원위 대퇴골의 고립성 골연골종에서 발생한 속발성 연골 육종 1례 보고

정필현,황장수,강석,김용민,오형호,채동주,김종필 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

연골육종은 비교적 서서히 자라며 늦게 전이하는 악성 연골 종양으로 알려져 있다. 골 연골종에서 발생한 속발성 연골육종은 발생빈도는 드물며 타부위로의 전이가 적고 악성도가 낮은 경우가 많아 적합한 수술적 치료로서 좋은 예후를 보이는 것으로 보고되고 있다. 본 동국대학교 정형외과학 교실에서는 우측 대퇴골 원위부 골간단부에 생긴 고립성 골 연골종에서 이차적으로 발생한 연골육종을 치험한 바 문헌고찰과 함께 보고하는 바이다. A case of Secondary Chondrosarcoma Arising from Solitary Osteochondroma of the Distal Femur Department of Orthopaedic Surgery, College of Medicine, DongGuk University Phil Hyun Chung M.D., Jung Su Hwang M.D., Suk Kang M.D., Yang Mln Kim M.D., Hyung Ho Oh M.D., Dong Ju Chae M.D., Jong Pil Kim M.D. Chondrpsarcoma is a malignant cartilage-forming tumor that grows slowly and metastasis of this tumor occurs in late stage. Secondary chondrosarcomas arising from a solitary osteocartilaginous exostosis are rare and those have a better prognosis than other chondrosarcomas, and they rarely metastasize. We present our experience with a case of secondary chondrpsarcoma arising in solitary osteochondroma of distal metaphysis of right femur with clinical details.

니세틸 정(아세틸 - 엘 - 카르니틴 500mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,오인준,이용복,임동구,문재동,심영순,김은아,정현철 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.1

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetile^(TM) (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^(TM) (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07±7.98 ㎏ in body weight, were divided into two groups and a randomized 2 × 2 cross-over study was employed. After one tablet containing 500 ㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_(max) and T_(max) were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_(max) and T_(max) between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^(TM) tablet. The powers (1-β) for AUC_t and C_(max) were 94.87% and 87.17%, respectively. Minimum detectable differences (△) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_(max), respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_(max), respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^(TM) tablet is bioequivalent to Nicetile^(TM) tablet.

서울 서남부지역 노인 인구에서 비만증 유병률과 고지혈증과의 상관성

최경묵,조영직,김경오,김동림,김난희,백세현,안정천,서홍석,오동주,최동섭 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.3

니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,김은아,정현철,심영순,임동구,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetiler^TM (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^TM (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07 7.98㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 94.87% and 87.17%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_max, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^TM tablet is bioequivalent to Nicetile^TM tablet.

당뇨병성 신경병증에서 근위부 비골신경전도 검사를 이용한 병태생리학적 접근

김동현,이강건,박종원,박태환,안병철,권오상 대한신경과학회 1998 대한신경과학회지 Vol.16 No.2

비장경색이 동반된 쯔쯔가무시병 1예

오종찬,이범주,장재현,원경준,박경희,김동민,박치영,정춘해 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Tsutsugamushi disease is an acute febrile illness caused by Orientie. tsutsugsmushi. It is characterized by fever, myalgia, lymphadenopathy, and rash. And it can be easily diagnosed by characteristic eschar and serologic testing. Nearly all of the patients with tsutsugamushi disease improve with antibiotics such as doxycycline. However, the fatality rate of untreated cases is seven to ten percent. Splenic infarction is not common disease which is caused by occlusion of the main splenic artery or any of its branches. It is mainly caused by emboli that arise from cardiovascular disease, but sometimes by regional thrombosis associated with leukemia, myeloproliferative disorder, sickle cell anemia, pancreatitis, splenic torsion and septicemia. We experienced one case of tsutsugamushi disease with splenic infarction, which was improved after doxycycline treatment finished.

