Mycobacterium mageritense에 의한 당뇨병성 족부 감염증 1예

김충종,김낙현,김문석,김계형,전재현,박문석,박경운,박완범,박상원,김홍빈,김남중,오명돈,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.6

Diabetic foot infection is one of the important complications in patients with advanced diabetes mellitus. Limb threatening infections such as osteomyelitis, abscess, and necrotizing fasciitis are frequently accompanied by the disease. Non-tuberculous mycobacterium (NTM) is a rare causative organism of diabetic foot infection. Thus, if one is not suspicious or meticulous, infection due to NTM will be easily overlooked and this will result in delayed diagnose and treat. Therefore, it is necessary to consider NTM as the causative organism if the wound does not respond to the conventional antibiotic treatment and the culture from the adequately obtained specimen reveals atypical acid-fast bacilli. We present a case of diabetic foot infection with osteomyelitis and abscess due to Mycobacterium mageritense, one of the rapid growing mycobacteria, that was successfully treated with surgical debridement and appropriate antibiotic treatment.

Duty, Task, Step 분석울 통한 전기·컴퓨터 분야의 DACUM Chart 활용 방안

박성종,지명석,류지호 한국직업능력개발원 2003 직업능력개발연구 Vol.6 No.2

Recently the DACUM methodology is widely used in vocational education fields because Curricula in vocational education, especially in engineering technology education, do not adequately mirror the needs of the work fields. DACUM Chart which contains a graphic portrayal of the duties and tasks identified, plus the descriptive lists of general knowledge and skills, future trends and concerns, worker behaviors, tools, equipments, supplies and materials is also useful. Certainly the DACUM methodology is effective, quick and low cost, but do not reflect the educational situation of internal vocational education institute effectively. The purpose of this study is to modify DACUM Chart for various work based learning strategies aimed at providing hands-on experience for students and consequently apply to curricula development. We performed the duty, task and step analyses through the verifications by expert workers, technicians and engineers of the workplace on the electricity and computer fields. Through this study, the practical tasks which must be instructed on the vocational education institute are suggested and modules are developed through the step analyses. So, we can reflect both the educational situation of vocational education institute internally and workplace effectively. And also we can manage curricula emphasizing the smooth transition of students from school to work to accept the needs of strategies for work based learning.

흰 민들레 추출물의 항산화능 및 항균활성

박명수, 라만, 임우종, 김기윤, 우성만, 이선미, 사동민 忠北大學校 農業科學硏究所 2011 農業科學硏究 Vol.27 No.4

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정신분열병 증상을 동반한 진행성 핵상 마비 1례

박종익,조영래,홍진표,이민규,한오수,이명종 대한신경정신의학회 2001 신경정신의학 Vol.40 No.1

저자들은 환청과 망상을 주소로 정신과를 방문한 진행성 핵상 마비 환자를 진단하고 치료하였다. 진행성 핵상 마비는 보행 장해, 치매, 수직성 안구 운동의 장해가 특징적인 증상이며, 아직까지 특별한 치료법은 알려져 있지 않다. 정신과적 증상으로는 인지기능의 장해, 정동 및 행동의 변화, 수면 장해, 정신병적 증상 등이 있으며 정신분열병과 비슷한 증상을 보이는 경우는 극히 드물다고 한다. 본 증례에서는 파킨슨 증상과 정신병적 증상이 비슷한 시기에 발현된 진행성 핵상 마비의 예를 보고하면서 진단적 중요성을 강조하고자 한다. We have experienced a rare case of progressive supranuclear palsy with hallucination and delusion. The common manifestations of progressive supranuclear palsy are gait disturbance, mental change and sign of vertical ophthamoplegia but no efficacious therapy has been known. Neuropsychiatric symptom clusters include cognitive impairment, affective and behavioral changes, sleep disturbance, and psychotic symptoms. Though schizophrenia-like psychosis has been reported but this is certainly rare. Addressing a case of progressive supranuclear palsy, in whom parkisonian symptoms appeared with concurrent psychotic symptoms, we emphasize accurate diagnosis.

