항우울제와 연관된 성기능 장애에 대한 조사

조성일,이영식,서동수,나철,민경준 한국정신신체의학회 2003 정신신체의학 Vol.11 No.1

Tetracyclic Isoquinoline유도체의 합성

조수동,정윤성,김정주,안철진,신동수 Institute of Genetic Engineering Changwon National 1998 Gene and Protein Vol.2 No.1

To develop new pharmacological charactization of isoquinoline derivatives, we have synthesized 3-benzyl-9,10-dimethoxy-6,7,11b,12-tetrahydropyridazino [4',5': 5,6] [1,4] -oxazino [3,4-а]isoqinolin-4(3H) -one. We have developed a convenient cyclization of novel isoquinoline derivatives starting from 3,4-dimethoxy phenethylamine using boron trifluoride diethyl etherate.

복합레진의 표면거칠기에 따른 투명도와 표면 색상의 차이에 관한 연구

조규정,박수정,조현구,김동준,황윤찬,오원만,황인남 大韓齒科保存學會 2006 Restorative Dentistry & Endodontics Vol.31 No.4

본 연구는 복합레진의 표면 연마에 의한 표면 거칠기가 표면 색상과 투명도에 어떤 영향을 미치는가를 알아보고자 시행하였다. Charisma (Heraeus Kulzer GmbH, Domagen, Germany)의 B1과 A3, Esthet-X (DENTSPLY Caulk, Milford, USA)의 B1과 B3 레진으로 거칠기에 따른 표면 색상을 평가하기 위한 직경 8㎜, 두께 5㎜의 시편을 제작하고, Sof-Lex finishing & polishing system(3M, ESPE Dental Products. St. Paul USA)의 C, M, F, 및 SF 디스크로 시편의 한쪽 면을 연마하였으며, 연마 전 Mylar strip으로 압축된 면을 대조군으로 하였다. 거칠기에 따른 투명도의 차이를 평가하기 위한 두께 1 ㎜의 시편을 Charisma의 A3로 제작하여, 한쪽 면을 600, 1000, 1500 및 2000번 사포로 연마하였다. 각 시편의 연마 전과 후, 연마면의 CIE L^(*)a^(*)b^(*)값과 1 ㎜ 시편의 백색과 흑색 배경판 상에서의 Y값을 spectrophotometer인 Spectrolino (GretagMacbech, Regensdorf, Switzerland)를 사용해 측정 분석하였으며, 각 시편의 연마 전과 후의 평균 표면 조드 (Ra)값을 Surface Roughness Tester SJ-301 (Mytutoyo, Tokyo, Japan)로 측정했다. L^(*)값은 재료와 색상에 상관없이 가장 거친 Sof-lex C 디스크로 연마한 군에서 가장 높은 값을 보였으며 (p < 0.05). Esthet-X B3군을 제외한 모든 군에서 Ra값이 감소함에 따라 L^(*)값도 낮아졌다. a^(*)값은 표면 거칠기에 따라 특정한 변화 양상을 보이지 않았으며, b^(*)값은 Esthet-X B1군을 제외한 모든 군에서 Sof-lex SF 디스크로 연마 시 가장 높은 값을 보였으며 (p < 0.05), Charisma B1과 Esthet-X B3군에서 Ra값과 비교적 높은 상관 관계를 보였다. Contrast ratio는 1000번과 1500번 사포로 연마한 군간을 제외한 모든 군 간에 유의한 차이를 보여으며 (p < 0.05). 표면 거칠기가 감소함에 따라 contrast ratio도 감소하였다(R2 = 0.801). The objectives of this were to evaluate the effect of surface roughness on the surface color and translucency of the composite reins. Two composite resins (Esthet-X, Dentsply, Milford, USA and Charisma, Kulzer, Domagen, Germany) were used to investigate the surface color. Charisma was used to investigate the translucency. 40 disc samples (diameter: 8 ㎜, thickness: 5 ㎜) were made by each product to measure the surface color. Ploymerized each sample's one side was treated by Sof-Lex finishing and polishing system (Group C, M, F, SF). 40 disc samples (diameter: 6 ㎜, thickness: 1 ㎜) were prepared to measure the opacity. 1 ㎜ samples were ground one side with #600, #1000, #1500 and #2000 sandpapers. CIE L^(*)a^(*)b^(*) values of each 5 ㎜ thickness samples, and XYZ values of 1 ㎜ thickness samples on the white and black background were measured with spectrophotometer (Spectrolino, GretagMacbeth, Regensdorf, Switzerland). Mean surface roughness (Ra) of all samples before and after surface treatment was measured using the Surface Roughness Tester SJ-301 (Mytutoyo, Tokyo, Japan). Regardless of type and shade of the composite resin, L^(*) values measured in group C were higher than others (p < 0.05), and L^(*) value decreased as the Ra value decreased except B3 shade of Esthet-X. But there were no significant difference in a^(*) values among groups. In control group and SF, highest b^(*) values were measured (p < 0.05), except B1 shade of Esthet-X. Contrast ratio decreased as the Ra value decreased (p < 0.05). With the above results, difference of surface roughness has influence on surface color and translucency of dental composite resins. 〔J Kor Acad Cons Dent 31(4):312-322, 2006〕

