골반내에 발생한 Proximal-type 유상피성 육종 1예

길준철,이상수,전병화,김성훈,손우석,목정은,박양순,강길현 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4

유상피성 육종은 매우 드문 악성 연조직 육종으로, 전형적인 경우들은 주로 젊은 남성의 수부, 전완부와 같은 신체의 원위부에 피하 혹은 심재성 피부 종괴로 발생하며, 조직학적 소견상 적은 비정형성을 나타내는 유상피성 세포와 방추형 세포의 증식에 의한 다발성 결절 형태의 배열을 보인다. 최근에 전형적인 유상피성 육종과 조직학적 유사성을 가지나 더 공격적인 형태인 proximal-type 유상피성 육종이 보고되었으며, proximal-type은 전형적인 유상피성 육종에 비하여 현저한 유상피성 세포의 발현과 매우 심한 비정형성을 나타내며, 세포가 매우 크고, 소포성 핵과 뚜렷한 핵소체를 보이며, 자주 rhabdoid 세포의 양상을 띈다. 임상적으로는 전형적인 형태에 비하여 호발 연령이 조금 늦고, 주로 체간부에, 특히 골반, 회음부, 생식기 등과 같은 심부에 발생하고, 더욱 공격적인 양상을 나타낸다. 저자들은 13세 소녀에서 원발부위를 알 수 없는, 골반내에 발생한 proximal-type 유상피성 육종 1예를 경험하여, 문헌 고찰과 함께 보고하는 바이다. Epithelioid sarcoma is a rare malignant soft-tissue sarcoma with an unknown histiogenesis, typically presenting as a subcutaneous or deep dermal mass lesion in the distal portions of the extremities of young adults. Recently, a more aggressive, so-called 'proximal-type' epithelioid sarcoma has been reported. In contrast to conventional epithelioid sarcoma, the proximal type is characterized by a predominantly large cell epithelioid cytomorphology, marked cytologic atypia, and frequent occurrence of rhabdoid features in most patients. Proximal-type epithelioid sarcoma has a predilection for appearing in the genitalia, especially the vulva, penis, pelvis and buttocks. Also this lesion appears to be somewhat more aggressive or at least metastasizes earlier than the conventional epithelioid sarcoma. We report a 13-year-old girl who presented with a buge mass filling the pelvic cavity which was painful, hard and fixed on palpation, and was radiologically diagnosed as a malignant germ cell tumors on the CT scan. The mass was surgically excised and pathologically proved to be an proximal-type epithelioid sarcoma of unknown origin.

단순 스무딩 스플라인 함수 추정

강상길,이우동,윤용화,김종태 慶山大學校 基礎科學硏究所 1998 基礎科學 Vol.2 No.1

본 논문의 목적은 선형 스무딩 스플라인에 대한 단순하고 구체화된 형태를 제안하고, 구체화된 선형 스무딩 스플라인 형태를 통하여 스무딩 스플라인의 특성을 이해하고는 어떻게 비모수 함수 추정량의 도구로서 사용될 수 있는지를 보인다. 또한 예제를 통하여 다른 비모수적 추정량들과 비교하였다. In this paper, we give simple and closed form of linear smoothing spline. Through the form, we understand the characteristics of smoothing spline, and show that how the smoothing spline can be used as a tool for estimator of nonparametric functin. And an example is given for comparison of our esttimator with another nonparametric estimators.

모터구동 밸브 주기적 안전성 확인을 위한 중요도 분류

강대일,성태용,김길유 한국산업안전학회 2002 한국안전학회지 Vol.17 No.2

Safety-related motor operated valve(MOV) safety significance for Ulchin Unit 3 was categorized. The safety evaluation of MOV of domestic power plants affects the generic data used for the quantification of MOV common cause failure(CCF) events in Ulchin Units 3&4 PSA> Therefore, in this paper, MGL(multiple greek letter) parameter β, used for the evaluation of MOV CCF probabilities in Ulchin Units 3&4 probabilistic safety assessment(PSA), was re-estimated and the MOV safety significance was categorized. The re-estimation results of MGL parameter show that the value of(is decreased by 30% compared with the current value used in Ulchin Unit 3&4 PSA. The categorization results of MOV safety significance using the changed value of MGL parameter(show that the number of HSSCs(high safety significant components) is decreased by 54.5% compared with those using the current value of it used in Ulchin Units 3&4 PSA>

