entering an entirely new phase in the second half of the 1980s. In the late 1960s, doubts began to be expressed about Modernism, which until then had been the recogniged mainstream of architecture. There was much discussion, but it was only in the early '80s that an active debate was initiated concerning Post-Modernism. Today, however, matters have gone beyond this, and the situation appears particulary significant the Japanese architecture world was hither to understand to be fundamentally very different from its western counterparts. It is also true that many contemporary Japanese architects have reinforced this view that japanese architecture is unknowable by using abjectives such as "mysterious" and "Far Eastern" to describe their works, albeit in part in a metaphorical sense. This was probably due to a communication gap. There are several trends in current Japanese architecture which have still come out of the Japanese tradition of life, culture, region, climate itself. At the same time, stance of comtemporary Japanese architecture start from a common basis in world's design stream which can be called Post-Modernism, Deconsrtuctivism, Neo or New-Modernism. This study is aimed at analysis of common characteristics in comtemporary Japanese architecture.

레이저 스페클간섭법에 있어서 스페클크기와 측정 한계에 관한 연구

윤성운,김경석,양승필,정현철,김정호,이도윤 한국공작기계학회 1996 한국생산제조학회지 Vol.5 No.1

The high coherence of laser beam has made it possible to observe interference effects even in the light scattered from rough surfaces. That's why, when object with a scattering surface is illuminated with laser light, we do see a speckled appearance due to random interference. This sort of unique property of laser speckle has brought into existence the new noncontacting techniques such as speckle metrology method of measuring deformation, displacement, and vibration etc of objects with high optical sensitivity. The measurable range of speckle metrology especially used to measure in-plane information, however, is limited by some factors, the so-called strain, rotation, tilt of surface and out of displacement perpendicular to the plane of analysis. This restrictions severly limits the measurable range of speckle metrology by causing the decorrelation of speckle patterns. It is the purpose of this paper to give a survey on the measurable limitation of speckle photography method that is one of speckle metrology. Namely we will discuss the mutual relationships and problems of each limitations adding the restriction of the largest and smallest displacement measurable with speckle methods.

解體主義 建築 디자인의 表現特性에 관한 硏究

尹道根,李正旭,李一珩,黃泰周 弘益大學校 1993 弘大論叢 Vol.25 No.2

The characteristic of Formal Expressions in Deconstructive Architecture were summerized in four features through the results of the analysis. They are as follows. 1) `The relation of architectural element and intertextuality' is expressed in discontinuation of context and refusal of functional building. 2) The concept of trace expresses as connection of place, decomposing of excavation of trace, trace of axis, trace of fragments. 3) Anti-gravity expression is there to express of open cubic, to outgrow of rectangular system, to outgrow of volume, to separate of ground connection. 4) The complex compositon of abstracted geometric form is there to abstracted geometry about indefinite shape, to layer through the overlap and collage, to de-meaning and amusement of form through the pursuit of uncertainty, to indeterminate of formal meaning through operation and composion of similar form cause to the diverse of meaning.

후두 및 하인두 편평세포암종에서 E-cadherin의 면역조직화학적 발현

도남용,나한조,이도용,허준,최지윤,이홍영,임성철 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Background and Objectives : The cell-cell adhesion molecule E-cadherin is necessary for the maintenance of the epithelial cellular structure. We were designed to confirm the significance of E-cadherin as a marker for differentiation and invasiveness of squamous cell carcinoma of the larynx and hypopharynx. Materials and Methods : Our study was investigated for the immunohistochemical expression of the epithelium-specific cell adhesion molecule E-cadherin in formalin fixed paraffin embedded tissue specimen of 32 cases of squamous cell carcinoma of larynx and hypopharynx. Results : The positive expression of E-cadherin was 56.3%(18 cases) in squamous cell carcinoma of the larynx and hypopharynx. Decreased E-cadherin expression was a stastistically significant correlation with a increased grade of lymph node stage and clinical stage. Reduced expression was seen in the large tumor size and poorly differentiated tumors, but these result was not statistically significant. Conclusion : The expression of E-cadherin may be related with progression of squamous cell carcinoma of the larynx and hypopharynx. But these correlation were not sufficient for the prognostic indicators in squamous cell carcinomas of the larynx and hypopharynx.

