四君子湯 抽出液이 家兎의 體液性 免疫反應에 미치는 影響

林圭庠,文炳淳,李起男 圓光大學校 醫科學硏究所 1987 圓光醫科學 Vol.3 No.1

The present experiment was investigated on the effects of Sagunjatang extract on the humoral immune response of rabbit. In order to understand the immune respone of the extract, one of the experimental groups was treated with the antigen, E. coli Ry 13 suspension and the extract. And the serum separated from the treated group was analyzed. The results obtained were as follows : 1. The body weight of the rabbit treated with Sagunjatang extract was increased remarkably. 2. Sagunjatang extract did not affect the number of erythrocytes, however, it increased the number of WBC in small amount. It means that the extract activates the WBC related with producing antibody. 3. The synthesis of γ-globulin was stimulated by the Sagunjatang extract in the present experiment.

Columella 缺損例의 成形外科的 治療 : 1例報告

임풍,조문제,빈주원,함기선 大韓成形外科學會 1976 Archives of Plastic Surgery Vol.3 No.1

Columella defect is a noticable deformity which is seen following its loss secondary to injures, diseases, or surgical excisions. The reconstruction of the defect can be achieved by one of the following four methods as advocated by Converse in 1964, i.e. 1) the cervical tubes, 2) the forehead flaps, 3) the nasolabial flaps, and 4) the composite grafts. There is tendency for most surgeons to prefer the nasolabial flap method because of the lesser extend of resulting scar and deformities. Authors obtained a good result in correcting a columella defect from a chronic inflammatory disease in 27 years old woman. Vomerian and nasal tip flaps were employed to make a new columella and the resulting inner raw surface was covered with buccal mucous membrane of the upper lip. The pedicle of the mucosal flap was detached on 10th postoperative day.

소켓 용접부 내부 결함 검사용 초음파 자동 검사 장비 개발

이정기,박문호,박기성,이재호,임성진 한국비파괴검사학회 2003 학술대회 논문집 Vol.- No.1

대구경 배관에서 소구경 배관으로 연결하는 부위 및 배관의 방향 전환을 위해 연결하는 소켓용 접부의 용입 불량 및 사용시간이 경과되면서 내부로부터 진전될 수 있는 균열 검출을 위한 초음파 검사 기법을 확립하였고, 검사를 수행할 수 있는 초음파 탐촉의 개발과 더불어 자동으로 검사할 수 있는 검사 장비와 제어용 운영 프로그램을 개발하였다. 개발된 장비는 컴퓨터를 기반으로 하고 있으며, pulser/receiver를 내장하고 고속 A/D board를 사용하여 초음파 탐상기 역할을 프로그램으로 구현하였으며, ISA interface type으로 4축 제어용 motion controller를 개발하여 자동 검사를 수행하는 scanner를 제어하도록 하였으며, 검사 결과는 소켓용접부 단면을 실시간 영상으로 나타내도록 되어 있다. 개발된 장비는 원자력 발전소나 화학플랜트에 많이 널려 있는 소켓용접부 내의 용입불량, 피로 균열 등을 검출하여 객관적인 검사 결과를 제시할 수 있으므로 설비 안전 관리 및 보수 부위 결정에 기여가 있을 것으로 기대된다.