인체 체액내 황색포도상구균의 증식과 철 획득 기전

신성희,이강길,이명희,양남웅,임용,김진호 대한감염학회 2000 감염 Vol.32 No.5

당뇨병 백서의 간세포에서 Glucokinase 활성도 및 유전자 발현에 대한 인슐린의 영향

강성이,팽정령,서광식,안규정,우정택,김성운,양인명,김진우,김영설,김광원,최영길 경희대학교 유전공학연구소 1993 遺傳工學論文集 Vol.5 No.-

목적 당대사의 조절 상태에 따른 생체 변화를 분자 수준에서 이해하고자 식이 조건을 달리한 정상 백서와 화학적으로 유도된 당뇨병 백서의 간조직에서 혈당수준과 인슐린치료 정도에 따라 나타나는 글루코키나제 활성도 및 유전자 발현을 분석하였다. 방법 스트렙토조토신 정맥투여 후 당뇨병의 유발을 확인하고, 인슐린을 1일 3회 3일간 복강내로 투여하여 상태를 안정시킨 후, 인슐린 투여군은 인슐린 투여 6시간이내에 그리고 인슐린 비투여군은 24시간 후 단두하여 채혈하고 복강을 열어 간조직을 채취하였다. 채취한 간조직에서 글루코키나제 활성도는 인산화된 포도당에서 NADH의 형성을 형광분광계로 측정하였으며, 글루코키나제 유전자 mRNA발현은 Northern 분석법을 이용하였다. 성적 정상 백서에서 공복상태와 식이를 섭취한 경우에 간조직의 글루코키나제 효소의 활성은 차이가 없었으나, 글루코키나제 유전자 mRNA 발현은 증가되었다. 당뇨병이 유발된 백서의 간조직에서 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA 발현은 정상 백서에 비하여 낮았다. 인슐린 투쳐 후 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA 발현이 증가되었고, 특히 혈당이 정상화된 경우에서 글루코키나제 유전자의 mRNA 발현이 증가도었다. 결론 인슐린에 의한 간조직에서 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA을 증가를 볼수 있었다. 당뇨병 백서에서 인슐린 투여 후에 혈당조절이 안된 경우 간조직의 글루코키나제 유전자의 mRNA 발현이 증가가 없는 것으로 보아 글루코키나제 mRNA의 발현에는 인슐린 이외의 다른 요소가 관여할 것으로 생각된다. The liver-specific hexokinase isoenzyme, referred to as glucokinase, is thought to play a key reglulatory role in hepatic glucose metabolism. The glucokinase gene is, therefore, of interest both because of its tissue-specific expression and because of the several regulatory processes that can be analyzed. The level of hepatic glucokinase activity appears to be determined essentially by regulation of the rate of enzyme synthesis, with insulin playing a leading role as an inducer. We investigated the role of insulin for the induction of glucokinase in the liver of diabetic rats. Experimental diabetes was induced by injection of streptozotocin 7 days before the experiment. Regular insulin was given by three days intraperitoneal injection at 8-h interval. The glucokinase mRNA in the liver was estimated by Nothern blot assay, as well as by fluorometric enzyme activity assay. Glucokinase activity was not reduced in the liver of normal fasting rats as compared to normal fed rats. And glucokinase activity was reduced in the liver of diabetic rats as compared to normal rats. In diabetic rats treated with insulin, glucokinase enzyme activity were increased. But glucokinase mRNA expression was only increased in normoglycemic diabetic rat with treated with insulin as compared to hyperglycemic rat. These data indicate that insulin stimulates hepatic glucokinase enzyme activity and mRNA expression. But other hormonal or metabolic factors may be contribute to regulation of glucokinase mRNA expression.