치질을 투과한 조사광에 의한 복합레진 중합시 치질의 두께, 광세기 및 조사 시간이 복합레진의 표면 경도에 미치는 영향

조수경,김동준,황윤찬,오원만,황인남 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.2

본 연구에서는 치질을 투과한 광에너지량을 측정하고 치질을 투과한 광에너지에 의한 광중합 복합레진의 중합 정도를 표면 경도를 측정하여 분석하였다. 광조사기로는 할로겐 광원을 사용하는 Optilux 501 (Demetron, USA)을 사용하였으며, 중합용 light guide는 840 mW/cm²의 광세기를 갖는 직경 12 mm의 light guide와 1100 nW/cm²의 광세기를 갖는 직경 7 mm의 Turbo light guide를 사용하였다. 광원을 투과시킬 치질은 건전한 상악 중절치의 순면에서부터 법랑질과 상아질을 포함하도록 0.7x0.7cm 의 크기로 두께 1.0 mm와 2.0 mm의 치아 절편을 준비하였다. 직경 5 mm, 두께 2 mm의 주형에 Al 색상의 광중합 복합레진(Charisma, Kulzer, Germany)을 충전하고 각 군에 주어진 조건에 따라 광중합하였다. 시편은 크게 치질의 두께에 따라 (대조군, 1 mm, 2 mm) 3개의 군으로 나누었으며, 각 군은 다시 light guide의 종류와 광조사 시간에 따라 4개의 군으로 나누었다. 제작된 시편은 미세경도측정기를 이용해 광조사면의 비커스 경도를 측정한 결과, 2 mm 치질군과 대조군의 Turbo-light guide으로 40초 동안 중합한 시편이 가장 높은 표면 경도값을 보였으며, 2 mm 치질군에서 light guide의 종류에 상관없이 20초 동안 중합한 시편들이 가장 낮은 표면 경도값을 보였다 (p < 0.05). 이상의 결과는 1 mm 이하와 같은 얇은 치질을 투과하여 복합레진을 중합하는 경우 광세기와 광조사 시간을 증가시키면 중합 정도도 증가하나, 특정 두께 이상의 치질을 투과 시 광세기나 광조사 시간을 증가시키더라도 중합 정도의 증가는 기대하기 어렵다는 것을 시사한다. In this study we measured the amount of light energy that was projected through the tooth material and analyzed the degree of polymerization by measuring the surface hardness of composites. For polymerization, Optilux 501 (Demetron, USA) with two types of light guide was used: a 12 mm diameter light guide with 840 nW/cm² light intensity and a 7 mm diameter turbo light guide with 1100 nW/cm². Specimens were divided into three groups according to thickness of penetrating tooth (1 mm, 2 mm, 0 mm). Each group was further divided into four subgroups according to type of light guide and curing time (20 seconds, 40 seconds). Vickers' hardness was measured by using a microhardness tester. In 0 mm and 1 mm penetrating tooth group, which were polymerized by a turbo light guide for 40 seconds, showed the highest hardness values. The specimens from 2 mm penetrating tooth group, which were polymerized for 20 seconds, demonstrated the lowest hardness regardless of the types of light guides (p < 0.05). The results of this study suggest that, when projecting tooth material over a specified thickness, the increase of polymerization will be limited even if light intensity or curing time is increased.