소켓 용접부 결함 검사용 초음파 자동 검사 장비 개발

이정기,박문호,박기성,이재호,임성진 한국비파괴검사학회 2004 한국비파괴검사학회지 Vol.24 No.3

대구경 배관에서 소구경 배관으로 연결하는 부위 및 배관의 방향 전환을 위해 사용하는 소켓용접부는 용입불량 및 사용기간이 경과되면서 내부로부터 진전될 수 있는 균열 등의 결함을 가질 수 있다. 그러나 지금까지 적용하고 있는 비파괴검사법인 액체침투탐상과 방사선투과검사로는 내부에 존재하는 균열성 결함의 검출이 어렵다. 본 연구에서는 소켓용접부 내부의 균열성 결함 검출을 위한 초음파 검사 기법을 확립하였고, 검사를 수행할 수 있는 초음파 탐촉자를 설계 제작하였으며, 자동으로 검사할 수 있는 검사 장비와 제어용 운영 프로그램을 개발하였다. 개발된 장비는 컴퓨터를 기반으로 하고 있으며, pulser/receiver를 내장하고 100㎒ 고속 A/D board를 사용하여 초음파 탐상기 역할을 프로그램으로 구현하였으며, ISA interface type으로 4축 제어용 motion controller를 개발하여 자동 검사를 수행하는 scanner를 제어하도록 하였으며, 검사 결과는 소켓용접부 단면을 실시간 영상으로 나타내도록 되어 있다. 인공결함 ㅅ험편의 결함을 평가한 결과 결함의 깊이가 1㎜인 결함의 평가 길이는 실제 크기보다 작게 나타내고 있으며, 결함의 깊이가 증가할수록 결함의 길이가 더 크게 평가되었다. 본 연구로 개발한 장비는 원자력 발전소나 화학플랜트에 많이 널려 있는 소켓용접부 내의 용입불량, 피로 균열 등을 검출하여 객관적인 검사 결과를 제시할 수 있으므로 설비 안전 관리 및 보수 부위 결정에 기여할 수 있을 것으로 기대된다. Socket weldment used to change the flow direction of fluid may have flaws such as lack of fusion and cracks. Liquid penetrant testing or Radiography testing have been applied as NDT methods for flaw detection of the socket weldment. But it is difficult to detect the flaw inside of the socket weldment with these methods. In order to inspect the flaws inside the socket weldment, a ultrasonic testing method is established and a ultrasonic transducer and automated ultrasonic testing system are developed for the inspection. The automated ultrasonic testing system is based on the portable personal computer and operated by the program based Windows 98 or 2000. The system has a pulser/receiver, 100 ㎒ high speed A/D board, and basic functions of ultrasonic flaw detector using the program. For the automated testing, motion controller board of ISA interface type is developed to control the 4-axis scanner and a real time iC-scan image of the automated testing is displayed on the monitor. A flaws with the size of less than 1 ㎜ in depth are evaluated smaller than its actual size in the testing, but the flaws larger than 1 ㎜ appear larger than its actual size on the contrary. This tendency is shown to be increasing as the flaw size increases. A reliable and objective testing results are obtained with the developed system, so that it is expected that it can contribute to safety management and detection of repair position of pipe lines of nuclear power plants and chemical plants.

Electromyography 기법을 이용한 씨름 덧걸이 기술의 상체 근 동원 비교분석

신성휴,임영태,김태완,박기자,권문석 한국운동역학회 2003 한국운동역학회지 Vol.13 No.1

Shin, S-H · Lim, Y-T · Kim, T-H · Park, K-J and Kwon, M-S. Electromyographical Analysis of Muscle Activities of Upper Trunk for Ssireum Dutguri Technique. Korean Journal of Sport Biomechanics, Vol. 13, no. 1, pp. 95-108. The purposes of this study were to analyze the muscle activities and the characteristics of muscle recruiting patterns of upper trunk for Ssirum dutguri technique using three top-ranked elite Ssirum players. The EMG technique was used to record muscle activities of both right and left sides of latissimus dorsi, biceps brachii, and erector spinae. Six surface electrodes were placed on the surface of the selected muscles and one ground electrode was also attached on the back of neck(C7). One video camera was also used to record the Ssirum motion to define 4 events and 3 phases for further analysis. The raw EMG data were filtered with band pass filter (50-400 Hz) to remove artifacts and then low pass filtered (4 Hz) to find the linear envelope which resemble muscle tension curve. This filtered EMG data were normalized to MVIC for the purpose of comparion between the subjects. The results were indicated that each subject with different physical characteristics showed very different muscle activity patterns. Although Ssirum dutguri is considered as foot technique the player grasped opponent's satba(belt) with both hands when they play. Because of this reason, activities of upper trunk muscles were relatively high. However, direct comparison between upper and lower body muscles was not possible due to the lack of the data in present study. Interestingly, all threes subjects showed that erector spinae muscle activity was comparatively higher than those of latissimus dorsi and biceps brachii. This implies to reinforce back muscle as a routine of training to improve performance or to prevent back injury. implies to reinforce back muscle as a routine of training to improve performance or to prevent back injury.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)

김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.