우리나라 企業의 企業金融에 관한 硏究 : Laying Emphasis on the Fund Application 資本運用을 中心으로

吳東弦 제주대학교 1983 논문집 Vol.16 No.2

In general, Korean business enterprises have the poor factors that are stayed at relatively low level in efficiency of plant and equipment investment. Although it was inevitable owing to the boundary of the industrial policy of a light industry center, it was involved many problems in the process of propelling a heavy chemical industry. The typical examples bring about the unbalanced growth between the types of an industry, and also greatly decrease investment efficiency. Thus as it is lower efficiency investment of the big business centering a heavy chemical industry, it gives rise to waste of resoures and then, arises from declining investment in connection with a change for the worse of the business accounts. This investment efficiency that brings out the worse of the business accounts by unsoundness of the capital application repeats a vicious circle to the frailty of a capital structure. And also the propensity depended excessive creditor's capital is growing worse by the payability to a heavy burden of financial expenses. Besides, the loss of liguidity by a shortage of working capital appears on the primary factors obstructed the safty of business enterprises. Consequently, for solving the problems of the business fund application and achieving the long-range and continuous growth, we should make an every effort through a business by oneself as well as a government policy concern in the following. First, the drastic enlargement of the investment research development. Second, the inducement of an equivalent growth. Third, the investment for the high department of a related effect. Fourth, the central investment for a growing industry of comparative predominance.

다이아몬드용 자동연마기의 성능평가

오재국,김우순,김동현 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

The present study deals design and manufacture of automatic polishing machine that can cut diamond to have 58 facets in a brilliant cutting which has been hardly achieved by a conventional manually operating polishing machine. Upon the 3-dimensional Sarin M/C test and analysis on the diamond processed by the automatic polishing machine developed in this study its proportion and finishing turned out to be better than the diamond processed by the conventional method, by being rated as "very good".

우리나라 製造業의 資本調達動向과 財務構造에 관한 硏究

吳東弦 제주대학 1980 논문집 Vol.12 No.2

Economic growth a nation is achieved by a continuing equipment investments in business enterprise, and then raising funds requiring in its investments can be divided into the two ways of internal financing and external finaning. Internal financing means raising funds by the self-saving of a business like retained earning reserved inside a business after the distribution of net income, such as devidends, tax payments and so on, among profits of results into business activities. External financing spells raising funds through capital markets or money markets, when a business cannot be full enough to being only the self-financing reqiring funds. This external financing can be classified into direct and inderect financing, whether intervened of financial intermediaries or not. If we look into the structure of raising funds in the department of a corporative business, we could point out that the majority depended upon external financing because the ratio of self-financing was too low. It seems that such a condition was continued since the enlargement of investments was supported by making rapid progress of external financing according to favorably proceeding the plan of economic development. Next, indrect financing holds a high ratio among external financing. Especially, long-termloans from banks in indirect financing take a much share. A supply of funds in the advanced countries has been already in charge of important roles of financial intermediators of insurance, trust, short-term financing facilities, otherwise, it makes remarkable features different from that coutry in Korea. As the stated above, Korea has achieved a high growth of economy by flourishing equipment investments of business enterprises, and gone on quantitavely increasing savings, investments and financial trade. But in regard to the contents, being relatively too large for a degree of dependance of a overseas department, investment intermediareis in a domestic department shrunk up. Finally, such a difficulty make it'strong to be possibility of being appeared on the factors of final hindrance in lasting economic growth.

