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손용준,노재형,고영규,김종하,이희철,Son, Yong-Jun,No, Jae-Hyeong,Kho, Young-Gui,Kim, Jong-Ha,Lee, Hee-Chul 대한악안면성형재건외과학회 1997 Maxillofacial Plastic Reconstructive Surgery Vol.19 No.1
Mucoepidermoid carcinoma occurs more freguently than any other in the major sacivary glands. It is relatively more common in parotid than in submandibular gland. Stewart at al published the first large series of these tumors in 1945 and suggested the name "Mocoepidermoid tumor". Now it is divided three categories : low-grade, intermediate-grade, high-grade. And Mucoepidermoid carcinomas are composed of mucous cells, epidermoid cells, and intermediate cells. We freated low-grade mucoepidermoid carcinoma patient with induction chemotherapy, surpery, and adjuvomt chemotherapy.
두경부 편평상피암에서의 MIB-1, p53, bcl-2와 apoptosis의 발현 및 상호 연관성
손용준,한지용,윤형기,장수원,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4
Objective : Squamous cell carcinoma of the head and neck represents approximately 2.0∼4.0% of all malignant tumors, with an etiology closely associated with smoking, drinking and various genetic alterations. The purpose of this study was to investigate the correlation of MIB-1, p53, bcl-2 and apoptosis according to degree of differentitation of squamous cell carcinoma. Methods and Material : forty-eight cases of squamous cell carcinoma of the head and neck were selected for this study. MIB-1, p53, bc1-2 expression rate were studied by iromunogistochemical staining and the number of apoptosis observed by TUNEL method. Results : The expressioins of MIB-1, p53, bcl-2 and apoptosis were found in 56.3%, 50.0%, 14.6%, 85.4%, of 48 cases of squamous cell carcinoma, respectively. The expression of MIB-1, p53 and apoptosis were more higher in poorly differentiated cases than well differentiated cases. MIB-1 expression was related with p53 mutation (p<0.05) and apoptosis rate(p<0.05). Conclusion : From these results. the expressions of MIB-1, bcl-2 and apoptosis were related with degree of differentiation of squamous cell carcinoma and correlation among these parameters.
손용준(Yong Joon Sohn),박병호(Byung Ho Park),한용운(Yong Oun Han) 대한기계학회 2011 大韓機械學會論文集B Vol.35 No.7
대칭익형 단면에 미세한 피치각의 차이를 가지는 두 개의 로터 블레이드의 끝에서 발생하는 와류들의 상호 간섭을 관측하기 위하여 2차원 LDV를 활용하여 끝와류의 회전속도 성분과 축방향속도 성분들을 후류시기에 따라서 측정하였다. 선행 블레이드는 끝와류 축방향 성분이 정규분포를 나타내는 상사성을 위배한 반면, 후행 블레이드는 회전속도 성분이 복합와류를 나타내는 Vatistas' n=2 모형의 상사성을 위배하는 것으로 관찰되었다. 또한, 후류시기 200~240도 근방에서 두 끝와류의 궤적이 근접되어 상호 간섭을 나타내는 것으로 밝혀졌으며 이 시기 동안 후행블레이드의 와류이완 현상이 발생하는 것으로 확인이 되었다. 이러한 후류 간섭은 관절형 허브를 가지는 로터에서도 발생될 것으로 예측된다. In order to observe the wake interaction between tip vortices generated by a two-bladed rotor with slightly different pitch angles, the velocity components of the tip vortices were measured by using a two-dimensional LDV system. It was observed that the swirl velocity components of the ensuing blade deviated from the Vatistas' n = 2 vortex model and the axial velocity components of the preceding blade deviated from the Gaussian profile. It was also found that in the wake-age range of 200° to 240°, the filament of the ensuing blade tip vortex was stretched as result of the closing in of two vortices. The results from these observations suggest the possibility that a similar wake interaction is generated in actual rotor blades, especially, in the ones with articulated hubs.
NACA0015익형을 가지는 로터 깃 끝와류의 후류유동구조
손용준(Yong Joon Sohn),김정현(Jeong Hyun Kim),한용운(Yong Oun Han) 한국항공우주학회 2011 韓國航空宇宙學會誌 Vol.39 No.3
대칭익형 단면을 가지는 모형 깃 끝와류의 후류유동구조의 전개과정을 관찰하기 위하여 2차원 LDV 시스템을 이용하여 끝와류의 회전성분과 축성분을 상평균 기법으로 측정하였다. 비대칭익 로터 깃의 특징에 비하여 대칭익 로터깃의 끝와류는 27° 부근까지 성장과정이 진행되어 다소 늦게 형성되었으며 그 이후부터 상대적으로 완만하게 확산모드가 진행되었다. 회전성분은 실험이 진행된 360° 까지 Vatistas의 n=2모델에 우수한 접근성을 보이면서 자기상사성을 갖는 것으로 관찰되었고 축방향성분은 비대칭익에 비하여 훨씬 강한 세기로 나타나면서 정규분포 성향을 나타내었다. 이들의 결과들은 대칭익의 경우 로터의 추력 발생면에서 끝단손실이 상대적으로 큰 것으로 확인이 되었다. Evolution of tip vortex generated by a model rotor blade which has a symmetric blade section has been investigated by use of the laser doppler anemometry. Swirl and axial velocity components of tip vortex were measured by the phase averaging technique within one revolution of a rotor blade. It was found that tip vortex becomes matured until 27 degrees and diffuses afterwards with diffusing rate becoming slower compared to the case of the asymmetric blade section, but the tip loss was expected to become more substantial. Swirl velocity components were well fit to n=2 model of Vatistas within measured wake ages, showing the self-similarity exists for the swirl velocity components. The axial components were followed with Gaussian profiles, but had much higher peak values than those of the symmetric blade section.
손용준(Yong Joon Sohn),박병호(Byung Ho Park),한용운(Yong Oun Han) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
미세한 피치각의 차이를 가지는 두 개의 로터 블래이드의 깃끝에서 발생하는 와류들의 상호 간섭을 관측하기 위하여 2차원 LDV를 활용하여 끝와류의 속도성분들을 후류시기에 따라서 측정하였다. 끝와류의 회전속도 성분은 후행깃의 결과에서 복합와류를 나타내는 상사성을 위배하였으며, 축방향성분은 선행깃의 결과들이 정규분포를 나타내는 상사성을 위배하였다. 또한, 후류시기 200~240° 근방에서 두 끝와류의 궤적이 근접되어 상호 간섭을 나타내는 것으로 밝혀졌으며 이 시기 동안 후행깃의 와 이완 현상이 발생하는 것으로 확인이 되었다. 이러한 후류 간섭은 관절형 허브를 가지는 로터에서도 발생될 것으로 예측된다. In ordert 10 observe wake interaction between tip vortices generated by two bladed rotor with a slightly different pitch angles velocity components of tip vortices were measured by use of the 2 dimensional LDV system. It was appeared that swirl velocity components of the ensuing blade were deviated from the Rankine combined vortex model and axial velocity components of the preceding blade. were deviated from the Gaussian profile, respectively. It was also found that in the wake age range of 200 ~ 240°, the filament of the ensuing blade tip vortex was stretched with two vortices corning close to each other. Based on these observations the similar wake interaction is expected in real rotor blade having the articulated hub especially.