PC U형의 단면을 사용한 포스트텐션된 넓은 보-기둥 내부접합부의 비탄성 거동

최윤철,임재형,문정호,이리형,권기혁 대한건축학회 2005 大韓建築學會論文集 : 構造系 Vol.21 No.1

Post-tensioned precast concrete system(PPS) consists of U-shaped precast wide beams and concrete columns. The continuity of beam-column joint is provided with the topping concrete on the PC shell beam and post-tensioning. The purpose of this paper is to evaluate the response of PPS interior beam-column joint subjected to cyclic lateral loading. To this end, the experimental investigation was performed with three half-scale specimens of interior connection. The design parameter is the ratio of beam width to column width. Test results showed that cracks were distributed well and plastic hinges spread toward midspan without any significant degradation of strength and ductility. And the specimens sufficiently resisted up to the limiting drift ratio of 0.035 given by ACI of acceptance criteria for concrete special moment frames.

Platinum sensitive 재발성 난소암에서 Carboplatin/Paclitaxel의 효과

장혜진,유희석,임윤경,문세희,장기홍,이정필 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4

목적 : 재발성 난소암에서 platinum 감수성을 기준으로 2차 항암요법으로 사용한 Carboplatin과 Paclitaxel의 효과를 알아보기 위하여 본 연구를 진행하였다. 연구방법 : 1998년 1월 1일부터 2003년 8월 31일까지 만 5년 8개월 간 아주대학교병원 산부인과에 재발성 난소암으로 입원한 환자 중에서 최초 수술로 난소암을 확진한 후 Cisplatin 또는 Carboplatin 등 platinum 제재가 포함된 항암치료를 받은 후 6개월 이후에 재발한 환자 29명을 대상으로 Carboplatin은 5 AUC를 그리고 Paclitaxel은 175 mg/m^(2)를 투여하였으며, 최소 3회에서 최고 16회까지 투여하였다. 치료효과의 판정은 CT, MRI, Ultrasonography등 영상진단상 암종괴의 크기가 완전히 소실되었을 경우를 완전반응(complete response)으로, 50%이상 감소되었을 경우를 부분반응(partial response)으로, 50% 미만으로 감소되었거나 20% 미만 증가하였을 경우를 불변(stable disease)으로, 그리고 20% 이상 증가되었을 경우를 진행(progressive disease)로 정의하였다. 결과 : 대상 환자에서 완전반응은 6명(21%), 부분반응은 11명(38%), 그리고 불변은 5명(17%)로 전체 반응율 (overall response rate)은 59% 그리고 임상적 유용성(clinical benefit=CR+PR+SD)은 76%이었다. 결론 : 재발성 난소암환자에서 기왕에 사용한 Platinum 제재에 민감한 환자에서는 Carboplatin과 Paclitaxel의 병행 투여가 효과적이었다. Objective : To ascertain the effect of Carboplatin and Paclitaxel combination as a second line regimen for recurrent ovarian carcinoma based on platinum sensitivity. Methods : From January 1st, 1998 through to August 31st, 2003, 29 patients were retrospectively reviewed who had previously underwent primary cytoreductive surgery and adjuvant chemotherapy with Cisplatin or Carboplatin for ovarian carcinoma, and who had later recurred during follow up. All 29 patients had recurred at least 6 months after therapy, and thereafter received second line chemotherapy consisting of Carboplatin (5 AUC) and Paclitaxel (175 mg/㎡) for a minimum of least 3 cycles and a maximum of 16 cycles. Treatment efficacy was assessed by imaging studies including Computerized tomography, Magnetic Resonance Imaging, or Ultrasonography. Complete response was determined as complete disappearance of tumor, partial response at least than 50% reduction in tumor volume, stable disease as less than 50% reduction or less than 20% increase in tumor volume, and progressive disease as more than 20% increase. Results : There was complete response in 6 (21%) patients, partial response in 11 (38%), stable disease in 5 (17%), showing an overall response rate of 59%. The clinical benefit (CR+PR+SD) was 76%. Conclusion : The combination of Carboplatin and Paclitaxel administration seems to be an effective mode of second line therapy in patients with recurrent ovarian carcinoma who had been sensitive to prior platinum based chemotherapy.