정신보건관련시설 입원(소)자의 주요 정신장애 유병률 : 전국 20개 시설의 입원(소)자를 대상으로

조성진,조맹제,서동우,함봉진,홍진표,배재남,이준영,이동우,박종익,전홍진,김성주,김용익 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.6

Objectives : One of the objectives of this study is to estimate the prevalence rates of psychiatric diagnoses in the combined populations of psychiatric hospitals, psychiatric nursing facilities and homeless asylums using the Korean version of the Composite International Diagnostic Interview (K-CIDI), which is a comprehensive and fully standardized interview schedule to assess psychiatric disorders for diagnosis. The Other objective is to compare with previously studied prevalence rates of Psy-chiatric diagnoses using the results of this study. Methods : The study subjects, aged from 181o 64 years, were randomly selected from 64,582 institutionalized population of psychiatric hospitals, Psychiatric nursing facilities and homeless asylums as of 30, June, 2001. Twelve trained interviewers administered the K-CIDI to the selected respondents. A total of 1,875 respondents (male 1,194, female 681) completed the interview. Results : The lifetime and one year prevalences of any diagnosis excluding nicotine dependence · withdrawal, anxiety disorder, eating disorder, somatoform disorder were 88.2% (male 88.1%, female 88.3%), and 65.8% (male 62.7%, female 73.7%), respectively. The lifetime and one year prevalences of schizophrenia and other psychotic disorders were 78.5% (male 75.3%, female 83.7%), and 56.8% (male 51.9%, female 64.8%), respectively. The lifetime and one year prevalences of alcohol use disorder (dependence/abuse) were 26.7% (male 37.9%, female 8.3%), and 8.7% (male 12.8%, female 2.1%), respectively. The lifetime and one year prevalences of mood disorder were 18.1% (male 13.5%, female 25.8%), and 10.4% (male 7.2%,female 16.9%), respectively. The lifetime and one year prevalences of schizophrenia and other psychotic disorders were comparable with the 2001 community survey by 1.19% to 1.32%, and 0.51% to 0.61%, respectively. The lifetime and one year prevalences of schizophrenia were also comparable by 0.16% to 0.28%, and 0.16% to 0.25%, respectively. There were no significant changes of prevalence rates when correction were applied to other psychiatric diagnosis. Conclusion : The results of this study could be used for evaluating the distribution of psychiatric diagnoses in mental health related facilities and for planning mental health policies.

한국 주요정신장애의 유병률 및 관련요인 : 2006 전국정신질환역학조사

조맹제,장성만,함봉진,정인원,배안,이영문,안준호,원승희,손정우,홍진표,배재남,이동우,조성진,박종익,이준영,김진영,전홍진,이해우 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.3