온주밀감의 수체부위에 따른 질소 함량 및 집적량

강영길,유장걸,오현도,오상호 濟州大學校 亞熱帶農業硏究所 1998 亞熱帶農業硏究 Vol.15 No.-

온주밀감에 있어 질소 시비법 개선의 기초자료로 활용하고자 흑색화산회토에 재식된 8년생 궁천조생 16 그루를 대상으로 수체부위별 건물중, N 함량, N 축적량, 건물중 및 N 축적량의 수체부위별 분포비율 등을 조사·분석한 견과를 요약하면 다음과 같다. 1. 그루당 건물중은 7.2~12.6 kg의 범위에 있었고 평균이 10.3 kg, CV가 16.5%이었다. 수체부위별 평균 건물중 분포비율은 뿌리에 총건물중의 22.6%, 줄기에 38.8%, 잎에 14.9%, 과실에 23.7%가 분포되어 있었다. 그루간 수체부위별 건물중 분포비율의 CV는 잎에서 가장 적었고(7.8%) 근간 및 수간에서 매우 컸다(38.5 및 42.6%). 2. 나무 전체 평균 N 함량은 1.13%이었고 뿌리, 줄기, 잎, 과실의 평균 N 함량은 각각 0.96, 0.75. 2.58, 0.99%이였으며, 세근, 녹지의 N 함량은 각각 1.83, 1.18%로 비교적 많은 편이었다. 수체부위별 N 함량의 CV는 4.3~14.6%로 건물중에 비하여 현저히 낮았고 잎(6.8%), 과육(4.6%), 과피(5.5%)에서 적었으나 녹지에서는 14.6%로 컸다. 3. 그루당 N 축적량은 80~145 9의 범위에 있었고 평균이 116 g이었는데, 뿌리에 N 총축적량의 19.3%, 줄기에 25.9%, 잎에 34.0%, 과실에 20.8%가 분포되어 있었다. 뿌리내 N 축적량의 16.4, 32.6, 51.0%가 각각 근간(stock), 중·대근, 세근에, 줄기내 N 축적량의 12.2, 19.8, 26 2, 41.8%가 각각 수간, 대지, 중지, 녹지에, 과실 N 축적량의 68.5%가 과육에 집적되어 있었다. 그루간 수체부위별 N 축적량의 CV는 수체부위별 건물중 분포비율에서와 대체로 비슷한 경향이었다. Dry weight, N content and accumulation, and the distribution of dry weight and N accumulation in various plant parts of sixteen 8-year old Satsuma mandarin trees (Citrus unshiu Marc. Cv. Miyakawa Wase) grown in volcanic ash soil were determined in December 1997 to obtain some information for improving N fertilization. Dry weight per tree ranged from 7.2 to 12.6 kg and averaged 10.3 kg (CV 16.5%) Roots, stems, leaves and fruits had 22.6, 38.8, 14.9, and 23.7% of total dry weight, respectively. The coefficient of variability for leaf dry weight distribution among 16 trees was least (7.8%) while the CV for stock and trunk dry weights great (38.5 and 42.6%, respectively). Average N content for whole tree, roots, stems, leaves and fruits had 1.13, 0.96, 0.75, 2.58 and 0.99%, respectively. Fine roots and twigs also had higher N content with 1.83 and 1.18%, respectively. The coefficient of variability for N content in the various parts of trees ranged from 4.3 (fruits) to 14.6% (twigs) and was much smaller than the CV for dry weight and N accumulation. Nitrogen accumulation per tree ranged from 80 to 145 g and averaged 116 g. Whole roots, stems, leaves and fruits had 19.3, 25.9, 34.0, and 20.8% of total N accumulation of whole tree, respectively. Stock, medium-big roots, and fine roots had 16.4. 32.6, and 51.0% of total N accumulation in whole roots, respectively, while trunk, big and medium branches, and twigs 12.2, 19.8, 26.2 and 41.8% of N accumulated in whole stems, respectively, and pulp 68.5% of N accumulated in whole fruit. The coefficients of variability for N a cumulation distribution among 16 trees had similar trend with dry weight distribution.