안산시 지역주민의 정신질환자에 대한 태도

이정은,이영문,임기영,이호영 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.3

연구목적 : 본 연구에서는 안산시 지역사회 정신보건사업을 시행하기에 앞서, 안산시 지역주민의 정신질환자에 대한 태도와 인식을 평가하고, 향후 설치될 정신보건시설에 대한 반응행동을 알아봄으로써 지역사회에 정신질환자들이 통합되어지기 위해서 시행해야 하는 사업계획을 수립하는데 기초자료로 활용하기 위함이다. 방 법 : 1997년 12월에 안산시 지역에 거주하는 주민을 대상으로 하였으며 1차 표본추출은 구역별로 무작위 추출을 하여 우편으로 3.000개의 설문지를 배포하여 176명에게서 수거하였다. 2차 방법으로 23개동을 각 지역별로 나누고 자원봉사자를 통해 직접 설문지를 전달하고 706개 수거하여 총 대상자는 882명이 되었다. 조사도구는 Community Attitudes to the Mentally Ⅲ(CAMI) inventory를 번역하여 사용하였다. 결 과 : 안산지역에 거주하는 사람의 전반적인 정신질환자에 대한 태도는 동정적이며 지역정신보건 개념에도 긍정적인 태도를 보였다. 여성, 고연령층과 저학력일수록 그리고 여론주도층이 더 권위적이고 사회적으로 제한을 해야한다는 경향이 있었다. 주택을 소유한 사람은 정신질환자에 대해 동정적인 태도를 보이나 지역내에 정신보건시설 설치에 대해서 반대하는 경향을 보였다. 결 론 : 정신질환자에 대해 부정적인 견해를 갖고 있는 여성, 고연령층, 여론주도층, 주택을 소유한 집단 등을 지역정신보건사업의 우선적인 대상이 되어야 할 것으로 생각된다. We investigated the range of knowledge about mental health and the attitude toward mentally-ill community residents and the results of the investigation were taken as a foundation of the program of a community mental health project. The results were as follows : 1) The residents of Ansan community showed sympathetic and positive attitude toward the community mental health ideology. 2) The opinion leaders and females had more authoritative and negative tendency to the mentally-ill. 3) The more aged the more negative, conservative, and socially restrictive attitudes were shown toward the mentally-ill. 4) The home-owners had sympathetic attitude toward the mental illness but opposed the establishment of mental health facilities in their community with behavioral reaction. Therefore, the community education about mental health should be actively and intensively concentrated upon the females, the people of old age, the opinion leaders and the home-owners.

방사선 조사에 의한 phospholipase D 활성화 연구

김영래,김기환,조문준,임규,황병두,박승길 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Activation of oleate-dependent phospholipase D (PLD) isozyme by irradiation was reported previously. However, the effects of irradiation on other PLD isotypes (PLD1 and PLD2) have not been studied. There are several kinds of PLD isozymes in a cell. Therefore, it is difficult to study PLD isotype-specific activation in a cell by irradiation. We tested which isotype of PLD responds to irradiation. We used the fibroblasts cell lines overexpressing PLDl or PLD2 by introducing recombinant PLD1 or PLD2 cDNA. Phospholipids in cells were labelled with [(3)^H] myristic acid. Before irradiation, l-butanol was added. After irradiation with doses of 1, 2, and 10 Gray, we measured the formed phosphatidylbutanol containing [(3)^H] myristic acid. The overexpressed PLD isotypes were functional in those cell lines. PLD2 activity was enhanced by irradiation when we compared the PLD activations between control and PLD1 or PLD2 overexpressing cells. However PLD1 was not activated by irradiation. PLD2 isozyme, but not PLD1, was activated by irradiation. One Gray irradiation showed the maximal effect on PLD2 activation. The activation mechanism and physiological significance of PLD2 activation by irradiation remain to be uncovered.