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화상시 T세포 및 자연살해 세포면역능의 변화에 관한 실험적 연구
김영진,백무현,엄익태,조문제,임풍 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.2
Studies of the immune system in both clinicl and experimental burn injury have noted impairment of cellular immunity and this impaired cellular immunity after burn has been demonstrated by prolonged survival allograft, marked depression on delayed hypersensitivety or failure of lymphocyte mitogenesis. However, the exact nature of the mechanisms leading to immunosuppression remains unclear. The aim of this study is to evaluate the level of cellular immunity in burned rats with immune paramenters of T cell subsets and colony forming unit-T lymphocyte (CFTL) as well as natural killer cell mediated cytotoxicity (NKMC). Lymphocytes were isolated sequentially from the blood of control and experimental animals on the 1st, 3rd, 5th, 7th and 14th postburn days (PBD). T-cell subsets were defined with monoclonal anti rat T lymphocyte antibody by the indirect immunofluoroscence method. The proportions of tatal T cell (Tan T), helper T cell (Th) and helper T cel/suppressor T cell ratio decreased from the 1st PND and revealed most significant reduction on the 5th PBD (Pan T)and 7th PBD (Th, Th/Ts ratio)respectively, but they recovered by the 14th PBC. On the contrary, the percentage of suppressor T cell (Ts) in creased after burn injury and was maximum on the 7th PBD, thereafter it decreased to the nearly control level on the 14th PBD, Number of T-lymphocyte colony (TL-colony) decreased after burn injury, and the changing pattern of its number was quite similar to that of Pan T. The cytotoxicity of natural killer cell against Molt 4 target cells depressed rapidly after burn injury and revealed most significant reduction on the 3rd PBD, but it restored completely on the 7th PBD. Sequential change of cortisol level didn't co-ordinate with that of cellular immunity, and it showed that stress after burn injury did not frnction as a major role to decrese cellular immunity. The results of this study give us a speculation that immunosuppression after burn injury was resulted from decreased helper T cell, increased suppressor T cell and depressed NKMC, and that damage or recovery fo natural killer cells after burn injury is of precedence to that of the T cells.
양안 격리증을 수반한 Encephalomeningocele의 치험예 : A Case Report
함기선,이덕주,김선무,조문제,임풍 大韓成形外科學會 1980 Archives of Plastic Surgery Vol.7 No.1
Encephalomeningocele result from developmental malformation in which brain and meninges are present. This anomalie usually associated with facial anomalie and may be accompany by other defects at birth or infancy. The authors experienced a case of encephalomeningocele covered with normal soft tissue on right canthal area, It was accompanied with moderate hypertelorism and drooped nostril deformity of affected side. Histologically, the specimen showed collagenous, hyalinized connective tissue with scattered glial cells. Many recent surgical approaches have been designed to correct deformites for psychosocial adaptation and anatomical reason. But difficult problem still remain particulary as to restoring binocular vision to correct hypertelorism. Authors obtained a good result in correcting deformity from the encephalomeningocele with hypertelorism employing intracranial cranioplasty and canthoplasty. Now, we describe a brief review of reference on encephalomeningocele.
함기선,조문제,임풍 대한성형외과학회 1976 Archives of Plastic Surgery Vol.3 No.2
The most annoying problem in the repair of a wide cleft palate is the frequently encountered fistular formation. In order to obviate complications resulting from excessive tension on repaired line. The authors have attempted the closure with an newly modified procedure with very favorable results. The procedure is the modification of the method originally described by VEAU and TRAUNER, instead of approximating two arterial flaps directly in the midline, The authors closed the defect with the both flaps in sigmoid fashion so that the distal flaps are overlapped one another on the area with the maximum tension at the junction of the hard and the soft palate.
Limberg 씨 被瓣術을 利用한 腋臭症 治療의 臨床的 考찰
金眞喆,李相虎,林豊 大韓成形外科學會 1984 Archives of Plastic Surgery Vol.11 No.1
Secretion of axillary appocrine glands is naturally odorless but a strong foul odor is developed by bacterial decomposition. The fundamental treatment of osimidrosis axillae is to remove majority of the central axillary glands, responsible for 70 to 80% of the axillary secretion. We elected to treat our osmidrosis axillae patients by excision of the leison and closure of the defect by Limberg's flap. Authors reviewed and evaluated the results of the treatment of 103 osmidrosis axillae patients who were treated in Catholic Medical Center from 1978 to 1982. The following results were obtained 1) During the period 103 patients with 206 osmidrosis axillae were admitted to the hospital. The patients were 83 female and 20 men. 2) Most of osmidrosis occurred in the age group of between 15 to 29 years. 3) The mean postoperative hospitalization date was 4.2 days. 4) Complications developed in 10 axillae (4.9%). 5) The complications were follows; 1) Hematoma : 4axillae 2) Partial wound distruption : 2 axillae 3) Partial flap necrosis : 2 axillae 4) Noticeable scar : 2 axillae 5) Recurrence and reoperation was absent Overall result of the surgery is very satisfactory and it is highly recommendable in treatment of osmidrosis axillae.