전자적 효과나 엔트로피 효과를 고려한 TFAP 유도체 탄산이온 선택성 물질의 합성

윤우진,이창석,전영무,변형정 광운대학교 기초과학연구소 1998 기초과학연구소논문집 Vol.27 No.-

Three analogs of ETH6024 were designed and synthesized as possible ionophores of carbonate ion considering the electronic effect of the para-substituents of the trifluoroacetophenone derivatives. In addition, the other three compounds were also designed and synthesized considering the entropic effect to form 1 : 1 complexes with carbonate ion. These syntheses were performed by N-alkylations of secondary amides followed by hydrolyses and trifluoroacetylbenzoylations.

다환방향족 탄화수소에 오염된 토양에서 분리한 Pseudomonas sp. KK1의 생리학적 특성

윤병준,강형일,오덕철 제주대학교 생명과학연구소 2001 제주생명과학연구 Vol.4 No.-

Strain KK1 was isolated from soil contaminated with polycyclic aromatic hydrocarbons and able to mineralize anthracene, naphthalene, and phenanthrene. In this study, strain KK1 was tested to evaluate carbazole-degrading potential using radiorespirometry. When KK1 was pre-grown on phenanthrene the cells were able to mineralize carbazole much more rapidly, suggesting a possible close linkage between the pathways for catabolism of carbazole and phenanthrene. Such an increase in carbazole degradation was not appreciable when KK1 was pre-grown on naphthalene. Strain KK1 was identified as the genus Pseudomonas with over 90 % confidence based on BIOLOG system and FAME analysis. Analysis of PLFAs extracted from kk1 cells on carbazole medium revealed that lipids 10:0 3OH, 17:0 cyclo, and 18:0 were representatives produced or significantly increased in response to carbazole. Tests for antibiotics provided the data that strain KK1 was resistant to antibiotic ampicillin, but susceptibile to chloramphenicol, gentamycin, kanamycin, streptomycin, and tetracycline. Strain KK1 demonstrated strong resistance to most heavy metals such as Ba, Cd, Fe, Hg, Pb used in this study.

척수공동증을 동반한 척수내 다형성교아세포종 : 증례보고 Report of a Case

전병윤,김영수,박형천 대한신경외과학회 1987 Journal of Korean neurosurgical society Vol.16 No.4

A case of cervicothoracic intramedullary glioblastoma multiforme associated with syringomyelia is reported. The tumor was located between C5 and T1 level and a large syrinx was found below the tumor, T1-T12. Intramedullary uptake of contrast dye in the delayed CT scan after myelography was seen. The tumor was removed gross totally. And terminal syringotomy was performed.

혈장 중 theophyline 분석법 확립 및 약동학적 연구

김형기,권준택,염윤기 순천향대학교 의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

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단일 치근을 가진 하악 제1유구치

윤상일,최형준,김성오,이제호,손흥규 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.4

본 증례에서는 단일 치근을 가진 하악 제1유구치에 대해 서술하고자 한다. 5세 남아의 하악 제1유구치는 방사선 사진 검사결과 양측성으로 분명한 단일치근을 가진 것으로 나타났다. 보통 상악 구치는 3개의 치근을, 하악 구치는 2개의 치근을 가지나, 치아의 발육시기도중 Hertwig상피근초가 제 시기에 적절히 함입되지 못하면 치근이 서로 나뉘지 못하여 치근의 융합이 발생될 수 있다. 융합된 치근을 가진 구치는 정상적인 구치보다 불리한 치관-치근 비율을 가질 뿐 아니라, 여러 보고에 의하면 융합된 치근을 가진 사람은 다수 치아의 선천적 결손이나, 상악 전치에서 치내치가 발현될 확률이 높아 예방적 치과 치료가 필요할 수 있다. 그리고, 외배엽이형성증, 합지증, 만지증, 청색공막증과 같은 전신 질환과 연관되어 나타날 수도 있다고 한다. 치근융합은 유전적으로 상염색체 열성 유전을 따른다고 밝혀진 바 있다. 현재까지 단일 치근을 가진 구치는 대부분 영구 구치에서 많이 보고된 바 있지만, 유구치에서는 거의 보고된 바가 없기에 이에 보고하는 바이다. In this case, we would like to discuss about the single rooted deciduous mandibular first molar. The deciduous mandibular molar of a five years old boy was shown to have a single root, bilaterally. Ordinarily, the maxilary molars have three roots and the mandibular molars have two roots. However, when the hertwig's epithelial root sheath do not invaginate properly during tooth development, root fusion can occur from the absence of root separation. Molars with fused roots not only have unfavorable crown to root ratio, but also according to many reports, have higher probability of having multiple congenitally missing teeth or dens invaginatus in the maxillary incisors, consequently requiring preventive dental treatment. In addition, disorders such as ectodermal dysplasia, syndactyly, clinodactyly, bluish sclera can also be related to this condition. Root fusion is known to be of autosomal recessive inheritance. Up to date, single rooted molars have been reported several times in permanent dentitions but hardly in deciduous dentition, which is the motive for this paper.