산도가 가토의 자궁수축에 미치는 영향

정택상,강길전 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.1

The effecs of hydrogen ion concentration changes on the contractility as well as patterns of contraction to hormones were investigated in the isolated rabbit uterine muscles. Contractility was recorded on a Physiography with force transducer by means of Magnus method in sodium lacate Ringer's solution used were normal (pH 7.4), acidic (pH 6.3), and alkaline (pH 9.4), were titrated by 0. 01 N HCI or 0. 01 N NaOH solution respectively. Used hormones and its doses were 0.1ug/ml epinephrine, 50 mu/ml oxytocin, 30ug/ml and 100 pg/ml prostaglandin F_2a and prostaglandin E_2. Obtained results are summerized as follows: 1. Increased hydrogen ion concentration inhibited the contractility of uterine muscle, and dereased concentration increased the motility. 2. Decreased hydrogen ion from pH 7. 4 to pH 9. 4 increased the tension of the uterine contraction to 215±40%. 3. Epinephrine increased the uterine contractility in each pH. In pH 7. 4, the contraction tension of the uterine muscle was increased to 510±65% of the control value, but in pH 6.3 and 9.4, increased contraction tension were significantly lower than pH 7. 4 (p<0.01). 4. The increased contraction tension of oxytocin in pH. 7.4 was 197±25% of the control value In pH 6. 3, the increased contraction tension was significantly lower than pH 7. 4 (p<0.01), but in pH 9.4, the increased contraction was significantly higher (p<0.01). 5. Prostaglandin F2α and E2 increased the contraction tension to 305±34% and 391±73% in pH7. 4. But in pH 6. 3 and 9.4 were lower increased than pH 7.4(p<O.01).

융모성 질환의 임상적 연구

남상륜,손영선,이영일,노흥태,강길전 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

Seventy nine cases of trophoblastic disease were analyzed at the Department of Obstetrics and Gynecology, Chungnam National University from January, 1985 to October, 1989. The results are as follows: 1. Incidence of trophoblastic disease was one per 31.8 deliveries(3.15%), and it was pathologically consisted with partial mole(27.8%), complete mole(45.6%), invasive mole (17.7%), choriocarcinoma(8.9%). 2. Age group of 26 to 30 was found most frequent(40.5%) and primipara was the most frequent group(43.0%). There was no increase for the persistent disease according to age and para. 3. Clinical manifestations were vaginal bleeding(91.1%), the most common, nausea and vomiting(20.3%), abdominal pain(10.1%) and etc. 4. Molar pregnancies with excessive uterine enlargement were found in 35.6% and were at increased risk for the persistent disease. 5. Antecedant pregnancies prior to trophoblastic disease were abortion(43.0%), term pregnancy(16.5%) and molar pregnancy(16.5%). 6.β-hCG concentration before November, 1986 was significantly lower than after ten. And the first postevacuation β-hCG level was increased in cases of the persistent disease. 7. The treatment regimens in molar pregnancies were suction curettage with prophylactic Act-D(41.4%) and without Act-D(43.1%), hysterectomy with Act-D(13.8%), and hysterotomy(1.7%). There was no difference in complication persistent disease between with and without prophylactic chemotherapy. 8. Non-metastatic and metastatic low risk patients were treated with hysterectomy with or without MTX-CF(66.7%), curettage with MTX-CF, Act-D or MAC(33.3%) to attain remission without failure. All metastatic high risk patients were treated with hysterectomy with 1-6 courses of MAC triple chemotherapy except 1 case of death from respiratory failure and 1 lost case. 9. Side effects after chemotherapy include gastrointestinal symptoms(91.1%), fever(57.8%), leukopenia(49.0%), hepatotoxicity(46.9%), stomatitis(40%), alopecia(28.9%), thrombocytopenia(15.3%) and etc, in order of frequency.