Paraquat 독성에 미치는 Dicumarol과 Allopurinol의 병합 투여 효과

송명화,정미숙,오순식,박재윤,차종희 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

Despite intensive investigation into paraquat toxicity, neither the final cytotoxic mechanism nor a clinically useful antidote has been discovered. The mechanism of paraquat cytotoxicity is also debatable, but it is generally accepted that a redox reaction occurs between reduced paraquat and molecular oxygen. The intracellular reduction of paraquat occurs by various enzymes, such as DT-diaphorase, xanthine oxidase and glutathione reductase. In present study, we investigated that the effects of allopurinol, a xanthine oxidase inhibitor, and dicumarol, a DT-diaphorase inhibitor, in paraquat-intoxicated rats. The survivals of paraquat-intoxicated rats were increased by allopurinol treatment compared to paraquat-treated control rats , but not effected by dicumarol treatment. The activity of xanthine oxidase in the liver of allopurinol-treated rats was decreased and DT-diaphorase activity in liver of dicumarol treated rats was also decreased compared to normal control rats. The contents of glutathione in liver of paraquat treated rats was decreased but in paraquat+allopurinol treated rats, the decrements of glutathione contents was reduced but in paraquat+dicumarol treated rats, liver glutathione level was not changed compared to paraquat-treated rats. These results suggest that paraquat toxicity maybe reduced by administration of allopurinol but dicumarol did not have such effects .

백서 적혈구에서 glutathione이 paraquat 독성에 미치는 영향

김명철,박재윤,채기영,천영욱,박평심,차종희 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.2

The participation of superoxide in initiating tissue damage from administration of a xenobiotics is best illustrated by paraquat intoxication, in which it is known that one electron reduction of paraquat leads to the formation of radicals which react with molecular oxygen to give superoxide. In the present study, the effects of paraquat on the level of glutathione and activities of superoxide dismutase(SOD), catalase, glutathione peroxidase, glutathione reductase and glutathione stransferase were investigated in rat liver and erythrocytes. The contents of glutathione in liver and blood were sinificantly decreased by paraquat administration, but the activities of enzymes were unaltered. Incubation of the buffered aerobic mixture of erythrocyte in the presence of 5mM glucose, Paraquat and/or N-ethylmaleimide(NEM) resulted in the formation of lipid peroxide, the activities of various enzyme and the levels of glutathione were determined. The malondialdehyde(MDA) contents as a indicator of lipid peroxidation was decreased and the levels of total glutathione were not changed but the levels of oxidized glutathione(GSSG) were in creased in paraquat treated erythrocytes. The activites of ezyme were decreased in paraquat treated erythrocytes but in reduced glutathione(GSH) treated erythrocyte, the enzymes activities were less decreased by paraquat. These results suggest that paraquat toxicity was probably somewhat reduced by GSH, but paraquat-induced injury were not increased by GSH depletion in erythrocytes.

동종골수이식 환자에서 발생한 지역사회발생 Parainfluenza virus 3형 폐렴 1예

신종욱,조요한,강철인,김성한,이상윤,김의석,오명돈,이환종,박선양,김병국,최강원 대한감염학회 2002 감염 Vol.34 No.5

액체크로마토그래피/질량분석법을 이용한 랫트 혈장내의 Surfactin C의 정량법에 관한 연구

임종환,김명석,이동연,이상훈,백경진,김태원,정두순,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Surfactin isolated from Bacillus subtilis has a strong surface tension-lowering activity, together with antiviral, antitumor, fibrinolytic and hypocholesterolemic activities. LC/MS is a simple, rapid and effective technique for the determination of surfactin C in rat serum. The separation of surfactin was achieved on reverse phase column. The mobile phase consisted of 0.1% trifluoracetic acid in water (A) and acetonitrile (B). As a result of analysis of blank rat serum samples, matrix interference was not shown. The values of precision and accuracy were satisfied w the guideline. A newly developed LC/MS method for the determination of surfactin C was successfully applied in its pharmacokinetic analysis.