요골동맥을 이용한 관동맥 조영술의 유용성

윤정한,이승환,이한요,김장영,김일회,최윤종,이형준,이명옥,김승년,황성오,홍인수,최경훈 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.10

유도선수의 체급별 득점빈도 비교 분석

전윤수,김도형 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

This study has been performed by analysing the scoring frequency of technical styles of male and female Judo players between weight groups compared to the scoring frequency of technical styles of male and female Judo players in each weight group participated in the 29th Chairman Cup National Judo Tournament (251 men players and 146 women players: Total: 397). The results was analyzed using the SPSS/win statistic program. 1. Analysis result of scoring frequency in each weight group: First, man -60kg weight players scored in an order of Hyokwa, Yuhyo, Jeolban and Hanpan and woman -48kg weight players scored in an order of Hyokwa, Hanpan, Yuhyo, and Jeolban. Second, man -66kg weight players scored in an order of Hyokwa, Yuhyo, Hanpan and Jeolban and woman -52kg weight players scored in an order of Yuhyo, Hyokwa, Hanpan, and Jeolban. Third, man -73kg weight players scored in an order of Hyokwa, Hanpan, Jeolban and Yuhyo and woman -57kg weight players scored in an order of Hyokwa, Hanpan, Yuhyo, and Jeolban. Fourth, man -81kg weight players scored in an order of Hyokwa, Hanpan, Jeolban and Yuhyo and woman -63kg weight players scored in an order of Hanpan, Hyokwa, Jeolban and Yuhyo. Fifth, man -90kg weight players scored in an order of Hyokwa, Yuhyo, Hanpan and Jeolban and woman -70kg weight players scored in an order of Hyokwa, Jeolban, Hanpan, and Yuhyo. Sixth, man -100kg weight players scored in an order of Yuhyo, Hyokwa, Jeolban and Hanpan and woman -78kg weight players scored in an order of Yuhy, Jolban, Hyokwa, and Hanpan. Seventh, man +100kg weight players scored in an order of Hyokwa, Hanpan, Yuhyo, and Jeolban and woman +78kg weight players scored in an order of

Simvastatin 정제의 생물학적 동등성 연구

김형기,권준택,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

The bioequivalence of generic simvastatin tablet(Dongsung Pharmaceutical Co.) to the simvastatin tablet(Zocor^(®), MSD Korea Co.) as a reference drug. Single dose of 20 mg simvastatin was administered to 20 healthy male volunteers in a balanced, randomized crossover design with a washout between the two study periods. Blood samples were collected up to 12 hours and plasma concentration of simvastatin was measured by well validated LC-MS/MS. Pharmacokinetic parameters were analyzed by non-compartmental analysis and ANOVA test was used for the statistical analysis of parameters. No statistically significant formulation, period, or sequence effect was encountered. Ninety percent confidence intervals of log transformed C_(max) and AUC_(t) were comprised in the stipulated 0.80-1.25 range. These results suggest that test formulation of simvastatin is bioequivalent with the reference, both formulations in 20 mg tablet.