인간 재조합 인터루긴-32 면역조절작용에 대한 유세포 분석

이광수,김영관,채정일,심정현,김은미,강형식,김수현,윤도영,명평근 충남대학교 생물공학연구소 2006 생물공학연구지 Vol.12 No.-

Xenotransplantation of porcine organs has the potential to overcome the severe shortage of human tissues and organ available for human transplantation. however, it remains various hurdles for clinical xenotransplantation. In pig and mouse xenotransplantation, porcine xenograft evoke a strong cellular rejection response in immunocompetent host and grafts are destroyed within a week. This cellular immune response could involved both T cells and NK cells. A number of groups have shown that human NK cells can recognize and damage porcine endothelial cells. In addition, human T cells can respond to porcine endothelial cells through both direct and indirect mechanisms. Cellular rejection of porcine tissues requires T cells, particularly CD4^(+) cells. A new cytokine recombinant human interleukin-32α,β(IL-32α,β) has a role innate and acquired immune system. In order to investigate the role of recombinant mouse IL-18 and recombinant human IL-32α,β in xenograft rejection, we transplanted the PK(15) cells to C57BL/6 mice with or without intraperitoneal injection of recombinant mouse IL-18 or recombinant human IL-32 α,β. It was analyzed the population of NK cell, T cell and B cell in the C57BL/6 mice transplanted with PK(15) cells and recombinant mouse IL-18 or recombinant human IL-32α,β by flow cytometry analysis. As a result, lymph node and thymus of PK15/IL18, PK15/IL32α and PK15/IL32β injected group were increased to T cell activation population than normal injected groups. CD8^(+) T cells were decreased in lymph node of PK15/IL18, PK15/IL32α and PK15/IL32β injected groups. CD4^(+) T cells were increased in lymph node cell of PK15/IL32α and PK15/IL32β injected group and also, B cell population were increased in lymph node cell and spleen of PK15/IL18, PK15/IL32α and PK15/IL32β injected group. Therefore, we suggest that recombinant mouse IL-18 and recombinant human IL-32α,β suppress xenograft rejection in cellular xenotransplantation.

계절성 정동장애에 관한 임상적 연구

이경규,윤도준,장환일 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.1

The purpose of this study was to investigate : (l) whether seasonal affective disorders (SADs) exist among affective disorders in Korea ; (2) if there were SADs in Korea, whether they would be different from other countries' reports describing SAD as having atypical depressive symptoms ; and (3) Is there any difference between winter depression and summer depression as shown in the studies from other countries ; ie. WD shows atypical depressive symptoms and SD shows typical depressive symptoms ? The 76 subjects, having had suffered relapses for at least 2 years in succession, were selected from 375 patients with affective disorder who had been admitted to the Department of Neuropsychiatry of Kyung Hee University Hospital during the 10 years, from 1 January 1980 to 31 December 1989. This study was done by reviewing their records, making a comparison between SAD with depression (n=23) and nonseasonal affective disorder (NSAD) with depression(n=25). Also, another comparison was made between SD(n= 14) and WD(n=9) in SAD. They were analyzed according to sex, age of onset, season of birth, occupation, premorbid personality. family history of psychosis, and atypical depressive symptoms-hypersomnia. hyperphagia. carbohydrate craving, and irritability. The results were as follows : 1) There indeed were patients with SAD in Korea. The prevalence of SAD in this study was 10.9%. 2) Comparison between SAD and NSAD with depression : There was a significantly higher number of patients with NSAD with depression among those with indoor occupations and in families with a history of psychosis compared with patients with SAD with depression (p<0.05). There were no significant difference between them in other factors. 3) Comparison between SD and WD in SAD : There were no significant difference between them in all factors. In conclusion, SAD exists in Korea. But, there are no significant differences in depressive symptoms between SAD and NSAD with depression, or between SD and WD as is the case in the previous studies from other countries.