CRW형식 무인항공기 추진시스템의 밸브작동을 고려한 비행모드 전환에 따른 천이성능 특성 연구

공창덕,박종하,강명철,양수석 朝鮮大學校 機械技術硏究所 2005 機械技術硏究 Vol.8 No.1

본 연구는 CRW형식 무인항공기 추진시스템의 밸브작동을 고려한 비행모드에 따른 천이 성능특성을 파악하기 위해 SIMULINK를 이용하여 모델링 하였다. 주 엔진시스템의 천이 모사에는 ICV방법이 적용되었다. 그리고 밸브시스템은 로터리 덕트와 메인 덕트로 빠져나가는 유량을 제어하는 시스템으로서 밸브를 통해 로터리 덕트로 빠져나가는 유량과 메인 덕트를 빠져나가는 유량의 합은 터빈의 출구 유량과 같다는 가정하에 수행되었으며, 이 때 밸브각 변화에 따른 손실, 유량 및 유효면적 등이 고려되었다. 성능해석은 비행 천이 영역인 고도 1Km 비행마하수 0.1에서 엔진최대회전수시 회전익 모드에서 고정익 모드로 변환시외 고정익 모드에서 회전익 모드로 변환 경우들이 수행되었다. In order to investigate transient behaviour of the CRW(Canard Rotor Wing) type UAV(Unmanned Aerial Vehicles) propulsion system during flight mode transition considering flow control valve operation, the propulsion system was modelled using SIMULINK commercial program. For transient simulation of the main engine system, the ICV(Inter-Component Volume) method was applied. The valve system is to control the gas flow of the rotary duct system and the main duct system, and the analysis was performed with an assumption that the total gas mass flow of the main engine is the same as summation of the rotary duct flow and the main duct flow, and with consideration of valve loss, flow rate and effective area in valve angle variation. The performance analysis was carried out during flight mode transitions from the rotary flight mode to the fixed wing flight mode and vice versa mode at altitude of 1Km, flight Mach number 0.1 and maximum engine rpm.

진행된 HIV 감염 환자에서 십이지장의 미란성 병변으로 발현한 Mycobacterium genavense 감염 1예

진상만,박종선,김홍빈,오명돈,최강원,김희연,국윤호,김남중 대한감염학회 2007 감염과 화학요법 Vol.39 No.4

Mycobacterium genauense는 최근에 알려진 미코박테륨으로서, 식욕 부진, 체중 감소, 설사, 림프절 병증 등 파종성 Myocobacterium avium-intracellulare complex 감염과 유사한 임상상을 보이며, 위장관 침범을 잘 하는 것으로 알려져 있으나 아직 국내에서 증례는 보고된 바가 없다. 저자들은 진행된 HIV 감염 환자에서 십이지장의 미란성 병변으로 발현한 Mycobacterium genavense 감염 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. 환자는 상복부 동통과 발열, 설사로 내원하였다. 십이지장의 미란성 병변에서 시행한 조직검사에서 항산균이 가득 차있는 거품세포가 관찰되었으며, 이 검체에서 16S rRNA 유전자의 중합연쇄반응 검사를 시행하여 Mycobacterium genavense를 확인하였다. Mycobacterium genavense, first identified in 1990, is known as a pathogen that mimics disseminated Myocobacterium avium-intracellulare complex (MAC) infection with particular propensity for the gastrointestinal tract. In Korea, no case with the organism has been reported. Herein we report a case of Mycobacterium genavense infection that manifested with erosive lesion of duodenum in a patient with acquired immune deficiency syndrome. The patient presented with epigastric pain and fever, diarrhea. Duodenal biopsy showed histiocytic infiltration with numerous acid-fast bacilli. Identification of the mycobacterial isolate by the polymerase chain reaction restriction analysis of 16S rRNA gene revealed Mycobacterium genavense.