Objectives The aims of this study are to estimate the prevalence of the DSM-IV psychiatric disorders in the Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI), and to compare those with previous studies. Methods The Korean Epidemiologic Catchment Area study Replication (KECA-R) was Conducted between August 2006 and April 2007. The sampling of the subjects was carried out across 12 catchment areas. A multistage, cluster sampling design was adopted. The target Population included all eligible residents aged 181o 64 years. Face-to-face interviews were conducted with the Korean version of Composite International Diagnostic Interview (K-CIDI) based on the DSM-IV (N=6,510, response rate=81.7%). Results A total of 6,510 participants completed the interview. The lifetime and 12-month prevalence rates for all types of DSM-IV disorders were 30.0% and 17.3%, respectively. Those of Specific disorders were as follows : 1) alcohol use disorder, 16.2% and 5.6% ; 2) nicotine use disorder, 9.0% and 6.0% ; 3) specific phobia, 3.8% and 3.4% ; 4) major depressive disorder, 5.6% and 2.5% ; and 5) generalized anxiety disorder, 1.6% and 0.8%. Data relating to nicotine and alcohol use disorder revealed a very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among females than males. Conclusion The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in the distribution of psychiatric disorders across the country and times were observed.

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

초등학생의 뇌호흡 명상훈련에 따른 자연살해세포와 B림프구의 면역반응 분석

조동진,심준영 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.4

This study is to examine the immune reaction of natural killer cell and B lymphocyte when brain respiration program is applied to the male elementary students in fourth grade with 26 subjects who have not brain respiration training experience and regular exercise experience and the experiment was conducted with the subjects who are randomly assigned to 10 brain respiration group(30 min.), relaxation exercise group(20 min.) and 8 control group for six times a week for 12 weeks. The results of two measurements before and after experiment and at rest are analyzed. Natural killer cell was significantly reduced in brain respiration group compared to relaxation exercise group and control group before and after experiment, B-lymphocyte was reduced in brain respiration group and relaxation exercise group before and after experiment, but there was no statistically significant difference. In particular, brain respiration group in natural killer cell showed a significant change in interaction effect between group and time and it suggests that application of brain respiration meditation training has a potential influence on immune function.

10주간의 EEG Biofeedback 훈련에 따른 뇌파 영역별 상대적 활성도 비교

조동진,심준영 한국스포츠리서치 2005 한국 스포츠 리서치 Vol.16 No.2

This study was to examine changes of electroencephalogram (EEG) of frontal when EEG biofeedback training was conducted with ten shooters of girls' high school. Experiment was performed for 30 min per session. three times a week through ten weeks and two measurements before and after training at stable state were conducted. Measurement of EEG used FP1. FPz and FP2 attached to head band of Neuro-feedback system (Braintech Corp.. Korea) and left and right brain relative powers of theta, slow-alpha, mid-alpha. AMR (sensory motor rhythm), beta-low and beta-high waves were analyzed. As a result of analysis, left brain of mid-alpha and beta-low waves showed significant difference in group. period and group×period. In particular. after training mid-alpha wave showed significant difference and beta-low wave did significant decrease in mean value of left brain of mid-alpha and beta-low waves showing difference by groups. These results suggested that application of EEG biofeedback training program increased alpha wave and reduced beta-wave and then athletes' brain could be maintained efficiently.

20주간의 혼합운동프로그램이 정신지체 성인의 신체조성과 체력에 미치는 효과

전종귀,염동삼,조병준,이상기,박희근,한동수,장학영 한국특수체육학회 2004 한국특수체육학회지 Vol.12 No.3

The purpose of this study was to figure out the effects of participation in a combined exercise program on the body composition and physical fitness of adults with mental retardation. Fifteen adults with mental retardation in a special institute took part in aerobic and strength , combined exercise at 55 - 69%HRmax at least one hour a day, 3 times a week for 20 weeks. The body composition and physical fitness profiles of subjects were measured before and after training period, respectively. Dependent t-test was used to analyze the statistical significance. The results were as follows; First, participants showed more favorable % body fat, lean body mass, fat mass, WHR after training. Second, participants showed more improved upper body strength and balance after training. The findings imply that the combined exercise program for long duration had significant effects on the health promotion of adults with mental retardation.