정신과 입원환자의 다음증에 관한 연구

오동열,서현주 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

본 연구는 첫째, 국립서울정신병원 입원환자의 다음증유병율과 그 측정방법에 관하여 알아보고 둘째, 다음증환자의 특성을 알아보기 위해 다음증군과 대조군의 임상특성 및 생물학적 지표를 비교하였다. 국립서울서울정신병원에 입원중인 환자 634명을 대상으로 다음의 진단 기준 (1)(2)(3)중 하나라도 만족시키는 환자를 다음증 환자로 결정하였다. (1) 치료진의 보고상 입원 중 다음증으로 인한 물중독의 삽화가 명백히 있는 경우 (2) 3회 연속 뇨비증이 1.008이하이면서 하루 3리터 이상의 물을 섭취하는 경우 (3) 3회 연속 뇨비증이 1.008이하이면서 혈중 나트륨 농도가 135mEq/L이하인 경우 위 진단기준을 만족시키는 환자는 총 24명으로 전체 환자의 3.79%였다. 다음증군 20명과 대조군 20명의 임상특성 및 생물학적 지표의 비교를 통하여 다음증 환자의 특성을알아보았다. 연구 결과는 다음과 같다. 1) 유병기간, 항정신병약물 용량, 경련, 전기경련치료, 흡연, 기타 약물 사용은 두 군간에 차이가 없었다. 2) 다음증군에서 대조군보다 뇨비증이 더 낮았고 물 섭취량이 더 많았다. 일중 체중변화(normalized diu-mal weight gain)는 두 군간에 차이가 없었다. 3) 다음증군에서는 혈중 항이뇨 호르몬(antidiuretic hormone 이하 ADH)이 정상범주에 들었으나 대조군에서는 정상범주보다 높았다. 또한 다음중군에서는 혈중능동삼투농동(osmolality 이하 Osm)가 정상범주보다 낮았으나 대조군은 정상범주에 들었다. 본연구의 결과를 전체적으로 종합한다면, 저자들의 진단기준에 따른 국립서울정신병원 입원환자의 다음증 유병율은 3.79%이며 다음증 측정방법으로 치료진의 보고, 뇨비증, 혈증 나트륨 농도, 물 섭취량의 측정 등을 제시할 수 있겠다. 그리고 다음증군과 대조군의 비교에서 유병기간, 항정신병약물 용량, 경련, 전기경련 치료, 흡연, 기타 약물 사용 등의 임상특성의 차이는 없었으나 뇨비증, 물 섭취량, 혈중 ADH와 Osm 같은 생물학적지표는 분명한 차이를 보임으로서 다음증군의 특성을 나타낸다고 할 수 있겠다. We attempted to estimate the prevalence of polydipsia in psychiatric inpatients in Seoul National Mental Hospital and to find out the identification method for polydipsic patients. We also compared the clinical and biological characteristics of polydipsic patients with those in nonpolydispic patients. Methods &Results : The following inclusion criteria were applied to the study subjects for estimating the prevalence of polydipsia among psychiatric inpatients at Seoul National Mental Hospital. 1) By staff report, that a objective clinical evidence of water intoxication during hos-pitalization was noted. 2) Three consecutive urine specific gravities were all less than 1.008 and also water intake was more than 3 liters per day. 3) Three consecutive urine specific gravities were all less than 1.008 and also serum sodium level was less than 135 mEq/L. By these inclusion criteria, we found 24 polydipsic patients among 634 hospitalized psychiatric inpatients, with the prevalence of 3.79%. Comparison of the clinical characteristics and biological determinants between 20 polydipsic and 20 nonpolydipsic patients produced the following results : 1) No differences were found in duration of illness, dosage of neuroleptics, seizure history, electroconvulsive therapy history, smoking, use of medications other than neuroleptics, between the groups. 2) There was no difference in normalized diurnal weight gain. But polydipsic patients showed more water intake and lower urine specific gravities than nonpolydipsic ones. 3) Plasma antidiuretic hormone levels were within normal range and osmolalities were lower than normal range in polydipsic patients. BUT plasma antidiuretic hormone levels were higher than normal range and osmolalities were within normal range in nonpolydipsic patients. Conclusion : The prevalence of the polydipsia was 3.79%. We suggest that staff report, urine specific gravity, serum sodium level, and oral water intake can be identification markers for polydipsta. Clincal characteristics such as duration of illness, dosage of neuroleptics, seizure history, electroconvulsive therapy history, smoking, and use of medications other than neuroleptics did not differ between polydipsic and nonpolydipsic patients. But biological determinants such as urine specific gravity, oral water intake, plasma antidiuretic hormone level, and osmolality differed beween the groups. Therefore these biological determinants could be adopted as biological markers for polydipsia.