만성폐쇄성폐질환의 중증도와 폐고혈압 및 폐성심으로 진행과의 상관관계

김형호,박철진,이준,장광표,하성일,이재록,하재화,권세훈,권용운,윤성호,이승일 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Background: From many previous studies, Pulmonary hypertension is the known independent predictive factor of the mortality in COPD. Also pulmonary hypertension is the major cardiovascular complication of COPD and is associated with the progression to cor pulmonale and poor prognosis. Author want to analyze the correlation between pulmonary hypertension and the severity of COPD which are classified by forced expiratory volume in one second, and the extent of progression to corpulmonale. Methods: Retrospectively we investigated the medical records of 118 patients with COPD who had pulmonary function test and echocardiogaphy more than one times during one-year follow-up (from June, 2005 to May, 2006) at respiratory division in chosun university hospital, and then 50 patients were enrolled in this study. We classified the severity from FEVl in pulmonary function test based on the GOLD guideline, also this was comparably analyzed with RVSP, RVIDd, Visual Grading from echocardiography. Results: 16 patients out of 50 were classified as moderate severity, 25 patients were severe, and 9 patients were very severe group. RVSP was higher in more severe groups than less severe groups but when it comes to pulmonary hypertension that RVSP is over 35 mmHg, there was no valid difference lies in those groups. As FEVl decreases RVSP and RVIDd increases, and observed relationship between RVSP which was classified as below 35 mm and above 35 mm groups and visual grading which was classified as normal and dilatated groups revealed valid correlation, Conclusion: As pulmonary function decreases, progression to pulmonary hypertension and cor pulmonale increases but there was no remarkable difference of prevalence in above moderate severity groups. 연구배경 폐고혈압은 이전의 많은 연구에서 만성폐쇄성폐질환에서 독립적인 사망의 예측인자로 알려져 있다. 또한 폐고혈압은 만성폐쇄성폐질환의 주요한 심혈관계 합병증이며, 폐성심으로의 진행 및 불량한 예후와도 관련되어 있다. 이에 저자는 폐고혈압과 1초간 노력성호기량으로 분류되는 만성폐쇄성폐질환의 중증도 및 폐성심으로의 진행 정도를 비교 분석하여 이들의 상관관계를 밝혀보고자 한다. 방법 2005년 6월부터 2006년 5월까지 1년 동안 본 병원 호흡기 내과에서 폐기능검사와 심장초음파 검사를 각각 1회 이상 시행한 적이 있는 118명에 한하여 의무기록을 후향적으로 조사하여 이 중에서 50명을 대상으로 하였다. 폐기능검사 시행 결과 얻은 1초간 노력성호기량을 바탕으로 GOLD guideline에 따라 중증도를 분류하였으며 이를 심초음파 시행 결과 얻은 우심실수축기압, 확장기말 우심실내부간격, 시각등급과 비교분석하였다. 결과 대상 환자 50명중 16명은 중등증, 25명은 중증, 9명은 최고중증 그룹으로 분류되었다. 우심실수축기압은 중증도가 높은 그룹에서 낮은 그룹에 비해 더 높게 나타났으나 폐고혈압에 해당하는 우심실수축기압이 35 mmHg이상인 환자에 있어사는 각 그룹간에 유의한 차이를 보이지 않았으며, 확장기말 우심실내부간격, 시각등급 또한 중증도와 유의한 차이를 보이지 안항ㅆ다. 1초간 노력성호기량이 감소함에 따라서는 우심실수축기압, 시각등급은 증가하였으며 우심실수축기압을 35mmHg 미만과 이상인 그룹으로, 시각등급을 정상과 확장이 있는 그룹으로 분류하여 비교한 결과에서는 유의한 상관관계를 나타냈다. 결론 폐기능이 감소할수록 페고혈압 및 폐성심으로의 진행이 증가하였으나 폐기능검사에서 중등도 이상의 그룹에서 유병률의 차이는 크지 않았다.

두경부 편평상피암에서의 MIB-1, p53, bcl-2와 apoptosis의 발현 및 상호 연관성

손용준,한지용,윤형기,장수원,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : Squamous cell carcinoma of the head and neck represents approximately 2.0∼4.0% of all malignant tumors, with an etiology closely associated with smoking, drinking and various genetic alterations. The purpose of this study was to investigate the correlation of MIB-1, p53, bcl-2 and apoptosis according to degree of differentitation of squamous cell carcinoma. Methods and Material : forty-eight cases of squamous cell carcinoma of the head and neck were selected for this study. MIB-1, p53, bc1-2 expression rate were studied by iromunogistochemical staining and the number of apoptosis observed by TUNEL method. Results : The expressioins of MIB-1, p53, bcl-2 and apoptosis were found in 56.3%, 50.0%, 14.6%, 85.4%, of 48 cases of squamous cell carcinoma, respectively. The expression of MIB-1, p53 and apoptosis were more higher in poorly differentiated cases than well differentiated cases. MIB-1 expression was related with p53 mutation (p<0.05) and apoptosis rate(p<0.05). Conclusion : From these results. the expressions of MIB-1, bcl-2 and apoptosis were related with degree of differentiation of squamous cell carcinoma and correlation among these parameters.