모 제약회사 근로자들의 직업성 천식 유병률과 약제 분말 노출수준

오성수,최용휴,김은아,이영목,장재길,유장진,박승현,김태균,정수영,김규상,강성규 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 제약회사에서 직업상 천식의 유병 규모를 파악하고 작업공정에 대한 작업환경 측정을 통해 제약회사의 약제 분말에 대한 노출수준을 평가하고자 하였다. 방법: 제약회사에서 약제 분말에 노출되는 근로자를 대상으로 천식을 선별하기 위하여 설문조사 및 진찰, 혈액검사, 폐기능 검사 그리고 피부단자시험을 실시하였고, 각 부서별 공정에 따라서 총분진과 항생제 또는 효소제 분말에 대한 작업환경 측정을 실시하였다. 직업상 천식이 의심되는 근로자에 대하여 기관지과민성에 대한 검사(메타콜린을 이용한 비특이 기관지유발시험)와 약제 분말 기관지유발시험을 실시하여 확진하였다. 결과: 설문조사 및 진찰에서 작업 관련 천식 증상이 있는 근로자는 11명(34.4%)이었고, 약제 분말을 이용한 피부단자시험에서 1+ 이상 반응을 보인 근로자 10명(31.2%)이었다. 비특이 기관지유발시험 결과 8명(25.0%)이 양성(PC20 ≤16 mg/ml)이었다. 약제 분말 기관지유발시험을 통해 직업상 천식으로 확진된 근로자는 5명(15.6%)이었다. 작업환경 측정에서 원료를 충진하거나 투입하는 작업 그리고 정립작업에서 약제 분말에 대한 노출이 많았다. 결론: 제약회사에서 직업상 천식은 주로 제조공정 중 약제 분말에 노출된 근로자에서 발생하여, 증상 및 직업성 천식의 유병률이 높았다. 따라서 원료를 충진 또는 투입하는 작업과 정립작업 등 제조과적에서 약제 분말 노출을 줄이기 위한 세심한 주의가 필요하여, 약제 분말을 취급하는 근로자에 대해서는 천식 증상 조사뿐 아니라 정기적으로 피부단자시험, 비특이 기관지유발시험 등을 실시하여야 할 것이다. Objectives: After the investigation of one worker with occupational asthma, we surveyed the preva- lence of occupational asthma and the exposure level of pharmaceutical dust of 32 workers in a pharmaceutical company. Methods: Thirty-two of the 90 employees participated in the survey which consisted of questionnaire, blood sampling, spirometry and skin prick tests with 8 common allergens as well as 9 antibiotics and 2 enzymes. Various indices of the working environment were also measured. Subjects who had a symptom suggestive of work-related asthma or positive skin prick test were further investigated by PC20 methacholine. Nine subjects who had a PC20 result of 16 mg/ml or less (n=7) or had work-related symptoms and positive skin prick test (n=2) were referred to undergo a specific bronchial provocation test to phar- maceutical dust in an academic allergic disease center. Results: Eleven of 32 workers (34.4%) had a work-related symptom suggestive of occupational asthma. Ten (31.2%) showed positive skin prick test. 8 (25.0%) had a PC20 result of 16 mg/ml or less (indicative of significant bronchial hyperresponsiveness), and 5 (15.6%) had a positive result on the specific bronchial provocation test. Exposure levels of stuffing, input of raw materials and screening process were relatively high. Conclusions: This survey showed that pharmaceutical workers have an increased risk of occupational asthma. Although pharmaceutical factories maintain a relatively good working environment, careful control of respiratory tract exposures, especially during stuffing, input or raw materials and screening process, is important to prevent occupational asthma. Pharmaceutical workers need to undergo regular skin prick and methacholine bronchial provocation tests, as well as asthmatic symptom survey, to ensure the early detection and prevention of occupational asthma.

스포츠 政策의 國際比較硏究 : 3個國의 스포츠振興法을 통하여

정길상,이강우 동국대학교 경주대학 1998 東國論集 Vol.17 No.1

Sports are said to be like a mirror which reflects society. Also, sports are of universal culture in that sports are performed on the basis of Internationally common rules and at the same time of culture characterized with a much national, publicly common feature which has the ability to form or build human relations between the members of society. Accordingly, an internationally comparative study on sport policies as a supportive system has a significant meaning in respect that it promotes understanding between countries as well as internalization. For that reason internationally comparative study on sport policies is considered to be very useful in that the performance of it can be really used as reference and it can be applied to the policies of a certain country. So far, internationally comparative study on sport policies seem to have been at a descriptive level of comparatively studying each of cases respectively, and such studies are at a level of describing similarities and dissimilarities between two countries. However, a comparative study is necessary in the future to develop the framework and scale in order to build the universal principle and general theory based on the similarities and dissimilarities of the sport policies of each nation. Also, in internationally comparative study on sport policies, there should be no a ethnocentrism.The culture of sport systems in any of races, peoples, nations has a special value. Accordingly, the attitude of such a kind study may improve sport programs or heighten the efficiency of them, thereby achieving new development of them.